• Reproductive and Developmental Biology
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• 제34권3호
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• pp.143-151
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• 2010

Pluripotency of human embryonic stem cell (hESC) is one of the most valuable ability of hESCs for applying cell therapy field, but also showing side effect, for example teratoma formation. When transplant multipotent stem cell, such as mesnchymal stem cell (MSC) which retains similar differentiation ability, they do not form teratoma in vivo, but there exist limitation of cellular source supply. Accordingly, differentiation of hESC into MSC will be promising cellular source with strong points of both hESC and MSC line. In this study, we described the derivation of MSC like cell population from feeder free cultured hESC (hESC-MSC) using direct differentiation system. Cells population, hESC-MSC and bone marrow derived MSC (BM-MSC) retained similar characteristics in vitro, such as morphology, MSC specific marker expression and differentiation capacity. At the point of differentiation of both cell populations, differentiation rate was slower in hESC-MSC than BM-MSC. As these reason, to verify differentially expressed molecular condition of both cell population which bring out different differentiation rate, we compare the molecular condition of hESC-MSC and BM-MSC using 2-D proteomic analysis tool. In the proteomic analysis, we identified 49 differentially expressed proteins in hESC-MSC and BM-MSC, and they involved in different biological process such as positive regulation of molecular function, biological process, cellular metabolic process, nitrogen compound metabolic process, macromolecule metabolic process, metabolic process, molecular function, and positive regulation of molecular function and regulation of ubiquitin protein ligase activity during mitotic cell cycle, cellular response to stress, and RNA localization. As the related function of differentially expressed proteins, we sought to these proteins were key regulators which contribute to their differentiation rate, developmental process and cell proliferation. Our results suggest that the expressions of these proteins between the hESC-MSC and BM-MSC, could give to us further evidence for hESC differentiation into the mesenchymal stem cell is associated with a differentiation factor. As the initial step to understand fundamental difference of hESC-MSC and BM-MSC, we sought to investigate different protein expression profile. And the grafting of hESC differentiation into MSC and their comparative proteomic analysis will be positively contribute to cell therapy without cellular source limitation, also with exact background of their molecular condition.

• 정보화연구
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• 제9권4호
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• pp.391-400
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• 2012

본 연구는 전구 탄도미사일 방어(TBMD)를 위한 협동교전의 기능아키텍처 도출에 관한 논문이다. TBMD는 다층으로 구성되며 네트워크 기반의 센서체계, 슈터체계, 그리고 전장관리체계로 구성되는 복합시스템이다. 협동교전능력은 대표적인 실시간 전장관리체계이며, 협동교전능력의 핵심기능은 협동교전이다. 협동교전은 두 개 이상의 분산된 자산의 통합을 통해 얻어진 시너지 효과로 위협을 제거하는 전투개념이다. 이러한 관점에서 본 논문은 개념 분석을 통해 TBMD의 협동교전 기능아키텍처를 제시하였으며, 이는 협동교전 기반의 TBMD 전투체계를 개발하기 위한 선행연구로서 수행되었다.

• ETRI Journal
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• 제29권6호
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• pp.755-768
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• 2007

A very promising application of active RFID systems is the electronic seal, an electronic device to guarantee the authenticity and integrity of freight containers. To provide freight containers with a high level of tamper resistance, the security of electronic seals must be ensured. In this paper, we present the design and implementation of an electronic seal protection system. First, we propose the eSeal Protection Protocol (ePP). Next, we implement and evaluate various cryptographic primitives as building blocks for our protocol. Our experimental results show that AES-CBC-MAC achieves the best performance among various schemes for message authentication and session key derivation. Finally, we implement a new electronic seal system equipped with ePP, and evaluate its performance using a real-world platform. Our evaluation shows that ePP guarantees a sufficient performance over an ARM9-based interrogator.

• 대한원격탐사학회지
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• 제28권6호
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• pp.693-704
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• 2012

Space-born remote sensing camera systems tend to be developed to have very high performances. They are developed to provide extremely small ground sample distance, wide swath width, and good MTF (Modulation Transfer Function) at the expense of big volume, massive weight, and big power consumption. Therefore, the camera system occupies relatively big portion of the satellite bus from the point of mass and volume. However, the camera systems for lunar exploration don't need to have such high performances. Instead, it should be versatile for various usages under various operating environments. It should be light and small and should consume small power. In order to be used for national program of lunar exploration, electro-optical versatile camera system, called MAEPLE (Multi-Application Electro-Optical Payload for Lunar Exploration), has been designed after the derivation of camera system requirements. A ground model of the camera system has been manufactured to identify and secure relevant key technologies. The ground model was mounted on an aircraft and checked if the basic design concept would be valid and versatile functions implemented on the camera system would worked properly. In this paper, results of design and functional test performed with the field campaigns and air-born imaging are introduced.

