• Journal of Chest Surgery
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• v.23 no.2
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• pp.213-221
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• 1990

We have experienced 62 cases of modified Fontan operations in Seoul Nat’l University Hospital from Apr. 1986 to Jul. 1989, They were 38 males and 24 females, and their age was ranged from 16 months to 15.5 years of age. [mean age : 5.73$\pm$2.99 years] There were 16 operative deaths and 2 late deaths, therefore 29% of overall mortality. Their diagnoses were as follows; 28 single ventricle, 11 tricuspid atresia, 6 DORV with LV hypoplasia, 3 pulmonary atresia with hypoplastic RV, 3 TGA with hypoplastic RV, 3 cor\ulcornerGA with hypoplastic LV and PA, 6 AV canal defects with PA, and 2 others. Low cardiac output and pleural effusion were developed frequently, so we divide 40 patients into some groups to analyze the physiologic and anatomic causes of them. By the degree of the LCO, group A was no LCO[mean amount of inotropics used: 0-5 \ulcornerg/kg/min] with 17 cases, B mild LCO [5-10] with 11, C moderate to severe LCO but alive[>10] with 8, D severe LCO to death with 4 cases. For the pleural effusion, group 1 was to be removed the chest tube within 1 week with 8 cases, group II within 3 weeks with 21 cases, group III beyond 3 weeks with 12 cases. We considered their age, diagnosis, pulmonary artery size[PA index], pulmonary artery abnormality, palliative shunt, systemic ventricular type, pulmonary artery wedge pressure, as preoperative factors, and operative methods, and as postoperative factors, CVP, LAP, arrhythmia, thrombosis, atrioventricular valvular insufficiency, etc. In the view of LCO, pulmonary artery size and PCWP were statistically significant [P<0.05], and arrhythmia, A-V valve insufficiency were inclined to the group C and D Pleural effusion was influenced by the pulmonary artery size, pulmonary artery resistance, PCWP, and CVP significantly. [P<0.05] And arrhythmia, residual shunt, and A-V valvular insufficiency were inclined to group II and III, too. As a results, the followings are to be reminded as the important factors at the care of post-Fontan LCO, and persistent pleural effusion [1] pulmonary artery size, [2] pulmonary artery resistance, [3] PCWP, [4] CVP, [5] arrhythmia, [6] residual shunt, [7]A-V valvular insufficiency.

• Journal of Chest Surgery
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• v.31 no.11
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• pp.1056-1062
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• 1998

Background: We prospectively investigated types, incidences, and risk factors for arrhythmias after open heart surgery in adults. Materials and methods: From June 1994 to May 1995, we performed 302 cases of adult cardiac surgery at our department. This study group consisted of 150 men and 152 women, with a mean age of 43.9±28.0(range 16 to 75)years. We included all the patients irrespective of their operative types or disease entities. Results: The overall incidence of arrhythmias after open heart surgery in adults was 58.3%. The incidence of postoperative arrhythmias for redo-valvular heart surgery was 77.8%, and those for simple valvular procedure, coronary artery bypass surgery, aortic surgery, and congenital heart disease were 70.8%, 45.3%, 40.0%, and 29.5%, respectively. Eight out of twelve risk factors showed statistical significance for the development of postoperative arrhythmias. They were preoperative history of arrhythmias, antiarrhythmic drug medication, previous cardiac surgery, larger left ventricular end-diastolic, end-systolic dimension, left atrial dimension on preoperative echocardiogram, longer cardiopulmonary bypass time and aortic cross clamping time. Univariated analyses for age and types of cardioplegic solution did not show statistical significance. Conclusions: Prospective study on postoperative arrhythmias occurrence, treatment and prevention of is warrauted to draw more clear conclusion.

• Journal of Chest Surgery
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• v.20 no.1
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• pp.112-127
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• 1987

