• Clinical and Experimental Reproductive Medicine
• /
• v.51 no.3
• /
• pp.192-204
• /
• 2024

Objective: Cisplatin (CP) is a widely used chemotherapeutic agent, but its severe side effects impact testicular function. We investigated the potential protective effects of bilberry extract against CP-induced testicular toxicity. Methods: Forty adult male albino rats were divided into four groups. Control animals received a single oral dose of 0.9% saline. Bilberry-treated rats received oral bilberry extract (200 mg/kg body weight [BW] dissolved in 1 mL of saline) daily for 10 consecutive days. CP-treated animals were administered a single intraperitoneal dose (7.5 mg/kg BW). Finally, a bilberry+CP group received oral bilberry extract (200 mg/kg BW) daily for 10 consecutive days, with one intraperitoneal dose of CP (7.5 mg/kg BW) on day 2. We assessed sperm count, motility, viability, and abnormalities, along with testis weight, testis weight-to-BW ratio, antioxidant activity, levels of oxidative stress markers (malondialdehyde [MDA] and hydrogen peroxide [H₂O₂]), sex hormones (follicle-stimulating hormone [FSH], luteinizing hormone [LH], and testosterone), and apoptotic and anti-apoptotic markers, and DNA damage. Testicular tissue underwent histopathological examination. Results: Among CP-treated rats, significantly lower values were observed for testis weight; testis weight-to-BW ratio; levels of FSH, LH, testosterone, superoxide dismutase, catalase, glutathione S-transferase, glutathione, and B-cell lymphoma 2; and sperm count, motility, and proportion of normal sperm. CP administration was associated with higher MDA, H₂O₂, p53, Bax, cytochrome c, caspase 9, and caspase 3 levels, along with elevated tail moment. However, bilberry extract administration significantly improved all altered parameters. Conclusion: Bilberry treatment demonstrated protective effects and reduced CP-induced testicular toxicity via antioxidant activity and cytoprotection.

• Lingua Humanitatis
• /
• v.7
• /
• pp.271-289
• /
• 2005

Dans cet article, nous discutons de certains $probl{\grave{e}}mes$ syntaxiques en ayant recours $\grave{a}$ la $th{\acute{e}}orie$ linguistique de Milner. Nous remettons en question $l'ind{\acute{e}}pendance$ et $l'identit{\acute{e}}$ de la structure syntaxique, la relation entre le plan syntaxique et le plan lexical, le $caract{\grave{e}}re$ de la $g{\acute{e}}om{\acute{e}}trie$ de la syntaxe, etc.. La discussion est non seulement linguistique mais aussi interdisciplinaire et ${\acute{e}}pist{\acute{e}}mologique$, dans la mesure $o{\grave{u}}$ nous examinons la nature de $l'entit{\acute{e}}$ syntaxique et la $m{\acute{e}}thode$ "scientifique" de la syntaxe qui donne $acc{\grave{e}}s$ $\grave{a}$ $l'entit{\acute{e}}$ syntaxique. Selon Milner, il faut distinguer la place du terme lexical avec la position syntaxique qui est $l'entit{\acute{e}}$ syntaxique. La $premi{\grave{e}}re$ n'est pas syntaxique $\grave{a}$ strictement parler, mais elle, observable contrairement $\grave{a}$ la seconde, sert $\grave{a}$ conjecturer la dimension syntaxique, $c'est-\grave{a}-dire$ le $syst{\grave{e}}me$ positionnel. Le dispositif $th{\acute{e}}orique$ dans la $th{\acute{e}}orie$ linguistique de Milner n'est rien d'autre que l'ensemble des propositions qui permet, en absence d'observatoire, de conjecturer le $syst{\grave{e}}me$ positionnel sur la base du $syst{\grave{e}}me$ des places. Dire $l'ind{\acute{e}}pendance$ de la structure syntaxique revient $\grave{a}$ dire qu'il y a une coupure entre le $syst{\grave{e}}me$ positionnel et le $syst{\grave{e}}me$ des places. Autrement dit, sans cette coupure, on ne peut parler de $l'ind{\acute{e}}pendance$ de la structure syntaxique. Ainsi $distingu{\acute{e}}s$, les deux $syst{\grave{e}}mes$ en cause se mettent en relation soit naturels soit non naturels ou par distorsion $d'apr{\grave{e}}s$ Milner. La relation naturelle est une relation lexico-syntaxique $n{\acute{e}}e$ au moment $o{\grave{u}}$ un terme lexical occupe une position syntaxique dont la $cat{\acute{e}}gorie$ est identique $\grave{a}$ celle de son occupant. A la $diff{\acute{e}}rence$ de cette relation d'occupation naturelle $suppos{\acute{e}}e$ chez Milner comme une tendance du langage naturel, la relation d'occupation non naturelle est "paradoxale" dans le sens $o{\grave{u}}$ elle est produite dans la rencontre plus ou moins "anomale" entre l'occupant lexical et $l'occup{\acute{e}}$ syntaxique. Le $degr{\acute{e}}$ de l'anomalie qu'une langue autorise peut ${\hat{e}}tre$ $mesur{\acute{e}}$ empiriquement et doit ${\hat{e}}tre$ $vari{\acute{e}}$ en fonction de la langue $concern{\acute{e}}e$. Le $caract{\grave{e}re$ $g{\acute{e}}om{\acute{e}}trique$ de la syntaxe $am{\grave{e}}ne$ ${\grave{a}}$ remettre en cause, entre autres, $l'empiricit{\acute{e}}$ et la $mat{\acute{e}}rialit{\acute{e}}$ de la $g{\acute{e}}om{\acute{e}}trie$ syntaxique. En ce qui concerne ces sujets, nos $th{\grave{e}}ses$ sont les suivantes : la nature de la $g{\acute{e}}om{\acute{e}}trie$ syntaxique n'est pas a priori mais empirique ; la $g{\acute{e}}om{\acute{e}}trie$ de la syntaxe peut et doit ${\hat{e}}tre$ construite $\grave{a}$ l'aide de la logique "empirique".

