• Journal of Pharmaceutical Investigation
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• v.4 no.1_2
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• pp.7-12
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• 1974

The isolative determination of 4-Morpholine carboximidoylguanidine Hydrochloride in the ophthalmic solutions was examined by means of colorimetric method using oxidized nitroprusside and sodium hypobromite. According to the results, the following could be summerzied. 1) The wave length of maximun absorption in $650\;m{\mu}$. 2) Beer's Lew is obeyed for $20{\sim}80\;mcg/ml$ in colored solutions. 3) Absorptions of colored solutions must be measured 5 minutes after the addition of oxidized and 5 minutes after the completion of sodium hypobromite. 4) 4-Morpholine carboximidoylguanidine hydrochloride can be determined within standard deviation 2.0%.

• Archives of Pharmacal Research
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• v.13 no.2
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• pp.166-173
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• 1990

The structure of the anti-inflammatory agent, naproxen sodium was determined by single crystal X-ray diffraction analysis. Crystal of the compound, which was recrystallized from methanol solution, is nomoclinic, space group $P2_1$ with a = 21. 177(6), b = 5.785(2), c = 5.443(2) $\AA, \beta$ = 91.41(3)$\{\circ}$ and Z = 2. The calculated density is 1.346; the observed value is nements based on 1093 reflections ($F\geq3\sigma$(F)) gave the final R value of 0.043. There are of one water per one compound molecule in the crystal. The carboxyl group of the molecule is nearly perpendicular to the naphthalene ring. The molecules are arranged along with the screw axis, and stabilized by five 0...Na type interactions. The molecule retains nearly same dimensions and similar conformation compared to its parent compound, naproxen, except for the torsion angles around C(5)-C(11) bond.

• Archives of Pharmacal Research
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• v.16 no.2
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• pp.123-128
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• 1993

The surface of cyarabine-entrapped albumin microspheres, the surface modified albumin microspheres hsowed remakably incrased hydrophilicity, good dispersability in aqueous medium and reduced aggregation during storage which met the requirements of injectable drug carriers in acqueous vehicle. In vitro cytarabine release from hydrophilic albumin microspheres (HAM) was a function of the cytarabine to albumin ratio, whereas no significant difference in the releasing capacity was obnserved between surface modified HAM within the small size range$(2\;to\;5\mu{m)}$ studied. HAM containing 15-23% drug were gradually degraded by protease and continuously released up to 60% of the total entrapped cytarabine for 6h. These results thus suggest that HAM is a suitable cytarabine carrier which may be injected intraveneously with the benefits of a reduced risk of blood embolism induced by aggregates and prolonged cytarabine release.

• Bulletin of the Korean Chemical Society
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• v.14 no.6
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• pp.678-681
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• 1993

The new ternary phase $UP_2S_6$ has been prepared and structurally characterized. The compound is isostructural with $ZrP_2S_6$ and $ThP_2S_6$ but is different from $TiP_2S_6$. The structure has been determined by a single crystal X-ray diffraction technique. $UP_2S_6$ crystallizes in the the tetragonal system $({C^2}_{4h}-P4_2/m,\;a=6.797(7)\;{\AA},\;c=9.738(12)\;{\AA})$ with two formula units in the unit cell. The structure can be described in terms of $U^{4+}$ and ${P_2S_6}^{4-}$ ions. This hexathiohypodiphosphate anion $({P_2S_6}^{4-})$ has ideally staggered conformation. The $U^{4+}$ cation is coordinated by 8 sulfur atoms in a slightly distorted dodecahedral geometry (42m). The distribution of sulfur atoms is very well optimized for this geometry.

• Journal of the Korean Institute of Telematics and Electronics
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• v.23 no.5
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• pp.681-691
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• 1986

To represent the relations of the data dependency and resource conflict among micro-operations(MOP's) in the compaction process of microprograms, we propose a DDM (data dependent matrix) representation method instead of the DAG (conventional directed acyclic graph). Also, we propose a global compaction algorithm of microprograms to prevent a kind of block copying by cutting the trace at a junction block. The DDM method and compaction algoristhm have been applied to the Lah's example. The results shows that the proposed algorithm is more efficient than the conventional algorithms in reducing in reducing the total execution time and control memory space.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.6.1-6.19
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• 2022

Chimeric antigen receptor (CAR) T cells, which express a synthetic receptor engineered to target specific antigens, have demonstrated remarkable potential to treat haematological malignancies. However, their transition beyond haematological malignancy has so far been unsatisfactory. Here, we discuss recent challenges and improvements for CAR T cell therapy against solid tumors: Antigen heterogeneity which provides an effective escape mechanism against conventional mono-antigen-specific CAR T cells; and the immunosuppressive tumor microenvironment which provides physical and molecular barriers that respectively prevent T cell infiltration and drive T cell dysfunction and hypoproliferation. Further, we discuss the application of CAR T cells in infectious disease and autoimmunity.

