• Molecules and Cells
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• v.37 no.10
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• pp.713-718
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• 2014

Alteration in chromosome numbers and structures instigate and foster massive genetic instability. As Boveri has seen a hundred years ago (Boveri, 1914; 2008), aneuploidy is hall-mark of many cancers. However, whether aneuploidy is the cause or the result of cancer is still at debate. The molecular mechanism behind aneuploidy includes the chromosome mis-segregation in mitosis by the compromise of spindle assembly checkpoint (SAC). SAC is an elaborate network of proteins, which monitor that all chromosomes are bipolarly attached with the spindles. Therefore, the weakening of the SAC is the major reason for chromosome number instability, while complete compromise of SAC results in detrimental death, exemplified in natural abortion in embryonic stage. Here, I will review on the recent progress on the understanding of chromosome missegregation and cancer, based on the comparison of different mouse models of BubR1, the core component of SAC.

• Proceedings of the KSR Conference
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• 2011.10a
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• pp.287-296
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• 2011

Turnout is a mechanical installation enabling railway trains to be guided from one track to another at a railway junction. A movable nose crossing frog is a device used at a railway turnout to eliminate the gap at the common crossing (High manganese, block, assembly crossing)which can cause impact damage, noise and vibration. Our government has a plan speed up of conventional line to 250km/h semi-high speed. We had already developed flexible turnout with fixed crossing(High manganese) and SFC fastening system can cover in the semi-high speed line In this study is about development of the movable nose crossing turnout available Semi-high speed line on concrete track. This paper describes about geometry, attack angle, bending stress at the nose, switching force, safety of continuous welded long rails. This movable nose crossing turnout is expected greatly increases passing speed of turnout in national railway.

• Transactions of Materials Processing
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• v.22 no.5
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• pp.275-279
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• 2013

The tube hydroforming process has received much attention in the automotive industry because of its advantages compared to conventional manufacturing technologies. A wide range of products such as sub-frames, camshafts, radiator frames, axles and crankshafts are made by hydroforming process. The hydroformed parts often need to be structurally joined to other components during assembly. Therefore, these automotive parts need to be manufactured with a localized attachment flange. In this study, FE forming analyses of a part with a rectangular flanged shape was performed with Dynaform 5.5. Using the optimized conditions determined numerically, hydroforming experiments were performed. Then, the characterization of defects was analyzed. Finally, the accuracy of the optimized internal pressure condition as well as that of the initial ram position were evaluated. The results demonstrated that flanged parts can be successfully produced using the tube hydroforming process.

• Journal of Arbitration Studies
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• v.16 no.1
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• pp.153-185
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• 2006

This article deals with the Improvement of Compulsory Arbitration System on Trade Union and Labor Relations Adjustment Act in Korea. If a labor dispute occcur, the settlement of labor dispute must be reached for the parties' own accord. The autonomy of the parties concerned is the fundamental principle in the settlement of labor dispute. If the Rights Which are guaranteed by art. 33 Constitutional Law belong to civil liberties, we should consider Trade Union Act as the restriction of basic rights. Arbitration is a procedure which permits the most positive intervention by the arbitrator. It is carried out by an arbitration committe which is composed of three arbitrators appointed by the chairman of the Labor Relations Commission. Compulsory arbitration system of the labor for parties should be improved. In case of necessary public enterprises, more strict requirements on assembly for labor disputes should be prepared and the government should support institutions to prevent labor-management disputes by educating experts on labor-management relations and improving the quality of arbitration.

• BMB Reports
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• v.42 no.10
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• pp.623-630
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• 2009

Hsp90, an evolutionarily conserved molecular chaperone, is involved in the folding, stabilization, activation, and assembly of a wide range of 'client' proteins, thus playing a central role in many biological processes. Especially, several oncoproteins act as Hsp90 client proteins and tumor cells require higher Hsp90 activity than normal cells to maintain their malignancy. For this reason, Hsp90 has emerged as a promising target for anti-cancer drug development. It is still largely unknown how Hsp90 can recognize structurally unrelated client proteins. However, recent progress in structural studies on Hsp90 and its interaction with various co-chaperones has broadened our knowledge of how the Hsp90 ATPase activity, which is essential for its chaperone function, is regulated and coupled with the conformational changes of Hsp90 dimer. This review focuses on the roles of various Hsp90 co-chaperones in the regulation of the Hsp90 ATPase cycle, as well as in the selection of client proteins. In addition, the current development of Hsp90 inhibitors based on the structural information will be discussed.