• Korean Journal of Human Ecology
• /
• v.4 no.1
• /
• pp.31-38
• /
• 1995

The purpose of this study was to examine the relationship between social networks and perceived self-competence. The subject were 350 third and sixth graders selected from a public elementary school in Seoul. The children were administered the Pattison Psychosocial Network Inventory and The Self Perception Profile for Children. Three major questions are addressed; l)age changes 2)sex differences, and 3) the relation between the characteristics of social networks and self-perceived competence. Data were analyzed by pearson's product moment correlation, one-way ANOVA. Proportion measures were also used since they had allowed for the observation of relationship between two subsets of people within given categories(e.g.,the number of relatives divided by the number of relatives plus nonrelatives). The effects of age and sex of child on the number and daily contact with kin, nankin, peers, adults, males, and females were found. Sixth graders had a larger number of adults than third graders. While children had a greater number of adults than peers, they had more contact with peers than with adults in their network. It was found that boys had greater number of people in their network than girls. And boys had a larger number of and more contact with males, and girls had a larger number of more contact with females. The structure of childrens' social networks structure were correlated with perceived self-competence.

• Computers and Concrete
• /
• v.8 no.2
• /
• pp.207-227
• /
• 2011

In flexural strength design of unconfined reinforced concrete (RC) members, the concrete compressive stress-strain curve is scaled down from the uni-axial stress-strain curve such that the maximum concrete stress adopted in design is less than the uni-axial strength to account for the strain gradient effect. It has been found that the use of this smaller maximum concrete stress will underestimate the flexural strength of unconfined RC members although the safety factors for materials are taken as unity. Herein, in order to investigate the effect of strain gradient on the maximum concrete stress that can be developed in unconfined flexural RC members, several pairs of plain concrete (PC) and RC inverted T-shaped specimens were fabricated and tested under concentric and eccentric loads. From the test results, the maximum concrete stress developed in the eccentric specimens under strain gradient is determined by the modified concrete stress-strain curve obtained from the counterpart concentric specimens based on axial load and moment equilibriums. Based on that, a pair of equivalent rectangular concrete stress block parameters for the purpose of flexural strength design of unconfined RC members is determined.

• Steel and Composite Structures
• /
• v.21 no.5
• /
• pp.963-980
• /
• 2016

The jib system with middle strut is widely used to achieve the large arm length in the large scale tower crane and the deployability in the mobile construction crane. In this paper, an analytical solution for the out-of-plane buckling of the jib system with middle strut is proposed. To obtain the analytical expression of the buckling characteristic equation, the method of differential equation was adopted by establishing the bending and torsional differential equation of the jib system under the instability critical state. Compared with the numerical solutions of the finite element software ANSYS, the analytical results in this work agree well with them. Therefore, the correctness of the results in this work can be confirmed. Then the influences of the lateral stiffness of the cable fixed joint, the dip angle of the strut, the inertia moment of the strut, and the horizontal position of the cable fixed joint on the out-of-plane buckling behavior of the jib system were investigated.

