• Quality Improvement in Health Care
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• v.9 no.2
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• pp.176-197
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• 2002

Backgound : This study is to suggest the standardized format of the clinical sheets and the standardized items of every clinical sheet. The standardization of the medical records will increase the faithfullnes of the contents in them and it will contribute to construct the good health information system. Method : From Jan. 1st. 2001 to March 31st 2001, we gathered as many paper clinical sheets as possible by every class of institutions to review the faithfulness of the clinical contents in them. Clinical sheets of 9 tertiary care hospitals, 6 general hospitals and 56 clinics were gathered. Two experienced medical record administrators reviewed them. The review focus was to check whether the items recommend by the hospital standardization review criteria and hospital service evaluation organization were appeared in the clinical sheets and whether the contents of every item were written. Results : Tertiary care hospitals; In case of administrative data, the contents were filled well if the items were fixed. The clinical data like C.C, history,physical examiniation were filled well, but if the items were not fixed, some items were omitted. The result is that more items are to be filled if they are fixed. General hospitals Administrative data were filled more than 50%. Final diagnosis was filled about 66.7%.But other clinical data were not filled well and not many clinical related items were appeared in the sheets.In the legal point of view, the reason for visiting hosptals or the right diagnosis, patient condition at discharge could not be confirmed well.In surgery cases, surgical procedures could not be confirmed well as many surgical related information(surgery time, fluids and blood, number of sponges, biopsy, etc) were omitted. Clinics More than 70% administrative data were filled and fixed as items. Among the clinical related data, laboratory result was the most credible data. But without the right diagnosis, drug orders were given and doctors' written signatures were not appeared over 96.4%. So the clinical sheets cannot be used as a legal document. Conculusion : There was a tendency that the contents were filled well if the items were fixed in the documents, We also suggest a clinical check list to review the completeness and faithfulness of the clinical sheets. If many hospitals use the suggested clincal check list and if they make the necessary items fixed in the clinical sheets, the quality of the medical record will increase dramatically.

• Microbiology and Biotechnology Letters
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• v.38 no.4
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• pp.467-474
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• 2010

Cheonggukjang is one of the traditional fermented soy-based foods in Korean diets. Studies in cell cultures, humans have revealed anti-hypertension, anti-stress, anticancer, antioxidant, immune enhancing effects. Angelica gigas, Rehmanniae radix, and Red ginseng are popular medicinal plants and widely used for oriental medicine. In this study a strategy had been developed to mobilize beneficial phenolics from Angelica gigas, Rehmanniae radix, and Red ginseng combined with fermented soy by Cheonggukjang fermentation for antioxidant and Type II diabetes management. The quality and functional characteristics of Chenggukjang fermented with Angelica gigas, Rehmanniae radix and Red ginseng. Cheonggukjang (CKJ), Angelica gigas Cheonggukjang (CKJ-DD), Rehmanniae radix Cheonggukjang (CKJ-RG), Angelica gigas and Rehmanniae radix Cheonggukjang (CKJ-DD+RG) and Red ginseng Cheonggukjang (CKJ-RED) were evaluated. The mobilized phenolic profile was evaluated for antioxidant activity and the potential to inhibit ${\alpha}$-amylase linked to hyperglycaemia. This research has important implications for the development of functional soy-based-fermented foods enriched with Angelica gigas, Rehmanniae radix and Red ginseng phenolics for oxidative stress - induced diabetic complications. Furthermore, Hunter's color values of 5 types cheonggukjang, lightness (L-values), redness (a-values) and yellowness (b-values) were evaluated. Free amino acid content of CKJ-RED (0.993 mg/gd. w.) showed higher than that of CKJ (0.205 mg/g-d.w.).

