• 대한본초학회지
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• 제39권2호
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• pp.11-18
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• 2024

Objectives : High blood pressure (also called Hypertension), which is the blood pressure that is higher than normal, is a chronic disease and causes various complications. Historically, Traditional Herbal Prescriptions (THP) have treated many diseases. However, there are not many studies on the treatment of hypertension with THP, very few studies have investigated the interactions between the co-administration of synthetic anti-hypertensives and THP. Therefore, the objective of the present study was to investigate the vasorelaxant activities of 10 THP in rat thoracic aortas pre-contracted with potassium chloride (KCl). Methods : An electric extractor was used to extract THP in distilled water for 2h. Rat thoracic aortas were isolated and pre-contracted using KCl in organ chambers containing 10 ml Krebs Henseleit (KH) buffer. THP extracts were added in increasing concentrations (10-1000 ㎍/mL) to investigate vasorelaxant activities. The vasorelaxant activities induced by THP were expressed as a percentage in response to contraction generated by KCl. Results : Among the 10 THP, Dangguisu-san, Mahwang-tang, Bulwhangeumjeonggi-san, Jakyakgamcho-tang, and Hyangsapyeongwi-san showed significant vasorelaxant activities. Maekmundong-tang, Bojungikgi-tang, Samryeongbaekchul-san, Yukmijihwang-tang, and Insampaedok-san showed no significant effect. Also, in co-administration with amlodipine, Mahwang-tang showed higher vasorelaxant activities than amlodipine alone, and Hyangsapyeongwi-san showed greater vasorelaxant activities at low concentrations but inhibited amlodipine's vasorelaxant activities at high concentrations. Conclusion : The results of these experiments are expected to provide useful data to establish guidelines for THPs and co-administration with western antihypertensive drugs to treat hypertension.

• 대한예방한의학회지
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• 제11권2호
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• pp.87-99
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• 2007

Background : Most traditional Korean doctors use "Packed Herbal Medicine", which is made from boiling various herbs together. However, the current insurance system doesn't cover the act of making packed herbal medicine. Therefore it is urgent for these doctors to study and find the best and most logical insurance program to cover the Packed Herbal Medicine system. Objectives : The purposes of this study were to investigate whether Announced System of Herb Price is proper for stability of medical herbs's price. Methods : This study made these following results by studying medical herbs's price of KOMD(The korea oriental medicine distribution company) from 2004 March to 2007 March The results are summarized as follows ; The 50 most frequently used herbs were chosen from the 831 standard prescriptions according to 26 pre-determined specific diseases. These prescriptions are considered the most important for this study and insurance purposes. fluctuations of fifty medical herbs which were used much about a predetermined list of 831 prescriptions are multiple function not linear equation. fluctuations of fifty medical herbs which were used much about a predetermined list of 831 prescriptions are different according to time. Therefore, to notify medical herbs's price is valid method for stability of medical herbs's price.

• 동의생리병리학회지
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• 제26권4호
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• pp.432-436
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• 2012

Among a number of factors related to the effect of acupuncture and moxibustion treatment, prescriptions do important work. Traditional eastern doctors also placed emphasis on prescriptions of acupuncture and moxibustion, and a lot of experiences have been accumulated. The method forms prescriptions of Sa-am acupuncture therapy pivots on five transport points. Studies show prescriptions are made on the basis of the theory of 'Wang Xiang Xiu Qiu Si'(旺相休囚死) used engendering and restraining of five phases, and it is considered the principle of transformed prescriptions through this theory. Because there is still no study analyzing prescriptions of Sa-am acupuncture by existing principles, we report opinion about Combination principle of points in them. 1. We studied history of acupuncture and moxibustion, development and kinds of points' Combination principle. 2. Around Combination principles of points in Classic of Difficult Issues and Internal Classic, we analyzed and compared between Combination principles of points in Sa-am acupuncture therapy and them in Korea and overall acupuncture methods. 1. There were many Combination principles of acupunture point combination in Classic of Difficult Issues, Internal Classic and Korea acupuncture methods. For example, Point combination of the same meridian, Point combination of the different meridian, Exterior-Interior point combination, Point combination of the same name meridian, Point combination of the multiple meridian, Point combination of Adjacent and Distant points, Left-Right point combination, Anterior-Posterior point combination, Superior-Inferior point combination, Brook point and Stream point combination, Triple energizer point combination, Eight meeting point combination, Five transport point combination, Source-Connecting point combination, Alram point and Transport point combination, Mother-Sun meridian combination, Empirical point combination, Important point combination, Point combination according to syndrome. 2. Existing Combination principles of points in prescriptions of Sa-am acupuncture therapy included every rule. 3. They could be evidences that prescriptions of Sa-am acupuncture therapy are forms inheriting and developing acupuncture and moxibustion treatments.

