• 약학회지
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• 제52권5호
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• pp.323-330
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• 2008

This study was conducted to investigate the actual conditions of vitamin supplement usage, the importance of their agents for health management, and the distribution of basic data for their correct consumption. For a period of one month 2003, the study was conducted based on questionnaires to the parents of students in both a middle school and a high school, and the personnel of K Company at random. The material used the survey sheets by setting up the previous investigation. The collected data analyzed the frequency and percentage of the following items: General demographic characteristics of consumers; the supplements taking; the reasons for taking them; the kinds of supplements taken; the media used for distributing data on their use; the potential use in the future, etc. According to the survey, the number of people who were taking supplements was higher than the number of people who weren’t taking them. Multi-vitamins were mostly consumed. The rate of supplements consume was high in people of a higher income bracket, had the time to exercise and to enjoy physical recreation. Most of the consumers who were taking the supplements said they did it to maintain their health and to recover from the fatigue. Those who weren’t taking them said they had enough vitamins from eating the appropriate food, and they were also concerned about the effectiveness of taking the supplements. The majority of useful information or advice for purchasing vitamins came from doctors, medical experts, relatives, and various media sources such as TV, newspapers, and magazines.

• Journal of Pharmaceutical Investigation
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• 제32권1호
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• pp.27-33
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• 2002

A self-microemulsifying drug delivery system(SMEDDS) composed of Cremophor $EL^{\circledR},\;Labrasol^{circledR}$, and Lauroglycol $FCC^{circledR}$ was prepared for the enhancement of solubility, dissolution rate and bioavailability of ibuprofen(IBP), which is water-insoluble but soluble in oils and surfactants. Phase diagram with various regions including microemulsion area was depicted. The SMEDDS was encapsulated in soft gelatin capsules and their dissolution characteristics in various media were observed in comparison to the generic products commercially available in the market. Soft capsules of SMEDDS formulation showed better dissolution profiles, especially in acidic condition, than the others. For the period of 1 hr dissolution in pH 1.2 medium, it reached over 70% dissolution from soft capsules, compared to less than 40% dissolution from commercial reference tablets. On the other hand, in vivo pharmacokinetic parameters were obtained after oral administrations of different IBP preparations to Sprague Dawley rats. SMEDDS formulation showed higher $C_{max}$ and greater $AUC_{0-5hr}$ than the suspension of reference tablet or IBP powder. Therefore, it is possible to conclude that a newly developed soft capsules employing SMEDDS provides an alternative preparation to improve oral bioavailability of IBP.

• Korean Journal of Radiology
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• 제24권7호
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• pp.647-659
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• 2023

Objective: The study was conducted to investigate the effect of correct occlusion of the left atrial appendage (LAA) on intracardiac blood flow and thrombus formation in patients with atrial fibrillation (AF) using four-dimensional (4D) flow magnetic resonance imaging (MRI) and three-dimensional (3D)-printed phantoms. Materials and Methods: Three life-sized 3D-printed left atrium (LA) phantoms, including a pre-occlusion (i.e., before the occlusion procedure) model and correctly and incorrectly occluded post-procedural models, were constructed based on cardiac computed tomography images from an 86-year-old male with long-standing persistent AF. A custom-made closed-loop flow circuit was set up, and pulsatile simulated pulmonary venous flow was delivered by a pump. 4D flow MRI was performed using a 3T scanner, and the images were analyzed using MATLAB-based software (R2020b; Mathworks). Flow metrics associated with blood stasis and thrombogenicity, such as the volume of stasis defined by the velocity threshold ($\left|\vec{V}\right|$ < 3 cm/s), surface-and-time-averaged wall shear stress (WSS), and endothelial cell activation potential (ECAP), were analyzed and compared among the three LA phantom models. Results: Different spatial distributions, orientations, and magnitudes of LA flow were directly visualized within the three LA phantoms using 4D flow MRI. The time-averaged volume and its ratio to the corresponding entire volume of LA flow stasis were consistently reduced in the correctly occluded model (70.82 mL and 39.0%, respectively), followed by the incorrectly occluded (73.17 mL and 39.0%, respectively) and pre-occlusion (79.11 mL and 39.7%, respectively) models. The surfaceand-time-averaged WSS and ECAP were also lowest in the correctly occluded model (0.048 Pa and 4.004 Pa^-1, respectively), followed by the incorrectly occluded (0.059 Pa and 4.792 Pa^-1, respectively) and pre-occlusion (0.072 Pa and 5.861 Pa^-1, respectively) models. Conclusion: These findings suggest that a correctly occluded LAA leads to the greatest reduction in LA flow stasis and thrombogenicity, presenting a tentative procedural goal to maximize clinical benefits in patients with AF.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2004년도 하계학술대회 논문집 C
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• pp.1951-1953
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• 2004

In this study, we propose a small high voltage power supply which use a half-bridge ZCS resonant and Cockroft-Walton on circuit, for ESP (Electrostatic Precipitator). This power supply transfers energy from ZCS resonant inverter to step-up transformer and the transformer secondary is applied to the Cockroft-Walton circuit for generating high voltage as discharging source of electrodes. It is highly efficient because its amount of switching losses are reduced by virtue of the current resonant half-bridge inverter, and also due to the small size, low parasitic capacitance in the transformer stage owing to the low number of winding turns of the step up transformer secondary combined with the Cockroft-Walton circuit. From these results, the best operational condition is obtained at the switching frequency of 9 kHz and the duty ratio of 50 % in this ESP.

