• Journal of Microbiology and Biotechnology
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• v.33 no.12
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• pp.1657-1670
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• 2023

This study aimed to evaluate the effects of Limosilactobacillus fermentum and Lactiplantibacillus plantarum isolated from human feces coordinating with inulin on the composition of gut microbiota and metabolic profiles in db/db mice. These supplements were administered to db/db mice for 12 weeks. The results showed that the Lactobacillaceae coordinating with inulin group (LI) exhibited lower fasting blood glucose levels than the model control group (MC). Additionally, LI was found to enhance colon tissue and increase the levels of short-chain fatty acids. 16S rRNA sequencing revealed that the abundance of Corynebacterium and Proteus, which were significantly increased in the MC group compared with NC group, were significantly decreased by the treatment of LI that also restored the key genera of the Lachnospiraceae_NK4A136_group, Lachnoclostridium, Ruminococcus_gnavus_group, Desulfovibrio, and Lachnospiraceae_UCG-006. Untargeted metabolomics analysis showed that lotaustralin, 5-hydroxyindoleacetic acid, and 13(S)-HpODE were increased while L-phenylalanine and L-tryptophan were decreased in the MC group compared with the NC group. However, the intervention of LI reversed the levels of these metabolites in the intestine. Correlation analysis revealed that Lachnoclostridium and Ruminococcus_gnavus_group were negatively correlated with 5-hydroxyindoleacetic acid and 13(S)-HpODE, but positively correlated with L-tryptophan. 13(S)-HpODE was involved in the "linoleic acid metabolism". L-tryptophan and 5-hydroxyindoleacetic acid were involved in "tryptophan metabolism" and "serotonergic synapse". These findings suggest that LI may alleviate type 2 diabetes symptoms by modulating the abundance of Ruminococcus_gnavus_group and Lachnoclostridium to regulate the pathways of "linoleic acid metabolism", "serotonergic synapse", and" tryptophan metabolism". Our results provide new insights into prevention and treatment of type 2 diabetes.

• Journal of The Korean Astronomical Society
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• v.35 no.4
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• pp.175-185
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• 2002

Almost half of primeval galaxies show P-Cygni type profiles in the Ly$\alpha$ emission line. The main underlying mechanism for the profile formation in these systems is thought to be the frequency re-distribution of the line photons in expanding scattering media surrounding the emission source. A Monte Carlo code is developed to investigate the Ly$\alpha$ line transfer in an optically thick and moving medium with a careful consideration of the scattering in the damping wings. Typical column densities and expansion velocities of neutral hydrogen investigated in this study are $N_{H1}{\~}10^{17-20}\;cm^{-2}$ and ${\Delta}V{\~} 100 km\;s^{-1}$. We investigate the dependence of the emergent profiles on the kinematics and on the column density. Our numerical results are applied to show that the damped Ly$\alpha$ absorbers may possess an expanding H I supershell with bulk flow of ${\~}200 km\;s^{-l}$ and H I column density $N_{H1}{\~}10^{19}\;cm^{-2}$. We briefly discuss the observational implications.

• Structural Engineering and Mechanics
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• v.45 no.1
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• pp.1-18
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• 2013

The typhoon wind characteristics designing for buildings or bridges located in complex terrain and typhoon prone region normally cannot be achieved by the very often few field measurement data, or by physical simulation in wind tunnel. This study proposes a numerical simulation procedure for predicting directional typhoon design wind speeds and profiles for sites over complex terrain by integrating typhoon wind field model, Monte Carlo simulation technique, CFD simulation and artificial neural networks (ANN). The site of Stonecutters Bridge in Hong Kong is chosen as a case study to examine the feasibility of the proposed numerical simulation procedure. Directional typhoon wind fields on the upstream of complex terrain are first generated by using typhoon wind field model together with Monte Carlo simulation method. Then, ANN for predicting directional typhoon wind field at the site are trained using representative directional typhoon wind fields for upstream and these at the site obtained from CFD simulation. Finally, based on the trained ANN model, thousands of directional typhoon wind fields for the site can be generated, and the directional design wind speeds by using extreme wind speed analysis and the directional averaged mean wind profiles can be produced for the site. The case study demonstrated that the proposed procedure is feasible and applicable, and that the effects of complex terrain on design typhoon wind speeds and wind profiles are significant.

• Journal of computational fluids engineering
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• v.15 no.3
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• pp.39-45
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• 2010

The turbulent flows in a tunnel mock-up($10L{\times}0.5W{\times}0.25H$ m3 : scale reduction 1/20) with rectangular cross section were investigated. The instantaneous velocity fields of Re = 49,029, 89,571 were measured by the 2-D PIV system which is consisted of double pulsed Nd:Yag laser and the tracer particles in the straight-duct mock-up where the flows were fully developed. The mean velocity profiles were taken from the ensemble averages of 1,000 instantaneous velocity fields. Simultaneously, numerical simulations(RANS) were performed to compare with experimental data using STREAM code. Non-linear eddy viscosity model (NLEVM : Abe-Jang-Leschziner Eddy Viscosity Model) was employed to resolve the turbulent flows in the duct. The calculated mean velocity profiles were well compared with PIV results. In the log-law profiles, the experimental data were in good agreement with numerical simulations all the way to the wake region except the viscous sub-layer (near wall region).