• Journal of the Korea Concrete Institute
• /
• v.28 no.5
• /
• pp.563-570
• /
• 2016

The composited structural member in which two or more materials having different stress-strain relationships (steel & concrete) has increased greatly in recent years. This paper presents the experimental results of flexural capacity of the composited H-Pile subjected to bending moment. Eight composited beams were tested under direct loading condition using the frame tester. Based on the experimental results it is noted that flexural capacity of composited H-Pile increased about 20~30% and ductility ratio significantly increased. Limit state analysis of the specimens was conducted and the result shows that flexural strength by limit state analysis is conservative.

• Journal of the Korean Society of Safety
• /
• v.31 no.5
• /
• pp.102-108
• /
• 2016

This paper presents a new strength method of underground box structures under additional surface load. An L-bracing using pre-flexed steel member threads called the "Pre-flex strength method" is used to improve capacity of the RC box structure under earth pressure due to additional surface load. The pre-flexed steel member is fixed the top and bottom of the structure after chemical anchor was installed by drilling hole on the box structure. The structural performance was evaluated analytically. 3 types of underground RC box structure were used; $2.0m{\times}2.0m$, $3.0m{\times}3.0m$ and $4.0m{\times}4.0m$. For the performance evaluation, structure analysis were performed on moment and shear resisting structures with and without pre-flex strength method. Numerical results confirmed that the proposed strength member system installed on underground RC box structures enhanced the strength capacity. The feasible region of the proposed pre-flex strength method in accordance with the earth pressure due to additional surface depth was evaluated.

• Journal of computational fluids engineering
• /
• v.21 no.4
• /
• pp.90-95
• /
• 2016

Leidenfrost drops with ellipsoidal shaping can control the bouncing height by adjusting the aspect ratio(AR) of the shape at the moment of impact. In this work, we focus on the effect of the AR and the impact Weber number(We) on the non-axisymmetrical spreading dynamics of the drop, which plays an important role in the control of bouncing. To understand the impact dynamics, the numerical simulation is conducted for the ellipsoidal drop impact upon the perfect non-wetting solid surface by using volume of fluid method, which shows the characteristics of the spreading behavior in each principal axis. As the AR increases, the drop has a high degree of the alignment into one principal axis, which leads to the consequent suppression of bouncing height with shape oscillation. As the We increases, the maximum spreading diameters in the principal axes both increase whereas the contact time on the solid surface rarely depends on the impact velocity at the same AR. The comprehensive understanding of the ellipsoidal drop impact upon non-wetting surface will provide the way to control of drop deposition in applications, such as surface cleaning and spray cooling.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
• /
• v.43
• /
• pp.25-52
• /
• 2009

An acceptance is effected by a statement or other conduct of the offeree indicating assent. Silence or inactivity does not in itself amount to acceptance. An acceptance of an offer becomes effective at the moment the indication of assent reaches the offeror. It uses in stating rules on whether an acceptance is too late to form a contract and an offeree may withdraw an acceptance after transmission. The offeree may indicate assent by performing an act such as one relating to the dispatch of the goods or payment of the price without notice to the offeror. The acceptance by action also is to be performed within the time fixed between the parties or within a resonable time. However, an oral offer must be accepted immediately by an offeree. After an acceptance by action, the offeree avoid revocation of an offer by giving the offeror prompt notice to that effect. Even if a reply an offer contains additions, limitations or other modifications is a rejection of the offer and constitutes a counter offer, the reply to an offer contains additional and different terms which do not materially alter the terms of the offer constitutes an acceptance unless the offeror objects to the discrepancy or to that effect. Additional or different terms relating to the price, payment, quality & quantity of the goods, time & place of delivery, a party's liability or the settlement of disputes are considered to materially alter the terms of the offer.

• Advances in aircraft and spacecraft science
• /
• v.7 no.4
• /
• pp.353-369
• /
• 2020

This paper presents the flutter analysis and optimum design of axially functionally graded box beam cantilever wing section by considering various geometric and material parameters. The coupled dynamic equations of the continuous model of wing system in terms of material and cross-sectional properties are formulated based on extended Hamilton's principle. By expressing the lift and pitching moment in terms of plunge and pitch displacements, the resultant two continuous equations are simplified using Galerkin's reduced order model. The flutter velocity is predicted from the solution of resultant damped eigenvalue problem. Parametric studies are conducted to know the effects of geometric factors such as taper ratio, thickness, sweep angle as well as material volume fractions and functional grading index on the flutter velocity. A generalized surrogate model is constructed by training the radial basis function network with the parametric data. The optimized material and geometric parameters of the section are predicted by solving the constrained optimal problem using firefly metaheuristics algorithm that employs the developed surrogate model for the function evaluations. The trapezoidal hollow box beam section design with axial functional grading concept is illustrated with combination of aluminium alloy and aluminium with silicon carbide particulates. A good improvement in flutter velocity is noticed by the optimization.