• 한국의사학회지
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• 제26권2호
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• pp.135-148
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• 2013

This study analyzed surface-chemical transitions in manufacturing process of traditional acupuncture as proposed method by Dongeuibogam. The manufacturing process of traditional acupuncture from a used iron for a long time was divided by primary medicinal herbs treatment, secondary medicinal herbs treatment and tertiary treatment using by dog meat. The traditional acupuncture research process was measured according to the characteristics and changes of the specimens at each processing step of the manufacturing process. The following devices were used to Surface analysis. Scanning electron microscopy (SEM), Energy Dispersive Spectrometer (EDS), X-ray diffraction analyzer (XRD). As a result, medicinal herbs removed impurities on the surface and raised the antibacterial effect in the manufacturing process of traditional acupuncture. Furthermore, the ingredients of medicinal herbs were coated on the surface of the iron. Dog meat influenced to prevent surface corrosion, reduce friction when the acupuncture was inserted. Although the process empirically obtained, a glimpse of the wisdom of our ancestors was revealed. These ancestral wisdom can be expected to apply today, when used in manufacturing process of a modern stainless steel acupuncture to compensate for the defective part.

• 한방안이비인후피부과학회지
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• 제31권4호
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• pp.65-82
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• 2018

Objectives : The purpose of this study is 1) to explore the general tendency of the herbs or herbal formula for acne treatment in clinical practice 2) and to provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism by analyzing the herbs or herbal formula using for acne treatment in clinical practice. Methods : In the domestic databases (Oriental medicine Advanced Searching Integrated System-OASIS, Korean Traditional Knowledge Portal-KTKP, National Discovery for Science Leader-NDSL, Research Information Sharing Service-RISS), we selected among the papers published using search terms related to "acne". Reports related to sasang constitutional medicine were excluded and a total of 23 papers were finally selected. Results : 29 prescriptions were retrieved from 23 papers. Chungan-tang (淸顔湯) notified formulas ranked first by Cheongsangbangpung- tang (淸上防風湯), Hwangnyeonhaedok-tang (黃連解毒湯), Dangguijakyaksan (當歸芍藥散) and Bipachungpe-eum (枇杷淸肺飮). Commonly used herbs are Forsythiae Fructus (連翹), Scutellariae Radix (黃芩), Gardeniae Fructus (梔子), Ligustici Rhizoma (川芎), and Angelicae Gigantis Radix (當歸). In most patients with inflammatory lesions or excessive flushing, exterior-releasing medicinal (解表藥) and heat-clearing medicinal (淸熱藥) were mainly prescribed for acne treatment, while in patients with acne accompanied hyperkeratinization, Excess sebum secretion, Dysmenorrhea or indigestion, qi-tonifying medicinal (補氣藥) or blood-tonifying medicinal (補血藥) were mainly used. KAGS (Korean Acne Grading System) was the most commonly used method for acne severity assessment. Conclusions : These findings suggest that the herbs or herbal formula for acne treatment in Korean Medicine is prescribed differently according to the cause and symptoms of acne in a unique way for control the whole body balance. Also, our findings could provide a basis for explaining the principles of acne treatment in Korean Medicine in order to make patients understand more easily based on pharmacological mechanism in clinical practice.

• 대한한의학방제학회지
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• 제21권2호
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• pp.72-80
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• 2013

Objectives : Ontology is a good tool to represent the knowledge and has developed for Traditional Korean Medicine(TKM) in Korea Institute of Oriental Medicine. There are a lot of TKM terms, which have a complex meaning, especially major indication terms of medicinal treatment and terms of symptom and disease. These complex meaning terms result in the low linkage between major indication terms of medicinal treatment and terms of symptom and disease in TKM ontology. We studied to enhance the percentage of the linkage among those data in TKM ontology. Methods : We disassembled major indication terms of medicinal treatment into minimum meaning units and then linked them to enhance the percentage of the linkage among medicinal material, formula and disease ontology based on Traditional Korean Medicine. To retain objectivity, several experts of Korean Medicine used a web-based tool that supports users in refining terms and disassembling them into the minimum meaning efficiently. Results : The outcome shows that the percentage of the linkage among medicinal material, formula and disease ontology increased. By linking disassembled major indication terms to symptoms and diseases, the amount of information for medicinal materials and formulas also increased quantitatively in comparison with given formula for diseases in disease ontology. Conclusions : By this study, disassembled data increases the percentage of linkage between diseases and medicinal treatments. And the applicability of TKM ontology is also increased.

