• Archives of Pharmacal Research
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• 제18권1호
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• pp.1-7
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• 1995

IY-80843, N[2-(2-methoxyphenyl)ethyl]-N'-[4-(lmidazole-4-yl)phenyl] formamidine, is a new potent $H_2-receptor$ anagonist. The potential secondary pharmacologic effects of this agent, on the central nervous and cardiovascular systems were studied. IY-80843 caused ptosis, suppression of locomotion, hypotehrmia, prolongation of sleeping time and hypotensive effects in mice, rats and dogs. These results suggest that IY-80843 affects the funcition of the central nervous and cardiovascular systems in a dose-dependent manner.

• Journal of electromagnetic engineering and science
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• 제13권4호
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• pp.251-258
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• 2013

A procedure for antenna parameter selections is proposed that considers the relationships between synthetic aperture radar performance and the antenna parameters of a parabola-type reflector antenna with a central flat dish. The effects of a central dish designed for weight reduction on the antenna beam pattern are also quantitatively analyzed using commercially available software based on the physical optics algorithm. The results of the theoretical analysis and simulation predict that a larger size of the central dish results in an increase in the sidelobe level, which is the reason for the increase in two important ambiguities, such as range ambiguity ratio (RAR) and azimuth ambiguity ratio (AAR). The dependence of RAR and AAR on Pulse repetition frequency is also analyzed and discussed.

• 농촌계획
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• 제18권4호
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• pp.45-60
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• 2012

The purpose of this study is to approach for the flow analysis of changing central-place functions and basic demands between the central city and the small town. Under the rural society progressed, this study examines how the small town changes in the relation to the central city. The subject of study is based on changes in demand for retail and hospitality. The small town is providing basic demands and urban services primary for the rural in the settlement system. Because of the rural depopulation and the aging of society, Retail and hospitality in the rural is reducing of the facility followed. But the majority of related researches are stocks approach. These studies are useful to find out the characteristic of small town, but is difficult to consider the influence of the central city. In this situation after this study using the function index is set up a concept model, it examines for the basis of changes in demand for the small town. The result of the analysis is that the changes of retail and hospitality are more severe in the more small town than in the central city. Whereas the small town with a population decline is consistent with the reduced number of branches, Population growth in the central city is reduced to the number of the Number of branches. The central-place function has been strengthened in the central city. While the younger generation, recreation, etc. related retail are disappearing rapidly, the mainstream of small town is grocery, home improvement, restaurants.

• Nuclear Engineering and Technology
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• 제49권8호
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• pp.1772-1777
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• 2017

Korean nuclear power plants (NPPs) periodically evaluate the radioactive gaseous and liquid effluents released from power reactors to protect the public from radiation exposure. This paper provides a comprehensive overview of the release of radioactive effluents from Korean NPPs and the effects on the annual radiation doses to the public. The amounts of radioactive effluents released to the environment and the resulting radiation doses to members of the public living around NPPs were analyzed for the years 2011-2015 using the Korea Hydro & Nuclear Power Co., Ltd's annual summary reports of the assessment of radiological impact on the environment. The results show that tritium was the primary contributor to the activity in both gaseous and liquid effluents. The averages of effective doses to the public were approximately on the order of $10^{-3}mSv$ or $10^{-2}mSv$. Therefore, even though Korean NPPs discharged some radioactive materials into the environment, all effluents were within the regulatory safety limits and the resulting doses were much less than the dose limits.

• 물과 미래
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• 제29권4호
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• pp.139-147
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• 1996

유역의 하천형태학적 특성은 그 유역의 수문 및 수리학적특성과 밀접한 관계를 가지고 있다. 본연구는 우리나라 중부지방의 중소하천에 대한 계획하폭을 산정하는 공식을 제시하는데 목적이 있다. 계획홍수량과 유역면적 및 하천연장의 자료로서 하폭을 얻는데 다음과 같은 결론을 얻었다. : (1) 계획홍수량(Q)과 하폭(B)의 관계로 나타낸 하폭식은 $B=1.532A^{0.644.}$; (2) 유역면적(A)과 하폭(B)과의 관계로 나타낸 하폭식은 $B=12.392A^{0.511}$; (3) 하천연장(L)과 하폭(B)과의 관계로 나타낸 하폭식은 $B=10.509l^{0.852}$.

