• Journal of Veterinary Science
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• v.22 no.1
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• pp.4.1-4.13
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• 2021

Background: Microsporum canis is a zoonotic disease that can cause dermatophytosis in animals and humans. Objectives: In clinical practice, ketoconazole (KTZ) and other imidazole drugs are commonly used to treat M. canis infection, but its molecular mechanism is not completely understood. The antifungal mechanism of KTZ needs to be studied in detail. Methods: In this study, one strain of fungi was isolated from a canine suffering with clinical dermatosis and confirmed as M. canis by morphological observation and sequencing analysis. The clinically isolated M. canis was treated with KTZ and transcriptome sequencing was performed to identify differentially expressed genes in M. canis exposed to KTZ compared with those unexposed thereto. Results: At half-inhibitory concentration (½MIC), compared with the control group, 453 genes were significantly up-regulated and 326 genes were significantly down-regulated (p < 0.05). Quantitative reverse transcription polymerase chain reaction analysis verified the transcriptome results of RNA sequencing. Gene ontology enrichment analysis and Kyoto Encyclopedia of Genes and Genomes enrichment analysis revealed that the 3 pathways of RNA polymerase, steroid biosynthesis, and ribosome biogenesis in eukaryotes are closely related to the antifungal mechanism of KTZ. Conclusions: The results indicated that KTZ may change cell membrane permeability, destroy the cell wall, and inhibit mitosis and transcriptional regulation through CYP51, SQL, ERG6, ATM, ABCB1, SC, KER33, RPA1, and RNP genes in the 3 pathways. This study provides a new theoretical basis for the effective control of M. canis infection and the effect of KTZ on fungi.

• Proceedings of the Korea Water Resources Association Conference
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• 2019.05a
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• pp.267-267
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• 2019

Driftwood is one of serious problems in a river environment. In several countries, such as Indonesia, Japan, and Italy, the driftwood frequently appears in a river basin, and it can alter the channel bed, flow configuration by wood deposition and jam formation. Therefore, the studies related to driftwood have been actively conducted by many researchers to understand the mechanism of driftwood dynamics. In particular, wood motion by collision is one of the difficult issues in the numerical simulation because the calculation for wood collision requires significantly expensive calculation time due to small time step. Thus, this study conducted the numerical simulation in consideration of the wood motion by water flow and wood collision to understand the wood dynamics in terms of computation. We used the 2D (two-dimensional) depth-averaged velocity model, Nays2DH, which is a Eulerian model to calculate the water flow on the generalized coordinate. A Lagrangian type driftwood model, which expresses the driftwood as connected sphere shape particles, was employed to Nays2DH. In addition, the present study considered root wad effect by using larger diameter for a particle at a head of driftwood. An anisotropic bed friction was considered for the sliding motion dependent on stemwise, streamwise and motion directions. We particularly considered changeable draft at each particle and projection area by an angle between stemwise and flow directions to precisely reproduce the wood motions. The simulation results were compared with experimental results to verify the model. As a result, the simulation results showed good agreement with experimental results. Through this study, it would be expected that this model is a useful tool to predict the driftwood effect in the river flow.

• 한국신재생에너지학회:학술대회논문집
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• 2006.11a
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• pp.165-167
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• 2006

On our return to India from Germany, we have worked on the development of parabolic solar concentrators with input and collaboration of German and Austrian inventors. We have gradually improved the solar technologies to include food processing based on inputs and feedback from users to fulfill their specific requirements. We will discuss the acceptability and commercialisation of various systems that we have successfully developed, their implications and their benefit. These success stories can work as multipliers. These concentrators can have various other applications. The Global Treaty Kyoto Protocol's CDM (Clean Development Mechanism) can result in a win-win situation for both developing and developed nations and the world environment at large - whereby developed nations get carbon credits by supporting renewable energy projects in developing nations. North-South dialogue and South-South dialogue can effectively foster global co-operation meaningfully to benefit People and environments ensuring sustainable development and protection of Our planet Earth, our only HOME!!!

• 한국전산유체공학회:학술대회논문집
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• 2008.03a
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• pp.355-358
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• 2008

In order to investigate the physical mechanism of the energy cascade in homogeneous isotropic turbulence, we introduce Galilean-invariant energy and its transfer rate in the real space as a function of position, time and scale. By using a database of direct numerical simulations (DNS) of homogeneous isotropic turbulence, it is shown that (i) fully developed turbulence consists of multi-scale coherent vortices of tubular shapes, (ii) the energy at each scale is mainly confined in vortex tubes with the radii of the same order of the length scale, and (iii) the energy transfer takes place around pairs (especially, anti-parallel pairs) of such vortex tubes. Based on these observations, it is suggested that the energy cascade can be caused, in the real space, by the process of the stretching and creation of smaller (i.e. thinner) vortex tubes by the straining field around pairs of larger (i.e. fatter) vortex tubes. Indeed, it is quite easy to find such events (in our DNS fields) which strongly support this scenario of the energy cascade.

