• Environmental Analysis Health and Toxicology
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• v.22 no.4
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• pp.357-366
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• 2007

To investigate the possible enhancement of genotoxicity in stress environment, we examined the of effect of genotoxic material in oxidative stress-induced condition using human tell line. Human lymphoblast cell line, TK6 was treated with hydrogen peroxide ($H_2O_2$) for induction of oxidative stress, and treated with N'-methyl-N'-nitroguanidine (MNNG), af a genetoxic material. We carried out MTS assay to set treatment doses. TK6 was treated with $H_2O_2$ at 6.75 (low dote) or $13.5\;{\mu}M$ (high dose) for 2 h, and treated with MNNG af 0.117 (low dose), 0.234 (middle dose), $0.468\;{\mu}M$ (high dose) for 2 h. As results, a treatment of MNNG induced DNA dam age as dose dependently. And TK6 treated with $H_2O_2$ at low as well as high dose followed by MNNG treatment showed higher DNA damage compared to MNNG alone treated groups. Malondialdehyde, as a marker of lipid peroxidation was increased in $H_2O_2$ and MNNG treated groups. Real-time RT-PCR analyses for expression of several antioxidative enzymes showed that catalase mRNA and glutathione peroxidase 1 mRNA expression were decreased in $H_2O_2$ and MNNG treated groups. Taken together, we conclude that genotoxicity induced by MNNG is enhanced in a condition of oxidative stress induced by $H_2O_2$ and it suggests that it should be associated with induction of lipid peroxidation and decrease of antioxidant enzymes.

• Biomolecules & Therapeutics
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• v.15 no.4
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• pp.252-260
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• 2007

As it is needed to assay possible feasibility of extrapolation between in vivo and in vitro systems and to develop a new in vitro method for toxicity testing, we investigated global gene expression from both animal and cell line treated with thioacetamide (TAA) and compared between in vivo and in vitro genomic profiles. For in vivo study, mice were orally treated with TAA and sacrificed at 6 and 24 h. For in vitro study, TAA was administered to a mouse hepatic cell line, BNL CL.2 and sampling was carried out at 6 and 24 h. Hepatotoxicity was assessed by analyzing hepatic enzymes and histopathological examination (in vivo) or lactate dehydrogenase (LDH) assay and morphological examination (in vitro). Global gene expression was assessed using microarray. In high dose TAA-treated group, there was centrilobular necrosis (in vivo) and cellular toxicity with an elevation of LDH (in vitro) at 24 h. Statistical analysis of global gene expression identified that there were similar numbers of altered genes found between in vivo and in vitro at each time points. Pathway analysis identified several common pathways existed between in vivo and in vitro system such as glutathione metabolism, bile acid biosynthesis, nitrogen metabolism, butanoate metabolism for hepatotoxicty caused by TAA. Our results suggest it may be feasible to develop toxicogenomics biomarkers by comparing in vivo and in vitro genomic profiles specific to TAA for application to prediction of liver toxicity.

• Journal of the Korean Operations Research and Management Science Society
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• v.38 no.2
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• pp.1-24
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• 2013

The research about customer value has developed over the past years in the marketing field. On the other hand, the stream of the idea has not fully been structured yet. It is the purpose of this research to present the process of development together with the intellectual structure in the field of customer value researches using "Author Co-citation Analysis" (ACA). For the purpose of the research, authors chosen were ranked in order of frequency according to their citations which were used for network analysis. Further, it was of advantage in finding the development process for this research from 1996 to 2011. The trend were set into three time-line groups/trends (1996~2000, 2001~2005, and 2006~2011) that were respectively analyzed. In conclusion, the research represents the intellectual structure of customer value in each period. The research having been tried, influenced a variable field in other marketing researches. While still, many researches limit their focus on a "one-way customer value, used by companies in the past and some in the present, many researches now have a wider perspective about the value and relationship of their customer and their company, together with the society at large.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.27 no.4
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• pp.470-479
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• 1982