• Archives of Pharmacal Research
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• 제20권1호
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• pp.80-84
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• 1997

Substituted cinnamoyl-tyramine derivatives were synthesized by DCC-coupling of substituted cinnamic acid with tyramine or tyramine methyl-1-ether to evaluate PAF-receptor binding antagonistic activities and inhibitory activities on PAF-induced platelet aggregation with interest on structure-activity relations. The results show that 3,4-dimethoxy-cinnamoyl tyramine-amide or its methyl ether have significant PAF-receptor binding antagonistic activity and platelet anti-aggregatory activities.

• Archives of Pharmacal Research
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• 제18권2호
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• pp.69-74
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• 1995

In order to improve physico-chemical properties and to enhance stability of drugs, amino acid salt has been widely adoptd in pharmaceutical synthesis. Acetylsalicylic acid lysinate is one of the widely used analgesics and it is a good example of t5his synthesis. In the case of bacetylsalicylic acid lysinate synthesis, racemization of natrually occurred lysine is esential because the racemic lysine salt of the drug shows better yield, crystallinity and dryness than that of the L-lysine salt. To esatablish a simple, practical and economical process for L-lysine racemization, L-lysine treatments with phosphoric acid and with acetic acid were compared and the optimum conditions for its process and derivatization were investigated by chiral separation methods using GC_MS spectroscopy.

• Natural Product Sciences
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• 제17권2호
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• pp.104-107
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• 2011

In order to facilitate the quality control of betaine from the fruits of Lycium chinense, we have developed a rapid and simple method for quantitative determination. Determination was achieved on a Discovery C18 column with an isocratic solvent system of 0.32% perfluoropentanoic acid aqueous-acetonitrile at a flow-rate of 0.5 mL/min and detected an ELSD. The method was reproducible with intra- and inter-day variations of less than 6% (R.S.D). The recoveries were in the range of 90.01~100.05%. The method turned out to be fast and simple, furthermore, to have a good selectivity and sensitivity for the quantity determination of betaine in the fruits of L.chinense.

• Nuclear Engineering and Technology
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• 제45권4호
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• pp.513-522
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• 2013

The ODSCC detected in the TSP position of Ulchin 3&4 SGs are typical ODSCC of Alloy 600MA tubes. The causative chemical environment is formed by concentration of impurities inside the occluded region formed by the tube surface, egg crate strips, and sludge deposit there. Most cracks are detected at or near the line contacts between the tube surface and the egg crate strips. The region of dense crack population, as defined as between $4^{th}$ and $9^{th}$ TSPs, and near the center of hot leg hemisphere plane, coincided well with the region of preferential sludge deposition as defined by thermal hydraulics calculation using SGAP computer code. The cracks developed homogeneously in a wide range of SGs, so that the number of cracks detected each outage increased very rapidly since the first detection in the $8^{th}$ refueling outage. The root cause assessment focused on investigation of the difference in microstructure and manufacturing residual stress in order to reveal the cause of different susceptibilities to ODSCC among identical six units. The manufacturing residual stress as measured by XRD on OD surface and by split tube method indicated that the high residual stress of Alloy 600MA tube played a critical role in developing ODSCC. The level of residual stress showed substantial variations among the six units depending on details of straightening and OD grinding processes. Youngwang 3&4 tubes are less susceptible to ODSCC than U3 and U4 tubes because semi-continuous coarse chromium carbides are formed along the grain boundary of Y3&4 tubes, while there are finer less continuous chromium carbides in U3 and U4. The different carbide morphology is caused by the difference in cooling rate after mill anneal. There is a possibility that high chromium content in the Y3&4 tubes, still within the allowable range of Alloy 600, has made some contribution to the improved resistance to ODSCC. It is anticipated that ODSCC in Y5&6 SGs will be retarded more considerably than U3 SGs since the manufacturing residual stress in Y5&6 tubes is substantially lower than in U3 tubes, while the microstructure is similar with each other.

• Korean Membrane Journal
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• 제2권1호
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• pp.26-35
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• 2000