• Journal of Microbiology and Biotechnology
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• v.22 no.3
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• pp.378-384
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• 2012

In aquatic invertebrates, particularly marine gastropods, organotin compounds induce irreversible sexual abnormality in females, which is termed imposex, at very low concentrations. Organotin compounds are agonists for nuclear receptors such as RXRs and $PPAR{\gamma}$. However, the imposex phenomenon has not been reported to act as an antagonist on estrogen receptors in other species, including vertebrates and invertebrates. In order to gain insights into the antagonistic activity of organotin compounds on estrogen receptors (ERs), we examined the inhibitive effect of these compounds on estradiol-dependent ${\beta}$-galactosidase activity using the yeast two-hybrid detection system consisting of a combination of the human estrogen receptor ($hER{\beta}$) ligand-binding domain and the co-activator steroid receptor co-activator-1 (SRC1). Tributyltin-hydroxide (TBT-OH) and triphenyltin-chlorine (TPT-Cl) exhibited an inhibitive effect on $E_2$-dependent transcriptional activity, similar to antagonistic chemicals such as 4-hydroxytamoxifen (OHT) or ICI 182,780, at a very low concentration of $10^{-14}$ M TBT or $10^{-10}$ M TPT, respectively. The yeast growth and transcriptional activity with transcriptional factor GAL4 did not exhibit any effect at the tested concentration of TBT or TPT. Moreover, the yeast two-hybrid system using the interaction between p53 and the T antigen of SV40 large did not describe any effect at the tested concentration of OHT or ICI 182,780. However, the interaction between p53 and T antigen was inhibited at a TBT or TPT concentration of $10^{-9}$ M, respectively. These results indicate that TBT and TPT act as inhibitors of ER-dependent reporter gene transcriptional activation and of the interaction between $hER{\beta}$ LBD and the co-activator SRC1 in the yeast two-hybrid system. Consequently, our data could partly explain the occurrence of organotin compound-induced imposex on the endocrine system of mammals, including humans.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.10
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• pp.1235-1240
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• 2007

For this study, plant material for development of phytobiotics (feed additives made with plant extract) was screened. Among hot-water extracts of 9 medicinal plants, Fallopia japonin showed the highest antioxidative activity; the electron donating ability (EDA) and nitrite scavenging ability were 86.9% and 92.7%, respectively. Also, F. japonica had the antimicrobial activity for Pseudomonas aeruginora, Escherichia coli, Bacillus cereus, Salmonella Typhimurium, Listeria monocytogenes, Klebsiella pneumoniae, Staphyzococcus aureus. Specially, antimicrobial activity of F. japonica against K. pneumoniae, and S. aureus was vet strong. $IC_{50}$ of F. japonica against K. pneumoniae, and S. aureus was 6.24 mg/mL and 1.8 mg/mL respectively. These results suggested that F. japonica was a candidate for a phytobiotic material.

• YAKHAK HOEJI
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• v.46 no.2
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• pp.129-136
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• 2002

The pathogenesis of cholestatic liver injury as well as the modulation of hepatic fibrogenesis is causally associated with involvement of reactive oxygen species (ROS) and free radical reactions. In this study, we investigated whether dried extracts of oriental medicine (LH) have antioxidant and antifibrotic effect under the biliary liver fibrosis (cirrhosis) c ondition. The female Sprague-Dawley rats were divided in six groups (Normal, N-LH, op-2, op-4, opLH-2, opLH-4) and were observed in 2 weeks or 4 weeks. For this purpose the rats were operated by bile duct ligation/scission (BDL/S), which induced to liver fibrosis and cirrhosis. After surgery, the prepared LH was administered p.o. 2 mι/day/rat in 2 weeks or 4 weeks for opLH groups. During the observation period, jaundices appeared in eyes, ears and tail of all BDL/S operated rats. And at the time of sacrifice, cholestasis was observed in proximal bile duct, especially the color of bile juice and urine in opLH-4 group showed more clear than op-2, op-4 and opLH-2 group. The value of clinical parameters and product of lipid peroxidation (MDA) in sera and the hydroxyproline (hyp) content in liver tissue were significantly increased in all liver fibrosis (cirrhosis) developed rats (p＜0.001~0.05). Among the clinical parameters of sera, value of BUN, ALP in opLH-4 group showed significantly lower than in op-4 group (p＜0.05, p＜0.001). The content of hyp in opLH-2, opLH-4 group (478.0 $\pm$ 134.3 $\mu\textrm{g}$/g 897.5 $\pm$ 118.2 $\mu\textrm{g}$/g) showed lower than in op-2, op-4 group (528.9 $\pm$ 220.7 $\mu\textrm{g}$/g, 1023.8 $\pm$ 277.1 $\mu\textrm{g}$/g) and then the value of MDA in opLH-4 was also significantly reduced to 59.4% of that in op-4 group (p＜0.001). The histological change (bile duct proliferation, fibrosis, collagen bundle) was similarly observed in op-2 group and in opLH-2 group, but the weak fibrosis and bile duct proliferation were observed in opLH-4 group compared with in op-4 group. Our data indicate that the 4 weeks treatment with LH extract suppressed lipid peroxidation and inhibited fibrotic (cirrhosis) process, and experimental cholestatic liver disease is associated with increased lipid peroxidation in BDL/S operated rats. Hence we concluded that the measurement of MDA and hyp can be useful monitor for the screening of antioxidant and antifibrotic effect in experimental liver fibrosis (cirrhosis), and LH has been shown to have hepatoprotective effect, antifibrotic effect and antioxidant effect.