• Journal of Animal Science and Technology
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• 제47권4호
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• pp.501-512
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• 2005

본 시험은 약용식물(인진쑥, 오가피, 마늘)의 사료내 첨가가 모돈의 생산성, 포유자돈의 성장율 및 이유자돈에서의 성적 및 혈청 특성에 미치는 영향을 알아보고자 실시하였다. 시험 1은 3~5산차의 임신 모돈 48두를 공시하여 각각 1) CON(basal diet; Control), 2) MP1(basal diet added 0.05% of medicinal plant mixtures), 3) MP2(basal diet added 0.1% of medicinal plant mixtures) 그리고 4) MP3(basal diet added 0.2% of medicinal plant mixtures)로 하여 처리구당 12두씩 배치하여 21일동안 실시하였다. 시험 기간동안 포유모돈의 일당 사료섭취량은 약용식물을 0.1% 첨가한 처리구가 0.2%를 첨가한 처리구보다 유의적으로 높게 나타났다(P<0.05). 포유자돈의 개시시와 이유시의 체중 변화에서는 약용식물을 0.05% 첨가한 처리구가 대조구에 비하여 유의적으로 증가하는 경향을 보였다 (P<0.05). 혈액내 glucose의 함량에서는 MP3 처리구가 대조구에 비하여 유의적으로 높게 나타났다(P<0.05). 시험 2는 개시시 체중 4.70$\pm$0.63kg의 3원교잡종(Landrace$\time$Yorkshire$\time$Duroc) 이유자돈 120두를 공시하여 20일간 사양시험을 실시하였다. 시험설계는 옥수수－대두박 위주의 사료로서 NRC(1998)의 영양소 요구량에 따라 1) CON(basal diet; Control), 2) MP1(basal diet added 0.05% of medicinal plant mixtures), 3) MP2(basal diet added 0.1% of medicinal plant mixtures) 그리고 4)MP3(basal diet added 0.15% of medicinal plant mixtures)의 4개의 처리구로 하여 처리당 6반복, 반복당 5두씩 완전임의 배치하였다. 전체시험기간 동안의 이유자돈의 일당증체량(linear, P<0.067)과 사효효율(linear, P<0.018)에서는 약용식물을 첨가함으로서 증가하는 경향을 보였으며, 사료섭취량(linear, P<0.018)에서는 감소하는 경향을 보였다. 건물의 소화율에서는 약용식물을 첨가함에 따라 증가하는 경향을 보였다(linear, P<0.004; quadratic, P<0.03). 결론적으로 포유모돈 사료내 약용식물의 첨가는 0.1%까지 첨가 급여시가 모돈의 체손실 감소 및 포유자돈의 증체량의 향상을 가져 왔으며, 이유자돈에서는 약용식물을 0.05-1.0% 첨가시 자돈의 성장율 및 건물의 소화율을 개선시키는 결과를 보였다.

• Journal of Ginseng Research
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• 제44권1호
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• pp.123-134
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• 2020

Background: The lepidopteran Asiatic corn borer (ACB), Ostrinia furnacalis (Guenee), has caused huge economic losses throughout the Asian-Western Pacific region. Usually, chemical pesticides are used for the control, but excessive use of pesticides has caused great harm. Therefore, the inartificial ecotypic pesticides to ACB are extremely essential. In our previous study, we found that panaxadiol saponins (PDS) can effectively reduce the harm of ACB by causing antifeedant activity. Therefore, it is necessary to reveal the biological molecular changes in ACB and the functionary mechanism of PDS. Methods: We analyzed the global transcription of ACB with different PDS concentration treatment (5 mg/mL, 10 mg/mL, and 25 mg/mL) by high-throughput sequencing and de novo transcriptome assembly method. Results: PDS treatment could cause the changes of many gene expressions which regulate its signal pathways. The genes in peroxisome proliferator-activated receptor (PPAR) signaling pathway were significantly downregulated, and then, the downstream fatty acid degradation pathway had also been greatly affected. Conclusion: Through this experiment, we hypothesized that the occurrence of antifeedant action of ACB is because the PDS brought about the downregulation of FATP and FABP, the key regulators in the PPAR, and the downregulation of FATP and FABP exerts further effects on the expression of SCD-1, ACBP, LPL, SCP-X, and ACO, which leads to the disorder of PPAR signaling pathway and the fatty acid degradation pathway. Not only that, PDS treatment leads to enzyme activity decrease by inhibiting the expression of genes associated with catalytic activity, such as cytochrome P450 and other similar genes.

