• The Korean Journal of Applied Statistics
• /
• v.27 no.7
• /
• pp.1115-1123
• /
• 2014

The main purpose of phase I clinical trials is to estimate the Maximum Tolerated Dose (MTD), which minimizes side effect and assures safety of a new drug by evaluating the toxicity at each dose-level. The conventional MTD estimation methods is Standard method (Storer, 1989; Korn et al., 1994), Accelerated Titration Designs (Simon et al., 1997) and DM method (Dixon and Mood, 1948) etc. In this paper, MTD estimation method with de-escalation is suggested phase I clinical trials. The proposed MTD estimation method is compared to Accelerated Titration Designs, SM3 without de-escalation method and SM3 with de-escalation method using a Monte Carlo simulation.

• The Journal of the Korea institute of electronic communication sciences
• /
• v.2 no.4
• /
• pp.244-249
• /
• 2007

HL7 is well-Known standard protocol for text data generated in hospital information systems. In this paper, we have to design to obtain useful vital sign information, which is generated at data receiver modulor of HIS, that is offered by the central monitor. Vital sign informations of central monitor is composed of the row data of several bedsite patient monitors. We are willing to maintain vital sign information of real time and continuity that is generated from the bedsite patient monitor. It is able to apply to remote medical examination and treatment. we proposed integration method between vital sign database systems and hospital information systems. Through the proper exchange and management of patient vital sign information, real time vital sign information management will offer better workflow to all hospital employee.

• Proceedings of the Korea Concrete Institute Conference
• /
• 2005.11a
• /
• pp.17-20
• /
• 2005

Moment-curvature relation of RC pier is influenced greatly in occurrence form of crack and difference is happened according to consideration existence and nonexistence of tension stiffening effect. However, studies considering these is very insufficient misgovernment. Also, it is sometimes unavoidable lap splice of axial reinforcement in plastic hinge region of RC piers. However, specific design standard about lap splice of axial reinforcement is unprepared real condition and study about effect that lap splice of axial reinforcement get in occurrence form of crack is insufficient misgovernment. Therefore, in this paper, experiments are performed with hollow RC piers that do lap splice of axial reinforcement by main variable. And this study present analytical method about moment-curvature relation of hollow RC pier that consider tension stiffening effect and analyze effect that lap splice of axial reinforcement gets in occurrence form of crack. Analytic method of moment-curvature relation of RC pier that present in this study shows very similar motion with experiment result and crack interval of RC pier is suffering dominate impact in the augmented reinforcement amount by lap splice and average crack interval decreases as lap splice ratio increases.

• Proceedings of the IEEK Conference
• /
• 2008.06a
• /
• pp.525-526
• /
• 2008

This paper proposes a new high-speed level shifter using a special high voltage device with low threshold voltage. Also, novel low voltage swing method is proposed. The high voltage device is a standard LDMOS(Laterally Diffused MOS) device in a $0.18{\mu}m$ CMOS process without adding extra mask or process step to realize it. A level shifter uses 5V LDMOSs as voltage clamps to protect 1.8V NMOS switches from high voltage stress the gate oxide. Also, level-up transition from 1.8V to 5V takes only 1.5ns in time. These circuits do not consume static DC power, therefore they are very suitable for low-power and high-speed interfaces in the deep sub-quarter-micron CMOS technologies.

• Journal of Korea Spatial Information System Society
• /
• v.9 no.2
• /
• pp.35-53
• /
• 2007

GML is a mark-up language which is suggested by OGC(Open GIS Consortium) for use of encoding standard concerning with storing and transferring Geographic information. For general spatial network database, researches supporting GML documents can be classified into three categories : parsing, storing, and retrieval of GML documents. Among them, the 'Storing of GML document' is essential for efficient GML document retrieval. However, There is little research on schema for storing GML documents. In addition, the existing schema for storing XML documents can't be used for GML documents due to geographic information. Therefore, In this paper, we propose efficient schema for storing GML documents In addition, we do performance evaluation of the GML schema.

