• 대한한방내과학회지
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• 제38권5호
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• pp.548-554
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• 2017

Objective: A general prejudice exists that all herbal medicines are not good for liver. We report that herbal medicine can have positive effects on the liver, based on the improved liver function test levels observed in one patient. We also suggest the effectiveness of co-administration of herbal and western medicines. Methods: We checked the liver function test levels of one patient measured on 12 July at another hospital. We identified worse levels on 7 August, when he was first admitted to Semyung University Hospital. We measured liver function test levels of the same patient after treatment with Korean herbal medicine on 14 and 21 August during hospitalization at Semyung Hospital. We compared the figures and evaluated the effectiveness of 'Saenggangeonbi-tang' herbal medicine in the liver. Results: The patient's liver function test levels were normal on 12 July, but had become abnormal by 7 August, when he was admitted to Semyung Hospital. The cause of liver dysfunction was suggested as Atorvastatin, one of the western drugs he had started to take. Continuous treatment with Korean herbal medicine resulted in a definite improvement in liver function. Conclusion: Korean herbal medicine can provide positive improvements in liver function test levels.

• 동의생리병리학회지
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• 제17권5호
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• pp.1343-1346
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• 2003

Monitoring the skin temperature changes of the palm during video endoscopic thoracic sympathicotomy has been used as a measure of the success of the surgery for palmar hyperhidrosis. So we measured palmar skin temperature on both sides after administration of herbal medicine to learn whether we can use it as a indicator of herbal medicine effect, and to see it's mechanism. Seven patients (15 to 19 years old) with palmar hyperhidrosis underwent administration of herbal medicine. The palmar skin temperature was measured by comparing the changes of skin temperature before and after administration of herbal medicine for palmar hyperhidrosis. After the administration, temperature of the left palm was elevated(before. 26.16±2.13℃ vs. after. 30.62±1.84℃, p<0.05), and temperature of the right palm was also elevated(before. 26.14±2.28℃ vs. after. 30.91 ±1.67℃, p<0.05). These results suggest that the administration of herbal medicine is not only the symptoms of hyperhidrosis abolished but also the skin temperature of palm is elevated.

• 대한한방부인과학회지
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• 제23권3호
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• pp.101-111
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• 2010

Purpose: To provide the information of efficacy for herbal formulas of high frequency, it was evaluated the anti-inflammatory effect. In many studies, plantderived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of herbal formulas of high frequency on LPS-stimulated RAW 264.7 cells. Methods: Anti-inflammatory activity was investigated in 25 herbal formula extracts in vitro and in vivo. To investigate the anti-inflammatory effect in vitro model, using LPS-stimulated macrophages, RAW 264.7 cell line. The productions of nitric oxide(NO), prostaglandin(PG)$E_2$, interleukin(IL)-6 and tumor necrosis factor(TNF)-$\alpha$ were examined in RAW 264.7 cells, in the presence of the herbal formulas. RAW 264.7 cells were incubated with LPS $1\;{\mu}g/mL$ and herbal formulas for 18 hours. As an in vivo, using a rat model of carrageenin-induced paw edema. The paw volume was measured at 2 and 4 hours following carrageenin-induced paw edema in rats. Results: 8 kinds of herbal formula inhibited NO production by LPS-stimulated in some concentration, but the effect of NO inhibition is weak. 12 kinds of herbal formula inhibited $PGE_2$ production by LPS-stimulated over the 30%. Among them Gumiganghwal-tang, Sagunja-tang, Samchulkunbi-tang, Insampaedok-san and Hwangryunhaedok-tang inhibited IL-6 production by LPS-stimulated but TNF-$\alpha$ was not inhibited. 12 kinds of herbal formula reduced the carrageenin-induced paw edema in rats. Particularly, 3 kinds of herbal formula(Gumiganghwal-tang, Ssanghwa-tang and Soshiho-tang) were better than indomethacin. Conclusion: These results suggest that Gumiganghwal-tang, Sangunja-tang, Samchulkunbi-tang, Insampaedok-san and Hwangryunhaedok-tang have antiinflammatory activity.

