• Journal of Preventive Medicine and Public Health
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• 제41권1호
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• pp.23-29
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• 2008

Objectives : We examined the association between alcohol consumption and incidence of colorectal cancer in elderly Koreans. Methods : The cohort members (n=14,304) consisted of 4,834 males and 9,470 females derived from the Korea Elderly Pharmacoepidemiologic Cohort (KEPEC), a population-based dynamic cohort. They were aged 65 years old or older and lived in Busan between 1993-1998; they were beneficiaries of the Korean Medical Insurance Corporation (KMIC). Baseline information was surveyed by a self-administered, mailed questionnaire. This study population was restricted to 14,304 participants who reported alcohol drinking habits on the questionnaire and had not been diagnosed with colorectal cancer at baseline. The adjusted hazard ratios (aHR) of status, type, frequency and daily average amount of alcohol consumption were computed with Cox's proportional hazard model, with the never-drinkers as a reference group and controlling for age and gender. Results : After 4.82 person-years of mean follow-up 112 cases of colorectal cancer occurred. The incidence densities of colorectal cancer were 161 (95% CI=123-200) for never-drinkers, 219 (95% CI=125-339) for ex-drinkers, and 137 (95% CI=84-189) for current-drinkers per 100,000 person-year. The status, type, frequency, and daily average amount of alcohol consumption were not significantly related to the incidence of colorectal cancer after controlling for age and gender. Conclusions : There was no significant association between alcohol consumption and colorectal cancer among elderly people after controlling for age and gender.

• Journal of Preventive Medicine and Public Health
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• 제52권3호
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• pp.188-194
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• 2019

Objectives: Outbreaks of scarlet fever in Mexico in 1999, Hong Kong and mainland China in 2011, and England in 2014-2016 have received global attention, and the number of notified cases in Korean children, including in Jeju Province, has also increased since 2010. To identify relevant hypotheses regarding this emerging outbreak, an age-period-cohort (APC) analysis of scarlet fever incidence was conducted among children in Jeju Province, Korea. Methods: This study analyzed data from the nationwide insurance claims database administered by the Korean National Health Insurance Service. The inclusion criteria were children aged ${\leq}14years$ residing in Jeju Province, Korea who received any form of healthcare for scarlet fever from 2002 to 2016. The age and year variables were categorized into 5 groups, respectively. After calculating the crude incidence rate (CIR) for age and calendar year groups, the intrinsic estimator (IE) method was applied to conduct the APC analysis. Results: In total, 2345 cases were identified from 2002 to 2016. Scarlet fever was most common in the 0-2 age group, and boys presented more cases than girls. Since the CIR decreased with age between 2002 and 2016, the age and period effect decreased in all observed years. The IE coefficients suggesting a cohort effect shifted from negative to positive in 2009. Conclusions: The results suggest that the recent outbreak of scarlet fever among children in Jeju Province might be explained through the cohort effect. As children born after 2009 showed a higher risk of scarlet fever, further descriptive epidemiological studies are needed.

• 한국수산과학회지
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• 제30권5호
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• pp.903-905
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• 1997

Morphological differences were studied using the analysis of covariance between various partial length and mantle length of the common Todarodes pacificus by cohorts in the Korean waters. Analysis of seven morphological characters proved that each cohort has no sexual differences, except significant sexual differences only in the Summer cohort in term of relative growth between mantle length and body weight. The three cohorts represent significant differences in morphological characters.

• 응용통계연구
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• 제31권4호
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• pp.427-446
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• 2018

UN의 고령화사회(ageing society) 정의와 통계청의 장래인구추계 (2016)에 따르면 우리나라는 만 30여년 만에 초고령사회(super-aged society)를 맞이하게 되며, 세계 어느 나라와도 비교할 수 없는 빠른 고령화 속도를 보인다. 이러한 유례없는 고령화 속도에 비해서 장기 시계열의 사망관련 데이터 확보와 연금과 복지정책을 고민하는 인식은 뒤처져 있다. 본 연구는 과거 및 미래 예측을 통해 우리나라 1955-2200년까지 245여 연간의 사망률 자료를 추정 예측하여 가상코호트와 실제코호트의 기대수명을 비교함으로써 그 차이가 어느 정도인지를 가늠해 보았다. 더불어 우리나라 고령화수준을 파악하기 위해 국제비교도 하였다. 역 추계(back-projection) 기간의 추정치는 선행연구와 Lee-Carte (LC) 모형으로 비교 분석해 정확성과 객관성을 높였으며, 2016년 이후의 예측치는 LC method extended with rotation (LC-ER) 모형을 활용해 우리나라의 사망률 개선의 교대현상을 반영하였다. 분석결과 60년 동안(1955-2015년) 약 30년에 가까운 기대수명의 증가가 이루어졌고, 2세기(1955-2155)동안 실제코호트의 기대수명이 가상코호트보다 높게 도출되었다. 실제코호트의 기대수명 비교우위는 비교 국가들 모두 공통적인 경향임을 확인하였다. 그리고 일본과 우리나라가 기대수명의 상위를 점하고 있고, 모든 국가들이 85-90세를 기점으로 가상과 실제코호트의 기대수명에 대한 증가속도가 이전보다 높지 않음을 보였다.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.23.1-23.6
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• 2016

Objectives A stable follow-up participation rate is a very important factor for validity in a cohort study. This study analyzed the factors that affect the participation rate at one hospital-based birth cohort in South Korean. Methods The participants were recruited from the Mothers' and Children's Environmental Health study between 2006 and 2010. The analysis targeted 1751 mothers who participated in a birth cohort. We conducted analyses of general characteristics during pregnancy and those of infants at birth that affect the participation rate of the 6-month follow-up survey. Results The participation rate for the 6-month follow-up survey was 60.4%. The participation rate in the follow-up of the subsequent period decreased within a 5% to 10% range compared to the number of subjects. The participation rate of premature infants was 16.9% lower than that of a full-term infant (52.6% vs. 69.5%). Analysis showed a 16.7% difference between the participation rate of low-birthweight infants in follow-ups (53.7%) and the participation rate of infants with normal weight (70.4%). The participation rate of mothers who were employed during pregnancy was significantly lower for the 6-month follow-up compared to the participation rate of mothers who were unemployed during pregnancy. Conclusions In this study, factors such as premature birth, low-birthweight, and the employment status of the mother during pregnancy affected the participation rate of the follow-up survey for the birth cohort at six months. A specific strategy is needed to encourage survey participation for the high risk groups in the follow-ups.