• Journal of the Korea Safety Management & Science
• /
• v.11 no.2
• /
• pp.77-85
• /
• 2009

Considering heat insulation and beautiful sight of construction, making use of exterior panels is increasing. Recently the exterior panels now are weak very much, and so in consequence of the weakness fire spreads rapidly. Compared with internal fire, external vertical fire spread rate goes rapidly and it is extensive in spread range, therefore it is dangerous very much. Accordingly, under present condition of poor standard of exterior panels, it is required to take measure to meet the appropriate situation. In this study, by making use of FDS(Fire Dynamic Simulation) program about external vertical fire of high rise building, fire behavior is searched by computer. It is important that realizing by computer fire modeling about external vertical fire must be included certainly in procedure of fire performance design in the future. In modeling program, FDS version 5 is available, and aluminium composite panel is applied in external panels. In this study, for realizing of actual fire condition, FDS is applied by details of fire scenarios considering influence of wind.

• Journal of the Korean Solar Energy Society
• /
• v.35 no.6
• /
• pp.43-50
• /
• 2015

The G-SEED encourages the installation of new and renewable energy facilities through assessments of the new and renewable energy installation rates. The government also regulates the installation rate of new and renewable energy facilities in the 'Project on new and renewable energy obligation in public installations'. The current criteria concerning the new and renewable energy facilities in the G-SEED are the result of an amendment made in July 2010. As over five years have passed since this amendment, the assessment criteria needs to be reenforced. To improve the current criteria, the calculation results of the installation rate of new and renewable energy facilities in the G-SEED were analyzed and compared to the corresponding calculation results of the 'Project on new and renewable energy obligation in public installations'. And an improved draft for the assessment criteria of the new and renewable energy facilities in the G-SEED was proposed.

• Journal of the Korea Society for Simulation
• /
• v.17 no.3
• /
• pp.53-62
• /
• 2008

This paper proposes a new implementational model based on the security model of Oracle for Web ontology. Recently, several access control models using relational database security model for access control to Web ontology have been developing, and one of the most representative access control model is the RAC model. However, the RAC model is based on the standard security model, and thus it does not provide a implementational model for practical relational database management systems. In this paper, we propose an implementational model based on Oracle which is widely used and providing various security policies. This paper shows the implementation and experimental evaluation. Especially, the proposed model uses the VPD security model of Oracle and support high application and usability.

• Journal of the Optical Society of Korea
• /
• v.13 no.2
• /
• pp.279-285
• /
• 2009

Prediction of glucose concentration in the interstitial fluid (ISF) based on mid-infrared absorption spectroscopy was examined at the glucose fundamental absorption band of 1000 - 1500/cm (10 - 6.67 um) using multi-component analysis. Simulated ISF samples were prepared by including four major ISF components. Sodium lactate had absorption spectra that interfere with those of glucose. The rest NaCl, KCl and $CaCl_2$ did not have any signatures. A preliminary experiment based on Design of Experiment, an optimization method, proved that sodium lactate influenced the prediction accuracy of glucose. For the main experiment, 54 samples were prepared whose glucose and sodium lactate concentration varied independently. A partial least squares regression (PLSR) analysis was used to build calibration models. The prediction accuracy was dependent on spectrum preprocessing methods, and Mean Centering produced the best results. Depending on calibration sample sets whose sodium lactate had different concentration levels, the standard error prediction (SEP) of glucose ranged $17.19{\sim}21.02\;mg/dl$.

• Journal of Korea Society of Digital Industry and Information Management
• /
• v.11 no.1
• /
• pp.1-8
• /
• 2015

Recently, a high strength concrete(HSC) in excess of 80 MPa is popular to use in the domestic construction field. But there is no design standard of high strength concrete. It is reason why a study about structural behaviors of thin walls is required. In this paper, the accurate Finite Element Method as a virtual test is suggested considering material properties, which are concrete and steel, and the experimental fractural model suggested by Kupfer. It is conducted the comparison evaluation of the ultimate failure loads, lateral-displacements and crack propagation patterns between the results of experimental approach, which were carried on Saheb's test for normal strength concrete and Lee's test for high strength concrete. Therefore it is suggested to use the accurate virtual simulation test method and Ubiquitous Sensor Network(USN) by Finite Element Method for Internet of Things(IoT).