• YAKHAK HOEJI
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• v.43 no.2
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• pp.251-262
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• 1999

In order to investigate pharmacological properties of New Wonbang Woohwangchungsimwon Pill (NSCH) and Wonbang Woohwangchungsimwon Pill (SCH), the effects of NSCH and SCH on cerebral ischemia and central nervous system were compared. Cerebral ischemia insult was performed using unilateral carotid artery occlusion in mongolian gerbils. The histological observations showed preventive effects of NSCH and SCH treatments with ischemia-induced brain damage. The ATP in brain tissue was decreased in vehicle-treated ischemic gerbils. This decrease was prevented by SCH treatment. In contrast to what was inhibited by NSCH and SCH treatments. While NSCH and SCH had no effects on the hexobarbital-induced sleeping time, they prevented the seizures induced by electric shock and strychnine. NSCH and SCH showed sedative effect in rotarod and spontaneous activity test. Furthermore, NSCH and SCH showed anti-stress effect. Our findings suggest that the pharmacological profiles of NSCH on cerebral ischemia and central nervous system are similar to those of SCH.

• Macromolecular Research
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• v.14 no.4
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• pp.443-448
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• 2006

A novel ${\beta}$-cyclodextrin derivative (CCD-C) was synthesized with chitosan and carboxymethyl-${\beta}$-cyclodextrin. Its structure was characterized by elemental analysis, infrared spectra analysis, and X-ray diffraction analysis. The adsorption properties for guanosine 5'-monophosphate, cytidine 5'-monophosphate and uridine 5'-monophosphate were studied. Experimental results demonstrated that CCD-C had higher adsorption capability for guanosine 5'-monophosphate, and that the adsorption capacity for guanosine 5'-monophosphate was 74.20mg/g. The adsorption capacity was greatly influenced by pH, time and temperature. The introduction of chitosan enhanced the adsorption ability and adsorption selectivity of ${\beta}$-cyclodextrin for guanosine 5'-monophosphate. This novel derivative of chitosan is expected to have wide applications in the separation, concentration and analysis of nucleotides in biological samples.

• YAKHAK HOEJI
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• v.45 no.4
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• pp.397-406
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• 2001

It has been demonstrated previously that R(-)-2,10,11-trihydroxy-N-n-propylnora porphine (TNPA), a dopamine D$_2$receptor agonist, produced the antidiuresis through changes of central friction in dog. This study was investigated about effects of renal denervation and raclopride, a dopamine D$_2$receptor antagonist, on the antidiuresis of TNPA in order to elicidate the mechanism involved in this central antidiuresis induced by TNPA. Antidiresis exhibited by TNPA given into the vein or into carotid artery was not influenced by renal denervation, whereas antidiuresis of TNPA administered into carotid artery was blocked almost perfectly by raclopride pretreated into carotid artery. From these observations it is concluded that central antidiuresis induced by TNPA is brought about through activation of dopamine D$_2$receptor localized in brain, not related to renal nerve activity.

• Macromolecular Research
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• v.16 no.7
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• pp.590-595
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• 2008

The pressure driven membrane process has been a breakthrough in the removal of pollutants from drinking water. These experiments examined the removal of chlorophenol compounds from water using low pressure membranes. The removal performance of the membranes was based primarily on size exclusion. Apart from size exclusion, the polarity and pKa of the compounds also influences the membrane performance. The molecular size and dipole moments of the respective molecules were calculated using a quantum chemical method. The rejection of pollutants also followed the same trend as salt rejection by the membranes.

• Archives of Pharmacal Research
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• v.2 no.1
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• pp.17-24
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• 1979

A first systematic approach on new and simple preparation method of spherical granules in the system using organic granulating solution was carried out. Mixer granulation required narrow range of moisture content but gentle action of tumbling in the mixer and capilary forces were adequate to compact the porous mass and also were highly effective to produce granules close to sphere. Where the granules by massing and screening provided the more open structure, its pore distribution lied between 71 and 16 .mu.m by above 50% and on the contrary, that of the mixer granulated granules showed only below 25%. Increase in retention time in the mixer decreased the intragranular porosity of granules produced, and in comparison with granular particles produced by conventional wet granulation, those from the mixer granulation had the advantages of flow properties, packing characteristics and definite spherocity. They also had extremely low friability resulting in few fines.

