• Journal of Acupuncture Research
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• v.31 no.2
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• pp.1-10
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• 2014

Objectives : The aim of this study was to analyze the interrelation of therapeutic effects according to the bee venom pharmacopuncture-induced skin hypersensitivity reaction and the sasang constitution. Methods : Data were collected from 62 patients who had been treated with bee venom pharmacopuncture due to low back pain. The patient's symptoms were evaluated with visual analogue scale(VAS), oswestry disability index(ODI). And we classified the patients according to the manifestation of skin hypersensitivity reaction, sasang constitution by QSCC II. Results : 22 patients had the skin hypersensitivity reaction, 40 patients hadn't. And 12 patients were Soeumin, 30 patients were Soyangin, 17 patients were Taeeumin. After treatment with bee venom pharmacopuncture 6 times(three times per week for 2 weeks), VAS was changed from $6.15{\pm}1.63$ to $4.00{\pm}1.64$. ODI was changed from $19.61{\pm}8.15$ to $14.76{\pm}8.07$. And there were significant associations. By the change of VAS and ODI between skin hypersensitivity reaction group and not, there were no significant associations. By the occurrence of skin hypersensitivity reaction between the sasang constitution, there were no significant associations. By the change of VAS and ODI between the Sasang constitution, there were no significant associations. Conclusion : This study shows that there were no significant associations in the frequency of skin hypersensitivity reaction according to the Sasang constitution. And the therapeutic effects of bee venom pharmacopuncture had no concern with skin hypersensitivity reaction and the Sasang constitution.

• Journal of Acupuncture Research
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• v.19 no.6
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• pp.256-263
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• 2002

Objective : This study is to report the radiological change after bee venom therapy about the patient of sequestrated disc. Methods : there was a report that the bee venom therapy was effective treatment on the patient of extruded or sequestrated disc. So we treated the patient who was diagnosed as sequestrated disc and hospitalized, and investigated the change of DITI, simple X-rays and MRI before and after treatment. Results : There was remarkable improvement in condition of the patient who had extruded or sequestrated disc after treated by bee venom therapy. It showed that the region of sequestrated L4-5 dise remarkably decreased in MRI, degree of scoliosis decreased from 17 degree to 15 degree in simple X-ray and the difference of right and left became equal in DITI through the follow-up survey. Conclusions : There was reports that bee venom therapy had antinflammatory and antalgic effect and was effective in treating patient of sequestrated disc and in curing pain, functional disorder, and clinical symptom of HIVD patients by means of grade index of lumbago. We think that the result of this study will be supporting data (that will be able to) proves more objectively the change following the improvement of condition with radiological check.

• Journal of Acupuncture Research
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• v.17 no.1
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• pp.169-174
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• 2000

The immune response of Bee Venom Therapy is commonly appear in clinics. It is whole body delayed allergy type and generally like fatigue. Therefore, in order to analysis the clinical form, we have observed immune response of 100 patients who visited Sangji University Oriental Medical Hospital and treated Bee Venom Therapy over 10 times from November 1998 to October 1999. The results were summarized as follows. 1. The distribution of Sex was 60 females, 40 males, and the average of patients age was $50.6{\pm}1.5years$. 2. The distribution of disease was degenerative arthritis, HIVD of L-spine, RA, etc. 3. The total treated time is 2765 and is observed 361 immume responses. 4. The average of keeping time in immume response is $11.8{\pm}0.6(hr)$, and the cases of over 24hrs is occupied 24.0%. 5. In the correlation between treated times and immume response is generally in inverse proportion. 6. The general aspect of immume response is chilling, heating, powerless, headache, dizziness, etc. 7. $M{\ddot{u}}ller$ Grade II-III was observed only 1%.

