• 한국동물위생학회지
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• 제31권4호
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• pp.497-504
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• 2008

A cross-sectional study was undertaken to report prevalence and to identify risk factors of subclinical mastitis of dairy cattle in Sylhet district of Bangladesh. Among 325 dairy farms of the district 12 farms(3.7%) were selected conveniently for this study. All the dairy cows of the 12 farms were selected for sample collection. Fresh milk samples from each of the selected dairy cows were collected aseptically in separate sterilized test tube as RF, RH, LF and LH quarter of the udder. Rapid modified White Side Test(WST) was used to detect subclinical mastitis(SCM). Results of WST and data derived from filled in questionnaire were entered in Microsoft Excel 2003 and transferred to $STATA^{(R)}$, version 8.0/Intercooled(Stata Corporation, Texas, USA, 2003). The overall prevalence of SCM and its distribution in different categories of variables in cow and their exact binomial 95% confidence intervals were calculated in $STATA^{(R)}$. Simple bivariable associations among independent variables were investigated by $x^2$ test in $STATA^{(R)}$. Multiple logistic regression analysis with backward elimination method was used to identify risk factors of SCM. To identify significant variation in quarter SCM, linear regression analysis was performed after arcsine transformation of the data. The overall prevalence of SCM found in this study is 54%. Dairy cows with teat lesions had significantly increased SCM(OR=12342, P value=0.000, 95% CI=762, 199798) than others without teat lesions. The Holstein Friesian X Jersey X Sahiwal breed has significantly decreased(OR=0.18, p=0.03, 95% CI 0.04, 0.85) SCM than other breeds. The prevalence of SCM found in this study is in agreement with others. The injury in the teat increases the probability of getting infected with microbes and thereby mastitis. If the prevalence of teat lesion can be decreased the probability of subclinical mastitis will also be decreased. The negatively associated Holstein Friesian X Jersey X Sahiwall breed may help in planning mastitis control program if this finding can be validated by a more powerful case-control or cohort study design.

• Journal of Korean Neurosurgical Society
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• 제61권4호
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• pp.450-457
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• 2018

Objective : Very large (20-25 mm) and giant (${\geq}25mm$) intracranial aneurysms have an extremely poor natural course, and treatment of these aneurysms remains a challenge for endovascular and surgical strategies. This study was undertaken to describe our experiences of endosaccular treatment of very large and giant intracranial aneurysms with parent artery preservation. Methods : From January 2005 to October 2016, twenty-four very large or giant aneurysms in 24 patients were treated by endosaccular coil embolization with parent artery preservation. Nine (37.5%) aneurysms were ruptured and 15 were unruptured, and of these 15, 11 were symptomatic cases and 4 were incidentally discovered. The cohort comprised 17 women and 7 men of mean age 58.5 years (range, 26-82). Mean aneurysm size was 26.0 mm (range, 20-39) and 13 of the 24 aneurysms were giant. Results : Immediate angiographic results were complete occlusion in nine (37.5%) cases, remnant neck in six (25.0%), and remnant sac in nine (37.5%). Overall procedural related morbidity and mortality rates were 12.5% and 4.2%, respectively. Angiographic follow-up was available in 16 patients (66.7%). Mean and median follow-up periods were 27.2 (range, 2-77) and 10.5 months, respectively. In 12 cases (12/16, 75%) stable occlusion was achieved, four cases (4/16, 25%) had recanalized, and two of these were retreated with additional coiling. At clinical follow-up of the nine ruptured cases, three patients (33.3%) achieved a good clinical outcome (Glasgow outcome scale [GOS] score of 4 or 5), two (22.2%) a poor outcome (GOS score of 2 or 3), and four patients (44.4%) expired (GOS 1). On the other hand, of the 15 unruptured cases, 13 patients (86.7%) achieved a good clinical outcome (GOS 4 or 5), one patient a poor outcome (GOS score of 2 or 3), and one patient expired (GOS 1). Conclusion : The present study shows endosaccular treatment of very large or giant intracranial aneurysms with parent artery preservation is both feasible and effective with acceptable morbidity and mortality.