• Steel and Composite Structures
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• v.2 no.6
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• pp.441-460
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• 2002

In the design of bridges, it is important to consider the thermal stresses induced by the non-linear temperature distribution as well as the variation of effective temperature in the bridge deck. To cope with this, design temperature profiles are provided by design codes, which are normally based on extensive research work. This paper presents the results of a comprehensive investigation on the thermal behaviour of bridges in Hong Kong with special emphasis on composite bridges. The temperature distribution in bridges depends primarily on the solar radiation, ambient air temperature and wind speed in the vicinity. Apart from data of the meteorological factors, good estimates of the thermal properties of material and the film coefficients are necessary for the prediction of temperature distribution. The design temperature profiles for various types of composite bridge deck with bituminous surfacing and concrete slab of different thicknesses are proposed. The factors affecting the design effective temperature are also reviewed and suitable values for Hong Kong are proposed. Results are compared with recommendations of the current local code. The method facilitates the development of site-specific temperature profiles for code documents, and it can also be applied to create zoning maps for temperature loading for large countries where there are great climatic differences.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.2 no.1
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• pp.1-10
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• 1990

In the present study, the entrance length, velocity profiles and waveforms of developing transitional steady flows in a square duct are investigated analytically and experimentally. The systems of conservation equations for transitional steady duct flows are solved analytically by linearizing non-linear convective terms and adoption of modified eddy viscosity from empirical correlations. Analytical solutions of velocity profiles for developing transitional steady flow were obtained in the form of infinite series. The experimental study for transitional steady flow in a square duct with $40mm{\times}40mm{\times}4000mm$($width{\times}height{\times}length$) was carried out to measure velocity profiles and other parameters by using a hot-wire anemometer with data acquisition and processing system. The entrance length of developing transitional steady flows in a square duct was $L_e{\fallingdotseq}0.02{\cdot}Re,st{\cdot}D_h$, and the overshoot was occured at about 30 times of hydraulic diameter because of the effect of external velocity of boundary layer and instantaneous acceleration.

• Advances in concrete construction
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• v.15 no.4
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• pp.241-249
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• 2023

The unsteady mixed convection Casson type MHD nanofluid flow in the stagnation point with motile microorganism around a spinning sphere is investigated. Time dependent flow dynamics is considered. Similarity transformations have been employed to transfer the governing partial differential structure into ordinary differential structure. The impact of distinct parameters is examined via tables and graphs. The impact of rotational parameter (spin) on profiles of velocity profiles, temperature and concentration is revealed for unsteady mixed convection Casson type MHD nanofluid flow. It is observed that it is clear that rotational parameter has a great effect on non-dimensional primary velocity component but rotational parameter has a slight impact on non-dimensional secondary velocity component. The validity of the current investigation is authorized through comparing the existing outcomes with previous published literature.

• Korean Journal of Plant Resources
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• v.23 no.6
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• pp.513-518
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• 2010

In the present study, the antinociceptive profiles of Dianthus chinensis L extract were examined in ICR mice. Dianthus chinensis L extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, Dianthus chinensis L extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7\;{\mu}g$) was diminished by Dianthus chinensis L extract. Intraperitoneal (i.p.) pretreatment with yohimbine ($\alpha_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by Dianthus chinensis L extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by Dianthus chinensis L extract in the writhing test. Our results suggest that Dianthus chinensis L extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of Dianthus chinensis L extract may be mediated by $\alpha_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.384-387
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• 2006

Vertical L/UL (Load/Unload) velocity is very important parameter to determine the L/UL performance, and the vertical velocity is determined by the actuator velocity and the ramp profile. However, it is not easy to precisely control the actuator rotating velocity during the L/UL process. Especially in emergency parking, servo system doesn't operate, it is impossible to control an actuator velocity. Then, the vertical unloading velocity depends on only ramp profile. The ramp height and the sliding length for L/UL process in SFF (Small Form Factor) HDD are restricted due to slimness and small media. For these reasons, it is very difficult to design the ramp profile in SFF HDD. Therefore, this study analyzes the unloading dynamic characteristics for various ramp profiles and makes the thesis for ramp profile design.

• Food Science and Biotechnology
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• v.18 no.6
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• pp.1528-1531
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• 2009

In this study, we investigated a dose-dependent hypolipidemic and antioxidant effects of tocotrienol-rich fraction (TRF) from grape seeds. After induction of hyperlipidemia for 4 weeks, rats were supplemented with different dose (5, 25, and 50 mg/kg BW/day) of TRF for 1 week. Oral administration of TRF (50 mg/kg BW/day) decreased the plasma triglyceride (TG, 162.6 mg/dL), total cholesterol (TC, 83.7 mg/dL), low density lipoprotein-cholesterol (LDL-C, 20.3 mg/dL), malondialdehyde contents (MDA, 3.3 nmol/dL), and atherogenic index (AI, 2.0) compare to high-fat diet group. These data suggest that TRF supplementation has significant health benefits through the modulation of physiological functions that include various atherogenic lipid profiles and antioxidative status in hyperlipidemia.