• Mass Spectrometry Letters
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• v.13 no.1
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• pp.20-25
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• 2022

Fargesin, a tetrahydrofurofuranoid lignan isolated from Flos Magnoliae, shows anti-inflammatory, anti-oxidative, anti-allergic, and anti-hypertensive activities. To evaluate the pharmacokinetics of fargesin in mice, a sensitive, simple, and selective liquid chromatography-high resolution mass spectrometric method using electrospray ionization and parallel reaction monitoring mode was developed and validated for the quantification of fargesin in mouse plasma. Protein precipitation of 6 µL mouse plasma with methanol was used as sample clean-up procedure. The standard curve was linear over the range of 0.2-500 ng/mL in mouse plasma with the lower limit of quantification level at 0.2 ng/mL. The intra- and inter-day coefficient variations and accuracies for fargesin at four quality control concentrations including were 3.6-11.3% and 90.0-106.6%, respectively. Intravenously injected fargesin disappeared rapidly from the plasma with high clearance values (53.2-55.5 mL/min/kg) at 1, 2, and 4 mg/kg doses. Absolute bioavailability of fargesin was 4.1-9.6% after oral administration of fargesin at doses of 1, 2, and 4 mg/kg to mice.

• Journal of Microbiology and Biotechnology
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• v.30 no.3
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• pp.378-381
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• 2020

Fermentation has recently re-emerged as an approach for improved functionality of food products in addition to the traditional roles such as shelf life, taste, and texture. Here, we report dynamic changes in the metabolite profiles of Achyranthes japonica Nakai by Lactobacillus plantarum fermentation, primarily, the significant increases in representative functional ingredients, 20-hydroxyecdysone and 25S-inokosterone. Additionally, untargeted metabolite profiling showed 58% of metabolites underwent significant alteration. The most dynamic change was observed in cellobiose, which showed a 56-fold increase. Others were sugar alcohols and amino acids, while lyxitol and erythritol that were among the most dynamically down-regulated.

• Proceedings of the Korea Concrete Institute Conference
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• 2004.05a
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• pp.204-207
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• 2004

In this paper, mechanical properties of the high strength lightweight self-compacting concrete with simple mixed design method was investigated. Experimental tests were performed as such compressive strength, splitting tensile strength, modulus of elasticity and density of high strength lightweight self-compacting concrete. The 28 days compressive strength of high strength lightweight self-compacting concrete with the LC replacement ratio of $100\%$ reduces about $31\%$ but LF replacement ratio of $100\%$ increase about $20\%$ compared that of the control concrete. The structural efficiency of high strength lightweight self-compacting concrete increase with proportional to the replacement into of LF. The relationship between the splitting tensile strength and 28 days compressive strength can be represented by the equation $f_s=0.076f_{ck}+0.5582$. The modulus of elasticity was found to be lower than that of normal weight concrete, ranging form 24 to 33 GPa.

• Proceedings of the KIEE Conference
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• 1994.07a
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• pp.379-381
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• 1994

This paper is concerned with a zero-voltage soft-switching PWM DC-DC high-pelter converter using IGBTs, which Bakes the most of the parastic LC parameters of high-voltage transformer link, for diagnostic X-Ray power generator. The converter circuit basically utilizes phase-shift pulse width modulated series resonant full-bridge PWM DC-DC high-Power converter operating at a constant frequency:20kHz. This technique brings about dramatic decreases in the switching losses of power devices and their electrical stresses as compared with the commonly-used hard-switching PWM DC-DC power converter. The high-frequency switching operation of the converters has some effective advantages, which consist in the physical reduction in size and weight and lowered acoustic noise.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.17 no.3
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• pp.311-318
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• 2004

We have studied electro-optic characteristics as a function of pretilt angle ($\theta$$_{p}$) in the fringe-field switching (FFS) mode using the LC with positive dielectric anisotropy. When $\theta$$_{p}$ is increased from 0$^{\circ}$ to 20$^{\circ}$, a maximum transmittance and an operating voltage are obviously decreased. In the viewing angle characteristics, the cell with low pretilt angle has a wide region for the contrast ratio greater than 5 and has a best luminance uniformity. Therefore, in the FFS device, a low pretilt angle is favored for high transmittance and wide viewing angle.gle.

