• 동의생리병리학회지
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• 제25권3호
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• pp.496-502
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• 2011

The present study was undertaken to investigate the effect of bee venom acupuncture therapy on the hair follicle growth by macroscopic, microscopic and immunohistochemical observation of skin 10 and 17 days after treatment. The results were as follows : Macroscopic hair follicle growth of 0.2 ml S.B.V. acupuncture treated group was more prominent than those of 0.1 ml S.B.V. acupuncture treated group and control group. Microscopic observation indicated that the hair follicle growth of control group reached anagen phase IV of hair growing cycle, and that of 0.1 ml and 0.2 ml S.B.V. acupuncture treated groups reached anagen phase VI and catagen, respectively. Immunohistochemical observations of the expression of various cytokines, enzymes and receptors in association with hair follicle cycle after local treatment of S.B.V. acupuncture therapy are as follows: Expression of fibroblast growth factor was more intense in epidermis and outer root sheath in 0.2 ml S.B.V. acupuncture treated group than that of 0.1 ml S.B.V. acupuncture treated group and control group. Expression of epidermal growth factor was more intense in bulge and outer root sheath in 0.2 ml S.B.V. acupuncture treated group than that of 0.1 ml S.B.V. acupuncture treated group and control group. Expression of c-kit receptor was more intense in epidermis, bulge and outer root sheath in 0.2 ml S.B.V. acupuncture treated group than that of control group. Expression of vascular endothelial growth factor was more intense in epidermis, bulge and outer root sheath in 0.2 ml S.B.V. acupuncture treated group than that of control group. Expression of protein kinase C-${\alpha}$ was more intense in epidermis, bulge and outer root sheath in 0.2 ml S.B.V. acupuncture treated group than control group. It is concluded that bee venom acupuncture therapy promoted the expression of various cytokines, enzymes and receptors related to the hair growth cycle for hair growth. This findings indicates that bee venom acupuncture therapy is applicable to the treatment of hair loss.

• 동의생리병리학회지
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• 제22권4호
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• pp.982-986
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• 2008

This study was performed to evaluate the oriental obese therapeutic effect with Sweet Bee Venom Mesotherapy on obese female patient of 53th years old with $Tae\bar{u}min$. We applied herbal medication, electrolipolysis, auricular acupuncture to her during 6 weeks. But, Body fat mass(Kg) and Percent Body Fat(%) was increased. After that, We treated with Sweet Bee Venom Mesotherapy on Chung-wan, Sang-wan, both Yang-mun, both $Ch'\bar{o}nch'\bar{u}$, both $Taeh\bar{o}ng$, both $Taeg\bar{o}$, both $Pokky\bar{o}l$, Kihae acupoint of abdomen during 5 weeks. We had a results of such as decreasing change of Body fat mass(Kg) and Percent Body Fat(%) with Body composition analyzer(Inbody 3.0, Biospace, Korea). And Subcutaneous Fat was decreased at all abdominal acupoints after Sweet Bee Venom Mesotherapy with Ultrasonography(LOGIQ200MD, USA). Therefore we have suggested that Sweet Bee Venom Mesotherapy have possibility to be utilized for oriental obese treatment.

• Journal of Acupuncture Research
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• 제21권3호
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• pp.121-131
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• 2004

Objective : The purpose of this study was investigation how the bee venom(BV) prevents inflammation in human cell. Methods : we induced inflammation on human synoviocyte cell by lipopolysaccharide(LPS) and sodium nitroprusside(SNP), treated the bee venom and melittin on this cell, surveyed the expression of Nisotric oxide(NO), inducible nitric oxide synthase(iNOS), Cyclooxygenease-2(COX-2), cytolic phospholipase $A_2(cPLA_2)$, Prostaglandin $E_2(PGE_2)$ and nuclear factor-${\kappa}B$(NF-${\kappa}B$), and got below conclusions. Results : Compared with control 1. Expressions of LPS-induced $PGE_2$(BV 1, $5{\mu}g/m{\ell}$) and SNP-induced PGE2(BV 0.5, 1, $5{\mu}g/m{\ell}$)were decreased significantly. 2. Expressions of LPS-induced NO(BV 0.5, 1, $5{\mu}g/m{\ell}$) and SNP-induced NO(BV 1, $5{\mu}g/m{\ell}$)were decreased significantly. 3. Expressions of LPS-induced COX-2(BV 1, $5{\mu}g/m{\ell}$) and SNP-induced COX-2(BV $5{\mu}g/m{\ell}$)were decreased significantly. 4. Expressions of LPS-induced iNOS(BV 0.5, 1, $5{\mu}g/m{\ell}$) and SNP-induced iNOS(BV $5{\mu}g/m{\ell}$) were meanless by all dose. 5. Expressions of LPS-induced $cPLA_2$(BV 1, $5{\mu}g/m{\ell}$) and SNP-induced cPLA2(BV 1, $5{\mu}g/m{\ell}$)were decreased significantly. 6. Expressions of LPS-induced NF-${\kappa}B$(BV $5{\mu}g/m{\ell}$, melittin $5{\mu}g/m{\ell}$) and SNP-induced NF-${\kappa}B$(BV 0.5, 1, $5{\mu}g/m{\ell}$, melittin 5, $10{\mu}g/m{\ell}$)were decreased significantly. 7. Expressions of LPS-induced NF-${\kappa}B$ binding activity (BV $1{\mu}g/m{\ell}$, melittin $5{\mu}g/m{\ell}$, melittin $5{\mu}g/m{\ell}$+ DTT 20mM) were decreased significantly. Conclusion : The bee venom treatments on synoviocyte showed significant changes in LPS and SNP induced NO, iNOS, COX-2, cPLA2, PGE2 and NF-${\kappa}B$, these results suggest that bee venom is effective to inflammations and establish the process of bee venom therapy, so we expect active use of bee venom to control the inflammation.

