• Biomolecules & Therapeutics
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• 제31권1호
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• pp.97-107
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• 2023

Aristolochic acid (AA), extracted from Aristolochiaceae plants, plays an essential role in traditional herbal medicines and is used for different diseases. However, AA has been found to be nephrotoxic and is known to cause aristolochic acid nephropathy (AAN). AA-induced acute kidney injury (AKI) is a syndrome in AAN with a high morbidity that manifests mitochondrial damage as a key part of its pathological progression. Melatonin primarily serves as a mitochondria-targeted antioxidant. However, its mitochondrial protective role in AA-induced AKI is barely reported. In this study, mice were administrated 2.5 mg/kg AA to induce AKI. Melatonin reduced the increase in Upro and Scr and attenuated the necrosis and atrophy of renal proximal tubules in mice exposed to AA. Melatonin suppressed ROS generation, MDA levels and iNOS expression and increased SOD activities in vivo and in vitro. Intriguingly, the in vivo study revealed that melatonin decreased mitochondrial fragmentation in renal proximal tubular cells and increased ATP levels in kidney tissues in response to AA. In vitro, melatonin restored the mitochondrial membrane potential (MMP) in NRK-52E and HK-2 cells and led to an elevation in ATP levels. Confocal immunofluorescence data showed that puncta containing Mito-tracker and GFP-LC3A/B were reduced, thereby impeding the mitophagy of tubular epithelial cells. Furthermore, melatonin decreased LC3A/B-II expression and increased p62 expression. The apoptosis of tubular epithelial cells induced by AA was decreased. Therefore, our findings revealed that melatonin could prevent AA-induced AKI by attenuating mitochondrial damage, which may provide a potential therapeutic method for renal AA toxicity.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2006년도 추계학술대회 및 정기총회
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• pp.82-82
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• 2006

• 대한견주관절학회:학술대회논문집
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• 대한견주관절학회 1999년도 학술대회
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• pp.74-74
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• 1999

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2006년도 춘계학술대회
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• pp.137-137
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• 2006

• 대한견주관절학회:학술대회논문집
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• 대한견주관절학회 2000년도 학술대회
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• pp.19-19
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• 2000

• 한국시스템다이내믹스연구
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• 제9권1호
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• pp.93-105
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• 2008

This study suggests a Causal Loop Diagram(CLD) of Causality Mechanism which are intergrating matter of for-profit hospital, non-for profit hospital, healthcare development, national medical spending. To coordinate each part theory, we suggest more developed medical system in our study. Through the system thinking, development of hospital as research center in industry can lesson the rise of medical spending effectively.

• 한국임상수의학회:학술대회논문집
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• 한국임상수의학회 2006년도 추계학술대회 및 정기총회
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• pp.133-133
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• 2006

• Clinical and Experimental Pediatrics
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• 제64권5호
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• pp.247-250
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• 2021

• Journal of Acupuncture Research
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• 제32권2호
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• pp.197-207
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• 2015

Objectives : The purpose of this study is to report the effect of Korean medical treatment on 4 patients with acute traumatic meniscal tear, presenting severe knee pain and limitation of range of motion of the knee joint. Methods : 4 patients with acute traumatic meniscal tear had been treated with acupuncture, herbal treatment, moxibustion, and wet-cupping therapy. From administration to discharge, we recorded subjective pain by using a visual analogue scale and by measuring the range of motion of the knee joint once per week. Results : The visual analogue scale of knee pain of all 4 cases reduced to 0 after treatment. The range of motion of the knee joint also increased considerably after treatment. Conclusions : In this study, Korean medical treatment may have been effective in reducing knee pain and increasing the range of motion of the knee joint.

• 간호행정학회지
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• 제18권1호
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• pp.96-105
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• 2012

Purpose: This study was done to examine the influence of nursing service quality and medical service satisfaction on intent to revisit the hospital, and to identify mediating effects of medical service satisfaction between nursing service quality and intent to revisit the hospital. Methods: This study was a cross-sectional survey. Participants were 390 hospitalized patients at one general hospital in Gyeonggi Province. Data were collected from July 21 to September 10, 2010 and analyzed using SPSS/PC version 18.0. Results: The score for nursing service quality continuously improved but the scores for medical service satisfaction and intent to revisit the hospital did not changed significantly after estimated. Factors influencing intent to revisit the hospital were nursing service quality, medical service satisfaction, 'same religion', and 'Christian', and the explanation power of these four factors was 79.7%. Medical service satisfaction had a partial mediating effect between nursing service quality and intent to revisit the hospital. Conclusion: Findings indicate that nursing service quality is a very important factor to improve both medical service satisfaction and intent to revisit the hospital. Nursing managers should develop strategies to improve nursing service quality.