• Journal of the Computational Structural Engineering Institute of Korea
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• v.30 no.3
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• pp.223-230
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• 2017

BIM(building information modeling) has been actively applied to construction industries and to maximize its application through the life cycle of structure, various relevant technologies have been proposed. In particular, 4D sequencing management and 5D cost-related management were introduced as an improved version of the design review and interface control by 3D information design. On the other hand, the virtual construction using virtual construction equipment can sophisticatedly handle capacity, dynamic movement, collision boundaries of actual construction machines but it still stays at a low level in a technical sense. In this study, simulation systems based on BIM involving virtual construction equipment have been developed; then it is applied to the actual construction project to evaluate the safety and efficiency of construction equipments. It was confirmed that the simulation systems can be utilized to construct virtual construction site by using an effective 3D library of construction equipment and can plays a key role to secure construction safety and economic feasibility. Specifically, the simulation system are very useful for decision making by construction managers to select the optimum equipment and construction method with a better understanding for safety and cost-saving.

• Architectural research
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• v.22 no.2
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• pp.41-52
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• 2020

Laboratory buildings with specialized equipment and ventilation systems pose challenges in terms of efficient energy use and initial construction costs. Additionally, lab spaces should have flexible and efficient layouts and provide a comfortable indoor research environment. Therefore, this study aims to identify the correlation between the facade of a building and its interior layout from case studies of energy-efficient research labs and to propose passive energy design strategies for the establishment of an optimal research environment. The case studies in this paper were selected from the American Institute of Architects Committee on the Environment Top Ten Projects and Leadership in Energy and Environmental Design (LEED) certified research lab projects. In this paper, the passive design strategies of space zoning, façade design devices to control heating and cooling loads were analyzed. Additionally, the relationships between these strategies and the interior lab layouts, lab support spaces, offices, and circulation areas were examined. The following four conclusions were drawn from the analysis of various cases: 1) space zoning for grouping areas with similar energy requirements is performed to concentrate similar heating and cooling demands to simplify the HVAC loads. 2) Public areas such as corridor, atrium, or courtyard can serve as buffer zones that employ passive solar design to minimize the mechanical energy load. 3) A balanced window-to-wall ratio (WWR), exterior shading devices, and natural ventilation systems are applied according to the space programming energy requirements to minimize the dependence on mechanical service. 4) Lastly, typical laboratory space zoning categories can be revised, reversed, and even reconfigured to minimize the energy load and adjust to the site context. This study can provide deep insights into various design strategies employed for construction of green laboratories along with intuitive arrangement of various building components such as laboratory spaces, lab support spaces, office spaces, and common public areas. The key findings of this study can contribute towards creating improved designs of laboratory facilities with reduced carbon footprint and greenhouse emissions.

• The Journal of Advanced Prosthodontics
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• v.7 no.1
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• pp.51-55
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• 2015

PURPOSE. Bone density at implant placement site is a key factor to obtain the primary stability of the fixture, which, in turn, is a prognostic factor for osseointegration and long-term success of an implant supported rehabilitation. Recently, an implant motor with a bone density measurement probe has been introduced. The aim of the present study was to test the objectiveness of the bone densities registered by the implant motor regardless of the operator performing them. MATERIALS AND METHODS. A total of 3704 bone density measurements, performed by means of the implant motor, were registered by 39 operators at different implant sites during routine activity. Bone density measurements were grouped according to their distribution across the jaws. Specifically, four different areas were distinguished: a pre-antral (between teeth from first right maxillary premolar to first left maxillary premolar) and a sub-antral (more distally) zone in the maxilla, and an interforaminal (between and including teeth from first left mandibular premolar to first right mandibular premolar) and a retroforaminal (more distally) zone in the lower one. A statistical comparison was performed to check the inter-operators variability of the collected data. RESULTS. The device produced consistent and operator-independent bone density values at each tooth position, showing a reliable bone-density measurement. CONCLUSION. The implant motor demonstrated to be a helpful tool to properly plan implant placement and loading irrespective of the operator using it.