• Korean Journal of Acupuncture
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• 제30권1호
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• pp.27-36
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• 2013

Objectives : The focus of the analysis was laid on changes in research pertaining to bee venom in regards to time progression. Methods : We collected 365 articles on Bee venom study result from OASIS system using the Keyword 'bee venom, apitoxin, apitherapy, bee sting'. We figured out number and percentage of theses according to year, study method, journal, subject. Results : Bee venom papers published in the journal of korean medicine from 1976. The classification of papers associated with bee venom, clinical studies outnumbered the other study types by a ratio of 1.3 to 1, followed by 138 for experimental papers, and 22 for literature studies. Proportion of Experimental Papers Classified According to the Theme, 16 for pain-killing, 14 papers concentrated on apoptosis anticancer, 13 for anti inflammatory, 11 for arthritis, and other disorders were followed. Type analysis of papers associated with bee venom in clinical trials, lumbar disorders comprised 38 out of 205 papers, 35 papers concentrated on upper limb disorders, 34 papers concentrated on systemic disease, followed by the effect on body. Conclusions : Bee venom is a treatment method based on the unique theory of Korean traditional medicine. Its effort and academical approach on bee venom are expected to receive positive evaluation through numerous research works.

• Journal of Acupuncture Research
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• 제32권3호
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• pp.203-210
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• 2015

Objectives : The purpose of this study is to report the clinical effect of Korean medical treatment, specifically Homnis Placenta pharmacopuncture, bee venom injection and Danggwisu-powder, on a patient suffering from a lateral malleolus avulsion fracture. Methods : A 63-year-old female patient suffering from right ankle pain due to lateral malleolus avulsion fracture was treated with Homnis Placenta pharmacopuncture, bee venom injection, and herbal medicine(Danggwisu-powder). from May 20th to June $16^{th}$ of 2015. The change in patientcondition was measured with the American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale, the verbal numerical rating scale, and via the ankle's range of motion. Results : After treatment, all obtained results showed improvement. The American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale increased from 18 to 71, the verbal numerical rating scale changed from 8 to 3, and the ankle's range of motion improved. Conclusions : This study suggests that Korean medical care focused on Homnis Placenta pharmacopuncture, bee venom injection and Danggwisu-powder can be effective to treat lateral malleolus avulsion fracture.

• 대한추나의학회지
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• 제4권1호
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• pp.17-28
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• 2003

관절염에 대한 스테로이드의 관절강내 주사는 전신적인 부작용 등의 위험성이 적으면서 간편하고 경제적이며 비교적 양호한 항염효과를 얻을 수 있어 단일관절의 RA 또는 퇴행성 관절염에서 활액막의 염증증상이 있을 때 또는 보존적 치료에 반응하지 않는 경우 비교적 많이 사용된다. 하지만 이러한 스테로이드요법은 여러가지 만성 질환에서 과도한 염증이나 면역반응 자체를 치료하는 것이 아니라 부수되는 이차적 증상만을 완화시켜 주기 때문에 장기간의 스테로이드제 투여는 절병의 경과를 교정 하거나 변화시키지 못하고 예후에 악영향을 미칠 수도 있다. 또한 심각한 여러 부작용들을 야기할 수도 있다. 저자는 스테로이드 관절강내 주사에 호전되지 않은 부종과 통증을 주소로 하는 슬관절염 환자에 대해, 피하 봉독요법으로 양호한 효과를 얻었으며, 또한 기존에 알려져 있는 것처럼 당뇨병환자에게서 봉독요법이 혈당치를 지속적으로 높인다는 주장에 대해 다른 결과를 경험하였으므로 문헌조사와 함께 보고하는 바이다.

