• Journal of the Korean Data and Information Science Society
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• 제22권3호
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• pp.555-563
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• 2011

Osteoarthritis (OA) and rheumatoid arthritis (RA) are most popular types of arthritis in Korea. This study compared health-related quality of life (HRQoL) of homedwelling people with OA and RA in Korea. Data were drawn from the Korean nationwide representative survey. Subjects were 3,352 people with arthritis over 19 years of age (2,953 OA respondents and 399 RA respondents). Good HRQoL in OA respondents was dierentiated with limitation of mobility, perceived health status, age, economic status, presence of arthralgia, gender, medical coverage, and educational level. Good HRQoL in RA respondents was dierentiated with limitation of mobility, perceived health status, economic status, educational status, and presence of arthralgia. In conclusion, HRQoL and predictors of good HRQoL among people with arthritis diers for OA or RA. These results can be of use in development of health programs and clinical interventions for community-dwelling people with arthritis.

• 한국컴퓨터정보학회논문지
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• 제20권9호
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• pp.11-20
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• 2015

In order to prevent the elderly people from committing suicide attempts, it is necessary to verify attributes that affect the suicide attempts. It is noted that previous studies have focused on qualitative approaches, and simple correlation analyses to determine the attributes related to the suicide attempts in the elderly people. However, such previous approaches had led to insufficient performance when facing with complicated data sets. In this sense, this study suggests an alternative method in which attribute selection techniques are adopted to determine more relevant attributes of the suicide attempts occurring in Korean elderly people. To verify empirical validity of our proposed method, we used Korea National Health and Nutrition Examination Survey (KNHANES) from January 2007 to December 2012. Empirical results proved that the proposed attribute selection techniques showed better predictive effectiveness; 94.4% compared to the simple statistical methods. This study proposes a way to determining the elderly suicide and preventing it to happen.

• The Korean Journal of Physiology
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• 제1권2호
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• pp.215-230
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• 1967

It has been suggested by Krag and Kountz (1950), Horvath et al. (1955) and Spurr et al. (1955) that the mechanism for prevention of heat loss is less efficient in the aged than in the young. In addition, they observed that peripheral vasoconstriction occurred more rapidly and more intensively in the aged people in response to the cold stimulus. Although it is not clear on the basis of these reports whether the Physical insulation of the aged people in cold would be different from the younger, it is evident that the vascular reactivity in response to cold seems to be altered in the aged people. Hence this investigation was undertaken to investigate the physical insulation of the aged people in a systemic manner by water immersion method which has been successfully applied to the Eskimos and Korean diving women by Rennie et al.

• 한국환경보건학회지
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• 제22권1호
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• pp.65-81
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• 1996

This study was conducted from march 20 through April 20, 1992, jn order to figure out the factors affecting behavior of the people on environmental health. 1, 261 people were selected by sampling from Seoul, Pusan, Taegu, Taejon and Kwangju. Questionnaire forms were prepared and the persons selected were-interviewed by trained interviewers. The data collected were analyzed in order to determine factors affecting kowledge, attitude and practice on environmental health in major cities in Korea. The major results are as follows: 1. The people who got high KAP score were found not to practice what they know. The people who got lower scores were found to use their knowledge in practical life. 2. Correlation between knowledge, attitude, and practice (KAP) on environmental health was statistically significant (p < 0.001). 3. The levels of KAP on environmental health affected by variables of gender and marital status were statistically significant (p < 0.01). 4. Variables of education, occupation, religion and economic status affected the levels of KAP significantly (p < 0.01). 5. The levels of KAP on environmental health by variables of health education on environmental health were statistically significant (p < 0.001). 6. The levels of KAP of the people on environmental health by demographic variables showed a reverse relation statistically (p < 0.001). 7. The levels of KAP of the people on environmental health had correlation with education level and the KAP level had correlation with knowledge (p < 0.001). 8. The KAP levels of the people on environmental health had correlation with environmental health education (p < 0.001). 9. The total variables affecting KAP of the people on environmental health had 14% variance and environmental health education was the highest($\beta$=0.23827), education level was the next($\beta$=0.12442), and economic status was ($\beta$=-0.06970), age ($\beta$=-0.06710) and print media ($\beta$=0.06539). 10. The variables most affecting KAP of the people on environmental health were environmental health education(r=0.2980) and education(r=0.2419) and the next were age, marital status, religion, electronic media, print media, place of birth and gender. 11. The most important variable affecting KAP level of the people on environmental health was education level.

