• Asian Pacific Journal of Cancer Prevention
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• 제13권4호
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• pp.1693-1697
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• 2012

Objective: To explore the effect on radiosensitivity of arsenic trioxide ($As_20_3$) in conjunction with hyperthermia on the esophageal carcinoma EC-1 cell line. Method: Inhibition of EC-1 cell proliferation at different concentrations of $As_20_3$ was assessed using the methyl thiazolyl blue colorimetric method (MTT method), with calculation of $IC_{50}$ value and choice of 20% of the $IC_{50}$ as the experimental drug concentration. Blank control, $As_20_3$, hyperthermia, radiotherapy group, $As_20_3$ + hyperthermia, $As_20_3$ + radiotherapy, hyperthermia + radiotherapy and $As_20_3$ + hyperthermia + radiotherapy groups were established, and the cell survival fraction (SF) was calculated from flat panel colony forming analysis, and fitted by the 'multitarget click mathematical model'. Flow cytometry (FCM) was used to detect changes in cell apoptosis and the cell cycle. Results: $As_20_3$ exerted inhibitory effects on proliferation of esophageal carcinoma EC-1 cells, with an $IC_{50}$ of 18.7 ${\mu}mol/L$. After joint therapy of $As_20_3$ + hyperthermia + radiotherapy, the results of FCM showed that cells could be arrested in the $G_2$/M phase, and as the ratio of cells in $G_0/G_1$ and S phases decreased, cell death became more pronounced. Conclusion: $As_20_3$ and hyperthermia exert radiosensitivity effects on esophageal carcinoma EC-1 cells, with synergy in combination. Mechanistically, $As_20_3$ and hyperthermia mainly influence the cell cycle distribution of EC-1 esophageal carcinoma cells, decreasing the repair of sublethal damage and inducing apoptosis, thereby enhancing the killing effects of radioactive rays.

• 한국자원식물학회지
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• 제33권4호
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• pp.404-416
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• 2020

생물 다양성을 유지하고 기후 변화를 조절하는 데에 중심적인 역할을 하는 열대림에는 식품 또는 의약품 개발 등 산업적으로 이용 가능한 자원 식물이 풍부하다. 이들을 활용하기 위하여 열대 및 아열대 식물의 보존 및 증식에 관한 연구가 필요한데, 국내에서는 이에 관한 연구가 미비한 실정이다. 본 연구는 국립수목원 열대식물자원연구센터가 2013년부터 미얀마 천연자원 환경보전부(Ministry Of Natural Resources and Environmental Conservation)와 미얀마 산림과학원(Forest Research Institute)과 함께 미얀마 보호지역 및 Sagging 지역 내 식물 다양성 보존을 위한 공동 현장조사, 연구 및 출판 등의 협력사업을 진행하고 있는 정보를 제공하고자 한다. 국립수목원과 미얀마 산림과학원 공동연구의 성과로 2018년 12월 미얀마 산림과학원으로부터 미얀마 유용 및 관상식물 65과 326종의 식물 생체 및 표본 등을 기증받아 국립수목원 열대식물자원연구센터에 보존과 교육 목적으로 전시 중이다. 이 기증은 미얀마에서 식물 생체를 국외로 반출한 첫번째 사례이며, 국립수목원은 2008년 독일에서 열대식물을 기증받은 사례 다음으로 두번째로 외국 정부의 공식적인 대량 식물 도입 사례다. 도입한 식물 중 Santalum album L.은 IUCN Red List of Threatened Species (IUCN, 2017)에 취약종으로 분류되어 있다. 본 연구 결과를 토대로 열대 및 아열대 식물의 생육에 적합한 인공 환경을 구명하고 국내의 실내 정원소재 및 미세먼지, 공기정화 능력을 가진 열대식물의 발굴하고 추후 열대 및 아열대 식물의 보존 및 증식 방법과 더 나아가 생물 다양성 보존 및 산업적 이용을 위한 연구에 박차를 가할 수 있을 것이다.

