• 동의신경정신과학회지
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• 제16권2호
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• pp.189-199
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• 2005

We experienced a 71year-old man who had a traumatic subdural hemorrhage as well as delirium, and whose condition was improved through oriental medical treatment. Herbal medicine Hwaeo-jeon is administered three times a day. We did Mini-Mental State Examination-Korean(MMSE-K) and Korean-Dementia Rating Scale(K-DRS). After being treated, the patient showed that symptoms of delirium(diminished or altered state of consciousness, impairment of cognitive abilities or physical function) was improved considerably. This result suggests that Hwaeo-jeon has good effects on delirium with Traumatic Subdural Hemorrhage.

• 지역사회간호학회지
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• 제28권2호
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• pp.107-117
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• 2017

Purpose: The purpose of this study is to examine the cognitive function in the elderly and to identify the influencing factors. Methods: The design of this study was descriptive research design. A total of 139 elderly people (aged 65 years and over) visiting the electroencephalogram (EEG) center in Seoul, Korea were evaluated. Data were assessed by self-administered questionnaires and CNS Vital Signs (CNSVS). Data were analyzed using SPSS Statistics 23.0 for Windows. Results: There were significant differences in the Korean Mini-Mental State Examination (K-MMSE), executive functions and reasoning according to education level. K-MMSE, visual memory and executive functions were different depending on the jobs. Age was highly correlated with cognitive function. In addition, stepwise multiple regression analyses showed that the factor significantly associated with reaction time and visual memory was depression. Depression and Trait-Anxiety had significant impacts on executive functions and K-MMSE. Conclusion: CNSVS enabled the accurate and objective measurement of cognitive function. Therefore, this study provides useful data to improve cognitive function of the community-dwelling elderly. The results suggested that there is need for comprehensive interventional programs that manage cognitive impairment.

• 동의신경정신과학회지
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• 제30권3호
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• pp.185-198
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• 2019

Objectives: The purpose of this study was to identify the effectiveness of Korean medicine treatment in mild cognitive impairment (MCI) among a group of community dwelling elderly. Methods: Two-hundred and twenty-nine elderly living in a community and diagnosed with MCI were recruited. Participants were evaluated with various instruments such as the Korean version of Mini-Mental State Examination for Dementia Screening (MMSE-DS) and the Korean version of Montreal Cognitive Assessment (MoCA-K). Korean medicine treatment consisted of herbal medicine, acupuncture, and pharmacoacupuncture. The change in cognitive ability was assessed by using the MMSE-DS and the MoCA-K. Data were analyzed by SPSS/WIN 22.0 using the paired t-test, and the ANOVA. Results: The MMSE-DS and the MoCA-K score generally increased after six months of Korean medicine treatment and the differences in both instruments were statistically significant. Additionally, some consecutive participants maintained long-term cognitive improvement. When analyzed specifically by herbal medicine group based on syndrome differentiation and pharmacoacupuncture group, most showed improvement in the MMSE-DS and the MoCA-K but not all data were statistically significant. The satisfaction score was mostly high and most participants were willing to re-participate in the program. Conclusions: Korean medicine treatment may contribute to the improvement and prevention of cognitive decline in the elderly. However, further systematic research based on large scale sample data and standardized protocols is needed to uplift the welfare and mental health of the elderly.

• Journal of Preventive Medicine and Public Health
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• 제43권4호
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• pp.319-329
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• 2010

