• Korean Journal of Cognitive Science
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• v.17 no.3
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• pp.151-175
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• 2006

A common constraint-range model was suggested to explain the extraction of edge orientation from kinetic occlusion and five experiments were performed to verify this model. Results of the experiments show that the subjects' ability to identify the orientation of the kinetic edge increases as the angle of common constraint-range decreases. If the common constraint-range was fixed, the number of occluded elements or the interval between them had no effect on the accuracy. These results indicate that in the edge extraction process from kinetic occlusion, the angle of common constraint-range plays more important role than the density of background texture, supporting the common constraint-range model.

• The Korean Journal of Physiology and Pharmacology
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• v.12 no.5
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• pp.275-280
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• 2008

A brief ischemic insult induces significant protection against subsequent massive ischemic events. The molecular mechanisms known as preconditioning (PC)-induced ischemic tolerance are not completely understood. We investigated whether kinetic changes of cyclooxygenase (COX)-2 during reperfusion time-periods after PC were related to ischemic tolerance. Rats were given PC by occlusion of middle cerebral artery (MCAO) for 10 min and sacrificed after the indicated time-periods of reperfusion (1, 2, 4, 8, 12, 18 or 24 h). In PC-treated rats, focal ischemia was induced by occlusion of MCA for 24 h and brain infarct volume was then studied to determine whether different reperfusion time influenced the damage. We report that the most significant protection against focal ischemia was obtained in rats with 8 h reperfusion after PC. Administration of indomethacin (10 mg/kg, oral) or rofecoxib (5 mg/kg, oral) 48 h prior to PC counteracted the effect of PC. Immunohistochemical analysis showed that COX-2 and HO-l protein were induced in PC-treated rat brain, which was significantly inhibited by rofecoxib. Taken together, we concluded that the kinetic changes of COX-2 expression during the reperfusion period after PC might be partly responsible for ischemic tolerance.