• 생물정신의학
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• 제8권2호
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• pp.258-265
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• 2001

Objectives : Chronic alcohol consumption has been known to result in various neurocognitive deficits. Many neuropsychological studies revealed that the major disturbances occurred in the executive function, learning and short-term memory, visuospatial performance function, perceptuo-motor skills, and abstraction and problem solving abilities. This study was done to identify which cognitive areas might be mainly affected. Methods : The cognitive disturbance was evaluated using the Korean Version of the Mini Mental State Examination(MMSEK) and the 7 Minute Screen(7MS) in male inpatients with alcohol dependence(N=3 : as well as in age and education level matched healthy male controls(N=30). Four individual tests of the 7MS were consisted of the Benton Temporal Orientation Test, the Enhanced Cued Recall, the Clock Drawing and the Category Fluency. Results : 1) The average scores of four individual test of the 7MS for the alcoholics were $2.77{\pm}4.38$ for the Benton Temporal Orientation Test, $13.90{\pm}2.02$ for the Memory Test(the Cued Recall $6.77{\pm}1.94$, the Uncued Recall $7.10{\pm}2.45$), $5.84{\pm}1.86$ for the Clock Drawing, and $12.58{\pm}3.29$ for the Category Fluency. Except the Benton Temporal Orientation Test, there were statistically significant differences between test scores of alcoholics and those of controls(p<0.01). 2) The alcoholics who had MMSE-K score <24 were 9.68%. The average(${\pm}S.D.$) score of the MMSE-K for the patient group($27.23{\pm}2.62$) was significantly(p<0.001) lower than that of the healthy controls($29.20{\pm}1.24$). There were no statistically significant differences between four individual test scores of the 7MS of alcoholics with the MMSE-K score <24(N=3) and those of alcoholics with the MMSE-K score ${\geq}24$(N=28). 3) Four individual test scores of the 7MS seemed to have statistically significant association with such variables as MMSE-K, duration of alcohol drinking, blood magnesium concentration, liver function and thyroid function. Conclusion : Mild deficits of cognitive areas such as orientation, memory, visuospatial abilities and verbal fluency could be found in alcohol dependence.

• 한국신경인지재활치료학회지
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• 제10권2호
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• pp.9-18
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• 2018

목적: 본 연구는 스마트기기 애플리케이션 게임을 이용한 인지훈련이 외상성 뇌손상 환자의 인지기능에 미치는 영향을 알고자 하였다. 방법: 본 연구는 종합병원에서 작업치료를 받은 경미한 외상성 뇌손상 환자 17명을 대상으로 진행되었으며, 실험군 9명과 대조군 8명이 두 군으로 할당되었으며, 실험군은 스마트기기 애플리케이션 게임을 이용한 인지훈련과 전통적 인지훈련을 15분씩 실시하였으며, 대조군은 전통적 인지훈련만 30분 수행하였다. 모든 중재는 하루 30분, 주 5회, 4주간 수행하였다. 인지기능은 한국판 간이정신상태검사, Lowenstein 작업치료 인지평가와 시지각 검사(Motor-free Visual Perception Test-3)의 시각 기억 영역 1과 2를 포함하였다. 측정은 중재전과 후에 시행되었다. 결과: 두 군 사이의 변화량 비교에서, 실험군은 대조군보다 시지각 검사의 시각 기억과 한국판 간이정신상태검사의 회상 영역에서 유의한 향상이 있었다(p<.05). 결론: 본 연구의 결과는 스마트기기 애플리케이션 게임을 이용한 인지훈련이 전통적인 인지훈련보다 외상성 뇌손상 환자의 시각 기억력에 긍정적인 변화를 줄 수 있는 것으로 확인되었다.