• 한국중재학회지:중재연구
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• 제24권2호
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• pp.3-31
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• 2014

As all aspects of international activity have kept growing in good transaction, transnational investments, joint ventures, and the licensing of intellectual property, it is inevitable for disputes to increase across national frontiers. International disputes can be settled by arbitration and ADR. In the situation presented in the paper, any dispute shall be finalized by arbitration and conciliation in the Gaeseong Industrial Complex. Inter-Korean Commercial Arbitration in the Gaeseong Industrial Complex has become the principal method of resolving disputes in trade, commerce, and investment in accordance with the "Agreement on South-North Commercial Dispute Settlement Procedures," "Agreement on Organization and Operation of Inter-Korean Commercial Arbitration Committee," and the Annexed Agreement on "Organization and Operation of Inter-Korean Commercial Arbitration Committee" (2013). But the follow-up measures of the said agreements have not been fulfilled. Some prerequisite measures of the Inter-Korean commercial arbitration must be satisfied. In order to proceed with arbitration and conciliation in the Gaeseong Industrial Complex, we need to ask the following: Does the status of an arbitrational matter? Should an agreement to arbitrate contain a choice of law clause? Should one provide for one arbitrator or three? How should the arbitrators be selected? What is the relation between party-appointed arbitrators and the presiding arbitrator (neutral arbitrator)? Do arbitrators compromise more than the litigation? Can conciliation be combined with arbitration? To execute the enactment of arbitration regulations, the contents of the Arbitration Rules of the Korean Commercial Arbitration Board (South) and the Korea International Trade Arbitration Committee (North), together with the Korean Arbitration Act and External Arbitration Act of North Korea and the UNCITRAL Model Arbitration Law and UNCITRAL l Arbitration Rules are reflected in the Rules. There are many aspects of the Inter-Korean Commercial Arbitration. It is essential to understand key elements; namely, the arbitration agreement, appointment of arbitrator, arbitral proceeding and arbitral award, and enforcement and setting aside of arbitral award. This research deals with five chapters. Chapter 1 provides the introduction. Chapter 2 deals with trade volume between South and North Korea and the kinds of dispute in Gaeseong. Chapter 3 addresses contents and follow-up measures of the agreement on the "South-North Commercial Dispute Settlement Procedures," "Agreement on Organization and Operation of Inter-Korean Commercial Arbitration Committee," and the Annexed Agreement on "Organization and Operation of Inter-Korean Commercial Arbitration Committee" (2013). Chapter 4 features the problems and tasks of the pertinent agreements. Chapter 5 gives the conclusion. Enabling parties to find an amicable solution to the dispute in the Gaeseong Industrial Complex can lead to a useful and appropriate framework either through direct negotiation or by resorting to conciliation or mediation in accordance with pertinent agreements and follow-up measures contained in the agreements.

• 대한기계학회논문집A
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• 제40권11호
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• pp.979-986
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• 2016

등속조인트의 일종인 트리포드 축은 동력전달용으로 고속열차의 KTX와 KTX-산천에 모두 적용되고 있으며, 동력대차에서 모터 감속장치(MRU)와 차축 감속장치(ARU)를 연결해 고속회전동력을 전달하는 핵심 요소이다. 축 방향의 미끄럼 운동이 가능한 트리포드 축은 열차 구동을 위한 토크를 전달하며, 동력전달 시스템에 과토크 발생 시 축의 퓨즈부가 절단되어 동력을 차단한다. 본 연구에서는 리니어 액추에이터를 이용한 대용량 비틀림 시험장치의 개발과 이를 이용한 트리포드 축의 정적 비틀림 강도와 피로수명을 확인하고자 하였다. 또한 구조해석을 통해 축의 취약부를 파악하고 비틀림 피로해석 결과와 실제 피로시험의 결과를 비교분석하여 비틀림 성능 개선을 위한 설계안을 제시하고자 하였다. 한편 트리포드 축의 피로에 따른 열화를 파악하기 위해 히스테리시스 곡선을 이용하였으며, 히스테리시스 곡선의 기울기 변화를 통해 피로고장 시점을 확인하였다.

• 대한관절경학회지
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• 제11권1호
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• pp.20-23
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• 2007

목적: 슬관절의 외상 및 질환에 대한 관절경 수술 후 발생한 심부감염의 특성을 조사하고자 한다. 대상 및 방법: 1994년 2월부터 2006년 8월까지 슬관절의 관절경 수술을 시행 받은 총 894예의 슬관절을 대상으로 심부 감염의 빈도를 조사하였으며 감염으로 확진된 환자군에 관한 분석을 시행하였다. 결과: 총 894예의 슬관절 관절경 수술에서 7예의 심부 감염이 발생하여 0.9%의 발생율을 보였으며 419예의 절제와 봉합을 포함한 반월상 연골 수술에서 반월상 연골 봉합을 시행한 1예에서 감염이 발생하였다(1/419=0.2% 발생율). 십자인대 재건술 343예에서 6예의 감염 이 발생하였으며(6/343=2% 발생율) 전방 십자인대 단독 수술군에서 3예 (3/152), 후방 십자인대 단독 수술군에서 2예(2/70), 십자 인대에 부가하여 관절외 재건술을 시행한 25예의 환자 중에서 1예에서 감염이 발생하였다(1/26). 결론: 슬관절의 관절경 수술 후 감염 발생율은 비교적 낮았으나 이식물을 사용하여 관절강내 인대 재건술을 시행한 경우에서는 높게 발생 한 바 전후방 십자 인대 재건술 등의 수술시 이에 대한 주의를 요한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제32권6호
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• pp.544-558
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• 2006

