• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.1
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• pp.157-166
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• 2004

In order to understand the anti-carcinogenic effects of Boo-jung-bae-bon-bang(扶正培本方)-B1), Hwal-hyul-hwa-eo-bang(活血化瘀方-B2), Cheong-youl-hae-dok-bang(淸熱解毒方-B3), prescriptions of individual B1, B2, and B3 treatments or combined treatments (B4; B1+B2, B5; B1+B3, B6; B1+B2+83, B7; B2+83) were applied to cultured cancer cell lines. The major findings on their anti-cardnogenic effects in terms of mechanism and synergistic interactions are summarized below. Results of cytokine gene expression analyses are summarized as follows; IL-2 gene expression was increased by B1 and B6 treatments, IFN-v gene expression increased by B3, B1, B6, and 85, and CD28 gene expression increased by B1 and B5. IL-4 expression was not affected by any treatments. In the FACS analysis, increases in numbers of immunoreactive CD3/sup +//CD25/sup +/ T cells by B1 and B5 treatment, CD3/sup +//CD69/sup +/ T cells by B1, B3, B5, and B6 treatments, CD19/sup +//CD44/sup +/ B cells by B1 and B6 treatments were observed when compared to the corresponding non-treated control groups.

• IMMUNE NETWORK
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• v.4 no.3
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• pp.155-160
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• 2004

Background: B-1 cells differ from conventional B-2 cells both phenotypically and functionally. The aim of this study was to investigate the difference between peritoneal B-1 cells and splenic B-2 cells in proliferation. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. During the culture of these cells, immunoglobulin secreted into the culture supernatants was evaluated by enzymelinked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Results: Spontaneous Immunoglobulin M production occurred in peritoneal B-1 cells but not in splenic B-2 cells. LPS stimulated peritoneal B-1 cells secreted IgM at day 1, but splenic B-2 cells at day 2. In thymidine incorporation, peritoneal B-1 cells entered actively S phase after 24hours LPS-stimulation but splenic B-2 cells entered actively S phase after 48 hours. Conclusion: IgM secretion and S phase entering occurred early in peritoneal B-1 cells compared to splenic B-2 cells.

• IMMUNE NETWORK
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• v.6 no.1
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• pp.1-5
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• 2006

Background: B cell subset has been divided into B-1 cells and B-2 cells. B-1 cells are found most prominently in the peritoneal cavity, as well as constituting a small pro portion of splenic B cells and they are larger and less dense than B-2 cells in morphology. This study was designed to compare the differences in their proliferation and differentiation between B-1 and B-2 cell. Methods: We obtained sorted B-1 cells from peritoneal fluid and B-2 cells from spleens of mice. Secreted IgM was measured by enzyme-linked immunosorbent assay. Entering of S phase in response to LPS-stimuli was measured by proliferative assay. Cell cycle analysis by propidium iodide was performed. p21 expression was assessed by real time PCR. Results: Cell proliferation and cell cycle progression in B-1 and B-2 cells, which did not occur in the absence of LPS, required LPS stimulation. After LPS stimulation, B-1 and B-2 cells were shifted to Sand G2/M phases. p21 expression by resting B-1 cells was higher than that of resting B-2 cells. Conclusion: B-1 cells differ from conventional B-2 cells in proliferation, differentiation and cell cycle.

• Journal of Physiology & Pathology in Korean Medicine
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• v.16 no.4
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• pp.680-683
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• 2002

Bovine aortic endothelial cells(BAEC) produce two variant forms of laminin with a subunit composition of AB1B2 and A'B1B2. Analyses of the intracellular assembly of these subunits revealed that the B1B2 dimer formed first, and that A or A' joined to form the AB1B2 or A'B1B2 trimer. Angiostatic steroids shifted the relative size of the A and A' monomer pool in BAEC, and competition between the A and A' subunits in joining the B1B2 dimer produced AB1B2 and A'B1B2 in different ratios. This result suggests that subunit replacement is the general mechanism for producing laminin variants by various cells for tissue morphogenesis. When laminin subunits in BAEC were cross-linked with dithio-bis-succinimidylpropionate(DSP) and immunoprecipitated with anti-Iaminin antiserum, monomeric A,A',B1 and B2 monomers and the B1B2 dimer migrated as extremely large molecules in sodium dodecyl sulfate gel electrophoresis under nonreducing conditions. When the crosslinking disulfide bonds were cleaved under reducing conditions, they migrated as the usual subunits. This result suggests that molecular chaperones were involved in the process of the assembly and replacement of laminin subunits.

• Journal of the Korean Society of Food Science and Nutrition
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• v.30 no.5
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• pp.765-769
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• 2001

Starches of flavored glutinous rice were analyzed by using scanning electron microscope (SEM) and differential scanning calorimetry (DSC) and tested on the starch granule susceptibility to 15% H$_2$SO$_4$, glucoamylase and $\alpha$-amylase. The shape of starch granules form flavored glutinous rice varieties was polygonal and the size was 4~6 $\mu$m in diameter. According to DSC, glutinous rice starch showed onset temperature (T$_{o}$) range 59.8~62.5$^{\circ}C$ and KR92021-B-B-42-3-B and KR92021-B-B-165-1-B showed higher enthalpy ($\Delta$H) on gelatinization than others. The starches from KR92021-B-B-5-2-B and KR92021-B-B-42-3-B showed lower hydrolysis rate using 15% H$_2$SO$_4$ than KR92021-B-B-165-1-B. KR92021-B-B-5-2-B showed higher degree of hydrolysis of glucoamylase and $\alpha$-amylase than the others.