• Nutrition Research and Practice
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• 제11권3호
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• pp.214-222
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• 2017

BACKGROUND/OBJECTIVES: Glutathione S-transferase (GST) forms a multigene family of phase II detoxification enzymes which are involved in the detoxification of xenobiotics by conjugating substances with glutathione. The aim of this study is to assess the antioxidative status and the degree of DNA damage in the subclinical hypertensive patients in Korea using glutathione S-transferase polymorphisms. SUBJECTS/METHODS: We examined whether DNA damage and antioxidative status show a difference between GSTM1 or GSTT1 genotype in 227 newly diagnosed, untreated (systolic blood pressure $(BP){\geq}130mmHg$ or diastolic $BP{\geq}85mmHg$) subclinical hypertensive patients and 130 normotensive subjects (systolic BP < 120 mmHg and diastolic BP < 80 mmHg). From the blood of the subjects, the degree of the DNA damage in lymphocyte, the activities of erythrocyte superoxide dismutase, the catalase, and the glutathione peroxidase, the level of glutathione, plasma total radical-trapping antioxidant potential (TRAP), anti-oxidative vitamins, as well as plasma lipid profiles and conjugated diene (CD) were analyzed. RESULTS: Of the 227 subjects studied, 68.3% were GSTM1 null genotype and 66.5% were GSTT1 null genotype. GSTM1 null genotype had an increased risk of hypertension (OR: 2.104, CI: 1.38-3.35), but no significant association in GSTT1 null genotype (OR 0.982, CI: 0.62-1.55). No difference in erythrocyte activities of superoxide dismutase, catalase, or glutathione peroxidase, and plasma TRAP, CD, lipid profiles, and GSH levels were observed between GSTM1 or GSTT1 genotype. Plasma levels of ${\alpha}-tocopherol$ increased significantly in GSTT1 wild genotype (P < 0.05); however, plasma level of ${\beta}-carotene$ increased significantly in GSTT1 null genotype (P < 0.01). DNA damage assessed by the Comet assay was significantly higher in GSTM1 null genotype than wild genotype (P < 0.05). CONCLUSIONS: These results confirm the association between GSTM1 null genotype and risk of hypertension as they suggest that GSTM1 null genotype leads to an increased oxidative stress compared with wild genotype.

• 정신신체의학
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• 제25권1호
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• pp.27-32
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• 2017

연구목적 본 연구는 우울 증상과 혈중 콜레스테롤 농도의 연관성이 성별에 따라 차이가 있는지 살펴보고자 하였다. 방법 건강검진을 받은 일반인 중 27,452명(남자 15,044명, 여성 12,408명)을 대상으로 후향적 의무기록 조사를 통하여 이루어졌다. 대상자들의 벡우울척도(Beck Depression Inventory, BDI)점수를 구하고 총콜레스테롤(Total cholesterol, TC), 중성지방(Triglyceride, TG)), 고밀도 지단백 콜레스테롤(High density lipoprotein cholesterol, HDL-C), 저밀도 지단백 콜레스테롤(Low density lipoprotein cholesterol, LDL-C)을 분석하였다. 결과 남성은 총콜레스테롤(TC)과 벡우울척도(BDI) 점수 사이에는 통계적으로 유의한 상관성을 보이지 않았다. 중성지방(TG)은 벡우울척도(BDI) 점수와 양의 상관성을 보였으며(r=0.020, p<0.01), 고밀도 지단백 콜레스테롤(HDL-C)와 저밀도 지단백 콜레스테롤(LDL-C)은 벡우울척도(BDI) 점수와 음의 상관성을 보였다(r=-0.016, p<0.01 ; r=-0.015, p<0.05) 여성의 경우도 총콜레스테롤(TC)과 벡우울척도(BDI) 점수 사이에는 통계적으로 유의한 상관성이 없었으며 중성지방(TG)은 벡우울척도(BDI)점수와 양의 상관성을 보였고(r=0.020, p<0.01) 고밀도 지단백 콜레스테롤(HDL-C)과는 음의 상관성을 보였다(r=-0.019, p<0.01). 남성과 달리 저밀도 지단백 콜레스테롤(LDL-C)은 통계적으로 유의한 상관성을 보이지 않았다. 결론 남녀 모두 중성지방(TG)이 높을수록, 고밀도 지단백 콜레스테롤(HDL-C)이 낮을수록 우울 증상의 정도가 심한 것으로 나타났으며, 남성에서만 저밀도 지단백 콜레스테롤(LDL-C)이 낮을수록 우울 증상이 심한 것으로 나타났다.