• 방송공학회논문지
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• 제22권1호
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• pp.70-77
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• 2017

다양한 사람계수 측정 방법중에서 동적 관심점을 이용하는 지도-기반 기법은 우수한 성능을 보여준다. 그러나 정적인 사람의 계수측정은 정적 관심점이 배경에 포함되기 때문에 어려움이 있다. 계수에 정적인 사람을 포함하기 위해서 정적인 사람이 정적점과 배경을 구별하는 것이 필요하다. 본 논문에서는 동적 및 정적 점들을 고려하는 사람계수 방법을 제안한다. 제안방법은 모션정보를 활용하여 두 점을 분리한다. 그러면 정적인 사람의 정적점들은 전경 마스크 처리 및 점 패턴 분석를 하여 분류된다. 실험결과에서는 제안 방법이 정적인 사람을 계수에 포함하기 때문에 보다 정확한 사람계수 값을 얻는다. 또한 배경 갱신을 이용함으로써 배경 변화에 따른 정적점 오분류 문제를 해결한다.

• IMMUNE NETWORK
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• 제22권3호
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• pp.25.1-25.11
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• 2022

IL-34 can promote osteoclast differentiation and activation, which may contribute to steroid-induced osteonecrosis of the femoral head (ONFH). Animal model was constructed in both BALB/c and IL-34 deficient mice to detect the relative expression of inflammation cytokines. Micro-CT was utilized to reveal the internal structure. In vitro differentiated osteoclast was induced by culturing bone marrow-derived macrophages with IL-34 conditioned medium or M-CSF. The relative expression of pro-inflammation cytokines, osteoclast marker genes, and relevant pathways molecules was detected with quantitative real-time RT-PCR, ELISA, and Western blot. Up-regulated IL-34 expression could be detected in the serum of ONFH patients and femoral heads of ONFH mice. IL-34 deficient mice showed the resistance to ONFH induction with the up-regulated trabecular number, trabecular thickness, bone value fraction, and down-regulated trabecular separation. On the other hand, inflammatory cytokines, such as TNF-α, IFN-γ, IL-6, IL-12, IL-2, and IL-17A, showed diminished expression in IL-34 deficient ONFH induced mice. IL-34 alone or works in coordination with M-CSF to promote osteoclastogenesis and activate ERK, STAT3, and non-canonical NF-κB pathways. These data demonstrate that IL-34 can promote the differentiation of osteoclast through ERK, STAT3, and non-canonical NF-κB pathways to aggravate steroid-induced ONFH, and IL-34 can be considered as a treatment target.

• Journal of Gastric Cancer
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• 제24권3호
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• pp.300-315
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• 2024

Purpose: Gastric cancer (GC) is among the deadliest malignancies and the third leading cause of cancer-related deaths worldwide. Galectin-1 (Gal-1) is a primary protein secreted by cancer-associated fibroblasts (CAFs); however, its role and mechanisms of action of Gal-1 in GC remain unclear. In this study, we stimulated GC cells with exogenous human recombinant galectin-1 protein (rhGal-1) to investigate its effects on the proliferation, migration, and resistance to cisplatin. Materials and Methods: We used simulated rhGal-1 protein as a paracrine factor produced by CAFs to induce GC cells and investigated its promotional effects and mechanisms in GC progression and cisplatin resistance. Immunohistochemical (IHC) assay confirmed that Gal-1 expression was associated with clinicopathological parameters and correlated with the expression of neuropilin-1 (NRP-1), c-JUN, and Wee1. Results: Our study reveals Gal-1 expression was significantly associated with poor outcomes. Gal-1 boosts the proliferation and metastasis of GC cells by activating the NRP-1/C-JUN/Wee1 pathway. Gal-1 notably increases GC cell resistance to cisplatin The NRP-1 inhibitor, EG00229, effectively counteracts these effects. Conclusions: These findings revealed a potential mechanism by which Gal-1 promotes GC growth and contributes to chemoresistance, offering new therapeutic targets for the treatment of GC.

• Journal of Korean Biological Nursing Science
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• 제15권4호
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• pp.219-229
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• 2013

Purpose: The purpose of this study was to identify the prevalence of osteoarthritis and its risk factors among a community dwelling population age 60-74 and 75 and over (young-old vs. old-old) in Korea. Methods: A total of 1,389 of age 60-74 and 397 of age 75 and over from the 2010 Korean National Health and Nutrition Examination Survey (KNHANES) were selected. The data analysis was performed using the complex sampling function of SPSS version 19.0. Results: The prevalence of osteoarthritis was greater for old-old people (35.50%) compared to young-old people (18.20%). Univariate logistic regression analysis shows that the difference of risk factors for osteoarthritis between young-old and old-old elderly people. The prevalence of osteoarthritis in young-old people was associated with lower education levels; performance of moderate intensity physical activity; higher waist circumference, whereas old-old people was most affected in females; depression and experience. Conclusion: The finding of differences in the prevalence of osteoarthritis and its' risk factors between young-old and old-old people is expected to promote the screening strategy for the aged at risk of osteoarthritis in the Korean community.