• Korean Journal of Oriental Medicine
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• v.16 no.2
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• pp.119-124
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• 2010

Cervical disc herniations can press on the spinal cord and cause a problem called cervical myelopathy. The most common symptom of cervical disc herniation is neck pain that spreads down to the upper limb in various locations. There can also be associated with weakness and movement disorders of upper limb. In Oriental medicine, cervical disc herniation is treated with herb-med, physical therapy, acupuncture, Chuna, etc, but the Bee Venom therapy is the most common and effective. In this case, we used the Bee Venom therapy at cervical hyeopcheokhyeol for about 2 months to a patient who was diagnosed with disc herniation at Cervical 5-6, 6-7 and appealed weakness, limited elevation and abduction of the left upper limb. As a result, left upper limb disability was improved. Using the Bee Venom therapy at cervical hyeopcheokhyeol that are effective on movement disorders and neurological diseases of upper limb is an effective treatment to upper limb disability diagnosed with cervical disc herniation, and suggests the direction of the treatment to upper limb weakness and movement disorders diagnosed with cervical disc herniation.

• Journal of Acupuncture Research
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• v.33 no.4
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• pp.181-190
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• 2016

Objectives : This study reports the clinical effects of Korean medical treatment on a patient with suspected diabetic muscle infarction (DMI). Methods : A patient diagnosed with spinal stenosis was suspected of DMI. The patient was treated with acupuncture, bee-venom pharmacopuncture and gastrocnemius stretching. Symptoms were evaluated by verbal numeric rating scale (vNRS), Oswestry disability index (ODI) and Manchester foot pain and disability index (MFPDI). Results : After approximately 5 weeks of Korean medical treatment, including 8 bee-venom treatments, vNRS, ODI, and MFPDI all decreased. Conclusion : The results suggest that Korean medical treatment is effective for treating pain caused by DMI.

• Journal of Acupuncture Research
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• v.21 no.1
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• pp.149-158
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• 2004

Objective: Herniation of Nucleus Pulpous(HNP) of L-spine is the most important reason that causes low back pain. The aim of this study is to investigate the effectiveness of Bee venom acua-acupuncture therapy for HNP. Methods: We divided HNP patient into 2 groups: Control group with acupuncture therapy only, and Experimental group with both acupuncture and bee venom acua-acupuncture therapy. To estimate the efficacy of treatment that applied for two groups, we used visual analog scale(VAS) and Oswestry disability index(ODI). We compared the VAS and ODI score of two groups statistically. Results & Conclusions: 1. In VAS, experimental group shows statitically significant improvement rate, but control group does not show statistical significance. 2. In ODI, both the experimental and control group shows statistically significant improvement. 3. By comparing the experimental and control group, there was more significant improvement in experimental group than control group of VAS and ODI. As a result, bee venom acua-acupuncture therapy can be used with acupuncture therapy for highly effective treatment for HNP.

• Journal of Acupuncture Research
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• v.32 no.3
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• pp.197-202
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• 2015

Objectives : The purpose of this study is to report on the residual symptoms after decompression of traumatic compartment syndrome experienced by a patient whose condition was much improved by electroacupuncture and bee venom therapy. Methods : The patient was treated with electroacupuncture and bee venom therapy. The progress of symptoms was checked by visual analog scale, disabilities of the arm, shoulder, and hand(DASH) and range of motion. Results : All results were improved. Scores from the visual analog scale and DASH decreased, while the range of motion increased. Conclusions : Electroacupuncture and bee venom therapy have an effect on residual symptoms after decompression of traumatic compartment syndrome.

• Journal of Pharmacopuncture
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• v.3 no.2
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• pp.233-244
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• 2000

After observing a patient diagnosed with Progressive Muscular Dystropies from the August, 31, 2000 to the January, 2001, the following results are obtained. Method and Result: Under our assumption that the Korean Bee Venom Therapy is a good method to treat Progress Muscular Dystropies. Korean Bee Venom Therapy was applied on the following acupuncture points: BL23(Shinsu:腎兪), BL26(Guanyuanshu:關元兪), ST36(Chok-Samni:足三里), LI4(Hapkok:合谷), LV3(Taechung:太), SP10(Hyolhae:血海), SI9(Sojang-Kyonjong:貞). In addition CFC(Carthami Flos;紅花: and Cervi Pantotrichum Cornu;) Herbal-Acupuncture is also treated on the other acupuncture points. For herbal medication was given to the patient based on the Sasang Constitution, Taeyangin Ogapijangchuk-tang. Following these treatments in this case of Progressive Muscular Dystropies, the skeletal muscle functions made remarkable improvement. Conclusion: Based on the clinical results, traditional Korean Medical treatment is believed to be effective for treating Progressive Muscular Dystropies, and further studies should be conducted to provide more valuable information.