• 대한예방한의학회지
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• 제25권3호
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• pp.39-55
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• 2021

Objective : To investigate specific prescriptions, herbal medicines and treatment strategy, this study systematically reviewed case studies on traditional Chinese medicine (TCM) treatment for childhood cancer. Method : Literature searches were performed on database of China National Knowledge Infrastructure (CNKI). Studies published before December 2020 were categorized and analyzed according to the treatment strategy and we also investigated Chinese herbs used in the prescriptions. Results : Twenty-five studies including 17 case series and 8 single case reports were included in our review. Of the total 439 patients, 379 (85.7%) had leukemia and other myeloplastic disease. Conventional western medicine (CWM) treatment was also used with TCM based on the syndrome identification. Most studies reported favorable effect of combination treatment with CWM and TCM. Among 266 herbs in the studies, reinforcing herbs were more frequently used than anti-cancer herbs. Conclusion : Traditional herbal treatment for childhood cancer should be performed considering the syndrome identification as well as stage of CWM. Reinforcing herbs should be more focused because of the fragility and growth of the childhood.

• 대한한의학원전학회지
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• 제25권3호
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• pp.39-49
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• 2012

Objective : "Sikryochanyo"written by Jeon Soonyi is the first Food-Therapy book at Korea. In "Sikryochanyo", there are many kinds of food-Therapy including prescriptions for thirst disease. Conception of hirst disease in traditional mendicine contains diabetes in some aspects. One of the Ingeative methods in diabetes limits taking protein but "Sikryochanyo" shows several prescriptions including protein. Method : We will try to find out cases of Food-therapy for thirst disease in "Sikryochanyo" and classify several prescriptions including protein. Result : In "Sikryochanyo", several prescriptions for thirst disease including protein were treated as materia medica widely such as stomach of cow and pig, intestine of pig, head of dear, rabbit, chicken, goose, pheasant, milk and lung of sheep. Conclusion : On several types of prescriptions for thirst disease including protein there are plenty of usage with its own effectiveness.

• 셀메드
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• 제5권2호
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• pp.11.1-11.5
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• 2015

Traditional East Asian Medicine (TEAM) prescriptions typically consist of several herbs based on the assumption that the herbs operate synergistically and/or cooperate on several related pathways simultaneously. This is a general concept that is widely accepted in TEAM, but it has not been tested systematically. To check this assumption statistically, we have text mined traditional Korean medicine text the Inje-ji(仁濟志, Collections of benevolent savings), a text that contains more than 5000 herb-cocktail prescriptions. We created herb-pairing network based on herb-herb pairing specificity and performed a systematic network analysis. Herbs were shown to be used selectively with other herbs and not randomly. Moreover, herb pairs were more specifically associated with symptoms than were single herbs. Single herbs and combinations of herbs specifically used for diabetes mellitus were successfully identified. As conclusion, herb-pairings in TEAM are not randomly constructed; instead, each herb was selectively used with other herbs. In terms of statistical significance, herb pairs were more specifically associated with symptoms than were single herbs alone. Collectively, these results suggest that it may be important to understand the interactions among multiple ingredients contained in herb pairs rather than trying to identify a single compound to resolve symptoms.

