• 대한약침학회지
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• 제8권3호
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• pp.99-105
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• 2005

Objectives : The purpose of this study is to analyze the functional and clinical improvement effect on temporomandibular disorder by additional Hominis Placenta and bee venom herbal acupuncture treatment. Methods : A patient was treated with Hominis Placenta, bee venom herbal acupuncture, simple acupuncture, chiropractic therapy, and herbal medicine. We evaluated the improvement by visual analogue scale(VAS) score, mouth opening range, and X-ray image. Results : The VAS score was significantly decreased and mouth opening range was increased after treatment. X-ray image showed improved change after treatments. Conclusions : We think Hominis Placenta and bee venom herbal acupuncture treatment mainly contributed to the improvement of temporomandibular disorders. Further study is needed for the confirmation of this effect of on temporomandibular disorders.

• 혜화의학회지
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• 제17권2호
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• pp.149-153
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• 2008

Objective : Cold Urticaria is a symptom of edema and pruritus that appear when a patient is exposed to the coldness. The effect of Bee-venom Acpuncture Therapy is antiinflammatory, pain-killing, and blood circulation promotion. The aim of this study is to report the effect of Bee-venom Acpuncture Therapy to Cold Urticaria. Methods : The Cold Urticaria patients were treated with Bee-venom Acpuncture Therapy. Result and Conclusion : Edema and Pruritus of Cold Urticaria patient improved after Bee-venom Acpuncture Therapy.

• 대한약침학회지
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• 제10권2호통권23호
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• pp.93-98
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• 2007

Objectives : The aim of this study was to observe variation of Bee Venom content from the collection period. Methods : Content analysis of Bee Venom was rendered using HPLC method by standard melittin Results : Analyzing melittin content using HPLC, 478.97mg/g at june , 493.89mg/g at july, 468.18mg/g at August and 482.15mg/g was containing in Bee Venom at september. So the change of melittin contents was no significance from June to September. Conclusion : Above these results, we concluded carefully that collecting time was not important factor for the quality control of Bee Venom, restricted the period from June to September.

• 대한약침학회지
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• 제10권2호통권23호
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• pp.81-86
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• 2007

Objectives : This study was conducted to carry out quantitative evaluation and safety of Sweet Bee Venom. Methods : Content analysis was done using HPLC, measurement of LD$^{50}$ was conducted intravenous, subcutaneous, and intramuscular injection to the ICR mice. Results : 1. According to HPLC analysis, removal of the enzymes containing phospholipase A2 was successfully rendered on Sweet Bee Venom. And analyzing melittin content, Sweet Bee Venom contained 12% more melittin than Bee Venom. 2. LD$^{50}$ of ICR mice with Sweet Bee Venom was more than 20mg/kg in subcutaneous injection and intravenous injection, between 15mg/kg and 20mg/kg in muscular injection. 3. LD$^{50}$ of ICR mice with Bee Venom was between 6 and 9mg/kg in subcutaneous injection and intravenous injection, and more than 9mg/kg in muscular injection. Conclusion : Above results indicate that Sweet Bee Venom was more safe than Bee Venom and the process of removing enzymes was well rendered in Sweet Bee Venom.

• Journal of Acupuncture Research
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• 제31권1호
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• pp.121-130
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• 2014

Objectives : I investigated whether bee venom inhibit cell growth through enhancement of death receptor expressions in the human lung cancer cells, NCI-H460. Methods : Bee venom(1-5 ${\mu}g/ml$) inhibited the growth of NCI-H460 lung cancer cells by the induction of apoptotic cell death in a dose dependent manner. Results : Consistent with apoptotic cell death, expression of TNF-R1, TNF-R2, FAS, death receptors(DR) 3, 4, 5 and 6 was increased in the cells. Expression of DR downstream pro-apoptotic proteins including Caspase-8, -3, -9 was upregulated and Bax was concomitantly overwhelmed the expression of Bcl-2. NF-kB were inhibited by treatment with bee venom in NCI-H460 cells through TNF response change led by TNF-R1 and TNF-R2. Conclusions : These results suggest that bee venom should exert anti-tumor effect through induction of apoptotic cell death in NCI-H460 human lung cancer cells via enhancement of death receptor expression, and that bee venom could be a promising agent for preventing and treating lung cancer.

• 동의생리병리학회지
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• 제19권2호
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• pp.557-560
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• 2005

Bee Venom acupuncture has anti-inflammatory and analgesic effect that facilitates natural healing. So it is used in treatment of several musculoskeletal diseases. Recently, we experienced a case of De Quervain's disease that was not responded to steroid injection. It was successfully treated with intra-synovial Bee Venom acupuncture for two weeks. It is thought that Bee Venom acupuncture can be used in tenosynovitis. And Bee Venom injection techniques like intra-joint and subcutaneous method are need to be developed.