• 보건행정학회지
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• 제9권3호
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• pp.1-20
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• 1999

This study reviews the literature of influencing factor on hospital-employed physician's income, and it describes general distribution of hospital-employed physician's income, and analyzes influencing factor of hospital-employed physician's income. A total of 1.795 persons responded to the mail survey. through stratified sampling by 23 branches of medical society in Korean RBRVS study. The design of the study is cross sectional study. and the unit of analysis is a physician. To examine the change of average income per month. multiple regression was used to test the change according to physician's characteristics. demographic characteristics. scale of hospital. average intensity of ordinary work. and specialty. The major findings of this study are as follows; 1. As for physicians working in first referral hospital. the average income of neurosurgeon per month was the largest. being 1.34 times larger than that of the family physician, and that of the emergency physician was the smallest, being 0.78 times smaller than that of the family physician, but that of the ophthalmic and Orthopaedic physician was significantly larger than that of the family physician under the control of control variables. And average income per month was significantly larger for physicians who worked in Seoul metropolitan area than physicians who worked in rural area. 2. The year of physician's career, number of average out-patients per month significantly positively associated, but the number of hospital beds and average intensity of therapy significantly negatively associated with average income per month. 3. As for physicians working in second referral hospital. the average income of the psychiatric physician per month was the largest, being 1.33 times larger than that of the family physician, and that of the emergency physician was smallest, being 0.74 times smaller than that of the family physician., but no significant difference was seen under the control of control variables, and average income per month was significantly larger for physicians who worked in Seoul metropolitan area than physicians who worked in large municipal area. 4. The year of physician's career and number of hospital beds significantly positively associated, but average working hours per month significantly negatively associated with average income per month. In conclusion, the year of hospital-employed physician's career is the largest influencing factor on hospital-employed physicians. But the difference of average income per month according to working regions and to number of hospital beds existed in employed physicians under the control of control variables. So this study has implementation that we must consider the influence of working regions and the number of hospital beds on the income of hospital-employed physicians in making policy for hospital. Being a cross-sectional study, this study can not suggest causal explanations. In the future, experiment or cohort study is needed for causal explanations.

• Journal of Nutrition and Health
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• 제53권4호
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• pp.406-415
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• 2020

본 연구는 2013-2017년 국민건강영양조사 자료를 이용하여 만 19-64세 성인 남녀를 대상으로 채소·과일 섭취에 따른 일반적 사항과 식품 및 영양소 섭취 상태를 파악하고 채소·과일의 섭취와 천식 유병률의 관련성을 알아보고자 시행되었다. 전체 대상자의 천식 유병률은 2.6% 이었고, 채소·과일의 섭취량에 따라 1.8%-3.1%로 나타났다. 채소·과일 섭취량이 많을수록 평균 연령과 가구소득은 높았고 교육수준은 낮았으며, 흡연자의 비율과 알코올 섭취 빈도도 낮았다. 채소·과일의 섭취량이 많은 군이 우유 및 유제품을 제외한 모든 식품군의 섭취량이 많았고, 에너지를 포함한 영양소의 섭취량도 많았다. 열량영양소의 섭취비율의 경우, 채소·과일의 섭취량이 많은 군이 적은 군에 비해 탄수화물과 단백질의 섭취비율은 높고, 지방의 섭취비율은 낮았다. 채소와 과일 섭취량에 따른 3사분위군의 천식에 대한 위험도는 최하위 사분위군 대비 각각 35%, 40%까지 감소하였다. 그러나 최상위 사분위군의 경우, 최하위 사분위군과 비교하여 천식에 대한 위험도가 유의하게 감소하지 않았다. 이러한 결과를 통하여 권장량 수준의 적절한 채소·과일의 섭취가 천식을 예방 및 관리하는데 도움이 될 것이라 생각된다. 또한 채소·과일의 섭취가 천식의 발생과 치료효과에 미치는 영향을 파악하기 위해 장기간의 코호트 연구와 임상시험 연구가 필요할 것으로 생각된다.