• 농촌의학ㆍ지역보건
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• 제15권1호
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• pp.41-48
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• 1990

In order to find out the status of health care of the old aged people (age of 65 and over) in a rural area, a study was carried out, through analyzing the data of health care clinic for 207 old aged people with geriatric diseases, and of questionnired survey for 84 old aged people with geriatric diseases in a rural community. Su Dong-Myun. Nam Yang Zu-Gun, Kyung Gi-Do, Korea, during the year of 1989. The following results were obtained. 1) The composition rate of population of age of 65 and over was 9.8% in total, and sex-specific composition rate was 9.3% in male and 10.4% in female. 2) Utilization rate of health care clinic for old aged people with geriatric diseases was the highest rate with 37.9%, through individual letters at the first time, and showed gradually decreasing tendency afterward. 3) In the means of utilization advices to health care clinic for the old aged people. the individual letters(37.9%) at the first time were more effective than public information of the old aged hall or/and Myun office(18.4%). 4) In opinion on utilization of health subcenter-health care clinic for the old aged people "will utilize"(59.5%) was the highest and "do not know"(26.2%) "be difficult to utilize" (9.5%) and "will not utilize"(4.8%) were in the next order. 5) Out of 84 respondents, the old aged people With geriatric diseases, 73.8%(about three-fourths) of them answered "their diseases to the aggravated" (29.8%) "not to be changed"(25.0%) and "to be unknown"(19.0%), and the others(26.2% of them) "to be changed for the better". 6) Out of 62 respondents(the old aged people), answered their geriatric diseases not to be changed for the better, "no curative effect" was the highest with 43.5% of them. "could not know" (33.9%), "would not treat"(19.4%) and "could not be treated"(4.8%) were in decreasing order. 7) The old aged people, responded their diseases to be changed for the better, answered that they(patients) should make themselves(68.2%) responsible for basic effort of health care. However the old aged people responded their diseases not to be changed for the better answered that they should impute the responsibility of basic effort for health care to medical facilities or other conditions(63.0%). 8) In the reason of failure that the old aged people responded their geriatric diseases not to have curative effect, mis-control of regular habits of daily life was the highest(57.1%), and failure of taking selected medicine steadily(28.6%), and abuse of medicines(14.3%) were in decreasing order. 9) The reason order of being changed for the better that the old aged people responded their diseases to have curative effect, was keeping and control of regular habits of daily life (46.7%), taking selected medicines steadily(33.3%) and others (20.2%) respectively. 10) The courses of geriatric diseases itself are so chronic, duplicate and uncertain, and the old aged people activities for disease control are so slow, various and uncertain that continuous health education in home or/and community unit must be essential factors for effective geriatric health care.

• 사회복지연구
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• 제44권3호
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• pp.395-420
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• 2013

본 연구는 노인들의 자존감과 우울의 매개효과를 중심으로 노인들의 주거환경만족요인들(안전성과 편리성)이 그들의 삶의 질에 미치는 영향을 파악하기 위해 수행되었다. 이를 위해 본 연구에서는 청주시에 소재하고 있는 4개의 노인복지관 및 시니어클럽을 이용하는 60세 이상의 노인들을 대상으로 2012년 10월1일부터 10월31일까지 조사를 실시하였으며 총 386부가 최종 분석에 사용되었다. 연구결과를 요약하면 다음과 같다. 첫째, 노인주거환경의 만족요인 중 안전성은 노인의 삶의 질에 어떤 영향을 미치지 않았으나 편리성은 노인의 삶의 질에 정(+)의 영향을 미쳤다. 둘째, 안전성은 노인들의 자존감 및 우울에 어떤 영향도 미치지 않았으나 편리성은 노인들의 자존감에 정(+)의 영향을 미쳤고 우울에는 부(-)의 영향을 미쳤다. 셋째, 노인들의 자존감은 그들의 삶의 질에 정(+)의 영향을 미쳤으나 노인들의 우울은 그들의 삶의 질에 부(-)의 영향을 미쳤다. 넷째, 안전성과 노인들의 삶의 질 간에 매개변수로 설정한 자존감과 우울은 어떤 간접효과도 보여주지 않았다. 그러나 편리성과 노인들의 삶의 질 간에는 매개변수로 설정한 자존감과 우울의 간접효과가 나타났다. 본 연구의 결과 노인들의 주거환경의 편리성은 노인들의 삶의 질에 직접, 또는 자존감과 우울을 통해 간접적으로 영향을 미치는 만큼 노인주거환경의 편리성을 높이기 위한 다양한 대책이 마련되어야 할 필요성이 있음을 보여주고 있다.