• Journal of Digital Convergence
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• v.14 no.12
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• pp.65-72
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• 2016

Personal Health Record(PHR) service can be helpful to patients with diseases requiring strict everyday care and medical treatment, such as diabetes or cancer. In this paper, we propose a PHR system specialized in collecting and analyzing health record data of cancer patients, and present the process of how the system can improve the efficiency of cancer treatment process. Through the smart device application, cancer PHR system obtains daily PHR data which is highly related and critical to cancer therapy. The analysis report is provided to the medical staff with an available format suited for Electronic Medical Record used at medical institution. With the final result of PHR analysis which is easily merged with medical chart, most efficient Chemotherapy treatment can be provided for the patients. Also it is possible for the patients to give the information of side-effect and other pain experience during therapy to their doctors without loss of information. The proposed PHR system has the effect of improving the quality of patient care by allowing the medical staff to acquire the main objective data necessary for drug prescription and medical care benefits.

• Journal of Digital Convergence
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• v.18 no.9
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• pp.265-275
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• 2020

The burden of injury is widely considered to be very severe in our society. Nonetheless, we don't have enough data for injury surveillance. The objective of this research is to select and supplement CORE DATA for injury surveillance. For this purpose, this study had analyzed the literature such as the Quality Assessment Report about 'Causes of Death Statistics', 'Health Insurance Statistics' and 'Hospital Discharge Injury Surveillance' according to the six dimension of Statistics Quality. The analysis result is that 'Cause of Death Statistics' and 'Health Insurance Statistics' have the usefulness as the CORE DATA for injury surveillance. But there is a significant shortcoming in the Health Insurance Statistics, which is that there is a lack of the data about the external causes of injury. For supplementing the defect, this study proposes the system that the medical institutions should obligatorily report the external causes of injury when claim National Health Insurance Medical Care Expenses. As the results of this system, we can expect 'Establishing of Injury pyramid', 'Data Connecting with the National Pension' and 'Improving the Promptness of Injury Data'. And we expect the follow-up study for the realization of this system.

• Korean Journal of Child Studies
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• v.1
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• pp.40-64
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• 1980

The purpose of this study was to compare the different environment among the young children of large and small cities and rural areas in Korea, in order to know how these different environment have an effect on the children's intellectual and emotional development. For this subjects, 2,700 questionares with 51 items were distributed to the infants' mothers in each area to interview and answer. About 1,800 questionaires were gathered from 3 metropolitan, 6 cities and 6 rural areas in (each 2 farming, fishing and mining villages) The results of analyzing these questionaires were like following; 1. The average number of children of each family was 2.5 in large cities, 3.0 in small cities and 3.6 in the rural areas. 2. White about 75% of infants' parents of large cities graduated college education, only 6% of the rural parents did it. Most infants' parents of the rural areas have only graduated the elementary school. 3. About 90% of the rural, small and large cities family have had radios and T.V sets, and 90% of infants watched T.V program for 2 hours a day in average. 4. While about 50% of large cities' young children were not reared by their mother's milk but by milk and other foods, about 95% of rural infants by breasting mills. 5. Young children of large cities were wearing about 5 months earlier than those of the rural. 6. While 20% children of cities were taught in the kindergarten, most children of the rural areas could not be taught in the kindergarten. 7. About 45% young children of the rural areas and cities were understood and taught reading, writing letters and numbers by their parents, brothers and sisters before entering primary school. 8. While 50% young children of large cities have had pianos and were taught music in kindergarten or piano tutor's, most of the rural areas have not had pianos and could not be taught music. 9. Most children's favorite music songs were T.V signals or C.M songs in both the rural and cities. 10. While most children of cities have had lots of children's pictures or fairy tale books. most infants of the rural areas have had nothing or a few. 11. As lots of infants could not find their pleasure resorts of sport tools outside, they used to play in side streets or publicroads with their friends. 12. While most infant's parents in cities wanted to make their infants lawyer or medicine doctor, most parents in rural areas wanted to make their children teacher or technician. 13. About a half of Korean infants have had their own rooms or have lived in it together with their brother or sister. In conclusion, as children of large cities have had more various kinds of cultural circumstances than the rural areas in aspects of cultural institutions' tools and environment of their parents' education, books, toys, pleasure resorts and their own rooms, the intellectual development of the former could be considered to surpass those of the latter. In other words, the average IQ points of urban's young children are 10 point higher than those of the rural areas, which means the better circumstance would affect the infant's intellectual development. Therefore, the government must support to make good circumstances of the children in the rural areas.