• 한국전산유체공학회:학술대회논문집
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• 2008.10a
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• pp.355-358
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• 2008

In order to investigate the physical mechanism of the energy cascade in homogeneous isotropic turbulence, we introduce Galilean-invariant energy and its transfer rate in the real space as a function of position, time and scale. By using a database of direct numerical simulations (DNS) of homogeneous isotropic turbulence, it is shown that (i) fully developed turbulence consists of multi-scale coherent vortices of tubular shapes, (ii) the energy at each scale is mainly confined in vortex tubes with the radii of the same order of the length scale, and (iii) the energy transfer takes place around pairs (especially, anti-parallel pairs) of such vortex tubes. Based on these observations, it is suggested that the energy cascade can be caused, in the real space, by the process of the stretching and creation of smaller (i.e. thinner) vortex tubes by the straining field around pairs of larger (i.e. fatter) vortex tubes. Indeed, it is quite easy to find such events (in our DNS fields) which strongly support this scenario of the energy cascade.

• The Bulletin of The Korean Astronomical Society
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• v.35 no.1
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• pp.59.1-59.1
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• 2010

We present wide-field near-IR imaging polarimetry of 30 Doradus, using the InfraRed Survey Facility(IRSF) 1.4 m telescope at the South African Astronomical Observatory. We obtained polarimetry data in J, H, and Ks bands using the JHKs-simultaneous imaging polarimeter SIRPOL. 30 Doradus is located in the Large Magellanic Cloud(LMC) and it is the most active starburst region known in the Local group of galaxies. 30 Doradus is one of the best field to examine the behavior of the interstellar medium and star-formation mechanism under different conditions. We will investigate the structure of magnetic field in 30 Doradus region.

• Proceedings of the Safety Management and Science Conference
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• 2009.11a
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• pp.405-409
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• 2009

Most countries have been focused on the CDM(Clean Development Mechanism). According to Wikipedia, the free encyclopedia, CDM is an arrangement under the Kyoto Protocol allowing industrialized countries with a greenhouse gas reduction commitment to invest in projects that reduce emissions in developing countries as an alternative to more expensive emission reductions in their own countries. There are many environmental problems which resulted from development of IT field. The main objective of this paper is to find an effective methodology as an initial stage for applications of green IT in a real life. Therefore this paper addresses worldwide reviews on green IT products.

• The Korean Journal of Physiology and Pharmacology
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• v.28 no.4
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• pp.361-377
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• 2024

The dried rattan stem of the Fibraurea Recisa Pierre plant contains the active ingredient known as fibrauretine (FN). Although it greatly affects Alzheimer's disease (AD), the mechanism of their effects still remains unclear. Proteomics and transcriptomics analysis methods were used in this study to determine the mechanism of FN in the treatment of AD. AD model is used through bilateral hippocampal injection of Aβ_1-40. After successful modeling, FN was given for 30 days. The results showed that FN could improve the cognitive dysfunction of AD model rats, reduce the expression of AE and P-Tau, increase the content of acetylcholine and reduce the activity of acetylcholinesterase. The Kyoto Encyclopedia of Genes and Genomes enriched differentially expressed genes and proteins are involved in signaling pathways including metabolic pathway, AD, pathway in cancer, PI3K-AKT signaling pathway, and cAMP signaling pathway. Transcriptomics and proteomics sequencing resulted in 19 differentially expressed genes and proteins. Finally, in contrast to the model group, after FN treatment, the protein expressions and genes associated with the PI3K-AKT pathway were significantly improved in RT-qPCR and Western blot and assays. This is consistent with the findings of transcriptomic and proteomic analyses. Our study found that, FN may improve some symptoms of AD model rats through PI3K-AKT signaling pathway.

• Environmental and Resource Economics Review
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• v.13 no.4
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• pp.621-655
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• 2004

Emission Trading (ET) among Annex I countries as expounded in Kyoto mechanism can be an effective mean to control Greenhouse Gases(GHGs), particularly $CO_2$ emissions from fossil fuels. For the international ET to be an effective tool to reduce the global emissions, however, it presupposes that there are no carbon leakage, i.e. Annex I emitters will purchase emission permits if emitting above caps, rather than importing emission-intensive goods from non-Annex I countries thus inducing the foreigners to emit instead. The extent to which a country leaks carbon through trade can be revealed by its bilateral balance of current accounts and related Balance of Emissions Embodied in Trade (BEET) supplemented by Emission Terms of Trade (ETT). Earlier studies on BEET and ETT relied on few selected countries in a partial equilibrium context, Korea being treated as insignificant though she is not a minor emitter. This paper is an attempt to examine BEET in the global CGE framework and to compare its structural difference across countries, with a special emphasis on South Korea.

• Korean Journal of Remote Sensing
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• v.28 no.5
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• pp.587-596
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• 2012

Verifying about eligibility of targeted site is necessary for execute Afforestation and Reforestation Clean Development Mechanism (A/R CDM) project which is followed by system of Kyoto protocol. The site have to be identified by which could not be in conformity with definition of forest. This study tried to propose a technology of classify for site selection of A/R CDM. We chose several parts of Yangpyeng as study area and applied LiDAR data and remotely sensed imagery for considering about tree height, degree of crown closure, and land area which 3 factors for identify forest. LiDAR data was used for offset the shortage of remotely sensed imagery that cannot perfectly determine the forest definition due to absence of 3-dimentional information, but can be obtained from LiDAR. Considering tree height, degree of crown closure, and land area simultaneously by moving window, classified fields to forest and non forest based on pixel size. As a result, 124.06 ha for suitable to doing plantation and approximately 357.02 ha are in negative. Technology that applied for analyzing will provide fundamental methodology not only site selection for A/R CDM, but will be utilized in other Kyoto protocol.