• The Journal of the Korea Contents Association
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• v.9 no.11
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• pp.262-270
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• 2009

$^{18}F$-mefway has been developed as radioligand for serotonin receptor 5-$HT_{1A}$. The object of this study was to obtain the mefway precursor with the higher yield than previous method and to identify whether $^{18}F$-mefway can bind to 5-$HT_{1A}$ or not. from microPET imaging of small animal brain. Precursor was prepared by a modification of the reported procedure then [$^{18}F$] labeling was performed by adding $^{18}F$ ion at $130^{\circ}C$ in the hot cell for 30min. After purification of reaction mixture using alumina Sep-pak and HPLC, microPET images of small animal brain were determined. The chemical yield of precursor was increased from 9% to 34% using oxalyl chloride and LAH/diethylether. We synthesized a precursor which was successfully labeled with no-carrier-added $^{18}F$-by new synthetic route. This research suggest that $^{18}F$-mefway will be used a radiopharmaceutical for evaluation of central nerve system disorder as imaging a gent for 5-$HT_{1A}$ receptor.

• The korean journal of orthodontics
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• v.26 no.3
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• pp.247-254
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• 1996

This study was performed to evaluate the hyoid bone position and airway in skeletal class III malocclusion and to prove the correlation between airway, hyoid bone position and mandibular position. The sample, considered of 47 class III malocclusion patients for experimmtal group and 52 class I malocclusion students for control group. Twenty three linear and angular measurements about hyoid bone position, airway size, mandibular position were taken from the lateral cephalograms. The differences between skeletal class III malocclusion group and normal occlusion group were compared and the correlation were evaluated statistically. The results obtained were as follows, 1. There were significant difference in S-APH, A-APH, N-APH, LAH-PBR, AA-PNS, PNS-ad between class I and class III malocclusion groups. 2. The hyoid bone was more anteriorly positioned in class III malocclusion group than class I malocclusion group and skeletal airway size in class III malocclusion group was smaller than class I malocclusion group. 3. There were significant difference in several measurements especially vertical and angular measurements of hyoid bone position and airway size between male and female. Usually the measurements in male were larger than female. 4. There were no significant correlation between hyoid bone position and airway size also airway size, and didn't showe significant correlation with mandibular position, 5. S-APH showed negative correlation with Wits appraisal and A-APH, N-APH showed positive correlation with Wits appraisal. On the contrary vertical measurements of hyoid bone position showed positive correlation with lower facial height.

• Bulletin of the Korean Chemical Society
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• v.23 no.1
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• pp.98-102
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• 2002

The structure of a single crystal, grown by a slow cooling a melt of $Ca_{1.29}Bi_{0.14}VO_4$ composition, was analyzed. The crystals belong to the rhombohedral space group R3c and the dimensions of the unit cells are a = 10.848(1)${\AA}$, c = 38.048(6)${\AA}$, V = 3877.6(8)${\AA}^3$ for the pale yellow crystal, and a = 10.857(1), c = 38.063(6)${\AA}$, V = 3885.6(8)${\AA}^3$ for the yellow crystal, respectively. Unit cell dimensions of the crystal were larger than those of the host crystal, $Ca_3(VO_4)_2$, owing to the Bi that replaced Ca in the unit cell. Ca in the unit cell formed six, eight and nine coordinated polyhedra with O atoms and Bi replacing Ca entered the eight or nine coordinated Ca sites with different crystallographic environments in the unit cell. All the V in the unit cell formed four coordinated tetrahedra with O atoms, however V-O bond lengths in the tetrahedra were different from one another.

• Bulletin of the Korean Chemical Society
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• v.27 no.10
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• pp.1597-1600
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• 2006

The mononuclear iron complex 1, $Fe^{III}$(Hbida)Cl($H_2O$), was synthesized using a tripodal tetradentate ligand, N-(benzimidazol-2-ylmethyl)iminodiacetic acid (H3bida), which has two carboxylate groups, one benzimida- zoyl group, and one tertiary amine where it serves as a tetradentate chelating ligand for the octahedral Fe(III) ion. The four equatorial positions of the octahedral complex are occupied by two monodentate carboxylates, a benzimidazole nitrogen, and an oxygen of a water molecule. One of the axial positions is occupied by an apical nitrogen of the Hbida and the other by a chloride anion. The mononuclear octahedral complex 1 mimics the geometry of the key intermediate structure of the catalytic reaction cycle proposed for the FeSODs, which is a distorted octahedral geometry with three histidyl imidazoles, an aspartyl carboxylate, a superoxide anion, and a water molecule. The redox potential of complex 1, $E_{1/2}$ is -0.11V vs. Ag/AgCl (0.12 V vs. NHE), which is slightly lower than those reported for the most FeSODs. The magnetic susceptibility of complex 1 at room temperature is 5.83 $\mu$B which is close to that of the spin only value, 5.92 $\mu$B of high-spin d5 Fe(III).