• Korean Journal of Medicinal Crop Science
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• v.15 no.2
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• pp.89-94
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• 2007

The effects of angiogenesis inhibitor from the extract libraries of Korean and Chinese medicinal plants were investigated using a protein microarray chip. Protein chip was constructed by immobilization of integrin ${\alpha}_5{\beta}_1$ on protein chip base plates and employed far screening active extracts that inhibit the integrin-fibronectin interaction from the extract libraries. The 100 extracts of medicinal plants were obtained from extract bank of National Institute of Crop Science, RDA. The 14 extracts among 100 extract libraries were shown efficient inhibition activity for the interaction between integrin-fibronectin. The medicinal plants of 14 extracts were Vitex negundo var. incisa (Lam.) C.B. Clarke, Epimedium koreanum Nakai, Cedrela sinensis A. Juss, Ipomea aquatica Forsk, Schisandra chinensis Baill, Pulsatilla koreana Nakai, Paeonia lactiflora Pall. var.hortensis Makino, Oenothera odorata, Allium chinense, Allium victorialis var. platyphyllum MAKINO, Polygonatum odoratum Druce var. pluriflorum Ohwi, Hosta lancifolia, Agrimonia pilosa L. var. japonica Nakai and Potentilla chinensis SER. The Paeonia lactiflora, Oenothera, and Agrimonia pilosa from these 14 extracts libraries were shown strong inhibition activity of integrin ${\alpha}_5{\beta}_1$.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.4
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• pp.470-473
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• 2000

The experiment was carried out to evaluate the effect of varying levels of flaked com abomasally infused on energy metabolism and nitrogen metabolism in fattening steers. The starch levels of flaked corn of abomasally infused were 0, 300, 600 and 900 g/d. Four mature fattening steers fitted with permanent abomasum cannulas were allocated to a $4{\times}4$ Latin square design were fed at 1.2 maintenance requirement a basal diet of Chinese wildrye (Aneurolepidium Chinense). Compared with 0 g/d (control group), digestible nitrogen, retention nitrogen (RN, g/d) and the efficiency of digestible nitrogen converted into retention nitrogen (RN/DN, %) of 300, 600 and 900 g/d groups were higher (p<0.05). The post-ruminal starch digestion of flaked corn were 71.36, 80.27 and 64.71 % when the amounts abomasally infused were 300, 600 and 900 g/d, respectively. When the amount of starch abomasally infused was more than 600 g/d, the post-ruminal digestion of starch decreased. 300, 600 and 900 g/d starch infusion groups showed higher metabolizable energy intake (ME) and net energy gains (NEg, MJ/d) than the control group, and the efficiencies of metabolizable energy converted into body weight (Kf, %) of these groups were higher than the control group by 38.31, 73.18 and 67.06% (p<0.05). Kf (Y, %) had a positive curved relation to starch of flaked com abomasally infused (X, g/d), $Y=36.1605X^{0.0760}$ (n=16, r=0.9308).

• The Korean Journal of Food And Nutrition
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• v.25 no.3
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• pp.513-520
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• 2012

This research was planned and executed to evaluate how the composition of Yack-sun tea can affect the health conditions of people who are suffering from diet-related such as being overweight, are obese and have hyperlipidemia, by taking Yack-sun tea in a form of a nutritional supplement with our daily meals. We produced Kangjieum with Lycium chinense Mill., Polygonum multflorum Thunb, Cassia tora L., Crataegus pinnatifida Bge and Salvia miltiorrhiza Bge. Thus, we approach of oriental diet therapy area research of Kangjieum and analysis proximate composition, water soluble antioxidant content. The content(%, dry basis) of total carbohydrate was 60.23%, crude protein was 18.18%, crude ash was 11.36% and crude fat was 10.23% in Kangjieum. Total water soluble antioxidant content was 1.027 ${\mu}g/m{\ell}$ of Kangjieum. We think that scientific and objective evaluation was done on the components of the Kangjieum prescription. This basic data could help guide the application of oriental medicinal resources into other foods and serve as a stepping-stone for use of Kangjieum in the burgeoning field of nutraceutical foods. Last, the scientific effects of oriental medicinal foods developed according to oriental medicinal theory. This theory is believed to be essential for government policy development concerning validation of medicinal effects and assessment, with the aim of fostering systematic development and providing guidance to food development in the interest of national health.

• Korean Journal of Plant Resources
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• v.28 no.4
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• pp.475-486
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• 2015

This survey was conducted in order to investigate the vascular plants of Hak Reservoir Valley in the DMZ Area, Korea. The vascular plants were collected six times (from April 2014 to November 2014) and consisted a total of 238 taxa; 69 families, 172 genera, 206 species, 2 subspecies, 26 varieties and 4 forms. The observed rare plant species as designated by Korea Forest Service were 3 taxa including Carex capricornis Meinsh. ex Maxim., Acorus calamus L., Penthorum chinense Pursh. Endemic plant species were 2 taxa including Salix koriyanagi Kimura, Clematis brachyura Maxim. 17 taxa were listed as specific plant species based on phytogeographical in the investigated area. 25 taxa were recorded as naturalized plants, and their Naturalization Ratio and Urbanization Index were recorded as 10.46%, and 7.78%, respectively. Of the 238 taxa listed; 105 were pasturing plants, 92 edible plants, 76 medicinal plants, 24 ornamental plants, 6 stain plants, 4 timber plants, 2 fiber plants, 2 industrial plants and 55 unknown plants.

• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.4
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• pp.550-555
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• 2013

Extrinsic skin aging is characterized by the loss of skin tone and resilience, irregular pigmentation, and deep wrinkles. The aim of this study was to investigate the effects of Ehwa Makgeolli containing oriental herbs (Glycyrrhiza uralensis Fisch., Lycium chinense MILL., Morus alba L., and Saururus chinensis Baill) on skin whitening and wrinkling in human skin cells. We prepared Makgeolli extracts (HEE) with 70% ethanol. HEE significantly inhibited in vitro mushroom tyrosinase activity and reduced the cellular and secreted melanin content of mouse melanoma melanocytes (B16F1 cells). HEE down-regulated the protein expression of tyrosinase related protein (TRP)-1/-2, a key player in melanogenesis. Treatment with HEE in human keratinoctyes (HaCaT cells) inhibited the proteolytic activities of matrix metalloproteinase (MMP)-2/-9 in a dose-dependent manner and dramatically reduced the expression of MMP-2/-9. In addition, HEE attenuated lipopolysaccharide (LPS)-induced nitric oxide production in murine macrophages (RAW264.7 cells). These results indicate that HEE may be a great cosmeceutical ingredient for its whitening, anti-wrinkle, and anti-inflammatory effects.

• Korean Journal of Environment and Ecology
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• v.29 no.3
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• pp.309-332
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• 2015

To investigate the distribution of vascular plants growing in Mt. Taebaeksan, a survey was conducted from April, 2014 to October, 2014. The flora of Mt. Taebaeksan was classified as a total of 406 taxa comprising of 79 families, 238 genus, 352 species, 4 subspecies, 43 varieties and 7 forma. Among them, 8 taxa were identified as endemic plants in Korea including Salix koriyanagi Kimura, Aconitum pseudolaeve Nakai, Anemone koraiensis Nakai, etc. 16 taxa of Korean rare plants species were identified including 4 taxa in the degree of VU (Asplenium spinulosum (Maxim.) Milde, etc.) and 12 taxa in the degree of LC (Clematis koreana Kom., Eranthis stellata Maxim., Aristolochia manshuriensis Kom., etc.) The floristic special plants were a total of 107 taxa which consist of 3 taxa in degree V(Polypodium virginianum L., etc.), 14 taxa in degree IV(Asplenium otophorum (Miq.) Koidz., etc.), 31 taxa in degree III (Abies nephrolepis (Trautv.) Maxim., etc.), 32 taxa in degree II(Lycopodium chinense H.Christ, etc.) and 27 taxa in degree I(Dryopteris crassirhizoma Nakai, etc.). For the naturalized plants, 16 taxa were identified (Fallopia dumetorum (L.) Holub, Rumex crispus L., Cerastium glomeratum Thuill). Also, the percentage of urbanization index was 5 %, and the naturalized plant index was 3.9 % respectively.

• Journal of the Korean Society of Food Science and Nutrition
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• v.37 no.12
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• pp.1554-1559
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• 2008

This study was performed to investigate the hypoglycemic effect of single and repeated oral administration of medicinal herbal mixture (AD) in streptozotocin (STZ) induced diabetic rats. Angelica decursiva, Lycium chinense and Adenophora triphylla var. japonica Hara were selected by oral glucose tolerance test (OGTT) and mixed for AD mixture. In an oral glucose tolerance test, the AD inhibited the increase in blood glucose levels at 1 hr and 2 hr and decreased incremental glycemic response area under the curve. In a single administration of AD1 (100 mg/kg) and AD2 (500 mg/kg), significant reductions by 5.3% and 12.3% were observed in fasting blood glucose level for 4 hours. During the 1 month of the experimental period, AD1 and AD2 was given to the STZ induced diabetic rats. At 4th week, the fasting blood glucose levels of AD1 and AD2 caused a fall of 25.5% and 37.9%, respectively. In addition, the body weights were decreased by 7.7% (AD1) and 1.7% (AD2), respectively, compared with diabetic control (DC, decreasing of 10.2%). This study suggests that AD could be potentially useful for fasting and post-prandial hyperglycemia treatment and all these effects concluded to the use of this plant extract to manage diabetes mellitus.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.9
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• pp.1476-1485
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• 2004