• Advances in Traditional Medicine
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• v.7 no.4
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• pp.385-389
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• 2007

We undertook the present study to evaluate different pharmacological as antioxidant, antibacterial and cytotoxic activities of the crude ethanolic extract of Momordica charantia (Family: Cucurbitaceae) leaves. The antioxidant property of the extract was assessed by 1, 1-diphenyl-2-picryl hydrazyl free radical scavenging assay. The extract showed antioxidant activity where $IC_{50}$ was about ${\sim}500{\mu}g/ml\;and\;IC_{50}$ was about ${\sim}10{\mu}g/ml$ for standard drug ascorbic acid. The extract showed a broad spectrum of antibacterial activity against all the tested gram positive and gram-negative bacteria where Staphylococcus epidermidis, Staphylococcus aureus, Salmonella typhi and Shigella dysenteriae were prominent. And the zones of inhibition were ranging from 8-15 mm for all the tested bacteria. Its cytotoxic property was evaluated by brine shrimp lethality bioassay. The extract showed significant lethality and the $LC_{50}$ value was $20{\mu}g/ml$.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.283-286
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• 1999

A 2㎓, low noise, low power CMOS voltage-controlled oscillator (VCO) with an integrated LC resonator is presented. The design of VCO relies heavily on the on-chip spiral inductor. An optimized spiral inductor with Q-factor of nearly 8 is achieved and used for the VCO. The simulated result of phase noise is as low as -l14 ㏈c/Hz at an offset frequency of a 600KHz from a 2㎓ carrier frequency. The VCO is tuned with standard available junction capacitors, resulting in an about 400MHz tuning range (20%). Implemented in a five-metal 0.25${\mu}{\textrm}{m}$ standard CMOS process, the VCO consumes only 2㎽ from a single 2.5V supply. It occupies an active area of 620${\mu}{\textrm}{m}$$\times$720${\mu}{\textrm}{m}$.

• Carbon letters
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• v.13 no.4
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• pp.226-229
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• 2012

Polyacetylene (PA) films with vertically aligned fibril morphology were synthesized in homeotropic nematic liquid crystal (N-LC) solvent by using a magnetic field of 5 Tesla as an external perturbation. Scanning electron microscope (SEM) photographs indicated that the lengths of fibrils from the substrate were $5-35{\mu}m$, depending on polymerization time. Carbonization was carried out using iodine-doped PA film and a morphology-retaining carbonization method. From the SEM results, we confirmed that the vertical morphology of the PA remains unchanged even after carbonization at $800^{\circ}C$. The weight loss of the films due to carbonization at $800^{\circ}C$ is about 20% of the weight of the film before iodine doping. It is expected that vertically aligned carbon might be a precursor for preparing vertical graphite materials, which materials could be useful for electrochemical energy storage and cell electrodes.

• Proceedings of the Acoustical Society of Korea Conference
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• autumn
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• pp.251-254
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• 2001

본 논문에서는 ETRI와 연세대가 공동 개발한 AAC/MP3 복합 복호화기 ASIC 칩을 이용한 AAC/MP3 오디오 플레이어의 설계 및 구현에 대해 기술한다. 본 논문에서 사용한 AAC/MP3 복합 복호화 ASIC Chip은 20비트 고정소수점 DSP 코어를 이용하여 MP3와 MPEG-2 AAC LC 프로파일을 복호화하며, MPEG-2 AAC 메인 프로파일을 실시간으로 복호화하기 위하여 허프만 복호화 과정과 예측 과정은 전용 하드웨어 모듈을 이용하였다 이를 이용한 오디오 플레이어는 AAC/MP3 파일 재생 기능, USB를 이용한 호스트 PC와의 인터페이스 기능, Flash 메모리와의 인터페이스 기능 등의 특성을 갖는다.

• Proceedings of the KIPE Conference
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• 2006.06a
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• pp.149-151
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• 2006

고주파 유도가열은 무공해 에너지 절약을 기본으로 하는 전기가열의 한 방법으로 환경 친화와 에너지 절감에 많은 기대를 하고 있다. 본 논문에서는 절연체 용기내에 특수 발열체 부하를 수납하여 외부의 코일과 비접촉상태로 전자유도에 의해 와전류를 발열체에 흘림으로서 발열하게 되는 새로운 방식을 제안하였다. 설계한 인버터는 스위칭 주파수 20[kHz] 대역에서 작동되는 고주파 직렬 부하 공진형이며 LC 공진 설계에서 L을 부하로 설정하여 효율을 최대화 하였다.