• 대한한방내과학회지
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• 제39권4호
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• pp.592-604
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• 2018

Objectives: This study is to review the effect of Korean medicinal herbs on treatment of benign prostatic hyperplasia induced in rat models, as reported in domestic and foreign journals. Methods: Six electronic databases (EMBASE, PubMed, Oasis, RISS, CENTRAL, and Koreankt) were searched with terms including benign prostatic hyperplasia to identify study reports on treatment of benign prostatic hyperplasia impairment with Korean medicinal herbs. After selecting several studies, the analysis focused on items reflected in the diagnosis of benign prostatic hyperplasia, such as prostate weight, thickness of the prostate epithelium, and prostate specific antigen. Results: Six studies were reviewed. Testosterone propionate was used as a benign prostatic hyperplasia induction material in all the included studies. Cinnamomum verum (CV), Cynanchum wilfordii (CW), Ponciri fructus (PF), Quisqualis indica (QI), Acorus gramineus (AG), and Melandrium firmum (MF) had reduced prostate weight statistically significantly. The QI gave a better response than finasteride in terms of reducing epithelium thickness, and the response was statistically significant. The prostate specific antigen level was lower in the group treated with CV than in the control group. Conclusions: CV, CW, PF, QI, AG, and MF had distinct therapeutic effects. However it is difficult to determine which of these is better by comparing them numerically because the observation items evaluated in a rat model of benign prostatic hyperplasia.

• 한국약용작물학회지
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• 제26권3호
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• pp.227-232
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• 2018

Background: Angelica gigas Nakai is a perennial herb belonging to the family Umbelliferae. Its roots are utilized in traditional medicine. The aim of this study was to increase the yield of and the content of two indicator components (decursin and decursinol angelate) in A. gigas Nakai. Methods and Results: The roots of A. gigas Nakai were harvested 4-times from late August to late October in 2017. Two agents (trace element-TE, and plant hormone-HM) were applied 4 times at intervals of 2 weeks. The content of the two indicator components were analyzed by high performance liquid chromatography. The HM treatment showed the greatest increase in underground part yield and root diameter. The content of the two indicator components in the control (non-treatment) group was the highest in the underground part, but was higher in the aerial parts in the agent treatment group. After treatment with the agents, the content of the indicator components tended to decrease in the underground part. However, the total content of the indicator components in the two agent treatment groups exceeded the level of 6% set by the Korean Pharmacopoeia. Conclusions: The highest underground part yield was found in the HM treatment group, while the highest content of decursin and decursinol angelate were found in the control group. This study provides basic information for yield improvement in A. gigas.

• 동의생리병리학회지
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• 제29권6호
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• pp.510-516
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• 2015

The purpose of this study is to present the two treatment case of patient with dysfunctional uterine bleeding. Each patient has received the Korean Medicinal treatment including acupuncture, moxibustion, and herbal medication twice a week for a month or six months. This efficacy of treatment was evaluated with the degree of bleeding by the number of pad used per day. After finishing treatment, two patients had stopped bleeding, and their menstrual cycle returned to the normal range. Moreover, additional clinical manifestations including leukorrhea, hot flush, bloating, feeling tired and irritability which refers to the premenstrual syndrome were also alleviated. This case report showed that the acupuncture, moxibustion, and the herbal medicinal treatment can be effective for the treatment of the dysfunctional uterine bleeding.

• 한국약용작물학회지
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• 제15권5호
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• pp.319-323
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• 2007

Wild grapes have been used as traditional medicinal use and alcoholic beverage production in Korea. The objective of this study is to improve antioxidant properties in Sae-muru by far infrared ray (FIR) treatment, with expecting potential benefits of FIR treatment for wild grape products during manufacturing processes. FIR treatment in berries induced increased content of catechin, epicatechin gallate, epigallocatechin gallate, gallic acid, rutin, ellagic acid, and resveratrol, while content of epicatechin and epigallocatechin was decreased. Although FIR treatment resulted either increased or decreased chemical component groups, presenting in HPLC chromatograms, antioxidant activity in Sae-muru extract was significantly increased by the FIR treatment. Our results suggest that FIR treatment should be an efficient process in the production of high content of bioactive molecules in Sae-muru.

• 한국약용작물학회지
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• 제19권4호
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• pp.233-237
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• 2011

This study was carried out to investigate the seedling establishment and yield of direct-sown Platycodon grandiflorus seeds cultured by three ridge width, 0.4, 0.8, and 1.2 m and four mulching materials, rice straw, rice bran, black plastic film, and no mulching in upland. Seedling establishment rate (70%) was the highest in rice straw mulched plot of 500 seeds/$m^2$ sowed and root yield after one year was also the highest in rice straw mulched treatment and followed by rice bran, no mulching, and black plastic film treatment. In this result, ridge width 120cm and rice straw mulching combined treatment was best for getting the highest seedling establishment ratio and seedling numbers per area. However, ridge width and mulching materials should be considered soil moisture content and weed population for saving labor cost.