• Biomolecules & Therapeutics
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• v.20 no.5
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• pp.457-462
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• 2012

The stem-bark of Kalopanax pictus (KP, family Araliaceae), of which main constituent is kalopanaxsaponin B, has been used for asthma, rhinitis, and arthritis in Chinese traditional medicine. To clarify anticolitic effect of KP, we examined anti-inflammatory effect of KP extract and kalopanaxsaponin B in lipopolysaccharide (LPS)-stimulated peritoneal macrophage and 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitic mice. Of KP extracts, KP BuOH-soluble fraction most potently inhibited LPS-induced IL-$1{\beta}$, IL-6 and TNF-${\alpha}$ expression, as well as NF-${\kappa}B$ activation. However, KP BuOH fraction increased IL-10, an anti-inflammatory cytokine. KP BuOH fraction also inhibited colon shortening and myeloperoxidase activity in TNBS-induced colitic mice. KP BuOH fraction also potently inhibited the expression of the pro-inflammatory cytokines, IL-$1{\beta}$, IL-6, and TNF-${\alpha}$ as well as the activation of NF-${\kappa}B$. Kalopanaxsaponin B, a main constituent of KP, inhibited TNBS-induced colonic inflammation, including colon shortening, and TNBS-increased myeloperoxidase activity pro-inflammatory cytokine expression and NF-${\kappa}B$ activation in mice. Based on these findings, KP, particularly its main constituent, kalopanaxsaponin B, may ameliorate colitis by inhibiting NF-${\kappa}B$ pathway.

• Knowledge Management Research
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• v.9 no.3
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• pp.43-57
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• 2008

This study examines the impact of knowledge processes (KP) on the performance of knowledge management systems (KMS). It posits that task needs and available functionality of technology existing in an organization could influence the usability of KP and the KMS performance. A firm-level structural model was developed based on data collected from corporate KM users. Survey-based research was carried out to test this model. Following questionnaire development, validation, and pretest with a pilot study, data were collected from 886 knowledge management (KM) users including directors, managers, and workers in a South Korea-based company, Korea Asset Management Corporation (KAMCO), to measure the task needs and available functionality of technology to improve the KMS performance. Results show that the matching between the two factors-technology and task-had a significant influence on the usability of KP and the KMS performance, and a better usability of KP has positive impact on the KMS performance. Implications on KM practices and KMS designs are also discussed.

• The Korean Journal of Food And Nutrition
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• v.32 no.2
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• pp.106-113
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• 2019

The objective of this study was to evaluate the effect of fermented Kalopanax pictus (KP-F) on macrophage activation and its effect as a competitive inhibitor of LPS and inhibitory effect on endotoxemia. The results showed that KP-F could activate macrophage in a dose-dependent manner, and KP-F was confirmed to act as a ligand for TLR4. Also, it was found that KP-F did not exhibit the same biotoxicity as LPS in intraperitoneal injection, and that it could suppress the neutrophil migration induced by LPS administration. In normal mice, the body weight, tissue weight, and amount of nitrite and pro-inflammatory cytokines in serum showed no significant changes with KP-F diet for 2 weeks, confirming that administration of KP-F in normal mice did not lead to over activation of immune response and biotoxicity. In the mouse model of endotoxemia induced by LPS and D-galactosamine(D-GalN) in sub-lethal dose, the diet of KP-F effectively inhibited the amount of nitrite and cytokines in the blood, and thus was found to be able to relieve the hepatic and kidney injury. In addition, in the endotoxemia mouse model induced by LPS and D-GalN of lethal dose, the survival rate was increased by KP-F diet in a dose-dependent manner.

