• Smart Media Journal
• /
• v.10 no.3
• /
• pp.48-53
• /
• 2021

The authentication process is a key step that should be used to verify that a user is legitimate, and it should be used to verify that a user is a legitimate user and grant access only to that user. Recently, two-factor authentication and OTP schemes are used by most applications to add a layer of security to the login process and to address the vulnerability of using only one factor for authentication, but this method also allows access to user accounts without permission. This is a known security vulnerability. In this paper, we propose a Zero Knowledge Proofs (ZKP) personal information authentication scheme based on a Smart Contract of a block chain that authenticates users with minimal personal information exposure conditions. This has the advantage of providing many security technologies to the authentication process based on blockchain technology, and that personal information authentication can be performed more safely than the existing authentication method.

• Animal Bioscience
• /
• v.34 no.2
• /
• pp.312-319
• /
• 2021

Objective: Stress-induced cytotoxicity caused by xenobiotics and endogenous metabolites induces the production of reactive oxygen species and often results in damage to cellular components such as DNA, proteins, and lipids. The cytochrome P450 (CYP) family of enzymes are most abundant in hepatocytes, where they play key roles in regulating cellular stress responses. We aimed to determine the effects of the antioxidant compound, methylsulfonylmethane (MSM), on oxidative stress response, and study the cytochrome P450 family 3 subfamily A (CYP3A) gene expression in fetal horse hepatocytes. Methods: The expression of hepatocyte markers and CYP3A family genes (CYP3A89, CYP3A93, CYP3A94, CYP3A95, CYP3A96, and CYP3A97) were assessed in different organ tissues of the horse and fetal horse liver-derived cells (FHLCs) using quantitative reverse transcription polymerase chain reaction. To elucidate the antioxidant effects of MSM on FHLCs, cell viability, levels of oxidative markers, and gene expression of CYP3A were investigated in H2O2-induced oxidative stress in the presence and absence of MSM. Results: FHLCs exhibited features of liver cells and simultaneously maintained the typical genetic characteristics of normal liver tissue; however, the expression profiles of some liver markers and CYP3A genes, except that of CYP3A93, were different. The expression of CYP3A93 specifically increased after the addition of H2O2 to the culture medium. MSM treatment reduced oxidative stress as well as the expression of CYP3A93 and heme oxygenase 1, an oxidative marker in FHLCs. Conclusion: MSM could reduce oxidative stress and hepatotoxicity in FHLCs by altering CYP3A93 expression and related signaling pathways.

• Journal of Korean Society on Water Environment
• /
• v.36 no.6
• /
• pp.568-580
• /
• 2020

Calibrating a conceptual hydrologic model necessitates selection of a calibration period that produces the most reliable prediction. This often must be chosen randomly, however, since there is no objective guidance. Observation plays the most important role in the calibration or uncertainty evaluation of hydrologic models, in which the key factors are the length of the data and the hydro-climate conditions in which they were collected. In this study, we investigated the effect of the calibration period selected on the predictive performance and uncertainty of a model. After classifying the inflows of the Hapcheon Dam from 1991 to 2019 into four hydro-climate conditions (dry, wet, normal, and mixed), a conceptual hydrologic partitioning model was calibrated using data from the same hydro-climate condition. Then, predictive performance and post-parameter statistics were analyzed during the verification period under various hydro-climate conditions. The results of the study were as follows: 1) Hydro-climate conditions during the calibration period have a significant effect on model performance and uncertainty, 2) calibration of a hydrologic model using data in dry hydro-climate conditions is most advantageous in securing model performance for arbitrary hydro-climate conditions, and 3) the dry calibration can lead to more reliable model results.

