• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8759-8763
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• 2014

Background: Non-hodgkin lymphoma (NHL) is a diverse group of disease encompassing divergent tumor types with contrasting clinical behaviors. We aimed to evaluate the usefulness of Ki67 index in segregating indolent from aggressive NHL and its association with clinical parameters. Materials and Methods: During a study period of 4.5 years, a total of 215 cases of lymphomas were diagnosed among of which 172 cases were NHL. Ki67 immunohistochemical staining was performed by the DAKO envision method. Average proportion of tumor cells stained was calculated to determine the proliferative index. Results: The mean age at diagnosis was 46.2 years +19.8 (3-81) with a male to female ratio of 1.5:1. Mean Ki67 index for indolent NHL included 23% for small cell, 25% for mantle cell, 28.5% for marginal zone and 34.6% for follicular lymphoma. On the other hand, mean Ki67 index for aggressive lymphomas were 66.4%, 66.9%, 80.3%, 83.3% and 94.4% for diffuse large B cell, T cell (NOS), anaplastic large cell, lymphoblastic and burkitts lymphoma respectively. No significant correlation was found between Ki67 index and other clinical parameters like age and extra nodal involvement. Conclusions: Ki67 index is a valuable IHC marker to distinguish indolent from aggressive lymphomas especially in small needle biopsies where exact typing may not be possible.

• The Korean Journal of Physiology and Pharmacology
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• v.10 no.3
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• pp.155-159
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• 2006

Among the Shc proteins, p66shc is known to be related to oxidative stress responses and regulation of the production of reactive oxygen species (ROS). The present study was undertaken to investigate the role of p66shc on endothelial nitric oxide synthase (eNOS) activity in the mouse embryonic fibroblasts (MEFs). When wild type (WT) or p66shc (-/-) MEFs were transfected with full length of eNOS cDNA, the expression and activity of eNOS protein were higher in the p66shc (-/-) MEFs. These phenomena were reversed by reconstitution of p66shc cDNA transfection in the p66shc (-/-) MEFs. The basal superoxide production in the p66shc (-/-) MEFs was not significantly different from that of WT of MEFs. However, superoxide production induced by NADPH in the p66shc (-/-) MEF was lesser than that in WT MEFs. When compared with WT MEFs, cell lysate of p66shc (-/-) MEFs showed significantly increased H-ras activity without change of endogenous H-ras expression. Our findings suggest the pivotal role of p66shc adaptor protein played in inhibition of endothelial nitric oxide production via modulation of the expression and/or activity of eNOS protein.

• The Korean Journal of Physiology and Pharmacology
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• v.16 no.3
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• pp.199-204
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• 2012

We evaluated the role of Tat-mediated p66shc transduction on the activation of endothelial nitric oxide synthase in cultured mouse endothelial cells. To construct the Tat-p66shc fusion protein, human full length p66shc cDNA was fused with the Tat-protein transduction domain. Transduction of TAT-p66shc showed a concentration- and time-dependent manner in endothelial cells. Tat-mediated p66shc transduction showed increased hydrogen peroxide and superoxide production, compared with Tat-p66shc (S/A), serine 36 residue mutant of p66shc. Tat-mediated p66shc transduction decreased endothelial nitric oxide synthase phosphorylation in endothelial cells. Furthermore, Tat-mediated p66shc transduction augmented TNF-${\alpha}$-induced p38 MAPK phosphorylation in endothelial cells. These results suggest that Tat-mediated p66shc transduction efficiently inhibited endothelial nitric oxide synthase phosphorylation in endothelial cells.

• Proceedings of the Korean Vacuum Society Conference
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• 2001.07a
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• pp.66-66
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• 2001

• Bulletin of the Korean Space Science Society
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• 2005.10a
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• pp.66-66
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• 2005

• Proceedings of the Korean Society of Plant Pathology Conference
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• 2005.04a
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• pp.66.1-66.1
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• 2005

• Proceedings of the Korea Information Processing Society Conference
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• 2012.04a
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• pp.66-68
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• 2012

본 논문에서는 안드로이드 폰을 이용하여 쿼드콥터의 모터를 제어하기 위한 임베디드 리눅스 시스템을 제시한다. 제시한 시스템은 메시지 수신 및 파싱 모듈과 모터 제어 모듈로 나누어 설계한다. 제시한 시스템의 기능적 타당성을 겸토하기 위하여 각각의 모듈을 구현하고, ARM 프로세서 기반의 임베디드 보드가 탑재된 실험용 쿼드콥터를 이용하여 실험을 하였다.

• 한국도로학회:학술대회논문집
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• 2002.10a
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• pp.61-66
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• 2002

• Proceedings of the Costume Culture Conference
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• 1998.09a
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• pp.66-68
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• 1998

• Journal of Korean Medical Ki-Gong Academy
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• v.4 no.1
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• pp.66-77
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• 2000