• Nuclear Engineering and Technology
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• 제37권1호
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• pp.25-78
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• 2005

As a key and core knowledge for the design of various types of nuclear reactors, the discipline of reactor physics has been advanced continually in the past six decades and has led to a very sophisticated fabric of analysis methods and computer codes in use today. Notwithstanding, the discipline faces interesting challenges from next-generation nuclear reactors and innovative new fuel designs in the coming. After presenting a brief overview of important tasks and steps involved in the nuclear design and analysis of a reactor, this article focuses on the currently-used design and analysis methods, issues and limitations, and current activities to resolve them as follows: (1) Derivation of the multi group transport equations and the multi group diffusion equations, with representative solution methods thereof. (2) Elements of modem (now almost three decades old) diffusion nodal methods. (3) Limitations of nodal methods such as transverse integration, flux reconstruction, and analysis of UO2-MOX mixed cores. Homogenization and related issues. (4) Description of the analytic function expansion nodal (AFEN) method. (5) Ongoing efforts for three-dimensional whole-core heterogeneous transport calculations and acceleration methods. (6) Elements of spatial kinetics calculation methods and coupled neutronics and thermal-hydraulics transient analysis. (7) Identification of future research and development areas in advanced reactors and Generation-IV reactors, in particular, in very high temperature gas reactor (VHTR) cores.

• Structural Engineering and Mechanics
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• 제85권5호
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• pp.679-691
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• 2023

Many codes allow designers to use the bending moment diagram computed by elastic analysis and modify it by a certain amount of moment redistribution (MR) to account for plastic behaviour of continuous beams. However, several researchers indicated that the MR at the ultimate limit state (𝛽_u) for some beams deviate significantly from the specified values of various codes. This paper examines the applicability of the provisions on 𝛽_u in ACI 318-19 and Eurocode 2 through numerical investigations and comprehensively explores the influencing factors. The results show that some parameters not considered in those codes influence 𝛽_u to a certain extent, where the ratio of tensile reinforcement ratio at intermediate support to tensile reinforcement ratio at midspan (𝜌_s1/𝜌_s2) and load type are crucial parameters to consider. The specific combination of these two parameters may make the codes overestimate or significantly underestimate the 𝛽_u. On the other hand, the yield state of both critical sections is found to have an important influence on the influence degree of each parameter on 𝛽_u. The yield conditions are investigated, and an empirical judgment equation is proposed. In addition, the influence laws of the critical parameters on 𝛽_u have been further proved by theoretical derivation. Finally, due to 𝜀_t is found to have a better linear correlation with 𝛽_u than x_u/d, equations as a function of 𝜀_t for predicting the 𝛽_u of continuous beams under the two loads are proposed, respectively.

• 농업과학연구
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• 제31권2호
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• pp.135-148
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• 2004

Rice is not only main food but also key farm income source of Korean farmers. In spite of the above facts, rice productivity was decreased on account of drought in every 2 or 3 years interval owing to the vulnerability of irrigation facilities throughout Korea in the past decades. As an context of the first five year economic development plan, all weather farming programme including 4 big river basin comprehensive development projects and large and medium sized irrigation water development projects were carried out successfully. Therefore the area of irrigated paddy were increased from 58% in 1970 to 76.2% in 1999. In the past decades, the Government had invested heavy financial funds to develop irrigation water but as an factor share analysis, the contribution rates of irrigation water and investment for farmland base development project have not been identified yet in national agricultural economic level. It is very scarce to find out the papers concerned to macro-economic factor share analysis or contribution rates of water and investment cost to rice production value in Korea considering the production function of the quantity of irrigation water and investment cost as independent variables. Accordingly this paper covered and aimed at identifying (1) derivation of rice production function with the time serial data from 1965 to 1999 and the contribution rates of irrigation water and total investment cost for farmland base development project. The analytical model of the contribution rates was adapted the famous Cobb-Douglass production function. According to the model analysis, the contribution rate of irrigation water to rice production in Korea was shown 37.8% which was equivalent to 0.28 of the production elasticity of water. The contribution rate of farmland base development project cost was revealed 22% and direct production cost of rice was contributed 60% in the growth of rice production and farm mechanization costs contributed to 18% of it respectively. The two contribution rates comparing with the direct production cost were small but without irrigation water and farmland base development, application of high-pay off inputs and farm mechanization might be impossible. Considering the food security and to cope with the frequent drought, rice farming and investment for the irrigation water development should be continued even in WTO system.