Myasthenia gravis is a neuromuscular transmission function disorder characterized by fatigue and weakness of voluntary muscles. This muscular weakness is intensified by activity and stress, and improved by the use of anticholinesterase compounds. It was initially described by Erb in 1879 and later named myasthenia gravis by Jolly in 1895. Although the pathogenesis is Known to be an autoimmune related reduction in the number of available acetylcholine receptors at neuromuscular junctions, the role of thymus in myasthenia gravis is still unclear and under investigation. Thymectomy in the management of myasthenia gravis has become increasingly important since Dr. Blalock observed in 1939 that some patients with thymic tumors and myasthenia gravis improved following thymectomy. A clinical study of 102 cases of myasthenia gravis was performed at Yonsei University College of Medicine. Seoul, Korea from Jan. 1976 to Jun. 1986. In order to determine which factors are of prognostic significance, attention is focused upon pre-operative patient evaluation, problems in operative and post-operative care, and long-term follow-up observations. The results were as follows: 1. The sex distribution was 67 females and 35 males, the mean age of onset was 28.95*1.69 years, and the maximal incidence occurred between 21 and 40 years of age [56 cases: 54.9%]. 2. Clinical manifestations of ocular symptoms were seen to 70 patients [68.6%] extremities weakness in 33 [32.3%], bulbar weakness in 29 [28.4%], and dyspnea in 13 [12.7%]. 3. Study cases more than two thirds were classified as mild types [MG 1 and MG 11A] and 6 cases as grave [MG 1V] based on the modified Osserman`s classification system, 4. Thymectomy was performed in 19 cases which presented in severe myasthenia symptoms and showed no improvement with cholinergic drugs. Histologic examination of the excised thymus glands revealed no abnormalities in 4 cases, thymic hyperplasia in 5, benign thymoma in 5, and malignant thymoma in 5. 5. Immediate post-operative complications included 2 cases of pneumothorax which were treated by tube thoracostomies, there was no operative mortality. 6. The response to cholinergic drugs in 36 cases younger than 20 years old and in 27 cases older than 40 years was relatively poor, while that in 35 cases between the ages of 21 and 40 years old was good. 7. Thirty of 39 cases in groups IIB, III & IV improved markedly with medical or surgical management while only 16 of 59 cases in the mild groups [I and IIA] improved, almost all surgical cases improved in all categories. 8. There were 5 deaths. occurring between 7 months and 3 years 3 months of treatment of myasthenia gravis. The causes of death were myasthenic crisis in 2 cases, respiratory failure due to candidiasis & radiation pneumonitis in one case, cerebral hemorrhage due to high blood pressure in two case.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.29 no.2
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• pp.123-131
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• 2007

Introduction: Distraction osteogenesis is widely used as for bone lengthening in patients with maxillofacial deformity and alveolar bone atrophy. One of the major problems in distraction osteogenesis is long consolidation period for 2-3 months, in which the devices have to be fixed on the bone to prevent relapse. It results in scar formation on the face, disturbance of mastication and speech. This study was performed to evaluate the stimulating effect of pulsed electromagnetic field on the early bone consolidation in distraction osteogenesis. Materials and methods: Total 10 rabbit were used (5 for control group, 5 for experimental group). A vertical osteotomy in the mandibular body was performed and the distraction device was fixed. After 5 days distraction was done 1mm per a day for 7 days. A pulsed electromagnetic field (38 Gauss, 60 Hz) was applied for 8 hours per day and it continued for 5 days immediately after distraction in the experimental group. Both groups were sacrificed after 2 weeks. Histological specimens with H&E and Masson Trichrome staining were made and histomorphometrically analysed with image analyser. Results: The device for distraction osteogenesis was displaced in one animal for each group, therefore, only four animals in both groups were evaluated. In both groups, a new bone formation was observed in the distracted area after 2 weeks. The bone formation was enhanced in the experimental groups ($31.76{\pm}8.68%$) compared with control group ($9.94{\pm}3.23%$), its difference was statistically significant (p<0.001). Conclusion: This study suggests that electrical stimulation with electromagnectic field may be effective in the early bone formation after distraction osteogenesis. Further studies with large number of animals are needed before clinical application.

• Journal of Environmental Science International
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• v.24 no.1
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• pp.81-96
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• 2015

The characteristics of atmospheric dispersion of radioactive material (i.e. $^{137}Cs$) related to local wind patterns around the Kori nuclear power plant (KNPP) were studied using WRF/HYSPLIT model. The cluster analysis using observed winds from 28 weather stations during a year (2012) was performed in order to obtain representative local wind patterns. The cluster analysis identified eight local wind patterns (P1, P2, P3, P4-1, P4-2, P4-3, P4-4, P4-5) over the KNPP region. P1, P2 and P3 accounted for 14.5%, 27.0% and 14.5%, respectively. Both P1 and P2 are related to westerly/northwesterly synoptic flows in winter and P3 includes the Changma or typhoons days. The simulations of P1, P2 and P3 with high wind velocities and constant wind directions show that $^{137}Cs$ emitted from the KNPP during 0900~1400 LST (Local Standard Time) are dispersed to the east sea, southeast sea and southwestern inland, respectively. On the other hands, 5 sub-category of P4 have various local wind distributions under weak synoptic forcing and accounted for less than 10% of all. While the simulated $^{137}Cs$ for P4-2 is dispersed to southwest inland due to northeasterly flows, $^{137}Cs$ dispersed northward for the other patterns. The simulated average 137Cs concentrations of each local wind pattern are $564.1{\sim}1076.3Bqm^{-3}$. The highest average concentration appeared P4-4 due to dispersion in a narrow zone and weak wind environment. On the other hands, the lowest average concentration appeared P1 and P2 due to rapid dispersion to the sea. The simulated $^{137}Cs$ concentrations and dispersion locations of each local wind pattern are different according to the local wind conditions.