• Journal of Korean Neurosurgical Society
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• 제57권5호
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• pp.342-349
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• 2015

Background : Higher reperfusion rates have been established with endovascular treatment for acute ischemic stroke patients. There are limited data on the comparative performance of mechanical thrombectomy devices. This study aimed to analyse the efficacy and safety of the stent retriever device (Solitaire stent) by comparing procedure time, angiographic outcome, complication rate and long term clinical outcome with previous chemical thrombolysis and mechanical thrombectomy using penumbra system. Method : A retrospective single-center analysis was undertaken of all consecutive patients who underwent chemical thrombolysis and mechanical thrombectomy using Penumbra or Solitaire stent retriever from March 2009 to March 2014. Baseline characteristics, rate of successful recanalization (modified Thrombolysis in Cerebral Infarction score 2b-3), symptomatic intracerebral hemorrhage, procedure time, mortality and independent functional outcomes ($mRS{\leq}2$) at 3 month were compared across the three method. Results : Our cohort included 164 patients, mechanical thrombectomy using stent retriever device had a significant impact on recanalization rate and functional independence at 3 months. In unadjusted analysis mechanical thrombectomy using Solitaire stent retriever showed higher recanalization rate than Penumbra system and chemical thrombolysis (75% vs. 64.2% vs. 49.4%, p=0.03) and higher rate of functional independence at 3 month (53.1% vs. 37.7% vs. 35.4%, p=0.213). In view of the interrelationships between all predictors of variables associated with a good clinical outcome, when the chemical thrombolysis was used as a reference, in multiple logistic regression analysis, the use of Solitaire stent retriever showed higher odds of independent functional outcome [odds ratio (OR) 2.62, 95% confidence interval (CI) 0.96-7.17; p=0.061] in comparison with penumbra system (OR 1.57, 95% CI 0.63-3.90; p=0.331). Conclusion : Our initial data suggest that mechanical thrombectomy using stent retriever is superior to the mechanical thrombectomy using penumbra system and conventional chemical thrombolysis in achieving higher rates of reperfusion and better outcomes. Randomized clinical trials are needed to establish the actual benefit to specific patient populations.

• 한국인구학
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• 제18권2호
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• pp.1-22
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• 1995

이 논문은 평균초혼연령을 계산하는 여러 방법들의 특성과 차이점을 논의하고, 1970-1990년 기간 한국 여자의 자료를 이용하여 이들 계산 방법상의 차이가 평균초혼연령 측정치에 미치는 영향을 구체적으로 제시하였다. 또한 연구의 기초자료인 인구센서스와 표본조사결과 자료의 비교성에 대한 통계적 검정결과를 제시하고 있다. 주요 결과를 보면, 한국의 혼인행태에 관한 연구에서 주로 사용되는 지표인 Hajnal의 SMAM은 한 특정기간의 혼인행태에 근거한 측정치가 아니다. 이 때문에 생기는 편의(Bias)는 1970-1990년 기간 한국 여자의 경우 0.3세 미만으로 나타나, 이 기간 혼인형태의 변화를 고려할 때 예상보다 작은 것으로 생각할 수 있다. 그러나 더 큰 편의를 가져올 가능성을 배제할 수 없다. 또한 편의의 방향은 혼인연령이 상승하는 추세에 있을 때 평균연령을 높이는 영향을 주는 것으로 보인다. 한국의 자료사정에서는 단순평균방법과 Agarwala 방법에 의한 평균초혼연령 측정치(ASMAM)를 목적에 따라 이용하는 것이 바람직하다. ASMAM은 두 센서스 자료에서 계산된 연령별 혼인율 추정치를 근거로 함으로 같은 자료를 이용하여 얻은 조혼인표에서 계산할 수 있는 평균초혼연령과 일치한다. 인구센서스와 표본조사에 의한 연령별 미혼인구구성비의 시계열 자료들은 각기 일관성 있는 추세를 보이고 있으나, 같은 시점에서 두 결과자료를 비교했을 때 주요 연령계층에서 통계적으로 유의한 차이(\alpha=0.05)가 있는 것으로 검증되었다. 또한 이러한 차이는 표본틀이나 조사표 설계상의 문제가 아니며 그 원인에 대한 별도의 연구가 필요하다.

