• Journal of Korean Medical classics
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• v.29 no.1
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• pp.17-41
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• 2016

Subjects : A literature research on the constitution and medicinal effect & adaptation diseases of "Bullsusan". "Bullsusan" is a herbal prescription composed of Angelicae Gigantis Radix(當歸) and Cnidii Rhizoma(川芎). Objectives : Through the researching on the records of "Bullsusan" in Korean Traditional Medical Books, gain the literature evidence for adaptation to these days child labor as a pre-labor keeping herbal medicine. And have detailed consideration on the constitution of prescription and medicinal effect & adaptation diseases of "Bullsusan". Methods : First, researched the records of "Bullsusan" in Korean Traditional Medical Books which were included at A Series of Korean Medicine(韓國醫學大系) and analysed component ratio, nickname, herbal manufacture and drug processing method, medicinal effect and adaptation diseases. Second, referred related Korean and Chinese researches that examined the medicinal effect and adaptation diseases of "Bullsusan" by scientific experimentation. Conclusions : We found total 46 records of "Bullsusan" from 20 kinds of Korean Traditional Medical Books included at A Series of Korean Medicine. Prescription component ratio of Angelicae Gigantis Radix and Cnidii Rhizoma were 3:2, 1:1, 2:1, 1:1. 3:2 had most 20 records and 1:1 had second 14 records. Especially 1:1 had a tendency of having nickname "Goonguitang", but not must had. First herbal manufacture was powder, it had 8 records. First drug processing method was decocting with water and alcohol, had 19 records. Medical Effects of "Bullsusan" can be induced to next 8, that were "remove get bad blood, give birth new blood", "easy labor by reducing fetal volume", "acceleration of labor", "test of fetal survival, elimination of dead embryo", "elimination of placenta", "revive", "allaying pain", "nourish the blood". From these medical effects, 9 adaptation diseases can be induced. That were "threatened abortion", "womb ache and vaginal bleeding by spontaneous abortion", "pre-labor keeping(prevention of hard labor)", "acceleration of labor", "hard labor", "missed abortion", "postnatal vaginal bleeding, dizziness, asthma, headache, womb ache", "postnatal mastoptosis and mastodynia", "first aid symptom like as dizziness, unconsciousness, stroke caused by excessive bleeding". The medical effect of "acceleration of labor" and "elimination of placenta" have been examined by modern clinical research. The effect of "remove get bad blood, give birth new blood", "allaying pain" and "nourish the blood" have been examined by modern experimental study. But overdosing on "Bullsusan" to pregnant mouse can cause natural abortion, so the proper dose of "Bullsusan" in pregnant period is very important.

• Proceedings of the Korean Society of Life Science Conference
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• 2002.09a
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• pp.53-54
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• 2002

• The Journal of Pediatrics of Korean Medicine
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• v.18 no.2
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• pp.233-249
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• 2004

Objectives : Infectious mononucleosis is a clinical syndrome caused by Epstein-Barr virus that is particularly common in adolescents and children. This study was progressed for current oriental medical treatment of infectious mononucleosis in china. The purpose of this study is the opening oriental medical approach to infectious mononucleosis in Korea Methods : Authors conducted a literature search in data of Traditional Chinese Medical Journal. The data were extracted in a standardized, predefined manner and accessed critically. Results : The study for infectious mononucleosis consists of basic, clinical, experimental study. Basic study consists of etiology & pathogenesis and the rule of treatment. Clinical study consists of symptoms-based treatment and adequate prescription treatment. Experimental study consists of effective herbs and new traditional chinese medical injection. Conclusion : Traditional chinese medical approach using herbs works in children with infectious mononucleosis in Korea.

• Journal of Society of Preventive Korean Medicine
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• v.17 no.2
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• pp.17-28
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• 2013

According to "The Annals of the Joseon Dynasty", we know that korean ancestors confuse tea prescription with green tea. It makes cultural misunderstanding Tea doesn't mean green tea but tea prescription. It is caused that tea prescription has been called tea habitually in Korea. Korean don't drink green tea much. Instead, they have had a habit of drinking decoction of medicinal herbs and they called it tea. This habit has developed into Korean traditional tea culture. In the palace in the Joseon Dynasty period, Ginseng tea was used in the tea ceremony. When the king had poor health or had a disease or was even on the eve of death, a royal physician tried to cure him by tea. They used about 30 kinds of tea according to "The Annals of the Joseon Dynasty" Such as ginseng tea, astragalus tea, ginger tea. Tea in korea is not a drink but the way to cure a disease. Korean people usually get to drink decoction of other herbs instead of green tea. This became the basis of korean traditional tea culture. We need to change a definition of Korean tea like this way and study about it much more. With this research paper, korean tea culture should be studied on more various ways and established itself as original and unique tea culture. On the basis of this studies, Korean tea brand can be famous in the world like Chinese tea or Japanese tea.

• Journal of Korean Medicine for Obesity Research
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• v.7 no.2
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• pp.27-37
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• 2007

Background Clinical practice guidelines (CPG) are systematically developed statements to assist practitioners and patients on healthcare decisions. They provide recommendations for the average patient, which should take into account individual clinical judgment and the patient's values and expectations. Ephedra has sympathomimetic effect and has been used for weight loss worldwide. However, its safety is controversial especially in autonomic and cardiovascular systems. Therefore, the need of appropriate CPG for ephedra prescription in obesity was advocated in Korean Traditional Medicine. Methods The committee comprised of specialists of obesity, oriental herbology, oriental cardiology, constitutional medicine. The committee collected all relevant references about adverse effect and safety of ephedra in the forms of meta-analysis, systematic review, randomized controlled trial, case-control study and observational study from international and domestic databases and paper journals. 11 English- and 5 Korean-language references were gathered and categorized by PICO (Patient, Intervention, Comparison, Outcome) method. We could not complete strength of recommendation which should be clarified according to the evidence grade estimation. Result The first version of CPG for ephedra prescription in obesity was issued by Korean Oriental Association for Study of Obesity. It includes topics of introduction, pharmacokinetics, side effects and adverse events, constitutional aspect and recommendations for dose, indication and contraindication. Conclusion There should be periodic upgrade of this CPG from now on. Although there are some drawbacks in this version of CPG, it has significance as the first CPG in Korean Traditional Medicine.

