• The Korea Journal of Herbology
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• v.33 no.4
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• pp.53-58
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• 2018

Objectives : Kaempferia parviflora Rhizome is black ginger indigenous to Laos and Thailand. It has been used as a folk medicine to improve blood flow and promote vitality and longevity with good health and well being. For these reasons, Kaempferia parviflora Rhizome has been focused on developing it as a food or food supplement. In addition, Kaempferia parviflora Rhizome could be under consideration of new prescription based on its characteristic compounds, polymethoxyflavonoids. However, it needs to be certified as safe before it can be used. Here, a single-oral toxicity test and safety classification was carried out to identity acute information of the toxicity of Kaempferia parviflora Rhizome powder and to make sure of its safety in clinical applications. Methods : Test substance was orally administered to male and female SD-rat at dose levels of 5000 mg/kg to estimate approximate lethal dose(ALD). Based on the acute information of the toxicity, the safety classification was estimated using the HED(human equivalent dose)-based MOS(margin of safety). Results : At 14 days after treatment with test substance. there were no of test substance related with mortalities and clinical signs. In addition, no changes in the body or organ weights and no gross or histopathological findings were observed. Thus, the ALD of Kaempferia parviflora Rhizome powder was considered over 5,000 mg/kg in both female and male mice. Conclusions : Based on the single oral toxicity test using the highest and limit dose, 5,000 mg/kg and the decision guideline for safety classification based on HED-based MOS, it was estimated that Kaempferia parviflora Rhizome powder is classified as "Specified class B" indicating that clinical dose is not limited to patients as safe as food.

• Journal of Korean Public Health Nursing
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• v.35 no.2
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• pp.268-282
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• 2021

Purpose: This study sought to investigate health behavior (HB) and its affecting factors based on Anderson's behavioral model in Lao People's Democratic Republic (PDR). Also, it attempted to identify the mediation of the health locus of control (HLC) between HB and the affecting factors. Methods: Secondary data from 694 people without noncommunicable diseases (NCDs) from a survey conducted by the Ewha Womans and the Laos University were used. The measurements included predisposing, enabling, and needs factors, HLC, HB (current non-smoking, low-risk drinking, physical activity, fruit and vegetable consumption, medical checkup). The mediating effect was analyzed using Baron and Kenny's method and the Sobel test. Results: Predisposing (gender, educational level, ethnic), enabling (social support, item ownership in household) and the needs factors (body mass index) were affecting HB. Internal HLC had a positive influence on HB. The stronger the others and chance HLC, the lower the HB. Chance HLC mediated the relationship between the educational level and HB. Conclusion: There is a need to recognize the importance of chance HLC as a mediator between the educational level and HB. Through this result, high-quality nursing education for the prevention of NCDs should be developed considering the impact of chance HLC.

• Composites Research
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• v.35 no.3
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• pp.153-160
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• 2022

Cellulose nanofibrils (CNF) based on wood pulp fibers are gained much attention as part of biocompatible hydrogels for biomedical applications such as tissue engineering scaffolds, biomedicine, and drug carrier. However, CNF hydrogels have relatively poor mechanical properties, impeding their applications requiring high mechanical integrity. In this work, we prepare 2,2,6,6-tetramethylipiperidin-oxyl (TEMPO) oxidated cellulose nanofibrils hydrogels mediated with metal cations, which form the metal-carboxylate coordination bonds for enhanced mechanical strength and toughness. We conduct the large amplitude oscillatory shear (LAOS) test and Live/dead cell assay for obtaining nonlinear viscoelastic parameters and cell viability, respectively. In particular, the cell proliferation and viability change depending on the type of metal salt, which also affected the rheological properties of the hydrogels.