Trismus is a common problem to most people experiencing at once in his or her life and to most dental practitioners experiencing frequently. It has a number of potential causes which are single factor or complex factors. Its treatment will depend on the cause. The purpose of this study was to discuss the causes of trismus condition and the various treatments available. This study was made by reviewing of collected data from 86 patients complained of trismus among patients who were diagnosed by TMD, tumor, infection including tetanus, soft tissue anomalies, bony fracture and ankylosis from Jan 2002 to Dec 2004 on department of oral and maxillofacial surgery at Pusan National University Hospital, South Korea. The clinical reviews regarding chief complaints, clinical characteristics, diagnostic examination, treatments and the results on the patients were given as follows. 1. The etiology of trismus commonly were derived from temporomandibular joint(TMJ) disorder, TMJ ankylosis, TMJ tumor, odontogenic maxillofacial infection, mandibular condylar fracture, tetanus. 2. The chief complaints of trismus patients were progressive mouth opening limitation, TMJ pain, malocclusion, facial asymmetry, retrognathic state. 3. Especially, for the differential diagnosis between the fibrous ankylosis and true bony ankylosis, computed tomogram (CT) was useful. Surgical gap arthroplasty on bony ankylosis patients was applied and the gain of mouth opening after operation was average 35.8 mm during 19 months. 4. The tetanus, rarely, also induced the trismus with the range of mouth opening less than 10 mm. The average serum level of tetanus anti-toxin was 0.02-0.04 IU/mL. The limitation of mouth opening was improved into average 38 mm on 4 weeks after injection of 10,000 units of tetanus immune globulin. 5. In the treatment of osteochondroma, TMD, odontogenic infection and fracture, and the others inducing trismus, to obtian the maximum result and decreased inadequate time and effort, it is important to finding the causes from the exact clinical examination and diagnosis.

• Archives of Pharmacal Research
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• 제28권3호
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• pp.305-310
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• 2005

It has been suggested that nitric oxide (NO) derived from inducible nitric oxide synthase (iNOS) may act as a mediator of cytokine-induced effects on bone turn-over. NO is also recognized as an important factor in bone remodeling, i.e., participating in osteoblast apoptosis in an arthritic joint. The components of Agastache rugosa are known to have many pharmacological activities. In the present study, we investigated the effects of Agastache rugosa leaf extract (ELAR) on NO production and the iNOS expression in ROS 17/2.8 cells activated by a mixture of inflammatory cytokines including TNF-$alpha$ and IL-1$\beta$. A preincubation with ELAR significantly and concentration-dependently reduced the expression of iNOS protein in ROS 17/2.8 cells activated with the cytokine mixture. Consequently, the NO production was also significantly reduced by ELAR with an IC$_{50}$ of 0.75 mg/mL. The inhibitory mechanism of iNOS induction by ELAR prevented the activation and translocation of NF-$\kappa$B (p65) to the nucleus from the cytosol fraction. Furthermore, ELAR concentration-dependently reduced the cellular toxicity induced by sodium nitroprusside, an NO-donor. These results suggest that ELAR may be beneficial in NO-mediated inflammatory conditions such as osteoporosis.

• Journal of Acupuncture Research
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• 제17권3호
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• pp.125-139
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• 2000