• The Journal of the Institute of Internet, Broadcasting and Communication
• /
• v.21 no.3
• /
• pp.15-21
• /
• 2021

The type of crimes is diverse and the number of crimes is increasing as society changes. This phenomenon is showing a higher trend in places with higher population density. Accordingly, many organizations install CCTV to reduce crime and provide key evidence of crime. Nevertheless, it is still weak to deal with crimes such as video manipulation targeting CCTV. Although blockchain-based CCTV image integrity techniques are applied to prevent manipulation, they only guarantee the manipulation integrity of the entire video and can't explain how certain sections of the video has been manipulated. Therefore, in this research, we propose a system for supporting explainable CCTV video integrity based on a block chain.

• Journal of the Korea Institute of Information Security & Cryptology
• /
• v.17 no.1
• /
• pp.139-144
• /
• 2007

A broadcast authentication is important and fundamental consideration for security in wireless sensor networks. Perigg et al suggests ${\mu}-TESLA$ used a key chain. But it is unavoidable the delay of time to authenticate packets. so it is hard to meet the property that most application of sensor are performed in real-time. To cope with these problems we propose an efficient broadcast authentication scheme which has no delay of time and provides re-keying mechanism. we also describe an analysis of security and efficiency for this scheme.

• Journal of Nutrition and Health
• /
• v.54 no.4
• /
• pp.335-341
• /
• 2021

Purpose: Muscle mitochondria play a key role in regulating fatty acid and glucose metabolism. Dysfunction of muscle mitochondria is associated with metabolic diseases such as obesity and type 2 diabetes. Isorhamnetin (ISOR), also known as 3-O-methylquercetin, a quercetin metabolite, is a naturally occurring flavonoid in many plants. This study evaluated the effects of ISOR on the regulation of the mitochondrial function of C2C12 muscle cells. Methods: C2C12 muscle cells were differentiated for 5 days, and then treated in various concentrations of ISOR. Cytotoxicity was determined by assessing cell viability using the water-soluble tetrazolium salt-8 assay principle at different concentrations of ISOR and time points. Levels of the mitochondrial DNA (mtDNA) content and gene expression were measured by quantitative real-time polymerase chain reaction. The citrate synthase (CS) activity was quantified by the enzymatic method. Results: ISOR at a concentration of 10 µM did not show any cytotoxic effects. ISOR increased the mtDNA copy number in a time- or dose-dependent manner. The messenger RNA levels of genes involved in mitochondrial function, such as peroxisome proliferator-activated receptor-γ coactivator-1α, and uncoupling protein 3 were significantly stimulated by the ISOR treatment. The CS activity was also significantly increased in a time- or dose-dependent manner. Conclusion: These results suggest that ISOR enhances the regulation of mitochondrial function, which was at least partially mediated via the stimulation of the mtDNA replication, mitochondrial gene expression, and CS activity in C2C12 muscle cells. Therefore, ISOR may be useful as a potential food ingredient to prevent metabolic diseases-associated muscle mitochondrial dysfunction.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.13 no.1
• /
• pp.405-430
• /
• 2021

Production planning is a key part of production management of manufacturing enterprises. Since computerization began, modern production planning has been developed starting with Material Requirement Planning (MRP), and today Enterprise Resource Planning (ERP), Advanced Planning and Scheduling (APS), Supply Chain Management (SCM) has been spreading and advanced. However, in the shipbuilding field, rather than applying these general-purpose production planning methodologies, in most cases, each shipyard has developed its own production planning system. This is because the applications of general-purpose production planning methods are limited due to the order-taking industry such as shipbuilding with highly complicated construction process consisting of millions of parts per ship. This study introduces the design and development of the production planning system reflecting the production environment of heavy shipyards in Korea. Since Korean shipyards such as Hyundai, Daewoo and Samsung build more than 10 ships per year (50-70 ships in the case of large shipyards), a planning system for the mixed production with complex construction processes is required. This study draws requirements using PI/BPR (process innovation and business process reengineering) methodology to develop a production planning system for shipyards that simultaneously build several ships. Then, CBD software development methodology was applied for the design and implementation of planning system with drawn requirements. It is expected that the systematic development procedure as well as the requirements and functional elements for the development of the shipyard production planning system introduced in this study will be able to present important guidelines in the related research field of shipbuilding management.