• 대한임상독성학회지
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• 제13권2호
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• pp.78-86
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• 2015

Purpose: The purpose of this study is to understand what kinds of chemical substances have been used annually and to investigate incidents that occurred due to chemical hazard release and to analyze statistically clinically chemical injury patients who visited one regional emergency medical center in Gumi city with documented references review. Methods: Annual chemical waste emission quantity (Kg/Year) (Cwep) was reproduced using national web site data governed by the Ministry of Environment and 5 years (from 1 .Jan. 2010 to 31. Dec. 2014) of medical records of chemical injury patients who visited our emergency department were reviewed retrospectively. By applying exclusion criteria, 446 patients of 460 patients were selected. Results: Dichloromethane, Toluene, Trichloroethylene, and Xylene were always included within Top 5 of Cweq. Six cases of chemical incidents were reported and in 3 of 6 cases involving Hydrogen fluoride were included during the study period. Male gender and twenties were the most prevalent group. Injury evoking chemicals were Hydrogen fluoride, unknown, complex chemicals (over 2 substances) in sequence. The most frequent site of wounds and injuries was the respiratory tract. Gas among status, intoxication among diagnosis, and discharge among disposition was most numerous in each group. Conclusion: There have been no uniform clinical protocols for chemical wounds and injuries due to various kinds of chemicophysical properties and ignorance of antidotes. Therefore conduct of a multicenter cohort study and experiments for ruling out chemicals according to chemicophysical priority as well as development of antidotes and clinical protocols for chemical injury patients is needed.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제40권4호
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• pp.169-172
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• 2014

Objectives: The purpose of this retrospective study was to compare the amount of postoperative drainage via closed suction drainage system after intraoral vertical ramus osteotomy (IVRO) and sagittal split ramus osteotomy (SSRO). Materials and Methods: We planned a retrospective cohort study of 40 patients selected from a larger group who underwent orthognathic surgery from 2007 to 2013. Mean age (range) was 23.95 (16 to 35) years. Patients who underwent bilateral IVRO or SSRO were categorized into group I or group II, respectively, and each group consisted of 20 patients. Closed suction drainage system was inserted in mandibular osteotomy sites to decrease swelling and dead space, and records of drainage amount were collected. The data were compared and analyzed with independent t-test. Results: The closed suction drainage system was removed at 32 hours postoperatively, and the amount of drainage was recorded every 8 hours. In group I, the mean amount of drainage was 79.42 mL in total, with 31.20 mL, 19.90 mL, 13.90 mL, 9.47 mL, and 4.95 mL measured at 0, 8, 16, 24, and 32 hours postoperatively, respectively. In group II, the mean total amount of drainage was 90.11 mL, with 30.25 mL, 25.75 mL, 19.70 mL, 8.50 mL, and 5.91 mL measured at 0, 8, 16, 24, and 32 hours postoperatively, respectively. Total amount of drainage from group I was less than group II, but there was no statistically significant difference between the two groups (P=0.338). There was a significant difference in drainage between group I and group II only at 16 hours postoperatively (P=0.029). Conclusion: IVRO and SSRO have different osteotomy design and different extent of medullary exposure; however, our results reveal that there is no remarkable difference in postoperative drainage of blood and exudate.