• Journal of the Korea Concrete Institute
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• v.28 no.1
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• pp.13-21
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• 2016

A hybrid precast concrete beam system with a simple rigid connection was proposed to compensate the limitations and shortcomings of the conventional bolt connection associated with the H-beams embedded into concrete beams. Three beam specimens with fixed both ends were tested under one-point top cyclic loading to explore the effectiveness of the developed hybrid beam system in transferring externally applied flexure to a column. The main parameter considered was the length ($L_s$) of H-beam, which was selected to be $0.25L_I$, $0.5L_I$, and $1.0L_I$, where $L_I$ is the distance from the support to the point of inflection. All beam specimens showed a better displacement ductility ratio than the reinforced concrete beams with the same longitudinal reinforcement index, indicating that the cyclic load-deflection curve and ductility were insignificantly affected by $L_s$. The continuous strain distribution along the beam length and the prediction of the ultimate load based on the collapse mechanism ascertained the structural adequacy of the developed rigid connection.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.41 no.5
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• pp.427-433
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• 2017

In the case of high-strength or low thermal conductivity material milling, tool breakage occurs easily because of the high friction temperature. Therefore, the effectiveness of the coolant supply is very important for proper tool cooling. As the manually adjustable joint mechanism nozzle is generally used for coolant supply, the cooling efficiency is very low. It also has a bad influence on the workspace environment because of coolant scattering. In this study, the milling characteristics of STS316L were investigated according to the coolant spray position based on the automatic adjustable system. Tool wear and surface roughness were measured according to the coolant spray position. Through these experiments, the effectiveness of the fabricated system was explained.

• YAKHAK HOEJI
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• v.39 no.2
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• pp.103-112
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• 1995

Population pharmacokinetics for gentamicin were compared with 24 American patients (16 male and 8 female) and 16 Korean-American appendicitis patients(12 male and 4 female). Two to six blood specimens were collected from all patients at the following times: just before a regularly scheduled infusion and at 1/2 hour after the end of a 1/2 hour infusion. Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant(K), the slope of the relationship between K versus creatinine clearance(KS), the apparent volume of distribution(V), the slope of the relationship between V versus weight(VS), gentamicin clearance(CL) and the slope of the relationship between CL versus creatinine clearance and the VS(CS). The output includes a 3-dimensional plot of the joint probability density function(PDF), two marginal PDF, means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were 0.424$\pm$0.139(0.00429$\pm$0.00164) and 0.411$\pm$0.135 hr$^{-1}$ (0.00475$\pm$0.00180[hr.mL/min/1.73m$^{2}]^{-1}$) for American and Korean-American populations, respectively. The mean V(VS) were not different at 15.6$\pm$4.77(0.233$\pm$0.0526) and 15.1$\pm$3.84L(0.239$\pm$0.0492 L/kg) for American and Korean-American populations, respectively (P>0.2). The mean CL (CS) were 6.28$\pm$1.85(0.0634$\pm$0.0191) and 5.70$\pm$1.77 L/hr(0.0701$\pm$0.0215 L/kg[hr.mL/min/1.73m$^{2}$)] for American and Korean-American populations, respectively. There are no differences in gentamicin pharmacokinetics between American and Korean-American Appendicitis patients.

• Molecules and Cells
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• v.42 no.8
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• pp.604-616
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• 2019

Phosphoserine phosphatase (PSPH) is one of the key enzymes of the L-serine synthesis pathway. PSPH is reported to affect the progression and survival of several cancers in an L-serine synthesis-independent manner, but the mechanism remains elusive. We demonstrate that PSPH promotes lung cancer progression through a noncanonical L-serine-independent pathway. PSPH was significantly associated with the prognosis of lung cancer patients and regulated the invasion and colony formation of lung cancer cells. Interestingly, L-serine had no effect on the altered invasion and colony formation by PSPH. Upon measuring the phosphatase activity of PSPH on a serine-phosphorylated peptide, we found that PSPH dephosphorylated phospho-serine in peptide sequences. To identify the target proteins of PSPH, we analyzed the protein phosphorylation profile and the PSPH-interacting protein profile using proteomic analyses and found one putative target protein, IRS-1. Immunoprecipitation and immunoblot assays validated a specific interaction between PSPH and IRS-1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells. We suggest that the specific interaction and dephosphorylation activity of PSPH have novel therapeutic potential for lung cancer treatment, while the metabolic activity of PSPH, as a therapeutic target, is controversial.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.22 no.5
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• pp.334-342
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• 2021

In Korea, the training is performed through independent environments without interoperability among L-V-C systems. In the L system, training for large units is limited due to civil complaints at the training grounds and road restrictions. The V system is insufficient in training related to tactical training, and the C system lacks practicality due to a lack of combat friction elements. To achieve synchronicity and integration training between upper and lower units, it is necessary to establish a system to ensure integrated training for each unit by interoperating the currently operating L, V, and C systems. The interoperability between the C-C system supports Korea-US Combined Exercise. On the other hand, the actual development of the training system through the interoperability of L, V, and C has not been made. Although efforts are being made to establish the L, V, and C system centering on the Army, the joint composite battlefield and LVC integrated architecture technology are not yet secured. Therefore, this paper proposes a new plan for the future training system by designing and implementing the LVC integrated architecture technology, which is the core technology that can build the L-V-C interoperability training system. In conclusion, a division-level L-V-C interoperability training system can be established in the future by securing the LVC integrated architecture technology.

