• Advances in Traditional Medicine
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• 제10권2호
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• pp.116-122
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• 2010

Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-${\kappa}B$ p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.

• 동의신경정신과학회지
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• 제24권4호
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• pp.385-392
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• 2013

This case report presents a 34-year-old female patient. Her chief complaints are akinetic mutism and cognitive dysfunctions. We have diagnosed her with leukoencephalopathy. She was treated with Korean traditional herbal medicines (Joojackwhan) for 33 days continuously. The effects of treatment were measured by the Korean Mini - Mental State Examination and Modified Bathel Index. After treatment, her chief complaints have been improved. Furthermore, the K-MMSE, MBI scores increased. From this case, we deduced that the Korean traditional herbal medicines (Joojackwhan) could be effective for cognitive dysfunctions and akinetic mutism caused by leukoencephalopathy.

• 한국의사학회지
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• 제26권2호
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• pp.123-134
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• 2013

Traditional medicine has been exchanged constantly from prehistoric times up to the present. As the global market trade on traditional medicine increases, people now emphasized the importance of traditional medicine. Previously, knowledge about herbal medicines are taught or learned indirectly. Most of it was learned through medical books. But in these contemporary times, herbal medicine's knowledge is shared through journals, congress and some other events in where traditional medicine's information are shared. In the international congress gathering; traditional medicine's experts from many countries shared some additional knowledge. First, "an attitude to medicine that emphasizes on Naturalism". Second, "respect for experienced in traditional medicine". Third, "respect for locality on traditional medicine". Fourth, "a protection for domestic traditional medicine industry" Fifth, "acceptance of traditional medicine from other countries according to domestic health care system".

• 대한한의학회지
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• 제32권6호
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• pp.112-116
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• 2011

Objectives: To inform the clinical features of drug-induced liver injury (DILI), and study traditional Korean medicine (TKM)-based strategies or therapeutics. Methods: A female patient with hepatitis after long term use of medication for cold symptoms was treated with Oriental therapies, after which the clinical outcome was evaluated by serum biochemical parameters and ultrasonography. Results: Clinical and biochemical levels were fluctuating during administration of cold medicine, but the patient completely recovered her health with herbal medicines. Conclusion: This case report would provide information about a typical DILI by western medicine followed by treatment with traditional Korean medicine.

• 약학회지
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• 제42권2호
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• pp.132-139
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• 1998

Currently, cancer is the primary cause of death and 50% of cancer patients are incurable by surgery, radiotherapy and chemotherapy. Therefore, immunotherpy is interested as the fourth remedy. Biological response modifier (BRM), such as organometallic compounds, glycoproteins, polysaccharides and other natural products. Is the one which can enhance the immune response against cancer cell. To develop new BRM from natural sources, we investigated 63 species Korean traditional medicines by observing the mitogenic activity to splenocytes, generation of activated killer cells and activation of macrophages. Finally, we selected 9 species including Angelicae gigantis Radix, Mori Cortex Radicis, Arisaematis Tuber, Salviae Radix, Cnidii Rhizoma, Ligusti Fructus, Pasoraliae Semen, Loranthi Ramulus, Ginseng Radix. Bioassay-guided fractionation and purification is undergoing.

• 생약학회지
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• 제30권4호
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• pp.409-412
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• 1999

The in vitro anticoagulant and fibrinolytic activities of crude extract from insects which have been used as traditional medicines. The extracts of Formica, Huechys and Eupolyph-aga/Steleophaga prolonged activated partial thromboplastin time and thrombin time compared to the value of the control. The fibrinolytic activity of insect extracts was also tested by fibrin plate method. We found that the extracts of Cicadae Periostracum, Eupolyphaga/Steleophdga, Mantidis $O{\ddot{o}}otheca$ and Huechys directly could hydrolyze the fibrin clot without the activation of plasminogen by plasminogen activators.