• Journal of the Korean Ceramic Society
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• v.36 no.1
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• pp.7-14
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• 1999

TiZrB2 solid solution was synthesized using fine powders of Ti, Zr and B by SHS microwave process. The characterization of the synthesized powder and sintered bodies ws investigated. The combustion temperature and rate were increased with increasing the mole ratio of Zr in temperature profile, and showed the maximum combustion temperature and velocity values of 285$0^{\circ}C$ and 14.6mm/sec in Ti0.2Zr0.8B2 composition. Phase separation has been occured into a composite with TiB2 and ZrB2 phases from TiZrB2 solid solution, which was hot pressed sintering at 30 MPa for an hour at 190$0^{\circ}C$. At the composition of Ti0.8Zr0.2B2 the best properties has been obtained in relative density, bending strength, fracture toughness and hardness, with 99%, 680 MPa, 7.3MPa.m1/2 and 2750 Kg/$\textrm{mm}^2$ respectively.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.10a
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• pp.206-208
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• 2000

This paper focuses on what the philosophy and methodology of the Theory of Constraints contribute to B2B e-commerce. Typical characteristics of TOC methods applicable to B2B are explored in comparison with traditional MRP, JIT, TQM and cost accounting. Addressed are expected changes in various backend business areas supporting e-commerce. TOC provides B2B management with the capability of logistics transparency, speedy decision making, and better cashflow.

• 한국벤처창업학회:학술대회논문집
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• 2023.11a
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• pp.117-121
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• 2023

본 연구는 B2B (business-to-business) 비즈니스 모델 혁신(business model innovation, BMI)이 B2C (business-to-consumer) 비즈니스 모델 혁신 대비 혁신성과에 미치는 상대적 효과를 실증적으로 검증하고자 한다. BMI의 하위요인을 가치창출(value creation), 가치제안(value proposition), 가치획득(value capture)으로 나누어 각각의 요인 간의 관계를 구체적으로 분석한다. 본 연구는 실증분석을 위해 2022년 기업가정신 실태조사(기업편) DB의 3,120개 기업을 활용하였다. 분석 결과, BMI 중 가치창출은 B2B (vs. B2C) 혁신성과에 미치는 영향이 더 크며 유의한 것으로 나타났다. 반면 가치제안은 B2C (vs. B2B) 혁신성과에 미치는 영향이 더 크며 유의한 것으로 나타났다. 본 연구의 결과를 통해 주 비지니스 대상에 따라 BMI가 혁신성과에 상이한 영향을 미친다는 것을 실증했다는 점에서 학술적 의의가 있으며, 기업 특성에 따른 차별화된 BMI를 추구하는 것이 중요하다는 실무적 시사점을 가진다.

• Information Systems Review
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• v.8 no.1
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• pp.63-80
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• 2006

This paper suggests a normative performance measurement model for B2B e-marketplace. The model is for the neutral and systematic sourcing B2B e-marketplace. It is based on BSC that is very powerful and sound tool among all the available performance measurement systems. In addition, we used AHP to make the model more structured and to draw weights of performance measures from experts. We derived main features and factors affecting performance of e-business companies and especially of B2B e-marketplaces based on literature. In order to make the model usefulness, we co-worked with some experts who are engaged in real Korean B2B e-marketplaces. They included venture capitalists, top managers of B2B e-marketplaces, and consultants. By their assistances, we could find important evaluating factors and define the hierarchical structure. After defining the hierarchical structure, the expert group decided weights of performance indicators through the designed questionnaires. The weight for each measure was calculated using geometric mean of the questionnaire response. We made the case studies of two real Korean B2B e-marketplaces to apply the suggested model with some adjustments. The results of the case studies were so satisfactory that the suggested performance measurement model for B2B e-marketplace is useful and applicable to the real world.

• Journal of the Korean Magnetics Society
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• v.5 no.5
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• pp.412-415
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• 1995

By adding 1wt.% $HfB_{2}$ into $Nd_{3-4}Fe_{77-78.5}B_{18.5}$ alloys, the grain growth of $Fe_{3}B/Nd_{2}Fe_{14}B$ composite phases during annealing was found to be hindered by 40~50%. It is proposed that the addition of $HfB_{2}$ leads to the formation of fine dispersoids of $HfB_{2}$ in the $Fe_{3}B/Nd_{2}Fe_{14}B$ composite magnet. The maximum energy product($(B.H)_{max}$) as well as intrinsic coercivity($_{i}H_{c}$) for the $Nd_{3}Fe_{78.5}B_{18.5}\;+\;1wt.%\;HfB_{2}$ alloy were enhanced by more than 25% $(B.H)_{max}=10\;MGOe,\;_{i}H_{c}=2.5\;kOe)$ due to the addition of $HfB_{2}$ while remanent magntization($B_{r}$) was reduced slightly. Itis deduced that the formation of fine dispersoids will also play a role of magnetic domain pinning.