• 한국한의학연구원논문집
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• 제3권1호
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• pp.1-15
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• 1997

${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$(1445) is a book compiled the medical achievements of China and Choseon in those times and it's our source of pride to have it In this country. It also deserves careful investigation since this book can provide some clues of features of missing books in China and Korea. The extent of accuracy of xylographica of old books determines the possiblity of in depth further study. So authors attempted to investigate the xylographica of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ one of the 3 main books in Korea. Previous investigation done by Miki Sakae and Kim Doo Jong are noticeable. On the basis of their respective works, we analyzed 'Annals of the Choseon Dynasty' to find records related with ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ and estimated the situation of its publication. We tried figure the situation of those times of China, Japan and Korea(including North Korea) and tried to estimate the book's original xylographica as much as we could. By King Sejong's command, the first draft of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ consisted of 365 books was made by collaboration of civil officials and medical officers during the period from 1443 to 1445. And then from 1451(first year of Moonjong's reign) to 1464(l0th year of Sejo's reign) lots of manpowers were employed and through the process of countless erasure, proofreading, arrangement and rearrangement revised version of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ which is called by Sejo text was completed. After 3 years of wood engraving work, the first printed form of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ (alternately called Seongjong text) in folding case consisted of 266 chapters, 264 volumes came into the world in 1477.(8th year of Seongjong's reign). This was 32 years after the initial completion of the edition. So ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ exists in three forms as Sejong text, Sejo text and Seongjong text respectively. Since those texts were plundered during the Japanese invasion of Korea in 1592, none of the original copy remains within korea. The texts were constantly moved to kadeungcheongieong, to Kongdeungpyeongio, Jesookoan of Edo, to East University of department of classic books, to Cheoncho archives, to the Imperial Museum and finally is kept in the royal palace at present. (Doseoryo text Eulhae printing type) Reduced-size republication books of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ in wooden type were imported at the time of 'Byeongja Korea-Japan Treaty in 1876' and of those 2 books, one copy was treasured in the Royal Household of the Yi Dynasty and than was lost during the Korean War circa 1950. The other remaining copy has been kept succesively by Kojong's imperial grant, Royal doctor Hong Cheol Bo, Hong Taek Joo, Hong Ik Pyo the book agent, and now is kept In Yonsei University Library and this is the only existing copy in Korea at present. In 1965, Dongyang Medical college published the transcription version of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ consisting of 11 books and then in 1981 after edition and arrangement by Choonghoa(中華) publishing company, photoprint copy of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ was published in Keumgang(金剛) publishing company In 1991, October Yeokang(驛江) publishing company producd photocopies of ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ which were previously translated into Korean by North Korea Institute of Oriental Medicine and then issued by medical publishing company. In China, two institutes, Zhejiang Institute of Traditional Chinese Medicine and Huzhou Traditional Chinese Medical Hospital cooperated to publish a revised and marked text consiting of 11 books by adding marking points to japanse Edohakhoondang text which were used as a reference. Both the korean and chinese texts issued were grounded by the ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ kept in the royal palace. Any further study concerning ${\ulcorner}$Classified Collection of Medical Prescriptions${\lrcorner}$ can acquire its accuracy and objectivity when the japanese text kept in the royal palace is taken as an original copy.

• 한국식품과학회지
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• 제31권6호
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• pp.1661-1666
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• 1999