• Archives of Pharmacal Research
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• v.19 no.2
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• pp.91-94
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• 1996

In the course of a search for antitumor agents, we found that the extract of Curcuma longa was effective in inducing apoptosis or programmed cell death (PCD) in human myeloid leukemia cells (HL-60). Active compounds for PCD were isolated from the hexanic extraction of the rhizome of Curcuma longa. With the several chromatographies, and spectral data, they were identified as ar-turmerone and $\beta-atlantone$. The present results demonstrate that the exposure of human myeloid leukemia HL-60 cells to clinically achievable concentrations of arturmerone (TU) or .$\beta-atlantone$(AT) produced internucleosomal DNA fragmentation of approximately 200 base-pair multiples, and the morphological changes characteristic of cells undergoing apoptosis or PCD. This findings suggest that these agents may exert their antitumoral activity, in part, through induction of apoptosis(PCD).

• Entomological Research
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• v.48 no.5
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• pp.372-383
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• 2018

Leptocimbex formosanus group of Leptocimbex Semenov 1896, Cimbicidae is defined and the relationships and characteristics are provided. Two new species of this group are described from Hunan and Yunnan Provinces in China: Leptocimbex shinoharai Yan & Wei sp. nov. and L. naitoi Yan & Wei sp. nov. Redescriptions of the three known species of L. formosanus group (L. formosanus Enslin 1911, L. dendrobii Rohwer 1915 and L. nigropropodea Wei & Deng 2002) and a key to all known species of this group are provided.

• SUVANNABHUMI
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• v.5 no.2
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• pp.101-126
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• 2013

The place where models of Indonesian templed and sculpture remain in best condition is in central Java. Central Java was a center of culture from the 8th century to the 9th century. After the mid-10th century, a dynasty moved from central Java to eastern Java, because of frequent volcanic explosions and illness. Eastern Java became the center of politics and culture until the 16th century, when Islamic culture gained superiority. The classical temples of Indonesia before the rise of Islam are called 'Candi', which we can divide into the western Java period (?~8th century), the central Java period (8th~10th century), the eastern Java period (10th~16th century).

• Journal of the Korean Society of Combustion
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• v.4 no.1
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• pp.49-57
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• 1999

An experimental study on double-concentric diffusion flame has been carried out in order to investigate the shape, the flame length, and the other characteristics of the flame. Flow visualization of the flame by the $TiO_2$ particles and also the emission measurements are conducted. The commercial grade LP gases are used as fuel. The inverse diffusion flames are formed at the center when the central air flow rate is about 0.1 L/min. With a larger flow rate of the central air jet than 0.2 L/min the flame turns to be an annular-shaped flame, which is very bright. When the central air flow rate increases over 2.4 L/min, the flame turns to blue and the flame tips are opened because of the lifting of the inner part of the flame. Because of this lifting and the incomplete combustion, the CO emission increases abruptly from 25 ppm to more than 150 ppm. On the contrary, the NOx emission is decreased.

• The Journal of the Korea Contents Association
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• v.13 no.12
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• pp.519-529
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• 2013

This paper introduces a moving object tracing system using network-connected CCTV and smartphone. In an emergency situation, a smartphone of the reporter gains its GPS information and sends that to the central server. The central server stores received GPS information as a dangerous area in the database and keeps sending the order of tracing the reporter to a network-connected CCTV which can film the reporter. At the same time, the central server sends pictures of the reporter to his or her family and related organization in order to handle the emergency situation as soon as possible. In addition, when a reporter want to know the risk around destination, the central server informs dangerous areas to the reporter by using smart phone application and database of a danger spot.