• Journal of the Economic Geographical Society of Korea
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• v.18 no.1
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• pp.60-75
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• 2015

The Ruhr area in the Northwestern Germany grew rapidly from the 1850s based on coal mining and iron and steel industries, playing a key role as an engine of industrial growth. Since the 1950s, however, the area has been experiencing a serious economic crisis as the traditional industries declined. The crisis was comprised of increasing unemployment and abandoned industrial lands and facilities. Oberhausen and Gelsenkirhen are typical cities of the Ruhr, characterized by such economic crisis. Oberhausen attempted to solve the problems by developing a large leisure town, composed of a sopping mall, restaurants, and other arts and cultural activities, on a former steel mill site. Gelsenkirhen, on the other hand, went on to promote renewable energy industries, business incubators, and energy-saving housing complexes. This paper analyses the processes and outcomes of urban revitalization policies of the two cities, based on the path dependence theory, and draws theoretical and policy implications.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.64 no.2
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• pp.228-231
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• 2015

In power system research fields, one of current key issues is the construction and commercialization of micro grid site which is called green island, carbon zero island, energy independent island, building micro grid, etc. and various affiliated technologies have been being vigorously developed to realize. In addition, various researches about electric vehicles (EVs) are in progress and it is expected to penetrate rapidly with the next a few years. Some new load models should be developed integrating with electric vehicle loads because the EVs' deployment could cause the change of load composition rate on power system planning and operations. EVs are also resources for micro grid as well as distributed generation and demand response so that various supply and demand side resources should be considered for micro grid researches. In this paper, the load composition rate of residential sectors is prospected considering the deployment of EVs and the resource configuration of micro grid is optimized based on net present cost. In the optimization, the load patten of case studies includes EV's charging characteristics and various cases are simulated comparing micro grid environment and normal condition. HOMER is used to compare various cases and economic effects.

• BMB Reports
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• v.53 no.3
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• pp.142-147
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• 2020

Lipid accumulation in white adipose tissue is the key contributor to the obesity and orchestrates numerous metabolic health problems such as type 2 diabetes, hypertension, atherosclerosis, and cancer. Nonetheless, the prevention and treatment of obesity are still inadequate. Recently, scientists found that brown adipose tissue (BAT) in adult humans has functions that are diametrically opposite to those of white adipose tissue and that BAT holds promise for a new strategy to counteract obesity. In this study, we evaluated the potential of sinapic acid (SA) to promote the thermogenic program and lipolysis in BAT. SA treatment of brown adipocytes induced the expression of brown-adipocyte activation-related genes such as Ucp1, Pgc-1α, and Prdm16. Furthermore, structural analysis and western blot revealed that SA upregulates protein kinase A (PKA) phosphorylation with competitive inhibition by a pan-PKA inhibitor, H89. SA binds to the adenosine triphosphate (ATP) site on the PKA catalytic subunit where H89 binds specifically. PKA-cat-α1 gene-silencing experiments confirmed that SA activates the thermogenic program via a mechanism involving PKA and cyclic AMP response element-binding protein (CREB) signaling. Moreover, SA treatment promoted lipolysis via a PKA/p38-mediated pathway. Our findings may allow us to open a new avenue of strategies against obesity and need further investigation.

• Molecules and Cells
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• v.40 no.6
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• pp.410-417
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• 2017

Estimation of postmortem interval (PMI) is a key issue in the field of forensic pathology. With the availability of quantitative analysis of RNA levels in postmortem tissues, several studies have assessed the postmortem degradation of constitutively expressed RNA species to estimate PMI. However, conventional RNA quantification as well as biochemical and physiological changes employed thus far have limitations related to standardization or normalization. The present study focuses on an interesting feature of the subdomains of certain RNA species, in which they are site-specifically cleaved during apoptotic cell death. We found that the D8 divergent domain of ribosomal RNA (rRNA) bearing cell death-related cleavage sites was rapidly removed during postmortem RNA degradation. In contrast to the fragile domain, the 5' terminal region of 28S rRNA was remarkably stable during the postmortem period. Importantly, the differences in the degradation rates between the two domains in mammalian 28S rRNA were highly proportional to increasing PMI with a significant linear correlation observed in mice as well as human autopsy tissues. In conclusion, we demonstrate that comparison of the degradation rates between domains of a single RNA species provides quantitative information on postmortem degradation states, which can be applied for the estimation of PMI.