Of solvent-extracts prepared from the 90 kinds of Korean traditional tea and rice gruel plants, cold-water extract from peels of Citrus unshiu (CUI-0) showed the most potent intestinal immune system modulating activity through Peyer’s patch whereas other extracts did not have the activity except for cold-water extracts of Laminaria japonica, Polygonatum japonicum, Poncirus trifoliata, and hot-water extracts of Gardenia jasminoides, Lycium chinense having intermediate activity. CUI-0 was further fractionated into MeOH-soluble fraction (CUI-1), MeOH insoluble and EtOH-soluble fraction (CUI-2), and crude polysaccharide fraction (CUI-3). Among these fractions, CUI-3 showed the most potent stimulating activity for the proliferation of bone marrow cells mediated by Peyer’s patch cells, and contained arabinose, galacturonic acid, galactose, glucose, glucuronic acid and rhamnose (molar ratio; 1.00:0.53:0.45:0.28:0.28:0.19) as the major sugars, and a small quantity of protein (9.4%). In treatments of CUI-3 with pronase and periodate (NaIO₄), the intestinal immune system modulating activity of CUI-3 was significantly reduced, and the activity of CUI-3 was affected by periodate oxidation particularly. The potently active carbohydrate-rich fraction, CUI-3IIb-3-2 was further purified by anion-exchange chromatography on DEAE-Sepharose FF, Sepharose CL-6B and Sephacryl S-200. CUI-3IIb-3-2 was eluted as a single peak on HPLC and its molecular weight was estimated to be 18,000 Da. CUI-3IIb-3-2 was consisted mainly of arabinose, galactose, rhamnose, galacturonic acid and glucuronic acid (molar ratio;1.00:0.54:0.28:1.45:0.63) in addition to a small amount of proteins (3.2%). In addition, CUI-3IIb-3-2 showed the activity only through Peyer’s patch cells, but this fraction did not directly stimulate proliferation of bone marrow cells. It may be concluded that intestinal immune system modulating activity of peels from C. unshiu is caused by pectic polysaccharides having a polygalacturonan moiety with neutral sugars such as arabinose and galactose.

• Journal of the East Asian Society of Dietary Life
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• v.25 no.5
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• pp.791-805
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• 2015

Foxtail millet (Setaria italica L. Beaur) is a native Korean herbal medical food and a native millet, and Koreans have eaten it as a substitute for rice since ancient times. Foods using foxtail millet (Setaria italica L. Beaur) have been recorded not only in cookbooks but also in Korean traditional medical books several times. Therefore, the purposes of this study was to investigate Food-Therapy (食治) using foxtail millet (Setaria italica L. Beaur) recorded in the literature from 1300 to 1600 from early to mid-Joseon (朝鮮) and provide data required to develop menus for Yaksun (藥膳, herbal food). This study examined Food-Therapy using foxtail millet (Setaria italica L. Beaur) in 10 types of literatures from the 1300s to the 1600s. and is described in the literature a total of 63 times. According to classification by cooking method, porridge (粥) was most frequently mentioned in the literature at 27 times. The cooking method of Soup (湯) is described 11 times. Cooking methods such as porridge juice and soup are frequently used since those methods are digestive and absorptive. Other food ingredients described using foxtail millet (Setaria italica L. Beaur) are white leek (Allii Fistulosi Bulbus) ginger (Zingiber officinale), chicken egg, Allium chinense, sparrow (Passer montanus), rooster liver, Du-si, crucian carp (Carassius auratus L), and white broiler. Other medicinal herbs described with Setaria italica are Panax ginseng (人蔘), Poria cocos (茯笭), Angelica acutiloba (當歸), Ziziphus jujuba (大棗), Liriopeplatyphylla (麥門冬), and cinnamon (肉桂). Food-Therapy using Setaria italica L. Beauv was described as a prescription for stomach and spleen (脾胃), stomach reflux (反胃), defecation and urinary disorder (大小便難), cholera, deficiency syndrome (虛症), and tonification (補益). This focus on promoting health and preventing diseases by strengthening the stomach and spleen and improving defecation and urination using Food-Therapy when herbal medicine was rare.

• Journal of the Korean Society of Food Science and Nutrition
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• v.39 no.9
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• pp.1257-1262
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• 2010

This study investigated the anti-diabetic effects of the mixed water extract (JDG 100) composed of Lycii Cortex, Acanthopanax senticosus and Cordyceps militaris on glucose-regulating key enzymes such as glucokinase (GK), acetyl-CoA carboxylase (ACC). In the current study, HepG2 cells were exposed to pathological condition such as hyperglycemic condition (4.5 g glucose/L) with JDG 100 and then experiments such as RT-PCR and Western blotting were carried out. JDG 100 treated cells increased to $168{\pm}0.04%$ and $182.4{\pm}0.03%$ in GK mRNA and protein expressions, respectively, compared to control. Treatment of the JDG 100 up-regulated ACC mRNA ($127.3{\pm}0.02%$) and protein ($126.7{\pm}0.24%$) of HepG2 cells in the high glucose media. These observations suggest that JDG 100 mixed water extract may have a potential as an anti-diabetic agent in type 2 diabetes mellitus.