Study of the fourteen meridians that include name of P'ung(風) point. The results were summarized as follows. 1. Pyongp'ung(秉風) is located middle of the supraspinatous fossa(Small intestine Meridian, 手太陽小腸經). we can cute the local area disease and also use to cure the pathway of the Arm greater yang small intestine which is attacked by P'ung(風) disease. 2. Yep'ung(翳風) is located behind the lobule of the auricle, in the depression between the mastoid process and the mandible(Triple Energizer Meridian, 手少陽三焦經). we can cure the local area disease especially hyper yang disease and also use to cure the pathway of the Arm lesser yang triple energizer which is attacked by P'ung(風) and Yo'l(熱) disease. 3. P'ungmun(風門) is located 1.5 chon beside the lower end of the spine of the second thoracic vertebra(Bladder Meridian, 足太陽膀胱經). we can cure the local area disease and also use to cure the pathway of the Leg greater yang bladder which is attacked by P'ung(風) disease. 4. P'ungbu(風府) is located 1 chon above the middle of natural line of the hair at the back of the head, in the depression below the occiptal protuberance(Governor meridian, 督脈). It connects (Liver meridian, 足厥陰肝經) and Yin Link Vessel(陽維脈). we can cure the rigidity and pain in head and nape which is related Yin Link Vessel(陽維脈). 5. P'ungshi(風市) is located on the lateral part of the thigh, 7 hon above the patella(From the greater trochanter to the knee joint is 19 chon, Gallbladder Meridian (足少陽膽經). we can cure the local area disease(leg, knee, etc). 6. P'ungji(風池) is located Below the occipital bone, in the depression on the outer part of the trapezius muscle(Gallbladder Meridian, 足少陽膽經) on a level with P'ungbu(風府) (Governor vessel, 督脈). we can cure the local area disease and also use to cure the pathway of the Leg lesser yang gall bladder which is attacked by P'ung(風) disease.

• 철학연구
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• 제131권
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• pp.131-163
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• 2014

'우리는 누구이며, 어디서 왔는가?' 우리 스스로에게 질문하고 우리 자신을 이해하는 것, 이것이야말로 인류 역사상 가장 위대한 혁명일 것이다. 하지만 우리는 아직 우리의 정체성을 묻는 이 물음에 명확한 답을 얻지 못하고 있다. 물론 '사회적 동물' 혹은 '이성적 동물' 같은 전형적인 정의들이 있지만 이들 역시 매우 허약한 규정들이다. 우리가 왜 사회적 동물이 되고 이성적 동물이 되었는지에 대한 해명조차 담고 있지 않기 때문이다. 이 글의 목적은 이 물음의 해답을 찾아가는 단서를 발견하여 우리의 정체성을 좀 더 명확히 하는데 있다. 실마리는 진화론적으로 우리와 가장 가까운 혈족으로 불리는 침팬지에게서 출발한다. 우리와 침팬지는 무엇이 다른가? 침팬지에게도 '자아'가 있을까? 이런 물음들을 통해 우리가 찾아낸 답은 이렇다. 즉 인간이 침팬지와 다른 존재가 된 것은 뇌의 발달과 함께 정밀하게 움직이는 운동 시스템을 갖게 되었고, 나아가 이러한 운동 시스템이 내면화되어 마음을 갖게 되었기 때문이다. 그리고 마음의 생각하는 능력도 바로 이러한 내면화 메커니즘이 진화 발전한 것이다.

• 대한한의학방제학회지
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• 제29권3호
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• pp.127-145
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• 2021

Objectives : The purpose of this study was to evaluate the effects of Daeganghwal-tang on knee cartilage in monosodium iodoacetate(MIA)-induced osteoarthritis rats. Methods : Forty SD rats were randomly divided into five groups(n=8/group): normal group was SD rats group injected with normal saline at left knee joint and administrated orally distilled water, control group was MIA-induced osteoarthritis SD rats group administrated orally distilled water, Indomethacin group was MIA-induced osteoarthritis SD rats group administrated orally indomethacin 2 mg/kg, DGHT(L) group was MIA-induced osteoarthritis SD rats group administrated orally 1280 mg/kg of Daeganghwal-tang, and DGHT(H) group was MIA-induced osteoarthritis SD rats group administrated orally 2560 mg/kg of Daeganghwal-tang. After orally administration of drugs for 4 weeks, gross appearance and histological analysis were used to evaluate the degree of knee cartilage damage. In addition, pro-inflammatory cytokines, bone degrade factor and bone defence factors were analyzed to investigate the anti-inflammatory and cartilage protection effects of Daeganghwal-tang. Also, hematological test, biochemical test, and liver and kidney tissue were analyzed to determine the safety of Daeganghwal-tang. Results : Daeganghwal-tang inhibited the damage of the knee cartilage, and significantly prevented the reduction in cartilage thickness. In addition, the pro-inflammatory cytokines and the bone degrade factor significantly decreased, and the bone defence factors significantly increased. In the safety assessment of Daeganghwal-tang, there were no significant differences among the experimental groups and no abnormal findings were observed. Conclusions : Daeganghwal-tang has anti-inflammatory effect, inhibits cartilage damage, and protects cartilage in MIA-induced osteoarthritis rats.