• Journal of Preventive Medicine and Public Health
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• 제55권4호
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• pp.313-320
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• 2022

The KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) was launched in 2011 with the support of the Korea Disease Control and Prevention Agency. The study was designed with the aim of exploring the various clinical features and characteristics of chronic kidney disease (CKD) in Koreans, and elucidating the risk factors for CKD progression and adverse outcomes of CKD. For the cohort study, nephrologists at 9 tertiary university-affiliated hospitals participated in patient recruitment and follow-up. Biostatisticians and epidemiologists also participated in the basic design and structuring of the study. From 2011 until 2016, the KNOW-CKD Phase I recruited 2238 adult patients with CKD from stages G1 to G5, who were not receiving renal replacement therapy. The KNOW-CKD Phase II recruitment was started in 2019, with an enrollment target of 1500 subjects, focused on diabetic nephropathy and hypertensive kidney diseases in patients with reduced kidney function who are presumed to be at a higher risk of adverse outcomes. As of 2021, the KNOW-CKD investigators have published articles in the fields of socioeconomics, quality of life, nutrition, physical activity, renal progression, cardiovascular disease and outcomes, anemia, mineral bone disease, serum and urine biomarkers, and international and inter-ethnic comparisons. The KNOW-CKD researchers will elaborate a prediction model for various outcomes of CKD such as the development of end-stage kidney disease, major adverse cardiovascular events, and death.

• 아동학회지
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• 제19권2호
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• pp.115-132
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• 1998

The present study investigated the construction of the moral concepts of 3-, 4-, and 5- year old Korean children. Instruments were the Maternal Behavior Research Instrument by Schaefer for mother and feather nurturing attitudes, and the Domain Distinctiveness Model for children's moral judgments. Maternal and teacher attitudes were categorized by the affection-rejection factor consisting of affection-affection, affection-rejection, rejection-affection, and rejection-rejection dimensions, and by the permissive, -control factor consisting of permissive-permissive, permissive-control, control-permissive, and control-control dimension. Children's data were collected with an individualized interview in which children were asked to judge moral and social conventional transgression events. 30 children were assigned to each of the maternal/teacher attitude dimensions; thus, there were 120 children for each factor. Results showed that (1) the affection-affection cohort was must strongly related to moral rules using both the seriousness criterion and deserved punishment criterion, and (2) the permissive-permissive cohort was most strongly related to reasoning and action. However, this cohort did not break out of children's structural limitation (limited responses to the intangible).

• 한국환경과학회지
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• 제17권5호
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• pp.517-524
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• 2008

The purpose of this study was to investigate the characteristics of air quality using data from which obtain local air quality monitoring system for cohort study in Chungju, Korea. We analyzed the concentration data of $NO_2,\;SO_2$, and $PM_{10}$ in Chungju and industrial cities in 2006. We compared a industrial area with a cohort study area using by bicluster algorithm. In the case of $SO_2$, the rate of the cluster time was $10{\sim}60%$ and the cluster time number of two areas was similar. In the case of $NO_2$ and $PM_{10}$, the number of cluster time between a industrial area and cohort study area was clearly different.

• Journal of Preventive Medicine and Public Health
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• 제42권6호
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• pp.356-359
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• 2009

In the more than 100 genome wide association studies (GWAS) conducted in the past 5 years, more than 250 genetic loci contributing to more than 40 common diseases and traits have been identified. Whilst many genes have been linked to a trait, both their individual and combined effects are small and unable to explain earlier estimates of heritability. Given the rapid changes in disease incidence that cannot be accounted for by changes in diagnostic practises, there is need to have well characterized exposure information in addition to genomic data for the study of gene-environment interactions. The case-control and cohort study designs are most suited for studying associations between risk factors and occurrence of an outcome. However, the case control study design is subject to several biases and hence the preferred choice of the prospective cohort study design in investigating geneenvironment interactions. A major limitation of utilising the prospective cohort study design is the long duration of follow-up of participants to accumulate adequate outcome data. The GWAS paradigm is a timely reminder for traditional epidemiologists who often perform one- or few-at-a-time hypothesis-testing studies with the main hallmarks of GWAS being the agnostic approach and the massive dataset derived through large-scale international collaborations.

• 한국생활과학회지
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• 제21권1호
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• pp.41-58
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• 2012

The purpose of this study was to compare the job loss and job seeking experiences between middle-aged men and their younger cohort. Participants included 11 middle-aged unemployed men and nine younger unemployed men. The study adopted a phenomenological approach. In-depth individual interviews were carried out and the theme analysis was used to analyze the interview data. The results showed that the two cohorts experienced the macroeconomic crises, the foreign exchange crisis in 1997 and the global financial crisis in 2008, differently. Their experiences affected their attribution of the unemployment and job seeking process. They expressed ambivalence toward their family while dealing with social isolation from extrafamilial support. Most of the participants criticized government employment support policies and services.