• Journal of Electrical Engineering and Technology
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• v.10 no.4
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• pp.1830-1835
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• 2015

In this paper, we propose an algorithm for the automatic registration of two rigid parts using multiple 3D sensor systems on a robot. Four sets of structured laser stripe system consisted of a camera and a visible laser stripe is used for the acquisition of 3D information. Detailed procedures including extrinsic calibration among four 3D sensor systems and hand/eye calibration of 3D sensing system on robot arm are presented. We find a best pose using search-based pose estimation algorithm where cost function is proposed by reflecting geometric constraints between sensor systems and target objects. A pose with minimum gap and height difference is found by greedy search. Experimental result using demo system shows the robustness and feasibility of the proposed algorithm.

• International Journal of Precision Engineering and Manufacturing
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• v.1 no.1
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• pp.118-126
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• 2000

Die-casting burr to casting process is removed by post-process for assembly and quality control of product. Though robot has been widely used for deburring job before. CNC exclusive machine is currently developed for high power, high speed machining and quick tool change. Deburring tool path with complex 3D curve type is defined to make out deburring NC program. But there is no efficient method to define it currently used methods with teaching probe on machine. In this study the efficient method to make out deburring NC program is developed. 5-axis digitizing machine is used to receive data of deburring path. And the post process for NC program generation is developed in consideration of the machining conditions. The developed system is not dependent on the skill of operator and has the advantage to maintain the flexibility of job to modify NC program due to the wear of tool and aging of the die casting.

• Journal of Microbiology and Biotechnology
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• v.25 no.6
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• pp.765-770
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• 2015

Recent sequencing technology development has revolutionized fields of microbial ecology. MiSeq-based microbial community analysis allows us to sequence more than a few hundred samples at a time, which is far more cost-effective than pyrosequencing. The approach, however, has not been preferably used owing to computational difficulties of processing huge amounts of data as well as known Illumina-derived artefact problems with amplicon sequencing. The choice of assembly software to take advantage of paired-end sequencing and methods to remove Illumina artefacts sequences are discussed. The protocol we suggest not only removed erroneous reads, but also dramatically reduced computational workload, which allows even a typical desktop computer to process a huge amount of sequence data generated with Illumina sequencers. We also developed a Web interface (http://biotech.jejunu.ac.kr/ ~abl/16s/) that allows users to conduct fastq-merging and mothur batch creation. The study presented here should provide technical advantages and supports in applying MiSeq-based microbial community analysis.

• Journal of Welding and Joining
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• v.33 no.3
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• pp.32-39
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• 2015

With the simplicity of process and high reliability in chip or package bonding, epoxy solder paste (ESP) has been recently considered as a competitive bonding material. The ESP material is composed of solder powder and epoxy formulation which can remove oxide layers on the surface of solder powder and pad finish metal. The bonding formed using ESP shows outstanding bonding strength and suppresses electrical short between adjacent pads or leads owing to the reinforced structure by cured epoxy after the bonding. ESP is also expected to suppress the formation and growth of whisker on the pads or leads. With the mentioned advantages, ESP is anticipated to become a spotlighted bonding material in the assembly of flexible electronics and electronic modules in automotive vehicles.

• International Commerce and Information Review
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• v.9 no.1
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• pp.333-353
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• 2007

This paper is to explore that there are structural problems in the Korea-U.S. Free Trade Agrement negotiation by examining the Korean FTA policy and to introduce some alternatives to overcome them. The structural problem stems in part from the inefficient system in FTA policy making and its implementation. Most importantly, there is a lack of ex-ante consensus building among stake-holders. As an alternative to the current FTA policy, we suggest two things. First, we argue that an FTA negotiation strategy should correspond to Korea's overall industrial development strategy. Second, the National Assembly should play an important part for enforce of trade policies as a tool for advancing a comprehensive strategic measures.