• 한국건축시공학회:학술대회논문집
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• 한국건축시공학회 2005년도 춘계 학술기술논문발표대회 논문집
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• pp.9-12
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• 2005

This paper investigated the temperature history of mass concrete mock up structure considering different heat generation by varying with mixture proportion. Setting time difference between high early strength mixture (E-P) and retarding mixture (R-F30) was 14.5hours. Incorporation of $30\%$ of fly ash contributed to $10^{\circ}C$ of hydration heat reduction. In generally used C and D combination, bottom concrete shows earlier hydration, while E-J combination showed reverse tendency and thus, this method can reduce the crack occurrence. Therefore, heat generation difference method has beneficial effect on reducing crack induced by hydration heat resulting from heat generation difference between surface and center section.

• 한국조명전기설비학회:학술대회논문집
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• 한국조명전기설비학회 2005년도 춘계학술대회논문집
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• pp.467-472
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• 2005

In this paper, design and control of the novel SEPIC-Flyback converter(SF converter) is developed as a possible converter for fuel cell system. This output characteristic of SF converter is similar to Buck-Boost converter in that it can step-up or step-down the voltage. With the small signal equivalent circuit modeling of SF converter, control-to-output transfer function is obtained. SF converter couples up the inductive type converter to capacitive type converter with one transformer, which has less ripple current than its respective one does. To verify the validity of the proposed converter, 500W, 100kHz converter is designed and tested. ZVS switching and active clamping are also tested in practice.

• 전력전자학회:학술대회논문집
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• 전력전자학회 2009년도 정기총회 및 추계학술대회 논문집
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• pp.84-86
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• 2009

Isolated boost converter is desirable in the dc/dc converter applications where isolation is required and a large step up is needed. In this paper, it is proposed and analyzed the isolated boost converter which can step up low input voltage to high output voltage using transformer. Instead of using a conventional scheme, the proposed converter has the reset winding for volt-sec balance of transformer. Finally, the validity of the proposed isolated boost converter is verified by simulation.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.1568_1569
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• 2009

RFID 수동 태그의 동작 원리를 이용하여 USN/WBAN 센서 노드 시스템에 적용 가능한 웨이크 업 회로를 설계하였다. 웨이크 업회로 구성은 크게 전압 체배기, 복조기, 상태기계로 구성되었다. 상태 기계에 동작 가능한 전압을 공급하기 위해 전압 체배기는 문턱 전압 제거 방식을 적용한 구조를 사용하였고, 복조기 회로로는 AM 복조기로 구조가 간단한 포락선 검파기 방식을 사용하였다. 전압 체배기에 높은 전압이 인가될 경우 회로가 파괴되는 것을 막기 위해 제한 회로를 구성하여 최대 전압을 2.1V로 제한하였다. 또한 복조기에서는 안정적인 데이터 복조를 위해 비교기의 기준전압을 입력신호의 평균값을 사용한 슈미트 트리거 비교기를 사용하여 안정적으로 데이터를 추출하였다. 삼성 0.18um CMOS 공정을 이용하여 설계하였고, 측정 결과 전압 체배기의 체배 전압은 2.07~1.76V까지 체배 되는 것을 확인하였고, 복조기의 데이터 복조 역시 약 4M의 거리까지 데이터를 복조함을 확인하였다.

• 한국연소학회:학술대회논문집
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• 한국연소학회 2002년도 제24회 KOSCO SYMPOSIUM 논문집
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• pp.113-122
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• 2002

The purpose of this study is to verify that the modified Lagrangian model can predict temperature, flow and scalar fields in the high temperature recirculation region of swirling confined diffusion flame. In the meantime numerical results from EBU and Equilibrium PDF models as well as experimental results are compared with those from the modified Lagrangian model. Adaption of three different turbulent models were accompanied with this procedure. Look-up table of the ignition characteristic time scale which is one of important factors of the Lagrangian model was referred to the 11-step reduced mechanism. Eventually, results with the Lagrangian model show a good accordance with experimental results, which shows the validity of this model. Results from Chen's model differ from those of the others. Numerical results of ${\widetilde{k}$ show significant deviation from experimental results for three models.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 춘계학술대회 논문집
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• pp.562-567
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• 2005

F.C.M applied from Jin Jung Li to Yang Su Li(660m) in Puk Han River Bridge(1,414m) construction part is a construction method on the double-track construction which is the third section part of work, called Chung Ang Railroad Line(Deok-So${\sim}$Won-Ju). This method is the beginning application on Railroad Bridge. After completing upper slab structure, there are several following works such as setting up ballast, sleepers and laying long rails. So it is important to consider the properties of Railroad Bridge while designing the length of bridge and its single span. After the physical process study the shrinkage and creep of concrete, bending up by prestressing in general PSM bridge, relaxation of tendons as time goes by after post-tension, the conclusion of such a study is applied to the Puk-Han River Bridge in this construction field.