• The Journal of Pediatrics of Korean Medicine
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• v.24 no.1
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• pp.65-76
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• 2010

Objectives In the later period of Choseon dynasty, korean pediatrics became a pivot part of medicine. SoAUiBang was the most important book in that era. DongEuiBoGam was the most widely read of all oriental medicine books and published in early days of the Choseon dynasty. Therefore, this comparative study on the prescription and formation of SoAUiBang and DongEuiBoGam could be a useful way to understand SoAUiBang's characteristics. Methods This study was based on SoAUiBang and DongEuiBoGam, two literatures of oriental medicine. Results 1. Formation of SoAUiBang had a similar aspect with that of DongEuiBoGam's and enlarged the area of pediatrics by featuring general medical books. However, its formation did not follow the DongEuiBoGam's, but had its unique formation. It tried to include all diseases of pediatrics in the system of DongEuiBoGam. Plus, smallpox and measles belonged to the epidemic diseases were excluded from the area of pediatrics. 2. Comparing SoAUiBang's prescription of some important diseases with DongEuiBoGam's, it was almost a prescription based on DongEuiBoGam's prescription. However, adjustment of herbs and dosages could not be found in any oriental medicine books including DongEuiBoGam. Conclusions SoAUiBang maintained the traditional Oriental medicine based on author's scholarly creativeness. In addition, it also inherited the lineage of medicine in Korea along with the pedigree of DongEuiBoGam. Therefore, SoAUiBang should be re-evaluated as a medicine book that opened a new field of pediatric and had great academic values.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.1
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• pp.28-33
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• 2004

This study was performed to examine in vitro biological activities such as antioxidative, nitrite scavenging effect, tyrosinase inhibitory effect and antithrombotic activity of a Korean traditional prescription, Nogyong-daebotang, composed of oriental medical herbs and antler, nourishing the blood, helthiness, strengthening of vital power and promotion of growth. The concentration of total phenolic compounds of the prescription sample was 151.3$\pm$2.6 mg％. The electron donating abilities (EDA) by reduction of 2.2'-diphenyl-1-picrylhydrazyl (DPPH) was 80.9%, inhibition rate of lipid peroxidation in thiocyanate method used linoleic acid was 88.1%. Nitrite scavenging effects of the sample were more than 70% at acidic pH, but it was pH dependent, showing the highest at pH 1.2 and the lowest at pH 6.0. Inhibition rate against tyrosinase of the sample was above 80%. Platelet aggregation induced by ADP (adenosine-5'-diphosphate) was inhibited up to 30% and the inhibitory effect was dependent on concentration of the sample.

• Journal of Digital Convergence
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• v.10 no.5
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• pp.315-320
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• 2012

The purpose of this study is to establish management and support system for traditional medical manuscripts using bibliographical, linguistic and traditional medical methods in order to protect disappearing and take advantage of traditional medicine. We'll translate selective traditional medical manuscripts into Korean and build a database and computerized database, which improve value of future diverse application and restore and give shape to traditional medical documents by providing methods for ontology of traditional medicine. We also arrange and analyze the old traditional medical books with diverse study system and evaluate medical usefullness. We intend to provide practical use of the prescription in based medicine as well as clinical medicine by reinterpretation from modem viewpoint.

• Biomolecules & Therapeutics
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• v.14 no.2
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• pp.114-118
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• 2006

Depression is a very difficult disease to be cured because several nervous systems are involved. In the present study, we evaluated the effects of Keum-Ryung-Ja-San (KRJS), a traditional herbal prescription, on depressive behaviors in mice using the forced swimming test. KRJS was given 1 h prior to the forced swimming test (50, 100, 200, an400 mg/kg, p.o.). The duration of immobility time in the forced swimming test was significantly reduced by KRJS treatment (200 mg/kg, P<0.05) and similar effects were observed with a classical antidepressant, imipramine (15 mg/kg, i.p.). With subchronic administrations of KRJS and its constituents at several doses for 1 week, a decreased duration of immobility time was observed with KRJS and Corydalis ternata (200 mg/kg, p.o. P<0.05). These results suggest that KRJS may have antidedpressive activities and CT may contribute to the antidepressive activity of KRJS.

• Korean Journal of Pharmacognosy
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• v.26 no.1
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• pp.66-73
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• 1995

'Gyejakjimo-Tang(桂芍知母湯)', which is composed of Cinnamon bark(桂枝), Peony root(芍藥), Anemarrhena root(知母) and other seven herbs, is described as antipyretic, diuretic and analgesic prescription in traditional medical literatures including Geumgwe-Yoryak(金櫃要略). So it is being used in the treatment of gout clinically in oriental region. As the results of the pharmacological and biochemical trials of the prescription, it was found to have antiinflammatory and significant analgesic effects indicated by carrageenin edema, dye permeabilities and writhing behavior. And it potentiated the output of uric acid in blood and the increase of uric acid in urine of alcohol-toxicated rats, which mean the decrease of uric acid level only by excretion procedure. But the prescription didn't show any effects on the activities of adenine/guanine deaminase, purine nucleoside phosphorylase, xanthine oxidase or uricase, which are related with formation and metabolism of uric acid.