• 한방안이비인후피부과학회지
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• 제28권1호
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• pp.68-84
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• 2015

Object : The object of this study was effected of composed of 4 herbal medicines(Rubus coreanus, Rehmanniae Radix, Houttuynia cordata, Betulae cortex) on acute atopic dermatitis mice. Methods : BALB/c mice were divided 4 groups ; normal group, negative control group of acute atopic dermatitis mice induced by DNCB, treated apply to the back skin with the herbal medicine group, and treated orally with herbal medicine group. Treated with herbal medicine and DNCB during 2 weeks. After treated, measured WBCs, RBCs, and platelet in the blood, and analysed mRNA expression of spleen. Result : Composed herbal medicines could reduce WBCs, lymphocytes, monocytes, neutrophils, and eosinophils in the mouse blood. And, could down TNF-${\alpha}$ levels in spleen. In the skin tissue histology results, herbal medicines reduce the cells and T cells. Conclusion : Composed herbal medicines help to another inflammatory disease because they reduce the cells and T cells in the skin tissues. And they have inhibitory effects of TNF-${\alpha}$ mRNA expression, and Th 2 immune responses. Therefore herbal medicines use for an acute atopic dermatitis treatment.

• 대한한의학방제학회지
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• 제19권2호
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• pp.83-92
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• 2011

Objectives : This study was carried out to moniter microbial flora on freeze-dried herbal powder and identify isolated bacteria. Methods : We measured the total number of bacteria and fungi in 29 herbal powder which had made according to the guideline of KFDA. For the identification, we observed microscopic properties and carried out polymerase chain reaction(PCR). The purified DNA was analyzed by DNA sequencer. Results : Among the 29 herbal powders, the fungi were detected only one sample as unacceptable range of total aerobic bacteria. Isolated bacteria were identified as Bacillus cereus, B. subtilis, B. megaterium, B. licheniformis, Erwinia tasmaniensis, E. amylovora, and Pantoea agglomerans by 16S rDNA analysis. E. tasmaniensis was observed 20 herbal samples. Conclusions : According to above results, further studies for the effective sterilization of low herbal materials should be needed.

• 대한한의학방제학회지
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• 제23권1호
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• pp.1-14
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• 2015

Objectives : In Pharmaceutical Affairs Act, herbal medicinal preparations are defined as medicines made by Korean medicine principles. But in Act, Korean medicine principles are vague. Thus, there is a request to explain what the Korean medicine principles are. The aim of this study is to suggest implications of Korean medicine principles in definition of herbal medicinal preparations. Methods : With regard for definition of Korean medicine principles, we referred to the domestic and foreign regulations and literature about the history of herbal medicinal preparations. As a result, the meaning of Korean medicine principles was historically examined from various angles. Results : Through this study, we studied the Korean medicine principles from the past medical history. Due to the broad definition of Korean medicinal principles, we tried to extract general ideas of medicine principles first. We also found that we had scientific formulations based on korean medicine principles which could be used in modern society. In the end, we found that numerous medicine principles which include ‘Four qi and five flavors theory’, ‘Processing of medicinals’, ‘Yin and yang theory’, ‘Five phases theory’, ‘Meridian entry of viscera and bowels theory’, ‘Herb Couplet Interaction theory’, ‘Sovereign, minister, assistant and courier theory’, etc. Conclusions : Innumerable principles used from the past existed. These principles were broad and could be used as modern scientific principles. Based on these facts, we illustrated details of Korean medicine principles, hope this principles be widely shared and Korean herbal medicinal preparations be further developed.