• 한국조경학회지
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• 제49권5호
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• pp.79-96
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• 2021

그린인프라 계획은 미세먼지 저감을 위한 대표적인 조경 계획 방안 중 하나이다. 이에, 본 연구에서는 미세먼지 저감을 위한 그린인프라 계획 시 활용될 수 있는 요소를 텍스트 마이닝 기법을 활용하여 도출하고자 하였다. 미세먼지 저감계획, 그린인프라 계획 요소 등의 키워드를 중심으로 관련 선행연구, 정책보고서 및 법률 등을 수집하여 텍스트 마이닝을 통해 단어 빈도-역 문서 빈도(Term Frequency-Inverse Document Frequency, 이하 TF-IDF) 분석, 중심성 분석, 연관어 분석, 토픽 모델링 분석을 실시하였다. 연구결과, 첫째, TF-IDF 분석을 통해 미세먼지 및 그린인프라와 관련된 주요 주제어는 크게 환경문제(미세먼지, 환경, 탄소, 대기 등), 대상 공간(도시, 공원, 지역, 녹지 등), 그리고 적용 방법(분석, 계획, 평가, 개발, 생태적 측면, 정책적 관리, 기술, 리질리언스 등)으로 구분할 수 있었다. 둘째, 중심성 분석 결과, TF-IDF와 유사한 결과가 도출되었으며, 주요 키워드들을 연결하는 중심단어는 '그린뉴딜', '유휴부지'임을 확인할 수 있었다. 셋째, 연관어 분석 결과, 미세먼지 저감을 위한 그린인프라 계획 시, 숲과 바람길의 계획이 필요하며, 미기후 조절의 측면에서 수분에 대한 고려가 반드시 필요한 것으로 확인되었다. 또한, 유휴공간의 활용 및 혼효림의 조성, 미세먼지 저감 기술의 도입과 시스템의 이해가 그린인프라 계획 시 중요한 요소가 될 수 있음을 확인할 수 있었다. 넷째, 토픽 모델링 분석을 통해 그린인프라의 계획요소를 생태적·기술적·사회적 기능을 중심으로 분류하였다. 생태적 기능의 계획요소는 그린인프라의 형태적 부분(도시림, 녹지, 벽면녹화 등)과 기능적 부분(기후 조절, 탄소저장 및 흡수, 야생동물의 서식처와 생물 다양성 제공 등), 기술적 기능의 계획요소는 그린인프라의 방재 기능, 완충 효과, 우수관리 및 수질정화, 에너지 저감 등, 사회적 기능의 계획요소는 지역사회 커뮤니티 기능, 이용객의 건강성 회복, 경관 향상 등의 기능으로 분류되었다. 이와 같은 결과는 미세먼지 저감을 위한 그린인프라 계획 시 리질리언스 및 지속가능성과 같은 개념적 키워드 중심의 접근이 필요하며, 특히, 미세먼지 노출 저감의 측면에서 그린인프라 계획요소의 적용이 필요함을 시사한다고 볼 수 있다.

• 감성과학
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• 제25권1호
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• pp.3-20
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• 2022

최근 도심항공모빌리티(UAM) 상용화에 앞서 도심 내 항공 교통수단 관련 산업에 대한 연구개발 중요성이 급격히 증가하고 있다. 도심항공모빌리티(UAM) 환경을 조성하기 위해서 핵심 항공 이동 수단 비행체인 개인용 항공기(PAV) 기체에 관한 연구가 수행되고 있으나, 탑승자 관점의 연구가 상대적으로 부족한 상황이다. 특히 PAV는 탑승자의 새로운 생활공간으로 활용될 것으로 예상되기 때문에 탑승자의 실내행위를 지원하는 실내공간 설계를 위해서는 PAV 기체에서 발생하는 물리적 요소가 인체에 미치는 영향에 관한 연구가 필수적으로 이루어져야 한다. 이에 본 연구의 목적은 PAV의 공중 운항 특성으로 인해 인체에 영향을 주는 제약 요소를 도출하고, 이러한 제약 요소가 실내행위를 수행하는 탑승자 인체에 미치는 영향을 파악하는 것이다. 본 연구 결과, 항공 이동 수단 비행 기체 PAV는 4,000ft 이하에서 운항해야 하는 기준에 따라, 운항고도에 따른 제약 요소는 소음, 진동, 저주파 운동에 의한 멀미로 나타났다. 이러한 제약 요소가 실내행위에 영향을 미친다는 관점에서 PAV에서 행할 수 있는 실내행위를 자율주행 자동차, 비행기, PAV 컨셉 사례를 활용하여 도출하고 인체에 미치는 영향과 수준을 고려하여 실내행위 지원을 위한 제약 요소 권장기준을 설정하였다. 또한 실내행위 지원을 위한 제약 요소의 인체 영향 수준을 감소시키기 위해서는 시트의 형태 및 내장기능(진동 저감 기능, 온도조절, LED조명 등), 개인 좌석별 지향성 스피커를 활용한 외부소음 감소, 소음과 진동 감소를 위한 내장재 등을 실내공간 설계에 반영해야 함을 제시하였다. 본 연구는 PAV 실내행위에 영향을 주는 제약 요소를 도출하였고, 인체에 미치는 영향 수준을 확인하였으며, 추후 PAV 실내 설계 시 기초자료로써 활용할 수 있다는 점에서 의미가 있다.