• Journal of Acupuncture Research
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• 제25권1호
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• pp.155-167
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• 2008

Objectives : The objective of this study was to observe the positive effects of acupuncture and bee-venom acupuncture treatment on lumbar hypolordosis. Methods : Acupuncture and bee-venom acupuncture were performed twice a week for 30 days to treat patients with low back pain patients showing a Cobb's angle [L1-S1] of less than $35^{\circ}$(treatment group=20, control group=13). Lumbar lordosis(Cobb's angle [L1-S1], Centroid angle [L1-S1]) was measured using an L-spine Lat. X-ray before and after treatment. Pain scales(VAS scale, ODI) were also was measured before and after treatment. SPSS 12K for Windows was used for statistical analysis of the results. Results : 1. VAS and ODI decreased significantly in the treatment group. 2. Lumbar lordosis, presented by Cobb's angle, increased significantly from $25.00{\pm}7.06^{\circ}$ to $30.95{\pm}10.02^{\circ}$ (p = 0.006). The increase of Cobb's angle in the treatment group $5.95{\pm}8.60^{\circ}$, and that of the control group was $-3.08{\pm}8.41^{\circ}$(p = 0.006). The increase of the Centroid angle of the treatment group was $3.85{\pm}8.83^{\circ}$, and that of the control group was $-2.92{\pm}7.63^{\circ}$(p=0.031). 3. Cobb's angle and Vas scale showed a significant correlation coefficient of -0.250(p=0.043). Increase of Cobb's angle and decrease of Vas scale showed a significant correlation coefficient of 0.420(p=0.015). Conclusions : Acupuncture and bee-venom acupuncture were verified to have a positive effect on pain alleviation of lumbar lordosis decreased patients while also affecting lumbar lordosis to be increased as a result of structural changes. It was also shown that lumbar hypolordosis has significant correlation with pain.

• 한방재활의학과학회지
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• 제19권3호
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• pp.81-90
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• 2009

Objectives : To analyze the therapeutic outcomes of back pain modalities in patients with disc herniation according to the change of Magnetic Resonanse Imaging(MRI) whom were treated with herbal medicine, chuna, acupuncture, bee-venom acupuncture. Methods : Clinical outcomes of 35 patients diagnosed with lumbar disc herniation by MRI examination, treated conservatively, were analyzed according to MRI follow-up change. Patients underwent MRI examaintion at baseline and after 24th week of treatment. Patients are divided into three groups ; improved, unchanged, worsened. 35 patients with lumbar disc herniation were treated with chuna therapy, acupuncture, bee-venom acupuncture once a week and took herbal medicine after a meal two times daily. The patients' clinical outcomes were assessed at baseline, 12th week, 24th week by Visual analogue scale(VAS), Oswestry disability index(ODI). Results : 1. MRI follow-up exams on regression of disc herniation resulted on 42.86% of cases by conservative treatment. 2. VAS(low back pain and sciatica) and ODI of disability of daily activities showed significant decrease in "improved" and "unchanged" groups compared to "worsened" group(P<0.05). 3. VAS(low back pain and sciatica) and ODI change after treatment did not show any relationship with MRI follow-up change(P<0.05). Conclusions : This study suggests that "improved" and "unchanged" groups compared to "worsened" group on MRI follow-up in patients with lumbar disc herniation were more effective when treated with herbal medicine, chuna therapy, acupuncture, bee-venom acupuncture. MRI follow-up change does not affect clinical changes in patients with lumbar disc herniation.

• 한방재활의학과학회지
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• 제18권4호
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• pp.135-145
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• 2008

Objectives : To investigate therapeutic outcomes of back pain modalities in patients with disc herniation according to the duration by treated with herbal medicine, chuna, acupuncture, bee-venom acupuncture. Methods : We separated 36 patients with disc herniation into three group according to duration; acute patients within 4 week, subacute patients within 5-12 week, and chronic group within 13-24 week. 36 patients with lumbar disc herniation were treated with chuna therapy, acupuncture, bee-venom acupuncture one times a week and took herbal medicine after a meal two times daily. The patients' symptoms were assessed 1 week, 2 week, 4 week, 8 week by Visual analogue scale(VAS), Oswestry disability index(ODI), 36-Item short-form health survey(SF-36). Results : 1. ODI of disability of daily activities showed significantly decreased in acute stage group compared to subacute and chronic stage groups(P<0.05). 2. Physical functioning(PF), bodily pain(BP), social functioning(SF) score of SF-36 showed significantly increased in acute stage group compared to subacute and chronic stage groups(P<0.05). Conclusions : This study suggests that acute stage group compared to subacute and chronic stage groups in patients with lumbar disc herniation is the more effective to improve symptoms treated with herbal medicine, chuna therapy, acupuncture, bee-venom acupuncture.

• 대한약침학회지
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• 제7권2호
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• pp.75-81
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• 2004

Objective : The purpose of this study is to report the efficiency of Bee Venom Therapy by managering of radial nerve palsy patients. Method : Three patients were treatmented by Bee Venom therapy and acupucture therapy. And we took pictures of someone's wrist and checked the power of muscles by the improving phase. Results : Almost cases shows the improvement in the movement of wrist and the numbness of hand. By using acuputure and Bee Venom therapy, the symptoms of radial nerv palsy was more fastly recovered.