인체에 대해서 유익한 작용을 하며 실생활에서 쉽게 접할수 있는 3개의 보익제를 동의보감으로부터 선정하여 효능을 과학적으로 검증하기 위한 자료로서 항산화력을 조사하였다 동의보감의 처방에 따라서 약재를 혼합한 후 열수 추출한 물질의 항산화력을 전자공여능, SOD 유사 활성 및 지질과산화 억제능을 이용하여 조사한 결과 대표적 항산화제인 vitamin C에 비하여 낮은 활성을 보였으나 모두 항산화력을 나타내었다. 이 3개 탕제를 흰쥐에게 4주간 투여한 뒤 혈장에서 총항산화력이 대조군에 비하여 증가하였다. 또한, 탕제 투여한 흰쥐의 간 조직을 적출 하여 활성 산소발생제인 2.2'-azobis(amidinopropane)dihydrochloride(AAPH)를 처리한 결과 조직내의 대표적 비효소 항산화제인 환원형 glutathione의 감소가 억제되었으며, 산화형과 환원형의 비율 또한 증가하여 탕제 투여에 의해 간 조직 및 혈장의 항산화력이 증가함을 확인하였다. 이러한 결과 산화적 손상의 지표로 사용되는 지질과산화(TBARS) 단백질 분해도 역시 탕제 투여군이 비투여군에 비하여 감소하였다. 따라서, 보익제로 사용되는 3개 탕제는 체내 항산화력을 증강시켜 노화 및 다양한 질병의 원인이 되는 산화적 손상으로부터 체내를 보호할 수 있을 것으로 추측된다.

• 혜화의학회지
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• 제20권1호
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• pp.175-182
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• 2011

This study aims to summarize and make a reference of Sagunjatang and Samultang by investigating and comparing the effects of prescriptions. In this process, this review surveyed all papers used Sagunjatang and Samultang in PubMed database and finally 36 papers were included. The publication year, the nations of authors, the type of materials, the formation of experiments, the type of herbal medicine, and their action and mechanisms were analyzed. The number of studies on Sagjunjatang and Samultang has increased since 1990's. The main formation of experiments was in vivo study and the portion was 55%. The proportion of the research using prescriptions was 71%. Sagunjatang was investigated in the field of GI track function, anticancer effect, radioprotective effect and etc. Samultang was studied in the field of anticancer effect, brain cognitive function, anti-inflammatory effect, cell protective effect, and etc. Based on these results, Sagunjatang and Samultang showed the different bioactivities. This study will provide the useful information on differentiation and analysis of the effect of herbal prescriptions by the theory of Korean traditional medicine.

• 한국식품과학회지
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• 제43권5호
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• pp.624-632
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• 2011

본 연구에서는 민간 및 한방에서 관절염 치료 처방제로 널리 사용되고 있는 한방처방제 16종을 선정하여 향후 관절염 예방 및 치료용 기능성식품의 개발 기초 자료로 활용하기 위해 한방처방제로부터 물, 에탄올 및 효소처리추출물을 제조하고 그들의 항산화 및 항염증활성을 in vitro assay system을 사용하여 측정하였다. 16종 한방처방제의 각 추출물의 폴리페놀 함량은 10.03-78.03 mg/g의 범위를 나타내었으며, 이 중 마행의감탕(7번)의 에탄올추출물이 78.03 mg/g으로 16종의 한방처방제 중 가장 높은 폴리페놀 함량을 보였다. 총 플라보노이드 함량의 경우 총 폴리페놀 함량의 결과와 달리 효소추출물에서는 폴리페놀 추출 함량이 낮아지거나 비슷한 수치를 보였지만 총 플라보노이드 함량의 경우 마행의감탕(7번)을 제외한 나머지 15종의 한방처방제에서 열수 및 에탄올추출물보다 효소추출물에서 플라보노이드 함량이 증가하는 것을 확인하였다. 한편, 마행의감탕(7번) 추출물에서 DPPH 및 ABTS 라디컬 포착활성과 COX-2 저해활성도 가장 높게 나타난 반면, 효소추출물에서는 의의인탕(14번)이 가장 높은 COX-2 저해활성을 나타내었다. 이러한 결과를 종합해 볼 때 마행의감탕 및 의의인탕을 관절염 치료 한방처방제로 개발할 가능성이 높다고 생각되며, 향후 보다 상세한 그들의 항산화 및 항염증활성을 조사할 필요가 있다고 생각된다.