Researches on industrial crops in Korea before 1962 were concentrated on fiber crops such as cotton, kenaf, hemp, ramie and flax. Then research works on oil crops, sugar crops and other high income crops were followed. However, no land is shared for the production of kenaf, flax, sugar beet, sweet sorghum and sunflower at present in Korea, while the cultivation of cotton, hemp, ramie and mat rush is decreasing continuously to the marginal point. At present researches are emphasized on oil crops such as seasame, peanut and perilla and high income medicinal herbs of which cultivating acreages are increasing. Numerous varieties were released as a result of active breeding works on industrial crops since 1962, i.e. 3 sesame varieties including "Suweon 21", 3 peanut varieties including "Seoduntangkong", and 6 rape varieties including "Yudal" in oil crops, one cotton variety "Mokpo 7", one hemp variety "MS4-1", and one kenaf variety "Suweon 2" in fiber crops, and two stevia varieties "Suweon 2" and "Suweon II" in sugar crops. Quality improvement of rape seeds and development of hybrid rapes utilizing male sterile lines are the most significant results of breeding works, while the establishment of vinyl mulching cultivation of sesame and peanut are the most successful results in agronomic researches during the last 20 years.re the most successful results in agronomic researches during the last 20 years.

• Korean Parent-Child Health Journal
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• v.3 no.1
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• pp.15-26
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• 2000

These days Women have repented their past when they were inactive in attaining their own rights and they've payed attentions in gaining their fundamental rights, especially health rights. The spread of contraception use is important to fulfill women's health right. There are a lot of meanings in the contraception use. It makes women can control their reproductive activities such as pregnancy, delivery, and raising children etc. It gives each woman has autonomy of her life. The review reveals high contraceptive rate and high experienced artificial abortion rate in Korea. It means Korean married couples use contraception inefficiently. From 1970's to 1980's, most of the researches in contraceptions were descriptive and survey studies. Since 1990's, the studies have researched in the feministic perspectives. In order to understand experiences of contraceptive behaviors, qualitative researches through indepth interview did. But the number of researches were limited. The relating factors to contraceptive behavior are knowledge, communication between couples, efficiency of contraceptives, self efficacy, attitudes toward contraception, national policy, mass media, public opinion, age, parity, abortion history, ever-used contraceptive method and educational level. Theses factors affect contraception directly and indirectly. Therefore. researches about contraceptives in the future must focus on development of contraceptive behavior assessment tools and further study should be comprehensive and multidementional.

• Korean Institute of Interior Design Journal
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• no.12
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• pp.87-90
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• 1997

Interior design, evolved from interior decoration of the 20th century, is one of environmental designs which contribute to the overall well-being of human life-physically, psychologi-cally, and emotionally. Moreover, it is also a complex and multi-faceted profession that requires a strong understanding of not only human behaviors and the impact of the designed environment on them, but also of changing technologies and their potential effects. Furthermore, design is a participatory process which requires the application of research, and theoretical knowledge to resolve issues addressing the society. Indeed, there has been various kinds of researches in the interior design field that came about. Through scrutinization of master's theses and doctoral dissertations, this study intends us to grasp the current trend of interior design researches. Theses and dissertations related to interior design and architecture were and sources for this study. The subject of the analysis for this study was limited to the 560 titles of such like these, published from 1970 to 1996 by gradute schools related to interior design or architecture. The results were as follows : Since the '80s, there had been active researches on the interior design field. The subject space had extensively been expanded in its area, especially in the case of commercial environment. The content of those researches had focused on space design with the intention of applying the results to hypothetical one.

• Journal of the Korean Institute of Landscape Architecture
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• v.28 no.2
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• pp.49-60
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• 2000