Objectives: This study was performed to determine the levels of quality of life (QOL) according to the grade of long-term care service for the elderly people who were admitted from long-term care insurance, and to reveal its association with the physical and mental functioning such as the Activity of Daily Living (ADL), the Instrumental Activity of Daily Living (IADL), the Center for Epidemiologic Studies Depression Scale (CES-D), and the Mini-Mental State Examination-Korean version (MMSE-K). Methods: The interviews were performed during the period from March 1 to May 31, 2009, for 958 elderly people in urban and rural areas. The questionnaire items included various indices such as the ADL, IADL, CES-D, and MMSE-K, as independent variables and the index of QOL, as the dependent ones. For statistical analysis, t-tests were used for the mean scores of QOL according to gender and the grade of long-term care services, and Spearman's correlation was used for each variable. The effects of physical and mental functioning for QOL were assessed by covariance structure analysis. The statistical significance was set at p<0.05. Results: The mean scores of QOL among all the subjects was $55.4{\pm}15.62$ (Grade I: $49.7{\pm}14.17$, Grade II: $56.8{\pm}14.62$, Grade III: $59.4{\pm}16.36$), and it was lower according to the higher grade of long-term care insurance. In terms of the correlation matrix of the QOL and the physical and mental function factors, the QOL showed positive correlation with the ADL, IADL and MMSE-K, while it had negative correlation with depression. On the analysis of covariance, mental functioning (depression and the MMSE-K) had a greater influence on the level of QOL than the physical functioning (ADL and IADL). Conclusions: The level of the QOL in the elderly people who were admitted from long-term care insurance was lower according to higher the grade of long-term care insurance. Also, the mental functioning (depression and MMSE-K) was more influential on the level of the QOL than the physical functioning (ADL and IADL).

• 대한한의학회지
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• 제34권3호
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• pp.106-118
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• 2013

Objectives: The aim of this study was to evaluate the effect of a mild cognitive impairment (MCI) management program on traditional Korean medicine in a public health center. Methods: In order to examine the effect of the MCI management program, we investigated MCI patients who participated in the program. MCI patients were treated with Jodeung-san (JDS) or Dangguijagyag-san (DGJYS) for 6 weeks. Mini Mental State Examination-Dementia Screening (MMSE-DS), Geriatric Quality of Life-Dementia (GQOL-D), Geriatric Depression Scale in Korea (GDS-K), and biochemical examination of blood were conducted at intervals of 6 weeks. A satisfaction survey was collected after this program. Results: MMSE-DS mean score increased significantly, by 4.09 (p=0.000) in the JDS group and by 4.15 (p=0.000) in the DGJYS group. GQOL-D mean score also increased significantly, by 5.90 (p=0.000) in the JDS group and by 5.07 (p=0.000) in the DGJYS group. GDS-K mean score decreased significantly, by 10.63 (p=0.000) in the JDS group and by 9.69 (p=0.000) in the DGJYS group. MMSE-DS, GDS-K and GQOL-D scores were not significantly different between the JDS and DGJYS groups. All of the participants were satisfied with the program, and 90% of the participants expressed a high intention to participate in the program again. Conclusions: Both Jodeung-san and Dangguijagyag-san treatment showed improvement on cognitive function, depression and quality of life in this program. Additional studies with more subjects will be required to prove credibility and validity more clearly.

• 정신신체의학
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• 제24권2호
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• pp.184-190
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• 2016

연구목적 본 연구는 알츠하이머병(Alzheimer's disease, AD), 경도인지장애(Mild Cognitive Impairment, MCI), 정상군에서 체질량지수(Body Mass Index, BMI)의 차이를 분석하여 낮은 BMI 수치와 인지기능 저하와의 연관을 확인하고자 하였다. 또한, 한국판 간이정신상태검사(Mini Mental State Examination-Korean version, MMSEK), 치매임상평가척도(Clinical Dementia Rating, CDR), 전반적 퇴화척도(Global Deterioration Scale, GDS)과 BMI 사이에 연관성이 있는지도 알아보고자 하였다. 방 법 총 257명의 연구대상자들이 이 연구에 포함되었고, AD 및 MCI 진단을 위해 병력 청취, 정신상태검사, 신경인지기능검사, 신체 검사가 시행되었다. 대상자의 성별 및 연령과 신체 질환도 함께 조사하였다. 전반적인 인지기능과 질병의 심각도 단계 평가는 MMSE-K, GDS, CDR으로 측정하였다. 결 과 MMSE-K 점수는 정상군>MCI>AD 순이었으며 통계적으로 유의한 차이를 나타내었다(p=0.000). CDR과 GDS점수는 정상군이 가장 높았고, AD군이 가장 낮았으며 역시 통계적으로 유의한 차이를 나타내었다 BMI와 MMSE 점수 사이에는 유의한 양의 상관관계가 있었다(r=0.238, p=0.000). BMI와 CDR과는 음의 상관관계를 나타내었으며(r=-0.174, p=0.008), BMI와 GDS 역시, 음의 상관관계를 보였다(r=-0.233, p=0.000). 결 론 BMI와 인지기능과의 연관성이 있으므로, 치매나 경도인지장애 환자를 대상으로 BMI를 측정하는 것은 임상적 표지자로서 의미가 있을 것으로 예상된다. 본 연구는 AD의 진단 및 예방, 그리고 치료적 접근에 도움을 줄 수 있을 것으로 기대하며, 향후 이에 대한 대규모의 장기 추적 연구가 필요할 것으로 생각된다.