• Journal of Environmental Science International
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• v.23 no.8
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• pp.1429-1436
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• 2014

In this study, we investigated the effects of dietary supplementation (n = 40 pigs/treatment) with bamboo powder (0, 1, 2 and 3%) for 38 days. We evaluated growth performance, blood metabolites, and carcass characteristics of fattening pigs and gas emission and microbial populations in pig manure, to obtain data on pork producers for environmental management. We obtained the following results. First, supplementation with increasing amounts of bamboo powder had a significant (P < 0.05) effect on feed intake, feed efficiency, and glucose contents (except for initial and final body weight, weight gain, carcass characteristics, and blood urea nitrogen). In terms of blood metabolites, glucose and blood urea nitrogen tended to decrease with increasing amounts of bamboo powder. Second, the amounts of ammonia, methane, amine, hydrogen sulfide, and acetic acid were reduced by increasing amounts of bamboo powder when compared with the controls (P < 0.05). However, there were no significant differences in pH, propionic acid, iso-butyric acid, butyric acid, iso-valeric acid, and valeric acid among all treatments. The lowest gas emission was observed when 3% bamboo powder was used. Third, supplementation with increasing amounts of bamboo powder tended (P < 0.05) to increase the total number of bacteria, Lactobacillus spp., and yeast, but E. coli, Salmonella spp., and Shigella spp. were not detected in any treatment. In conclusion, the results of this study suggest that supplementation with bamboo powder was effective in reducing gas emission and inhibiting pathogen populations in pig manure by lowering the pH of the manure.

• Journal of Nutrition and Health
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• v.4 no.1
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• pp.49-62
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• 1971

한국인(韓國人)의 기초대사량(基礎代謝量)과 1일소비열량(日消費熱量)을 측정(測定)하기 위하여 Douglas씨(氏) ${\ulcorner}$빽${\lrcorner}$과 Scholander씨(氏) ${\ulcorner}$가스${\lrcorner}$ 분석기(分析器)를 사용(使用)하여 넓은 연령(年齡), 직종(職種), 활동(活動)의 영역(領域)에 긍(亘)하여 실험(實驗)을 행(行)하였다. 938 예(例)의 기초대사측정치(基礎代謝測定値)는 Boothby, Fleish, Robertson and Reid 등(等)의 표준치(標準値)와 근사(近似)하였다. 겨울에는 기초대사량(基礎代謝量)은 9.9%의 증가(增加)를 또한 수면중(睡眠中)의 대사량(代射量)은 기초대사량(基礎代謝量)의 약(約) 94%이었다. 또한 Sanborn Metabulator를 사용(使用)하여 1,000 명(名) 이상(以上)의 기초대사량(基礎代謝量)을 측정(測定)하였다. 또한 여러 가지 동작(動作) 활동중(活動中)의 소비열량(消費熱量)이 측정(測定)되었다. 하루의 전소비열량(全消費熱量)은 $3{\sim}7$일간(日間)에 긍(亘)하여 하루 24시간(時間)의 활동상황(活動狀況)을 분단위(分單位)로 기록(紀錄), 집계(集計)하고 이것과 기초대사량(基礎代謝量) 및 개별활동시(個別活動時)의 소비열량(消費熱量)을 참작(參酌), 계산(計算)하였다. 수면중(睡眠中)의 소비열량(消費熱量)은 기초대사량(基礎代謝量)에 준(準)하였는데 사무원(事務員), 교원(敎員), 의사(醫師), 약사(藥師), 점원(店員), 운전수(運轉手), 건축기사(建築技師), 설계사(設計師), 응원사(應園師), 목공(木工), ${\ulcorner}$펜기${\lrcorner}$ 공등(工等)의 1일소비열량(日消費熱量)은 FAO 한국협회책정(韓國協會策定)의 한국인(韓國人) ${\ulcorner}$칼로리${\lrcorner}$에 근사(近似)하였고 ${\ulcorner}$쿡${\lrcorner}$, ${\ulcorner}$웨이터${\lrcorner}$, 농부(農夫), 사공(士工), 기계공(機械工), 석공(石工)은 중등정도(中等程度)의 노동(勞動)의 3,000 ${\ulcorner}$칼로리${\lrcorner}$나 또는 중(重)한 노동(勞動)의 3,900 ${\ulcorner}$칼로리${\lrcorner}$에, 가정주부(家政主婦), 하녀(下女), ${\ulcorner}$디자이너${\lrcorner}$는 여자(女子)의 중등정도(中等程度) 노동(勞動)의 2,200 ${\ulcorner}$칼로리${\lrcorner}$, 간호원(看護員), 청소부(淸掃婦), ${\ulcorner}$쿡${\lrcorner}$ 방(房)바닥연마공(硏磨工)은 중(重)한 노동(勞動)의 2,800${\ulcorner}$칼로리${\lrcorner}$에 모심기 하는 날의 농부(農夫)는 격심(激甚)한 노동(勞動)의 4,100${\ulcorner}$칼로리${\lrcorner}$에 각각(各各) 가까웠다. 여자(女子)일지라도 포제용(鋪製用) 돌까기와 돌날르기는 남자(男子)의 중노동정도(重勞動程度)의 ${\ulcorner}$칼로리${\lrcorner}$를 소비(消費)하였다.