• Journal of Digital Convergence
• /
• v.20 no.4
• /
• pp.791-797
• /
• 2022

Through recent metaverse marketing case studies, success factors and activation methods were analyzed from the perspective of content, platform, network, and device of the metaverse ecosystem in each industry. The importance of contents and platform of metaverse could be found in entertainment, fashion, office space and real estate, education, advertisement and commerce industries. In order to vitalize the metaverse, firstly, it is necessary to strengthen active participation and retention by providing a stable revenue model for market participants. Secondly, the importance of attractive content to expand subscribers is a key trigger for metaverse activation. Thirdly, it is necessary to increase the convenience of using metaverse service by using a light and simple device for the user. Fourthly, a win-win cooperation strategy should be supported in the value chain of the industry through ecosystem scalability. In addition, business opportunities for market participants and additional revenue models should be continuously provided.

• Animal Bioscience
• /
• v.35 no.8
• /
• pp.1129-1140
• /
• 2022

Objective: With improvements in living standards and increase in global population, the demand for meat products has been increasing; improved meat production from livestock could effectively meet this demand. In this study, we examined the differences in the muscle traits of different male crossbred sheep and attempted to identify key genes that regulate these traits. Methods: Dubo sheep×small-tailed Han sheep (DP×STH) and Suffolk×small-tailed Han sheep (SFK×STH) were selected to determine meat quality and production performance by Masson staining. Transcriptome sequencing and bioinformatic analysis were performed to identify differentially expressed genes (DEGs) related to meat quality. The presence of DEGs was confirmed by real-time polymerase chain reaction. Results: The production performance of SFK×STH sheep was better than that of DP×STH sheep, but the meat quality of DP×STH sheep was better than that of SFK×STH sheep. The muscle fiber diameter of DP×STH sheep was smaller than that of SFK×STH sheep. Twenty-two DEGs were identified. Among them, four gene ontology terms were related to muscle traits, and three DEGs were related to muscle or muscle fibers. There were no significant differences in the number of single nucleotide mutations and mutation sites in the different male parent cross combinations. Conclusion: This study provides genetic resources for future sheep muscle development and cross-breeding research.

• Journal of Animal Science and Technology
• /
• v.64 no.4
• /
• pp.792-799
• /
• 2022

Dopamine (DA) is known to be a key modulator of animal behaviors. Thus, the plasma concentration of DA might be used as a biomarker for the behavioral characteristics of horses. The behavioral characteristics of horses vary depending on the breed, age, and sex. Moreover, the DA receptor genotypes are also related to horse behaviors. Thus, the aim of this study was to investigate the DA concentration variations of horse plasma by breed, age, sex, or genotype of its receptor. The horses were divided by breed into Thoroughbred (n = 13), Pony (n = 9), Warmblood (n = 4), and Haflinger (n = 5). The age variable was divided into three different groups: post-pubertal (2-5 years, n = 6), adult (6-13 years, n = 19), and aged horses (15-24 years, n = 6). The sex variable was divided into geldings (n = 8) and mares (n = 23). Approximately 10 mL of blood was collected, and an ELISA kit was used to measure the plasma concentration of DA. Polymerase chain reaction analysis was performed to identify the genetic variation in the DA D4 receptor gene (DRD4). SPSS statistical software was used for statistical analysis. The DA concentrations in geldings were significantly lower than those in mares. There was no significant difference in DA concentrations among breed and age groups. Horses with the GG and GA genotypes had significantly higher plasma concentrations of DA compared to horses with the AA genotype for the G292A gene. Briefly, the plasma concentration of DA varied depending on the sex and genotype of G292A. These factors should be considered when the concentration of DA is used as a biomarker for the behavioral characteristics of horses. In conclusion, the DA concentration or DRD4 genotype of horse plasma has the potential to be used as a biomarker that can predict the behavioral characteristics of horses.