• Korean Journal of Legislative Studies
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• v.23 no.1
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• pp.81-111
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• 2017

This article analyzes three major issues related to regional voting in South Korea. First, is regional voting a regional problem or an ideological problem? Second, is regional voting caused by regional identity or regional interest? Third, has regionalism waxed or waned? Analyses of the cumulative data set since the 15th presidential election yield the following results. First, Yongnam people are more conservative than Honam people. Second, regional voting consists of ideological and regional components. Third, there exist both a hometown effect and an abode effect in regional voting, but the latter is significantly greater than the former. Forth, regionalism had weakened between the 15th National Assembly election and the 16th Presidential election, but has not varied much since then.

• Animal cells and systems
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• v.7 no.1
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• pp.1-9
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• 2003

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis of higher organisms. Mitochondria, known to play a central role in regulating cellular metabolism, was found to be critical for regulating apoptosis induced under both physiological and pathological conditions. Mitochondria are a major source of reactive oxygen species (ROS) but they can also serve as its target during the apoptosis process. Release of apoptogenic factors from mitochondria, the best known of which is cytochrome c, leads to assembly of a large apoptosis-inducing complex called the apoptosome. Cysteine pretenses (called caspases) are recruited to this complex and, following their activation by proteolytic cleavage, activate other caspases, which in turn target for specific cleavage a large number of cellular proteins. The redox regulation of apoptosis during and after cytochrome c release is an area of intense investigation. This review summarizes what is known about the biological role of ROS and its targets in apoptosis with an emphasis on its intricate connections to mitochondria and the basic components of cell death.

• Nuclear Engineering and Technology
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• v.53 no.9
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• pp.2816-2829
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• 2021

Decay heat residuals of spent nuclear fuel (SNF), i.e., the differences between calculations and measurements, were obtained previously for various spent fuel assemblies (SFA) using the Polaris module of the SCALE code system. In this paper, we compare decay heat residuals to their uncertainties, focusing on four PWRs and four BWRs. Uncertainties in nuclear data and model inputs are propagated stochastically through calculations using the SCALE/Sampler super-sequence. Total uncertainties could not explain the residuals of two SFAs measured at GE-Morris. The combined z-scores for all SFAs measured at the Clab facility could explain the resulting deviations. Nuclear-data-related uncertainties contribute more in the high burnup SFAs. Design and operational uncertainties tend to contribute more to the total uncertainties. Assembly burnup is a relevant variable as it correlates significantly with the SNF decay heat. Additionally, burnup uncertainty is a major contributor to decay heat uncertainty, and assumptions relating to these uncertainties are crucial. Propagation of nuclear data and design and operational uncertainties shows that the analyzed assemblies respond similarly with high correlation. The calculated decay heats are highly correlated in the PWRs and BWRs, whereas lower correlations were observed between decay heats of SFAs that differ in their burnups.

• Nuclear Engineering and Technology
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• v.51 no.4
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• pp.968-976
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• 2019

This paper presents a number of verification case studies for a recently developed sensitivity/uncertainty code package. The code package, ROMUSE (Reduced Order Modeling based Uncertainty/Sensitivity Estimator) is an effort to provide an analysis tool to be used in conjunction with reactor core simulators, in particular the Virtual Environment for Reactor Applications (VERA) core simulator. ROMUSE has been written in C++ and is currently capable of performing various types of parameter perturbations and associated sensitivity analysis, uncertainty quantification, surrogate model construction and subspace analysis. The current version 2.0 has the capability to interface with the Design Analysis Kit for Optimization and Terascale Applications (DAKOTA) code, which gives ROMUSE access to the various algorithms implemented within DAKOTA, most importantly model calibration. The verification study is performed via two basic problems and two reactor physics models. The first problem is used to verify the ROMUSE single physics gradient-based range finding algorithm capability using an abstract quadratic model. The second problem is the Brusselator problem, which is a coupled problem representative of multi-physics problems. This problem is used to test the capability of constructing surrogates via ROMUSE-DAKOTA. Finally, light water reactor pin cell and sodium-cooled fast reactor fuel assembly problems are simulated via SCALE 6.1 to test ROMUSE capability for uncertainty quantification and sensitivity analysis purposes.

• Journal of Astronomy and Space Sciences
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• v.36 no.3
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• pp.181-186
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• 2019

The attitude information of spacecraft can be obtained by the sensors attached to it using a star tracker, three-axis magnetometer, three-axis gyroscope, and a global positioning signal receiver. By using these sensors, the spacecraft can be maneuvered by actuators that generate torques. In particular, electromagnetic-torque bars can be used for attitude control and as a momentum-canceling instrument. The spacecraft momentum can be created by the current through the electrical circuits and coils. Thus, the current around the electromagnetic-torque bars is a critical factor for precisely controlling the spacecraft. In connection with these concerns, a solar-cell array can be considered to prevent generation of a magnetic dipole moment because the solar-cell array can introduce a large amount of current through the electrical wires. The maximum value of a magnetic dipole moment that cannot affect precise control is $0.25A{\cdot}m^2$, which takes into account the current that flows through the reaction-wheel assembly and the magnetic-torque current. In this study, we designed a 300-W solar cell array and presented an optimal wire-routing method to minimize the magnetic dipole moment for space applications. We verified our proposed method by simulation.