• Journal of Preventive Medicine and Public Health
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• 제32권1호
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• pp.65-71
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• 1999

농촌노인들의 인지기능장애 정도와 일상생활 활동도 사이의 상관성을 성별과 연령에 따라 비교하여 추후 공공보건기 관에서 치매환자를 관리하기 위한 계획 수립과 우선순위 선정 등에 도움을 주기 위하여 1998년 2월부터 4월까지 경상북도 경주시 소재 l개 보건진료소 관할지역 내의 65세 이상 전체 노인 265명 중 부재중이거나 비협조적인 55명을 제외한 210 명을 대상으로 조사를 실시하였다. 성, 연령, 배우자 유무, 동거가족 수, 교육정도, 종교, 의료보장 형태 등을 설문조사하였고, MMSE-K와 K-MMSE로 인지 기능장애를 검사하였으며, 치매노인의 일상생활 활동도 측정도구인 Bristol ADL 평가척도로 일상생활 활동도를 조사했다. 수집된 자료를 성별과 연령에 따라 t-test, ANOVA 및 $\chi^2-test$를 사용하여 비교하였으며, 인지기능장애정도와 일상생활 활동도와의 상관관계 분석을 실시하였다. 인지기능검사 점수의 평균값은 두가지 검사 모두에서 성별에 따라 유의한 차이가 있었고, MMSE-K점수에 의한 확정적 치매는 전체 노인에서 12.9%였고 남자 7.0%, 여자 16.9%로 여자에서 유의하게 높았다(p<0.05). 인지기능검사 점수의 평균값은 두가지 검사 모두에서 연령에 따라 유의한 차이가 있었고, MMSE-K점수에 의한 확정적 치매가 남자에서는 연령에 따른 차이가 없었으나, 여자에서는 연령이 증가함에 따라 유의하게 증가했다(p<0.05). 일상생활 활동도의 평균값은 총점에서 성별에 따른 차이는 없었고, 연령에 따라서는 유의한 차이가 있었다(p<0.05). 인지기능검사 점수와 일상생활 활동도와의 상관관계에서는 MMSE-K와 K-MMSE의 두가지 성적 모두는 일상생활 활동도와 유의한 상관관계를 보였다(p<0.01). 여자가 남자보다 더 높은 상관관계를 보였으며 연령에 따라서는 65-69세, 70-79세, 80세 이상의 세 연령군 모두에서 유의한 상관관계를 보였다(p<0.01). 인지기능검사 점수와 일상생활 활동도 항목들과의 상관관계에서는 수단적 일상 생활 활동도, 자기관리, 인지능력이 유의한 상관관계가 있었다(p<0.01). 이상의 결과를 요약하면 인지기능검사 점수와 일상생활 활동도 사이에는 상관 관계가 있으며 추후 지역사회 공공의료 조직에서 치매노인을 관리할 때 그 대상자의 선정에서 인지기능장애 정도와 더 불어 일상생활 활동도의 정도를 감안하여 우선순위를 두고, 관리시에도 인지기능장애 정도와 성별, 연령, 교육수준에 맞는 일상생활 활동도를 고려하여야 할 것이다.