• 대한한의학회지
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• 제21권3호
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• pp.3-8
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• 2000

1. Definition : Bee-venom therapy does not involve actual bee-stings: it is a treatment method with acquired bee-venom extract through the electric stimulus on the bee, It is injected subcutaneusly on the acupuncture point after refining, according to the diagnosis of constitution and disease. 2. History : Around 2000 B.C., records that Bee-venom was used for therapy were written in the medical book of Babylonia and Papirus of ancient Egypt. Hippocrates, who is called the father of Medicine, said that Bee-venom is Arcanum, which means mysteric medicine. In Oriental medicine, B.C. 200, there was a clinical record that the meat suspended in front of the bee house on the tree in order to get bee-venom, was attached on the lesion. 3. Mechanism of Action : There are two aspects: 1) The effect of stimulating acupunture point It is similar to the chemical moxa. I think that there are several methods of stimulating the acupuncture point： For example, a simple needle is a mechanical stimulus, Moxa is a heating stimulus and electric and Raser acupunture etc. And another stimulus: in the ancient orient, a chemical stimulus called Chungu(Tianjiu), is attached to the lesions by using grinded insects (ex. Mylaris phalerate PALL.) which have toxin. So Bee venom therapy is similar to this. 2) The effect of biochemical ingredients Bee venom consists of 40 kinds of ingredients. For example, me Iii tin, Apamin, Pospholipase A2, MCD peptide, Adolapin and so on. They have effects which have been proven through experimentation l) tonifying mechanism of the body through increasing hormon secretion 2) tonifying immune system through proliferation of WBC, lymphocytes, macrophage 3) anti-inflammatory reaction Therefore Bee venom therapy is the representative 3rd Medicine, which combined East & West medicine. 4. Application of disease : L.B.P and HIVD, O.A, R.A, degenerative arthritis, shoulder pain and other pain diseases. 5. Therapic methods : According to constitution and disease, proper concentration of bee venom is injected on acupunture point, 2 times a week. Generally one term is consisted of 15times. 6. Contraindication : Heart disease, TBc, DM, kidney disease(nephritis), pregnancy, woman in menstruation 3-4 persons per 100,000 persons may have severe allergic reaction.

• 대한약침학회지
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• 제2권1호
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• pp.1-11
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• 1999

We have studied Bee Venom Therapy to treat Sequalae of Sprain, and obtained following results. 1. The treatment of sprain is using the effect of the affected part on Bee Venom Therapy. 2. For the treatment of sprain, it is often used the near acupuncture point of injury(近位取穴) or painful point to press(阿是穴). 3. Bee Venom Therapy is one of the powerful treatment, so we are using the sequalae of sprain in the case of not cured by Acupuncture, Cupping or another therapy. 4. Bee Venom injection is started a small quantity, and is increased slowly by degrees. 5. The immune response by Bee Venom Therapy is a sort of Allergy, and it is classified large delayed reaction. It is considered positive reaction. 6. We have selected Acupuncture Points from one to four by the degree of injury. 7. The period of treatment is some different from the degree of injury, but generally we have obtained good results to treat from 5 to 20 by Bee Venom Therapy.

• 혜화의학회지
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• 제17권1호
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• pp.167-172
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• 2008

Objective : This study shows the clinical effects on Bee-venom acupuncture and Burning acupuncture therapy for a patient who was diagnosed as Rheumatoid arthritis with ankle pain. Methods : This study was carried out a patient who was diagnosed as Rheumatoid arthritis with ankle pain. The patient was treated by Bee-venom acupuncture, Burning acupuncture therapy. To evaluate the effect of treatment, measured grade of pain by Visual Analogue Scale(VAS). Result and Conclusion: The ankle pain was reduced from VAS 10 to VAS 2 and the patient could walk on foot. In this study, Bee-venom acupuncture, Burning acupuncture therapy was effective in arthralgia of Rheumatoid arthritis.

• 대한한의정보학회지
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• 제11권2호
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• pp.49-56
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• 2005

Objectives To evaluate the treatment effect of Bee-venom Acupuncture on Neck Pain by Traffic Accidents, which is well known for anti-inflammatory effect and function of activating immune system. Methods We investigated 33 cases of patients with Neck Pain by Traffic Accidents by soft tissue injury. One group was treated by Bee-venom Acupuncture therapy, the other group was treated by General Acupuncture therapy . We evaluated the treatment effect of each group by Treatment Days & Number of Times, Distribution of Clinical evaluation grade, Visual Analog Scale before and after Treatment.