• Journal of Acupuncture Research
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• v.21 no.3
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• pp.107-119
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• 2004

Objective : The purpose of this study was to investigate the effect of Bee Venom and melittin on the lipopolysaccharide(LPS) and sodium nitroprusside(SNP)-induced expressions of Cell viability, nitric oxide(NO), inducible nitric oxide synthase(iNOS), extra-signal response kinase(ERK), jun N-terminal Kinase(JNK) and p38 kinase(p38)- mitogen activated protein kinase(MAPK) Family- in RAW 264.7 cells, a murine macrophage cell line. Methods : The expressions of cell viability by MTT assay, NO by Nitrite assay and iNOS, ERK, JNK and p38 were determined by Western blotting. Results : 1. Compared with the control group, 0.5, 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin increased cell viability of RAW 264.7 induced by LPS and SNP significantly respectively. 2. Compared with the control group, 0.5, 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin inhibited expression of NO induced by LPS and SNP significantly respectively. 3. Compared with the control group, 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin inhibited expression of iNOS induced by LPS significantly and 0.5, 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin inhibited expression of iNOS induced by SNP significantly. 4. Compared with the control group, the expression of ERK induced by LPS and SNP decreased significantly in the treatment groups of $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin, which of p-ERK by LPS also did in 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin, but which of p-ERK by SNP did not decrease. 5. Compared with the control group, the. expression of JNK induced by LPS and SNP decreased significantly in the treatment groups of 5, $10{\mu}g/m{\ell}$ melittin, which of p-JNK by LPS in 5, $10{\mu}g/m{\ell}$ melittin and by SNP in $1{\mu}g/m{\ell}$ bee venom and $10{\mu}g/m{\ell}$ melittin decreased significantly. 6. Compared with the control group, the expression of p38 induced by LPS did not have significant difference, which induced by SNP decreased significantly in the treatment groups of 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin. p-p38 induced by LPS decreased significantly in the treatment group of $10{\mu}g/m{\ell}$ of melittin, which induced by SNP also decreased significantly in 0.5, 1, $5{\mu}g/m{\ell}$ bee venom and 5, $10{\mu}g/m{\ell}$ melittin.

• Journal of Acupuncture Research
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• v.33 no.2
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• pp.173-180
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• 2016

Objectives : To treat the progression of fibroproliferative disease that affects the flexion contracture of the fingers for patients with Dupuytren's contracture, the purpose of this study is to report a case of a patient with Dupuytren's contracture after complex Korean medical treatment. Methods : A patient was treated with acupuncture, moxibustion and bee venom pharmacopuncture on their left palmar aponeurosis. Six rounds of acupuncture and moxibustion were administered from November 30, 2015 through to January 2, 2016. Three rounds of bee venom pharmacopuncture was administered from December 14, 2015 through to January 2, 2016. The degree of flexion contracture and the Tubiana's stage were measured to evaluate the clinical improvement. Results : After 30 treatment sessions the flexion contracture degrees of the 4th finger's metacarpophalangeal joint and proximal interphalangeal joint improved as much as $25^{\circ}$, $15^{\circ}$, respectively. And the flexion contracture degrees of the 5th finger's metacarpophalangeal joint, proximal interphalangeal joint and distal interphalangeal joint improved as much as $15^{\circ}$, $10^{\circ}$, $5^{\circ}$, respectively. The Tubiana's stage of each finger decreased from 4 to 3. Conclusion : This study suggests that acupuncture, moxibustion and bee venom pharmacopuncture could be effective for patients with Dupuytren's contracture.