• Journal of Preventive Medicine and Public Health
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• 제32권3호
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• pp.306-316
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• 1999

Objectives: In Korea, as in most countries, there will be a sharp increase in the number of dementia patients in the near future. However basic data on dementia prevalence, which is important in defining epidemiologic characteristics and in implementing preventive strategy, are limited. This study was conducted to estimate the prevalence rate of dementia in the urban elderly aged 65 or older in Kwangmyung, Korea. Methods: A two phase design was used for case finding and case identification. In phase I, a representative sample aged 65 or older was selected and interviewed by door-to-door survey with a Korean version of the Mini-Mental State Examination (K-MMSE). In phase II, Of the 946 subjects interviewed in phase 1,356 elderly were randomly selected disproportionately according to K-MMSE score. Of these elderly, 223 (61.5%) underwent standardized clinical evaluations, including psychiatric interview, neurological examination, and neuropsychological assessment. Dementia was diagnosed by the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria. The diagnosis of Alzheimer's disease (AD) was made by National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and feinted Disorders Association(NINCDS-ADRDA) criteria and vascular dementia (VD) by DSM-IV. Results: The overall weighted prevalence rate of all dementia among Kwangmyung residents aged 65 or older was 12,8%(age-adjusted rate: 13,0%, 95% Confidence Interval[CI]: 10.6-15.3%). Women had much higher prevalence rate than men even when age was controlled(15.9%[95% CI 12.6-19.2%] vs 7.5%[95% CI 4.0-10.4%]), The rates of dementia were 5.2%, 12.2%, 17.0%, and 34.3% for the age groups of 65-69, 70-74, 75-79 and 80 and over, respectively. The rate of AD appeared to be slightly higher than that of VD(5.2% vs 4.8%), though not statistically significant. Most of the cases(69%) were mild dementia according to CDR(<1) in these subjects. Conclusions : These results showed that the prevalence rate of dementia among urban elderly in Korea appears to be higher than those of other Asian countries.

• 한국농촌간호학회지
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• 제1권1호
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• pp.40-48
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• 2006

Purpose: This study was done to identify the experience of stress and burn-out in caregivers of patients with senile dementia. Method: To evaluate the degree of stress and burn-out in caregivers of patients with senile dementia, 64 caregivers and matched to 64 patients with senile dementia at a Primary Health Care Post in South Kyung Sung Province were selected. The study was carried out from March 6 to March 30, 2001. Data on the degree of dementia in the patients was measured by the MMSE-K (Mini-Mental State Examination-Korea) and caregiver characteristics such as, sex, age, marital status, educational level, job, socioeconomic status, religion, number in family, relationship with patient, duration of care, and chronic disease in caregiver were collected by direct interview with a questionnaire. Results: Of 64 patients with senile dementia, 15.6% were classified as mild dementia (MMSE score 20-24) and 84.4%, as severe dementia. There were no significant characteristics of caregivers associated with the degree of stress and burn-out experience. The degree of burn-out in these caregivers of patients with severe dementia (mean value 94.3) was significantly higher than the 81.4 for those caring for patients with mild dementia (p<0.05). However, the degree of stress was not significantly related with the degree of dementia. The proportion experiencing severe burn-out (above score 4) was 54.7% in the physical domain, 90.6% in the emotional domain, and 73.4% in psychiatric domain, respectively. Conclusion: The above findings suggest that the degree of stress and burn-out experienced by caregivers of patients with senile dementia are high. Also the degree of burn-out experienced by in caregivers of patients with severe dementia was higher than for those caring for patients with mild dementia.

• Journal of Preventive Medicine and Public Health
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• 제29권3호
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• pp.657-668
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• 1996

경상남도 일부 지역에서 60세 이상 노인들의 MMSE에 의한 인지 장애 유병률을 조사하고 인지 장애에 영향을 미치는 요인들을 조사하여 다음과 같은 성적을 얻었다. 1. MMSE에 의한 인지 장애의 유병률은 35.9%로 남자에서 18.4%, 여자에서 45.2%였다. 2. 인지 장애 유병률은 여자에서 유의하게 높았고(p=0.02) 무학력자와 문맹자의 인지 장애 유병률이 통계적으로 유의하게 높았다(p=0.03). 3.성별과 교육 수준에 따른 층화 분석에서 알루미늄의 인지 기능에 대한 독성 효과와 칼슘의 보호 효과에 대한 전체적으로 일정한 경향은 관찰되지 않았다(p>0.05). 4. 최종 분석 대상자 전체에서 음용수 중의 알루미늄과 인지 기능 검사 점수간의 상관 계수는 -0.066으로서 미약한 음의 상관관계에 있었으나 통계학적인 유의성은 보이지 않았고(p=0.434), 칼슘과 MMSE 점수와의 관계에서도 기대했던 바의 양의 상관관계는 관찰할 수 없었다.