• Molecules and Cells
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• v.41 no.3
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• pp.234-243
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• 2018

In recent years, the interest towards the relationship between incretins and bone has been increasing. Previous studies have suggested that glucagon-like peptide-1 (GLP-1) and its receptor agonists exert beneficial anabolic influence on skeletal metabolism, such as promoting proliferation and differentiation of osteoblasts via entero-osseous-axis. However, little is known regarding the effects of GLP-1 on osteoblast apoptosis and the underlying mechanisms involved. Thus, in the present study, we investigated the effects of liraglutide, a glucagon-like peptide-1 receptor agonist, on apoptosis of murine MC3T3-E1 osteoblastic cells. We confirmed the presence of GLP-1 receptor (GLP-1R) in MC3T3-E1 cells. Our data demonstrated that liraglutide inhibited the apoptosis of osteoblastic MC3T3-E1 cells induced by serum deprivation, as detected by Annexin V/PI and Hoechst 33258 staining and ELISA assays. Moreover, liraglutide upregulated Bcl-2 expression and downregulated Bax expression and caspase-3 activity at intermediate concentration (100 nM) for maximum effect. Further study suggested that liraglutide stimulated the phosphorylation of AKT and enhanced cAMP level, along with decreased phosphorylation of $GSK3{\beta}$, increased ${\beta}-catenin$ phosphorylation at Ser675 site and upregulated nuclear ${\beta}-catenin$ content and transcriptional activity. Pretreatment of cells with the PI3K inhibitor LY294002, PKA inhibitor H89, and siRNAs GLP-1R, ${\beta}-catenin$ abrogated the liraglutide-induced activation of cAMP, AKT, ${\beta}-catenin$, respectively. In conclusion, these findings illustrate that activation of GLP-1 receptor by liraglutide inhibits the apoptosis of osteoblastic MC3T3-E1 cells induced by serum deprivation through $cAMP/PKA/{\beta}-catenin$ and $PI3K/Akt/GSK3{\beta}$ signaling pathways.

• Journal of Information Technology Application
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• v.3 no.2
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• pp.83-102
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• 2001

Internet-based shopping business spread rapidly in Korea. Companies are trying to develop and use various strategic competences. The strategies employed by those companies include activities related to the design of shopping site, market positioning, assistance of purchasing process, payment mechanism, and provision of various consumer services. However, the success of these strategies depends on various environmental factors and internal capability of the companies. In this study, I examined four successful Internet shopping mall companies and compared them to draw useful guidelines for Internet-based intermediary business. These four companies were selected because they are all considered successful by now, but brought different background. We found follows. First, each company tried to economize their own historical and developmental background. All of the selected companies were alike in their focus on the whole Internet user group. Customer needs analysis was performed more systematically. The Importance of customer information and the use of it are not sufficient. Second, Each companies consistently emphasized the importance of market-related activities. Despite the differences in initial states, all companies used similar strategies and had similar focus in target market and products. Conclusively, implications from this research for Internet shopping business can be summarized as follows. First, One of the important future directions for Internet shopping mall business is to broaden target market. Second, the provisions of carefully designed customized services are one success factor. Third, As customer traffic increased, the provision of differential customer service becomes a key success factor.

• Explosives and Blasting
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• v.19 no.1
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• pp.71-84
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• 2001

Korean peninsula has the most mountainous areas such as mountains and hilly country, and it is surrounded by the sea on all sides but one. In this respect, a large scaled construction works have frequently been conducted. However, it is not easy to porform a large scale blasting work without giving any harm to houses or facilities nationwide. Therefore, blasting work becomes more closely related to maintenance thing due to the development of the downtown or a large structure for key facilities. Many researches on blast in the open space and tunnel blasting have been conducted. On the contrary, research on underwater blasting operations is comparatively scanty even though much more necessity of marine development is required. In this respect, this study aims to investigate the characteristics of underwater blasting operations and to make a comparative study with blast in the open space. As a result of examining into the characteristics during underwater blasting operations, the around oscillation in case of underwater blasting operations shows significantly low compared to that in case of blast in the open space, and this means that much more cautious altitude must be taken in designing underwater blasting operations compared to the design of blast In the open space. As a result of analysis on the difference between a square root and a cube root In the equation of estimating oscillations in the actual site, it is shown that it is shown to apply a square root for the estimation of oscillation at 60 meters in case of underwater blasting operations and at 22 meters case of general blast in the open space.