• Journal of Korean Dental Science
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• v.7 no.2
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• pp.49-57
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• 2014

Purpose: To evaluate the effect of different surface treatment methods (yttria-tetragonal zirconia polycrystal [Y-TZP] primers, air-abrasion, and tribochemical surface treatment) on the shear bond strength between (Y-TZP) ceramics and etch-and-rinse non-10-methacryloyloxydecyl dihydrogen phosphate (MDP)-containing resin cements. Materials and Methods: Y-TZP ceramic surfaces were ground flat with 600-grit silicone carbide abrasives paper and then divided into seven groups of ten. They were treated as the following: untreated (control), Monobond Plus (IvoclarVivadent), Z-PRIME Plus (Bisco Inc.), ESPE Sil with CoJet (3M ESPE), air-abrasion, Monobond Plus with air-abrasion, and Z-PRIME Plus with air-abrasion. The surface of Y-TZP specimens was analyzed under a scanning electron microscope (SEM). Non-MDP-containing cements were placed on the surface-treated Y-TZP specimens. After thermocycling, shear bond strength test was performed. Bond strength values were statistically analyzed using one-way analysis of variance and Student-Newman-Keuls multiple comparison test (P<0.05). Result: The Z-PRIME Plus treatment in combination with air-abrasion produced the highest bond strength ($14.94{\pm}1.70MPa$) followed by Monobond Plus combined with air-abrasion ($10.70{\pm}1.71MPa$), air-abrasion ($10.47{\pm}1.60MPa$), ESPE Sil after CoJet treatment ($10.38{\pm}0.87MPa$), Z-PRIME Plus application ($10.00{\pm}1.70MPa$), and then Monobond Plus application ($9.25{\pm}0.86MPa$). The control ($6.70{\pm}1.49MPa$) indicated the lowest results (P<0.05). The SEM results showed different surface morphologies according to surface treatment methods compared with the Y-TZP control. Conclusion: The shear bond strength between the Y-TZP ceramic and the non-MDP-containing resin cement was the greatest when the surface was treated with air-abrasion and MDP-containing Z-PRIME Plus primer.

• The Journal of Korea Assosiation for Disability and Oral Health
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• v.5 no.1
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• pp.12-17
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• 2009

Background : To do dental treatments successfully for dentally disabled patients who are unable to cooperate to procedures needs deep sedation (DS) or general anesthesia (GA). But there are some difficulties in selecting DS because of some disadvantages such as airway problem etc. But, if we select appropriate cases, DS would be better than GA. Methods : We reviewed total 238 cases of patients who had received dental treatments under GA or DS at the clinic for the disabled in Seoul National University Dental Hospital from November 2007 to February 2009. To compare anesthesia condition between DS and GA, we reviewed preanesthesia evaluation sheet, anesthesia or sedation records and PACU sheets retrospectively. Results : The number of DS cases was 25 (11%) and that of GA was 218 (89%). To maintain DS, intravenous propofol was infused with syringe pump (100%), and sevoflurane (134 cases) or propofol (13 cases) were used for sedation induction. Mean total treatment time for DS was 36 min and 2 hour 25 min for GA. The recovery time at PACU was 44 min for DS and 80 min for GA. There were no severe complications in DS, but 18 cases showed nausea and vomiting in GA. Conclusion : Deep sedation for disabled dental patients should be selected for effective behavioral control in conjunction with general anesthesia, considering duration and pain-evoking potentials of dental treatment and type and severity of patients' disabilities altogether.