• Nutrition Research and Practice
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• v.5 no.3
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• pp.198-204
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• 2011

Target herbal ingredient (THI) is an extract made from two herbs, Scutellariae Radix and Platycodi Radix. It has been developed as a treatment for metabolic diseases such as hyperlipidemia, atherosclerosis, and hypertension. One component of these two herbs has been reported to have anti-inflammatory, anti-hyperlipidemic, and anti-obesity activities. However, there have been no reports about the effects of the mixed extract of these two herbs on metabolic diseases. In this study, we investigated the metabolic effects of THI using a diet-induced obesity (DIO) mouse model. High-fat diet (HFD) mice were orally administered daily with 250 mg/kg of THI. After 10 weeks of treatment, the THI-administered HFD mice showed reduction of body weights and epididymal white adipose tissue weights as well as improved glucose tolerance. In addition, the level of total cholesterol in the serum was markedly reduced. To elucidate the molecular mechanism of the metabolic effects of THI in vitro, 3T3-L1 cells were treated with THI, after which the mRNA levels of adipogenic transcription factors, including C/$EBP{\alpha}$ and $PPAR{\gamma}$, were measured. The results show that the expression of these two transcription factors was down regulated by THI in a dose-dependent manner. We also examined the combinatorial effects of THI and swimming exercise on metabolic status. THI administration simultaneously accompanied by swimming exercise had a synergistic effect on serum cholesterol levels. These findings suggest that THI could be developed as a supplement for improving metabolic status.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.446-457
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• 2019

The purpose of this study was to analyze the association between family members and adolescent boys smoking. The data were evaluated by frequency analysis, 𝑥² test and logistic regression analysis using 27,276 people who responded to the 14th(2018) Korean Youth Risk Behavior Survey. Among male students, the nonsmoking rate was 91.5% and the smoking rate was 8.5%(2.5% of occasional smoking and 6.0% of frequent smoking). The study results showed that the smoking status of male students was varied significantly according to the number of smokers among the family members(p<0.001). Meanwhile, smoking based on the characteristics of socio-demographic factors was affected by grades, school records, economic status, and parents' educational background(p<0.001). Smoking by health factors showed a significant difference in alcohol consumption, suicidal thoughts, depression experiences, stress recognition, frequency of breakfast consumption, level of fatigue after sleep, and subjective perception of health(p<0.001). Male smokers were more likely to smoke when two family members smoked than only one(p<0.001). These results confirmed that smoking in boys was affected by the smoking status of family members and suggested that the smoking cessation program of family smokers can be effective in designing smoking cessation prevention and smoking cessation projects.

• Atmosphere
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• v.25 no.2
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• pp.221-233
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• 2015

Pollen is closely related to health issues such as allergenic rhinitis and asthma as well as intensifying atopic syndrome. Information on current and future spatio-temporal distribution of allergenic pollen is needed to address such issues. In this study, the Community Multiscale Air Quality Modeling (CMAQ) was utilized as a base modeling system to forecast pollen dispersal from oak trees. Pollen emission is one of the most important parts in the dispersal modeling system. Areal emission factor was determined from gridded areal fraction of oak trees, which was produced by the analysis of the tree type maps (1:5000) obtained from the Korea Forest Service. Daily total pollen production was estimated by a robust multiple regression model of weather conditions and pollen concentration. Hourly emission factor was determined from wind speed and friction velocity. Hourly pollen emission was then calculated by multiplying areal emission factor, daily total pollen production, and hourly emission factor. Forecast data from the KMA UM LDAPS (Korea Meteorological Administration Unified Model Local Data Assimilation and Prediction System) was utilized as input. For the verification of the model, daily observed pollen concentration from 12 sites in Korea during the pollen season of 2014. Although the model showed a tendency of over-estimation in terms of the seasonal and daily mean concentrations, overall concentration was similar to the observation. Comparison at the hourly output showed distinctive delay of the peak hours by the model at the 'Pocheon' site. It was speculated that the constant release of hourly number of pollen in the modeling framework caused the delay.