• Health Policy and Management
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• v.32 no.3
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• pp.247-257
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• 2022

The presidential election and the inauguration of the new government are a period of the policy window opening. The newly launched government is expected to improve the quality of life of the people. The Yoon Suk-yeol Government is also launched with new expectations with a transitional period in health care. The sustainability of health care in Korea is threatened. The environment of health care and the main policy issues of health care are difficult to secure the necessary finance for health care in spite of the increasing health care burden. Accordingly, the Yoon Suk-yeol Government's health care policy aims to provide intensive support to those in need of health and welfare and to improve the health of the people through investment in health. And for integrating fragmented health care and welfare services and creating people-centered community-based health care, a health care innovation center will be established for the evaluation platform of new delivery and payment systems, a health care development plan will be established for the blueprint of health care, and reorganizing the central & local government should be reviewed. Although we are facing unfavorable situations such as the distribution of the National Assembly, inflation, and the possibility of economic recession, we expect that announced health care policies will be implemented, recognizing that health care innovation is the only way to improve health care sustainability.

• Nuclear Engineering and Technology
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• v.53 no.5
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• pp.1391-1402
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• 2021

The aim of this work is to prepare a neutron noise calculator based on the second order of average current nodal expansion method (ACNEM). Generally, nodal methods have the ability to fulfill the neutronic analysis with adequate precision using coarse meshes as large as a fuel assembly size. But, for the zeroth order of ACNEM, the accuracy of neutronic simulations may not be sufficient when coarse meshes are employed in the reactor core modeling. In this work, the capability of second order ACNEM is extended for solving the neutron diffusion equation in the frequency domain using coarse meshes. For this purpose, two problems are modeled and checked including a slab reactor and 2D BIBLIS PWR. For validating of results, a semi-analytical solution is utilized for 1D test case, and for 2D problem, the results of both forward and adjoint neutron noise calculations are exploited. Numerical results indicate that by increasing the order of method, the errors of frequency dependent coarse mesh solutions are considerably decreased in comparison to the reference. Accordingly, the accuracy of second order ACNEM can be acceptable for the neutron noise calculations by using coarse meshes in the nuclear reactor core.

• Nuclear Engineering and Technology
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• v.53 no.7
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• pp.2095-2103
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• 2021

A small power ADS design using thorium oxide and diluent matrix reprocessed fuel is proposed for a high transmutation rate, small reactivity swing, and strong safety features. Two fuel matrices (CERCER and CERMET) and different recycled fuel compositions recovered from UO₂ spent fuels with 45 GWd/tU and 60 GWd/tU burnup were investigated to determine the suitable fuel for the ADS. It was found that the transmutation of each isotope depends on TRU initial loading amount. After examining the cores, the results show that CERCER fueled ADS has a negative coolant void reactivity (CVR) and a smaller radiotoxicity at discharge compared to that of CERMET core. It implies that CERCER fuel has enhanced safety features and more flavor in terms of radiotoxicity management. To increase fuel utilization and core operation efficiency, a simple assembly shuffling pattern for the CERCER fueled ADS is also proposed. Eigenvalue and burnup calculations were conducted using Serpent 2 with ENDF/B-VII.0 library in both kcode and external source modes, and it indicates that the results of transmutation analyses obtained by kcode only is reliable to discuss the transmutation potential of ADS. Burnup calculation with the fixed-source mode is essential to be used for more practical results of the transmutation by ADS.

• Biomolecules & Therapeutics
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• v.31 no.1
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• pp.48-58
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• 2023

Interferon regulatory factor 3 (IRF3) integrates both immunological and non-immunological inputs to control cell survival and death. Small GTPases are versatile functional switches that lie on the very upstream in signal transduction pathways, of which duration of activation is very transient. The large number of homologous proteins and the requirement for site-directed mutagenesis have hindered attempts to investigate the link between small GTPases and IRF3. Here, we constructed a constitutively active mutant expression library for small GTPase expression using Gibson assembly cloning. Small-scale screening identified multiple GTPases capable of promoting IRF3 phosphorylation. Intriguingly, 27 of 152 GTPases, including ARF1, RHEB, RHEBL1, and RAN, were found to increase IRF3 phosphorylation. Unbiased screening enabled us to investigate the sequence-activity relationship between the GTPases and IRF3. We found that the regulation of IRF3 by small GTPases was dependent on TBK1. Our work reveals the significant contribution of GTPases in IRF3 signaling and the potential role of IRF3 in GTPase function, providing a novel therapeutic approach against diseases with GTPase overexpression or active mutations, such as cancer.

• Korean Journal of Legislative Studies
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• v.15 no.1
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• pp.65-92
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• 2009

Political trust is defined as the degree to which people perceive that government is producing outcomes consistent with their expectations. Political trust as a concept has endogenous as well as exogenous characteristics in that it can cause and be caused by other political factors. The purpose of this study is to introduce and evaluate various theoretical perspectives related to the causes and effects of political trust. With respect to its causes, this study focuses on the following five factors: government policies, unethical behaviors of politicians, citizens' penchant for participatory democracy, the public's misperceptions on government, and political culture. On the other hand, this study discusses the impacts of political trust on each stage of political process by paying attention to the following factors: government's governability, election outcomes, political recruitment, and the directions of government policies.