• Clinical and Experimental Pediatrics
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• 제49권1호
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• pp.103-106
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• 2006

Kikuchi병은 주로 젊은 여성에서 호발하고 소아에서는 비교적 드문 질환으로 원인 및 발생기전은 자세히 알려진 바 없으나 특별한 치료 없이도 수개월 이내에 자연적으로 회복되는 양성질환이다. 진단은 침범된 림프절의 특징적인 병리조직학적 소견을 확인하면 가능하다. 대부분의 환자에서 임상증상으로 림프절 비대와, 발열이 나타나고 피부증상은 16-40%에서 동반되며 주로 안면부, 상지, 상부 체간에 발생하고 대부분 작은 반점, 구진, 드물게 판과 결절 형태로 나타난다. 국내에서는 1983년 아급성 괴사성 임파선염이라는 이름으로 처음 언급한 이래 드물지 않게 보고되어왔으나 기존의 보고들은 피부증상을 동반하지 않거나 얼굴과 상지에 국한된 피부병변을 가진 증례 보고가 대부분이었다. 저자들은 지속적인 발열과 우측 경부 림프절 비대를 주소로 내원한 9세 남아에서 림프절의 조직검사결과 Kikuchi병을 진단할 수 있었고 이후 하지를 포함한 전신에 반점과 구진형태의 홍반성 병변이 발생한 Kikuchi병 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Annals of Clinical Neurophysiology
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• 제9권2호
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• pp.93-96
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• 2007

A 34-year-old man presented with a severe headache, fever, and cervical lymphadenopathy followed by generalized tonic-clonic seizure. Evaluations showed splenomegaly, elevated liver enzymes, and 380 white blood $cells/mm^3$ in the cerebrospinal fluid. Two weeks after admission, he developed sudden vertigo. Examination revealed spontaneous horizontal-torsional nystagmus to the right and bithermal caloric tests documented left canal paresis. A cervical lymph node biopsy disclosed subacute necrotizing lymphadenitis. We report a case of aseptic meningitis and unilateral vestibulopathy associated with histiocytic necrotizing lymphadenitis (Kikuchi's disease).

• 대한두경부종양학회지
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• 제19권2호
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• pp.133-136
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• 2003

Background and Objectives: Kikuchi's disease or subacute necrotizing lymphadenitis is a cause of persistently enlarged lymph nodes unresponsive to antibiotic therapy. It affects predominantly young women under the age of 30, and it is seen primarily in the Asian population. Although this disease usually follows a benign course, all describing a clinical entity that has been mistaken for malignant lymphoma, lupus, and an assortment of infectious diseases. The purpose of this study is to report clinical characteristics and treatment outcome in order to contribute to the precise diagnosis and treatment. Materials and Methods: We reviewed 27 cases, who were diagnosed as subacute necrotizing lymphadenitis on excisional biopsy during the past 5 years from January 1998 to December 2002. Results: It occurred more often in females (20 cases ; 74%) than males (7cases ; 26%), and it was seen more frequently in the second and third decades (21 cases ; 78%). Cervical lymphadenopathy were usually multiple (24 cases, 89%) and measured less than 2cm (20 cases, 74%). The posterior cervical and deep jugular chains are the most common location(34 cases ; 81%). Leukopenia(18 cases, 67%) and elevated ESR(20 cases, 75%) were commonly noted in laboratory data. Conclusions: It is easy that Kikuchi's disease is mistaken for malignant lymphoma. So we should consider fine needle aspiration or open biosy of lymph node for histologic diagnosis in patients who have localized cervical lymphadenopathy unresponsive to antibiotic therapy.