The purpose of this study is to overview domestic and foreign trends in the study of the landscape evaluation through new framework of landscape evaluation studies. 108 studies on the landscape evaluation are summarized and categorized into theoretical studies, verification of theories, development of evaluation methods and applications in physical planning. Major theories in the landscape evaluation came from the psycho-physics, the evolutionary theory ann the cultural-learning theory, and were verified and applied into physical planning. Early experimental researches on landscape evaluation, based on psycho-physics, were focused on relatively simple responses to landscapes. But many studies have been gradually related to the evolutionary theory and the cultural learning theory, emphasizing biological and cultural effects on landscape evaluation. Especially, Appleton's Prospect-Refuge theory' and Kaplans' 'Information Processing model' have very strong influence in landscape evaluation. Relatively there have been many application researches in Korea, which tells there have been strong needs to solve pending practical problems caused by the rapid economic and social growth for several decades. Almost of applications in physical planning are focused on physical features of landscapes, but for more comprehensive landscape evaluation, many other factors such as cognitive and sociocultural variables should be integrated into the whole evaluation system. As a result of reviewing of landscape evaluation studies, I found the overall domestic and foreign trends and the necessity of more research on the applications in physical planning. Because this study mainly focused on academic researches, for more appropriate landscape evaluation and management there should be more practical researches including various approaches.

• Korean Institute of Interior Design Journal
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• v.26 no.2
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• pp.33-44
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• 2017

This study was intended to grasp the research trends related to the spatial composition of nursing homes. The 43 research papers were collected and analyzed. They were analyzed to focus on the research methodology and research contents related to the spatial composition of nursing home. The researches on spatial composition of nursing home were categorized into 5 types ; 1) the researches on the overall spatial composition of nursing homes, 2) the ones on space planning of each room in nursing homes, 3) the ones on the space size of nursing home, 4) the ones on the spatial composition of nursing homes in foreign countries, 5) the ones on the usage conversion of small-sized hospital and closed school into nursing home. The size and layout of a bedroom and common space were the main issue. These studies have been consistently carried out since late 1990 and many researches used the method of the analysis of floor plan and the field study. However, the number of the subject nursing homes and the categorized space areas were different depending on studies. Therefore, it was difficult to synthesize these various results. In order to compare and synthesizing the various results of these many studies, the same criteria for dividing the spaces of nursing home needs to be applied. However, many results from these researches related to the space composition of nursing home would be the useful data for planning the nursing home.

• Journal of the Korean Society of Costume
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• v.54 no.7
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• pp.91-106
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• 2004

The purpose of this study was to review the previous researches, analyze the clothing image, the make-up image and compare the analyses of clothing image and make-up image. The previous researches of clothing image and make-up image were reviewed in 6 kinds of Journal. The results of previous research review and analysis were followed as : Measuring mean of image are used to similarly that semantic differential technique and summated rating technique. Attention to proposed researcher abstraction image in make-up image, but there is problem that this hard to explain objectivity of image abstraction. There are a lot of occasions that 4 or 5 image factors were extracted by factor analysis. The make-up image researches that presented image stimulus were more than study that do not present. Image words were classified which were compiled words have similar sub image. Grace, activeness, lively. unique, modernity attractive, feminine. sexy and ripeness clothing images were classified factors. which were representative clothing image. Elegance, Sophisticate. romantic, natural, modern and youthfulness make-up image for factor were representative make-up image factors. However the problems were found that some representative image factor included the sub images which were different from some factor image. Compared with representation image words, same image words were used to not agree what clothing image and make-up image. Standardization of word should be made that show that clothing image and make-up image.

• Journal of Korean Biological Nursing Science
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• v.10 no.2
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• pp.184-193
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• 2008

Purpose: Anxiety and depression are the concepts that commonly used as an emotional approach in the nursing researches and most of researches have been used questionnaires as a marker of anxiety and depression. There were few researches using physiological markers in measuring anxiety and depression. Methods: Journals published between 1950 and 2007 that include depression and anxiety measuring through physiological markers were reviewed. Results: As in the case of the hypothlamus-pituitary-adrenal axis system, it appeared that cortisol, epinephrine, and norepinephrine belonged to the category of hormones which were responsive to anxiety and depression. Plasma norepinephrine was a marker of the anxiety whereas plasma cortisol was a marker of the depression. The anxiety and depression were correlated with immune and taste, but it considered as an outcome variable not a physiological marker. Conclusion: Catecholamine and cortisol reflect anxiety and depression state. Our findings suggest that further researches are needed to distinguish between markers and outcomes of depression and anxiety using physiological markers.