• Nutrition Research and Practice
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• 제12권5호
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• pp.415-425
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• 2018

BACKGROUND/OBJECTIVE: As aging progresses, the number of patients with cognitive impairment also increases. Cognitive function is not generally correlated with diet, and there is debate over that association. Thus, the present study aimed to investigate the association between dietary intake and cognitive function among adults aged 50 years or older. SUBJECTS/METHODS: Between July 2017 and March 2018, 324 adults aged over 50 years from Gwangju Sun-Han hospital participated in a dietary survey. The frequency of food intake and related information were collected using a semi-quantitative food frequency questionnaire (SQ-FFQ) and determining the mini-mental state examination (MMSE) level for 276 participants. The association between dietary intake and cognitive function was assessed by performing logistic regression analysis. RESULTS: Depending on the MMSE score, the participants' age, education level, inhabitation status, medications, alcohol consumption, sleep duration, physical activity, and short geriatric depression scale score were significantly different (P < 0.05). Moreover, those participant characteristics were associated with either decreased or increased odds ratios (OR) for the risk of mild cognitive impairment (MCI). Based on analysis of the participants' intake of 112 detailed food items, which were categorized into 20 food types, intakes of cooked white rice (< 2 times/day compared with ${\geq}3$ times/day) (P < 0.05), properly cooked rice with other grains and legumes (P < 0.001), fruits (P < 0.05), milk (low fat and normal) (P = 0.044), liquid-type yogurt (P = 0.019), and curd-type yogurt (P = 0.015) were found to significantly decrease the OR for the risk of MCI. CONCLUSIONS: Associations were significant between the risk of MCI and the intake of certain food types. Specifically, a moderate intake of cooked white rice and an adequate intake of whole grains, fruits, milk, and dairy products were associated with reduced risks of MCI among adults aged over 50 years.

• 정신신체의학
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• 제24권1호
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• pp.94-101
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• 2016

연구목적 본빈혈은 노인 환자들에서 흔한 내과적 문제이다. 최근 연구는 빈혈이 인지기능 저하 및 알츠하이머병 치매와 연관성이 있다고 보고되고 있다. 본 연구는 한국 노인들에서 헤모글로빈 농도와 알츠하이머병 치매 및 경도 인지기능 장애와의 연관성에 대해 연구하기 위해 실시되었다. 방 법 116명의 대상자들이 본 연구에 참여하였다(평균 연령 : 74.67세, 여성 : 60.3%). 한국판 간이정신상태검사(MMSE-K), 임상치매평가척도(CDR), 전반적 퇴화척도(GDS)를 사용하여 대상자들을 평가하였고, 혈액학적 검사를 실시하였다. 결 과 알츠하이머병 치매 환자들이 경도인지장애군과 정상군에 비해서 유의미하게 낮은 헤모글로빈 농도와 적혈구 용적율을 가진다는 것이 관찰되었다. 헤모글로빈 농도는 MMSE-K와 양의 상관관계를 나타내었으며, overall CDR 및 GDS와는 음의 상관관계를 보였다. 결 론 한국 노인들에서 낮은 헤모글로빈 농도는 인지기능손상과 연관이 있는 것으로 나타났다. 본 연구 결과 알츠하이머병 치매는 빈혈과 연관이 있었으며, 이를 통해 낮은 헤모글로빈 농도가 알츠하이머병의 유용한 임상적 표지자로서 의미를 가지고 있다고 생각해 볼 수 있겠다. 치매에 대한 위험 요소는 더 광범위한 환자 군에서 전향적 종단 연구에 의해 확인하는 것이 필요하겠다.

• 한국콘텐츠학회논문지
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• 제13권6호
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• pp.339-349
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• 2013