• Proceedings of the KIEE Conference
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• 2004.07c
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• pp.1775-1777
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• 2004

Taihan Electric Wire Co. developed accessories(PJ, EB-G, EB-A, EB-O) for 345kV XLPE $1C{\times}600mm^2$ cable as a small size conductor cable, after installed 345kV XLPE $1C{\times}600mm^2$ cable, PJ and EB-G on Youngseo${\sim}$Youngdeungpo project KEPCO planed in 2003. All of 345kV XLPE $1C{\times}600mm^2$ cable Accessories are finished the type tests successfully. Straight joint as a Prefabricated Joint(PJ) had shorter the days of assembling than those of TMJ used on the 154kV XLPE Cable. Particularly, the use of clean booth to prevent the dusts and the penetration of water also had made the quality of jointing improved.

• Steel and Composite Structures
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• v.21 no.5
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• pp.963-980
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• 2016

The jib system with middle strut is widely used to achieve the large arm length in the large scale tower crane and the deployability in the mobile construction crane. In this paper, an analytical solution for the out-of-plane buckling of the jib system with middle strut is proposed. To obtain the analytical expression of the buckling characteristic equation, the method of differential equation was adopted by establishing the bending and torsional differential equation of the jib system under the instability critical state. Compared with the numerical solutions of the finite element software ANSYS, the analytical results in this work agree well with them. Therefore, the correctness of the results in this work can be confirmed. Then the influences of the lateral stiffness of the cable fixed joint, the dip angle of the strut, the inertia moment of the strut, and the horizontal position of the cable fixed joint on the out-of-plane buckling behavior of the jib system were investigated.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.30 no.4 s.247
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• pp.435-441
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• 2006

The anterior cruciate ligament(ACL) is an important stabilizer of knee joint. The ACL injury of knee is common and a serious ACL injury leads to ligament reconstruction surgery. Gait analysis is essential to identify knee condition of patients who display abnormal gait. The purpose of this study is to evaluate and classify knee condition of ACL deficient patients using a nonlinear dynamic method. The nonlinear method focuses on understanding how variations in the gait pattern change over time. The experiments were carried out for 17 subjects(l2 healthy subjects and five subjects with unilateral deficiency) walking on a motorized treadmill for 100 seconds. Three dimensional kinematics of the lower extremity were collected by using four cameras and KWON 3D motion analysis system. The largest Lyapunov exponent calculated from knee joint flexion-extension time series was used to quantify knee stability. The results revealed the difference between healthy subjects and patients. The deficient knee was significantly unstable compared with the contralateral knee. This study suggests an evaluation scheme of the severity of injury and the level of recovery. The proposed Lyapunov exponent can be used in rehabilitation and diagnosis of recoverable patients.

• Tribology and Lubricants
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• v.16 no.1
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• pp.39-45
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• 2000

In this paper, the effects of shaft and bearing flexibilities are investigated for the accurate modeling of a shaft-bearing system supported by ball bearings. Generally, rolling bearings are modeled by simple rigid pin-joint in the mechanical design. However, they can no longer be modeled by ideal boundary conditions in the advanced applications because the rigid pin-joint model cannot satisfy the current trends of mechanical design decreasing mass and reducing volume. Consequently the flexible support model of ball bearing is investigated using the static analysis module developed by A .B. Jones and T. A. Harris. A simple two-bearing system, supported by two deep groove ball bearings and radially loaded on the shaft midway between the bearings, is utilized to validate the coupled model of shaft-bearing system. Numerical computations using the model indicate that the shaft span length, locating/floating bearing arrangements and applied bearing size are significant factors in determining the mechanical behaviors. The flexible support model of ball bearing can be escaped to over-estimate in the bearing fatigue life. The proposed simple design formulation obtained by numerical simulations can approximately predict a rate of bearing life reduction as a function of shaft span length/shaft diameter (L/d).

• Industrial Engineering and Management Systems
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• v.14 no.1
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• pp.1-10
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• 2015

In this paper, we consider multi-item inventory management. When managing a multi-item inventory, we coordinate replenishment orders of items supplied by the same supplier. The associated problem is called the joint replenishment problem (JRP). One often-used approach to the JRP is to apply a can-order policy. Under a can-order policy, some items are re-ordered when their inventory level drops to or below their re-order level, and any other item with an inventory level at or below its can-order level can be included in this order. In the present paper, we propose a method for finding the optimal parameter of a can-order policy, the can-order level, for each item in a lost-sales model. The main objectives in our model are minimizing the number of ordering, inventory, and shortage (i.e., lost-sales) respectively, compared with the conventional JRP, in which the objective is to minimize total cost. In order to solve this multi-objective optimization problem, we apply a genetic algorithm. In a numerical experiment using actual shipment data, we simulate the proposed model and compare the results with those of other methods.