• 대한본초학회지
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• 제39권1호
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• pp.39-47
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• 2024

Objectives : This study evaluates how various traditional Korean herbal medicines assess MUC5AC expression for esophageal mucosal defense and analyzes the associated mechanisms involved in inflammation. Methods : Forty types of traditional Korean herbal medicines were assessed for in vitro antioxidant activities, and the real-time PCR method was employed to analyze MUC5AC expression under pH 4.5 conditions in human esophageal epithelial cells (HET-1A). Eight types of Korean herbal medicines were evaluated for in vitro antioxidant activities, and Reactive oxygen specise (ROS) expression was analyzed under bile salt (480 𝜇M) and pH 5.5 conditions in human esophageal epithelial cells (HET-1A). Simulation experiments involving bile salts and acidity were conducted for one hour to assess the efficacy of four drugs, and the activities of Mitogen-activated Protein Kinase (MEK), Nuclear Factor Kappa B (NF-𝜅B), and Cyclooxygenase-2 (COX-2) were detected through Western blot analysis. Results : Compared to the Normal group, the Control group exhibited higher ROS generation. Such increased ROS levels were significantly reduced by four extracts: Citrus Unshius Pericarpium (CUP), Cnidium officinale Rhizoma (CR), Ginseng Radix (GR), and Linderae Radix (LR). The protein expression of COX-2 decreased with the treatment of LR, CUP, and CR. Particularly, CUP and CR exhibited superior effects compared to other groups in inhibiting the phosphorylation of NF-𝜅B. Conclusion : Based on the results obtained, we have identified drugs that inhibit oxidative stress and inflammation caused by bile acid in esophageal epithelial cells. Our future plans involve comparing and analyzing the efficacy of these herbal medicines through animal experiments.

• 자원환경지질
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• 제48권3호
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• pp.231-240
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• 2015

본 조사에서 사용된 중국 본초도감(本草圖鑑)에서는 총 93종의 광물성 약재가 보고되었고, 동의보감(東醫寶鑑)에서는 총 77종이 수재되었는데, 토부(토부) 18종, 옥부(玉部) 4종, 석부(석부) 55종으로 나누어 기술되었으며, 현재 전국한의과대학 교재인 본초학(本草學)에서는 23종이 수재되었다. 이 중 아토피피부염 외용제로 활용 가능한 약물은 동의보감(東醫寶鑑)에서는 주사(朱砂), 반석(礬石), 녹반(綠礬, 靑礬), 웅황(雄黃), 자황(雌黃), 석류황(石硫黃, 崑崙黃), 석회(石灰, 惡灰) 등 7종이 선별되었고, 本草圖鑑에서 15종으로 東醫寶鑑에서 선별된 광물약재 7종과 활석(滑石), 경분(輕粉), 연단(鉛丹), 노감석(爐甘石), 석(錫), 수은(水銀), 밀타승(密陀僧), 은주(銀朱) 등이 선별되었다. 本草學에서는 석고(石膏), 망초(芒硝), 활석(滑石), 주사(朱砂), 유황(硫黃), 비석(砒石), 웅황(雄黃), 경분(輕粉), 연단(鉛丹), 노감석(爐甘石), 붕사(硼砂), 금박(金箔), 한수석(寒水石) 등 14종이 선별되었다. 전반적으로 한의학적 이론인 이독치독(以毒治毒)에 의해 독성이 있는 약물이 대부분을 차지하고 있어, 매우 정교한 독성제거 방식 즉 수치 방식을 통한 독성제거를 실시한 후 사용되었다. 따라서 약물로 사용하는 경우 비독성 약물을 제외한 독성 약물은 현대적 방식에 의해 독성제거를 어떻게 것인가에 대한 논의가 필요할 것으로 보인다. 이 밖의 주요성분 또는 많은 함량을 가진 화합물 위주로 분류한 광물약재 역시 유의적인 결과 도출이 있을 수 있어 다양한 실험 및 분석기법을 통하여 효능 평가가 이루어질 경우 아토피피부염뿐만 아니라 염증성 질환에 광범위하게 활용될 수 있을 것으로 사료된다.

• 식품산업과 영양
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• 제18권2호
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• pp.12-16
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• 2013

• 한국의사학회지
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• 제21권1호
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• pp.29-36
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• 2008

The professionalization of unauthoritative medical service has been progressed over time, transforming based on the motive, strategy and the social environment of the medical society. Osteopathology and Chiropractic have been professionalized in totally different steps, even though their basic philosophy and the theory are very much the same. The historical suggestions of these osteolopathology and chiropractic in England and United States is that the economical conditions and the point of view that society has on the relationship between human and medicines affect decisively on the social transformation of the community. Observations through these examples will provide many informations as a source on political measures for a medical society to decide for its future direction.