뇌손상 환자들을 대상으로 한국판 간이정신상태검사(MMSE-K)와 한국형 컴퓨터 신경행동검사(KCNT)를 실시하여 관련성을 평가하고, 확정적 정상군과 치매 의심군을 구분하는데 있어서 KCNT의 유용성을 평가하기 위하여 수행되었다. 뇌손상 환자 50명 중 확정적 정상군과 치매 의심군의 KCNT 결과는 정규성 검정을 만족하여 두 군간 비교는 t 검정을, MMSE-K와 KCNT 결과간에는 이변량 상관분석을 실시하였다. 두 군의 특성은 유의한 차이가 없었으며, KCNT 결과는 두 군간 모든 항목에서 유의한 차이가 있었다(p<.05). 두 검사간 Pearson 상관계수는 단순반응시간(r=-.580), 선택반응시간(r=-.341), 글자색 맞추기(r=-.661), 숫자구분(r=-.703), 두 자리 숫자더하기(r=-.582), 세 자리 숫자더하기(r=-.610), 부호숫자 짝짓기(r=-.642), 숫자외우기(r=.807)로 유의한 상관관계가 있었다(p<.05). 이 중 단순반응시간, 두 자리 숫자더하기는 확정적 정상군과 치매 의심군에서 서로 다른 부호의 상관계수를 나타내 두 군을 구분하는 검사로 사용할 수 있을 것으로 생각되며, 제안된 KCNT 항목들을 검사 목적에 따라 선택하여 사용하면 두 군의 인지기능을 관찰하기 위한 검사로 유용하게 사용할 수 있을 것으로 생각된다.

• Journal of Preventive Medicine and Public Health
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• 제38권2호
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• pp.154-162
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• 2005

Objectives: To analyze the relationships of socioeconomic status(SES) to health status and health behaviors in the elderly. Methods: Data were obtained from self-administered questionnaire of 4,587 persons, older than 65 years, living in a community. We measured the sociodemographic characteristics, socioeconomic status, health status (subjective health status, acute disease, admission experience, dental state, chronic disease etc.), activities of daily living (ADL), instrumental activities of daily living (IADL), and mini-mental state examination-Korean (MMSEK). Binary and multinominal logistic regression analyses were employed to analyze factors affecting on the socioeconomic status of the elderly. Results: With regard to the SES and health status, those with a low SES had poorer subjective health states and lower satisfaction about their physical health. Also, acute disease experiences, admission rates and tooth deciduation rates were higher in those of low SES. In the view of physical and cognitive functions, the ADL, IADL and MMSE-K scores were also lower in those of low SES. However, with regard to health behaviors, lower smoking and alcohol drinking rates were found in the low SES group, and a similar trend was shown with regular physical exercise, eating breakfast, and regular physical health check-up. From these findings, we surmise that those with low SES have a poorer health condition and less money to spend on health, therefore, they can not smoke or drink alcohol, exercise and or have a physical health check-up. Conclusion: This study suggests that socioeconomic status plays an important role in health behaviors and status of the elderly. Low socioeconomic status bring about unhealthy behavior and poor health status in the elderly. Therefore, more specific target oriented(esp. low SES persons) health promotion activities for the elderly are very important to improve not only their health status, but their health inequity also.

• 재활치료과학
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• 제8권3호
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• pp.43-55
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• 2019

목적: 본 연구의 목적은 수행기반 인지기능 평가를 위한 예비연구로써 노인의 인지기능 저하 선별하기 위해 사용되는 수행기반 인지기능 평가도구를 분석하여 평가 문항을 구성하고 정상 노인을 대상으로 검사를 시행하여 타당도를 검증하는 것이다. 연구방법: 수행기반 인지기능 평가항목을 선정한 후, 만 65세 이상 정상 노인 9명을 대상으로 평가를 시행하였다. 평가도구의 신뢰도를 검증하기 위해 수집된 자료를 대상으로 내적 일관성을 분석하였으며, 공인 타당도를 검증하기 위해 기존 수행기반 인지기능 평가와 MMSE-K와의 상관관계를 분석하였다. 결과: Performance-Based Cognitive Function Test(PCFT)의 내적일치도 Cronbach's ${\alpha}$ 계수는 운동과제 .871 인지과제 .959 높은 신뢰도를 나타냈다. 공인타당도는 운동-인지 이중과제 평가를 이용하여 PCFT의 항목별 상관관계는 .755~.964으로 산출되었으며 통계적으로 유의하였다(p<.05). 또한 인지평가도구인 MMSE와의 상관관계는 .849~.943(p<0.01)로 나타나 높은 타당도를 보였다. 결론: 본 연구를 통해 수행기반 인지기능 평가의 신뢰도 및 타당도를 검증하였다. 추후 연구에서는 최종적으로 수정 보완된 인지기능저하 노인을 선별을 위한 수행기반 인지기능 평가도구를 대상으로 기타 신뢰도 및 타당도를 검증하여야 할 것으로 사료된다.