• Journal of Animal Science and Technology
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• v.46 no.3
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• pp.301-306
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• 2004

This study was conducted to develop new markers at the region that was related to QTL affecting intramuscular fat and backfat thickness on chromosome 6q28 - 6q32 in pigs. Dozens of repeated sequences were founded using shotgun sequencing of several BAC clones corresponding to that region, of which five new microstellite markers that identified polymorphism were discovered. The mean number of alleles at each locus observed 2.13(KP0290F2), 4.63(KP0248Cll), 7.38(KP1231C91), 2.75(KPI23IC92) and 6.2S(KP1231C93) in 8 breeds(Landrace, Korean native pig, Duroc, Yorkshire, Berkshire, Wuzhishan pig, Xiang pig, Min pig). The average estimated heterozygosity values at each locus varied from 0.2100(KP0290F2) to 0.8304(KPI23IC91) in all populations. In other hand, the average allele of all loci WlL'I within range of 0.4517(Berkshire) and 0.6957 (Yorkshire). Of these markers, KP0248C11, KP1231C91 and KP1231C93 were identified to have optimal number of alleles, high heterozygosity values and low standard deviation values. Especially, KPI23IC91 and KPI231C93 might be considered as a useful marker for genetic mapping and diversity study.

• Journal of Pharmaceutical Investigation
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• v.33 no.4
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• pp.273-279
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• 2003

Pancreatin is a enzyme mixture breaking down carbohydrates, proteins and lipids. Most pancreatin used in Korea is imported from foreign countries. However, guideline of each country for pancreatin produced from each country is different. Therefore, guideline for pancreatin imported from several countries, such as Europe, Japan and America, it is standardized to control its quality. Assay of enzyme activity for pancreatin in KP is similar to tat in JP, but it is significantly different from those in FP ad in USP. We measured pancreatin digestive activities of 17 commercial products. Activity assay of digestive enzymes, starch- and lipid-digestive enzymes, for pancreatin by KP method (including JP) was difficult compared to those by FIP ad USP methods. Particularly, activity assays of starch- and lipid-digestive enzymes by KP method were mistakable, ad varied in diluted samples than those by FIP. However, activity assay of protein-digestive enzyme by KP method was similar to that by FIP. Starch-digestive enzyme activities of 17 commercial pancreatins by KP method were lower 0.079-fold compared to those by FIP method. Their protein-digestive enzyme activities by KP method were higher 75.7-fold than those by FIP method. Their lipid-digestive enzyme activities by KP method were lower 0.234-fold compared to those by FIP method.

• Atmosphere
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• v.25 no.2
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• pp.367-374
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• 2015

Korean Peninsula has high potential for occurrence of aviation turbulence. A Korean aviation Turbulence Guidance (KTG) system focused on the Korean Peninsula, named Korean-Peninsula KTG (KP-KTG) system, is developed using the high resolution (horizontal grid spacing of 1.5 km) Local Data Assimilation and Prediction System (LDAPS) of the Korea Meteorological Administration (KMA). The KP-KTG system is constructed first by selection of 15 best diagnostics of aviation turbulence using the method of probability of detection (POD) with pilot reports (PIREPs) and the LDAPS analysis data. The 15 best diagnostics are combined into an ensemble KTG predictor, named KP-KTG, with their weighting scores computed by the values of area under curve (AUC) of each diagnostics. The performance of the KP-KTG, represented by AUC, is larger than 0.84 in the recent two years (June 2012~May 2014), which is very good considering relatively small number of PIREPs. The KP-KTG can provide localized turbulence forecasting in Korean Peninsula, and its skill score is as good as that of the operational-KTG conducting in East Asia.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.4 no.2
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• pp.443-451
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• 2000

Until now, there have been various kinds of science information databsae which databased the science technology information, but they do not satisfy the aspiration of the users. Therefore, in the position of the users, it suggests the technology information space as a now paradigm, which supplement the function of science information DB. ICPIS which inputs described papers with keywords, offers the itemized summary of these contents, the visual indication and comparison of similar thesis, and it also supplises the abundant summary information, survey information, more than ten volumes of info communication thesis with starting the casual relation extraction for the users, playing a significant role in ICPIS is called KP, and it is package of domain knowledge that unifies the extraction and structure narration of the technology information. ICPIS extracts the technology information among the thesis that are deserved by the natural language treatment in the itemized KP keywords described, and form the prescribed summary structure in KP.