• 한방재활의학과학회지
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• 제20권1호
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• pp.91-107
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• 2010

Objectives : The purpose of this study was to investigate which herbs and herbal formulae are frequently used for the treatment of osteoporosis since 2000. Methods : We searched the CENTRAL, MEDLINE, AMED, CINAHL, Scopus, KISS, Korea MED, KERIS, Kmbase, Dbpia, J-STAGE, CNKI, J Oriental Rehab Med., J Korean Oriental Med., J Oriental Gynecol. using search key words osteoporosis, osteopenia, bone density and bone loss combined with herbal, botanical plant and phytomedicine. Results : 73 studies were reconfirmed and 83 herbs have been found. For single herb, most of them were categorized into Boyik-yak(補益藥, Buyi-yao). For herbal formulae, various herbal formulae are used. Calculating each herb in consisted in each herbal formula, Angelica Gigas Radix(當歸) and Rehmanniae Radix Preparat(熟地黃) turned out to be the most frequently used herb. Conclusions : Further studies regarding herbal medicines on osteoporosis are needed.

• 패션비즈니스
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• 제19권5호
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• pp.128-138
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• 2015

The purpose of this study is to explore the characteristics and recent trends of Korean herbal medicine cosmetics brand logos and to shed light on the identities of herbal medicine cosmetics in Korea. Ultimately this study aims to seek ways to develop strategic global brands distinguished from other brands, and providing the basic data for such development. In order to investigate the characteristics of brand logos, the researcher of this study chose 11 Korean Herbal Medicine Cosmetics Brands marketed today and collected information related to the brands from their websites. The visual characteristics of the logos currently used by Korean herbal medicine cosmetics can be summarized as follows. Most brand logos include marks consisting of Chinese letters written in calligraphy styles to represent the brand information of'Korean herbal medicine.' As for colors, most brands use mostly black and gold to present luxurious images, or convey strong impressions through stark contrast between black, red and white, hoping to distinguish themselves from other cosmetic products. An analysis of the linguistic characteristics of herbal medicine cosmetics in South Korea revealed that most brands use associative and freestanding brand names which suggest that the user's appearance will improve by using the products they represent. Using such names that convey oriental purity and mysterious meanings, trying to capture the deepest beauty with the best quality, the brands construct brand images that are luxurious and high-class. Most of the brands currently used by Korean herbal medicine cosmetics employ components that emphasize the functional aspect of Korean herbal medicine cosmetics. To secure the status of world-class brands, however, it is imperative to conduct research on brand logos capable of establishing identities distinguished from others.

• KSBB Journal
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• 제32권1호
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• pp.46-53
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• 2017

There are four types (So-Eum, So-Yang, Tae-Eum, Tae-Yang type) in Sasang constitutional medicine (SCM). In SCM, not only people but also herbal medicine are classified into four types. To date, there has been very little evidence of experimental classifications in SCM. So, we adapted Issatchenkia orientalis in two different culture media made from the herbal medicines for So-Eum and for So-Yang type. And the adapted Issatchenkia orientalis was inoculated into another eight culture media made from the herbal medicines for So-Eum and for So-Yang type. The mass reduction was measured every 12 hours for 2 days. Then, we analyzed the statistical differences of herbal medicines for So-Eum and for So-Yang type. There were significant differences of variables (R: rate of change in mass reduction, S: convex degree of mass reduction graph) in herbal medicine media for So-Eum (p=0.001, 0.001, respectively.). Suggesting a microbiological method of Sasang medicine research, current study may contribute to the establishment of experimental Sasang constitutional herbal medicine.

• 대한한의학회지
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• 제31권3호
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• pp.128-132
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• 2010

Objectives: This study aimed to review the general features of drug induced liver injury (DILI) and the important factors in consideration of herbal drugs and DILI. Methods: We reviewed general aspects of DILI such as classification, inducible factors, diagnosis methods, prevention, and the status of herbal drug-associated DILI via literature. Results: Besides the drug itself, genetic and environmental factors affect hepatic toxicity. There is a lack of definitive diagnoses of DILI by drugs, including herbal remedies. The possibility of herbal drug-associated DILI is exaggerated, and majority of herbal drug-derived hepatic injury could be easily prevented if Oriental doctors pay attention to this issue. Conclusion: This study can provide Oriental doctors an overview and be helpful in minimizing the episodes of hepatotoxicity in use of herbal drugs.