• 대한지역사회영양학회지
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• 제24권6호
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• pp.525-534
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• 2019

Objectives: Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer's disease, in which ketone bodies are used as the only and effective alternative energy source of glucose. This study examined the effects of a low-carbohydrate and high-fat (LCHF) diet supplemented with a ketogenic nutrition drink on cognitive function and physical activity in the elderly at high risk for dementia. Methods: The participants of this study were 28 healthy elderly aged 60-91 years showing a high risk factor of dementia or whose Korean Mini-Mental State Examination (K-MMSE) score was less than 24 points. Over 3 weeks, the case group was given an LCHF diet with nutrition drinks consisting of a ketone/non-ketone ratio of 1.73:1, whereas the control group consumed well-balanced nutrition drinks while maintaining a normal diet. After 3 weeks, K-MMSE, body composition, urine ketone bodies, and physical ability were all evaluated. Results: Urine ketone bodies of all case group subjects were positive, and K-MMSE score was significantly elevated in the case group only (p=0.021). Weight and BMI were elevated in the control group only (p<0.05). Grip strength was elevated in all subjects (p<0.01), and measurements of gait speed and one leg balance were improved only in the case group (p<0.05). Conclusions: We suggest that adherence to the LCHF diet supplemented with a ketogenic drink could possibly influence cognitive and physical function in the elderly with a high risk factor for dementia. Further, we confirmed the applicability of this dietary intervention in the elderly based on its lack of any side effects or changes in nutritional status.

• 대한물리의학회지
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• 제14권4호
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• pp.115-123
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• 2019

PURPOSE: This study compared the scores of the Mini-Mental State Examination-Korean version (MMSE-K) and Korean version Montreal Cognitive Assessment (K-MOCA), which assess cognitive function, the Fugl- Meyer Upper-Extremity Assessment (FMA), which assess the upper extremity function; and Modified Barthel Index (MBI), which that assesses activities of daily living among patients receiving inpatient treatment following a diagnosis of stroke to determine the correlations among MMSE-K, K-MOCA, FMA, and MBI. METHODS: The study assessed the cognitive function using the MMSE-K and K-MOCA, upper extremity function using FMA, and activities of daily living using MBI. The data were analyzed using Pearson's correlation analysis and multiple regression analysis. RESULTS: An analysis of the differences in the MMSE-K, K-MOCA, MBI, and FMA scores according to the affected side, revealed differences in the, K-MOCA scores according to the affected side, where patients with right hemiplegia showed better cognitive function (p <.05). Correlation analysis among MMSE-K, K-MOCA, FMA, and MBI Showed significant correlations (p <.05). The results indicate that those with higher cognitive and upper extremity functions had higher performance of activities of daily living. CONCLUSION: The cognitive and upper extremity functions were correlated with the activities of daily living in stroke patients. Accordingly, applying physical therapy with a focus on improving the cognitive function and training activities of daily living could assist in the functional recovery of stroke patients significantly.

• 동의신경정신과학회지
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• 제13권1호
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• pp.117-125
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• 2002

Objectives: The purpose of this study was to investigate the clinical application of oriental medical therapy to a patient with memory disorders and quadriparesis caused by traffic accident. Methods: This study was carried out on a patient who was admitted to the Sangji oriental medical hospital, from January 21st in 2002 to May 2nd in 2002. We used 4 kinds of diagnosis(watching, asking, hearing, and toughing) and treated the patient with herbal medication and acupuncture therapy. Then we estimated the effect of memory disorders through MMSE-K(Mini mental State Examination-Korea) and K-DRS(Korean-Dementia Rating Scale). The numerical effect demonstrated ability of movement through range of motion. Results: Following the treatment the patient's mental state and the ability of movement improved. Conclusions: The present results suggest that oriental medical therapy has the positive effects on a patient with memory disorders and quadriparesis which were caused by traffic accident.