• Atmosphere
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• v.18 no.1
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• pp.43-53
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• 2008

A new proposition on the definition of the tropical cyclone (TC) which influences the Korean Peninsula (KP) is presented. The definition is based upon the TC track and intensity, 34 wind swath considering the TC size, and the line of 200 nautical mile (NM) from the KP shore which is the boundary of the official warning of Korea Meteorological Administration. Four types are proposed. First type is TC that hits the KP inland. Second is TC that falls within the 200-NM boundary. Third type is TC that passes outside the 200-NM boundary but large enough to significantly influence the KP. Last, the cases for a TC which are downgraded to the midlatitude cyclone and hit the KP are included. 30-year reanalysis reveals that 21 tropical cyclones should be included in the TC list that influenced the KP during the period from 1977 to 2006, which corresponds to 3.93 TCs per year. Among them, number of type I, II, III and IV TCs turn are to be 36, 47, 10, and 16, respectively. The net increase found in the current reanalysis is 2, 5, 7, and 7 for each type.

• Natural Product Sciences
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• v.18 no.1
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• pp.32-38
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• 2012

The herbs of Orostachys japonicus (Crassulaceae) have been used to treat gastric cancer, gastric ulcer or hemorrhage. Flavonoid glycosides, mainly kaempferol (Kp)- and quercetin (Qc) glycosides, have been isolated from O. japonicus; however, no quantitative information on those flavonol glycosides and no peroxynitritescavenging activity of the Orostachys extracts have been reported. In this study, Kp- and Qc glycosides were qualitatively and quantitatively analyzed by high-performance liquid chromatography (HPLC) in eight Orostachys and a Meterostachys species including O. japonicas, O. margaritifolius, O. chongsunensis, O. minuta, O. ramosus, O. malacophylla, O. latiellipticus, O. iwarenge, O. iwarenge for. magnus, and Meterostachys sikokiana distributed or cultivated in Korea. Distinctively, O. margaritifolius contained two flavonol 3,7-di-O-glycosides of Kp 3,7-di-O-glucoside and Kp 3-rhamnosyl-7-glucoside, but O. japonicus had two flavonol 3-O-rutinosides, Kp 3-rutinoside and Qc 3-rutinoside. The three species of O. margaritifolius (24.36 mg/g MeOH extract), O. japonicus (21.28 mg/g), and O. minuta (19.50 mg/g) showed relatively higher flavonoid contents. The flavonol glycosides were analyzed using eight standard compounds (Kp, Qc, Qc 3-O-rhamnoside, Qc 3-O-glucoside, Kp 3- O-rutinoside, Qc 3-O-rutinoside, Kp 3-O-rhamnosyl-7-O-glucoside, Kp 3,7-di-O-glucoside). The present HPLC method was validated to verify the linearity, precision, and accuracy. In addition, the peroxynitrite-scavenging activity was also discussed.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.39 no.4
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• pp.45-52
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• 2007

Whole, bast and core fibers of kenaf cultivar Tainung-2 were pulped under different pulping methods, thermomechanical and kraft pulping methods. The physical and optical properties of kenaf TMP(thermomechanical pulp) and KP(kraft pulp) handsheets were investigated and the results from the study are summarized as follows: Yields of TMP and KP were $77{\sim}87%\;and\;43{\sim}52%$, respectively. There was no significant change in apparent density between kenaf KP and USKP(unbleached softwood kraft pulp) but TMP showed a little lower apparent density. Bast pulp had the lowest apparent density regardless of pulping methods. Tensile strength of kenaf KP was higher than that of TMP but similar to that of USKP. Both TMP and KP handsheets of bast fraction showed the highest tear strengths among whole, bast, and core fractions. Core fraction showed the lowest tear strengths under different pulping methods. In general burst strength of kenaf pulp under different pulping methods was lower than that of USKP, and kenaf pulp had better stiffness than USKP. Brightness of kenaf KP and TMP was higher than that of USKP. There was no significant variation in opacity between kenaf pulp and USKP even though kenaf pulp showed a little lower opacity. The main difference in paper quality between the core fiber and bast fiber is derived from the fact that bast fiber is long and thin, whereas core fiber is short and thick.