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Aerobic Exercise Ameliorates Muscle Atrophy Induced by Methylglyoxal via Increasing Gastrocnemius and Extensor Digitorum Longus Muscle Sensitivity

  • Seong-Min Hong;Eun Yoo Lee;Jinho Park;Jiyoun Kim;Sun Yeou Kim
    • Biomolecules & Therapeutics
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    • v.31 no.5
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    • pp.573-582
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    • 2023
  • Muscle atrophy is characterized by the loss of muscle function. Many efforts are being made to prevent muscle atrophy, and exercise is an important alternative. Methylglyoxal is a well-known causative agent of metabolic diseases and diabetic complications. This study aimed to evaluate whether methylglyoxal induces muscle atrophy and to evaluate the ameliorative effect of moderate-intensity aerobic exercise in a methylglyoxal-induced muscle atrophy animal model. Each mouse was randomly divided into three groups: control, methylglyoxal-treated, and methylglyoxal-treated within aerobic exercise. In the exercise group, each mouse was trained on a treadmill for 2 weeks. On the last day, all groups were evaluated for several atrophic behaviors and skeletal muscles, including the soleus, plantaris, gastrocnemius, and extensor digitorum longus were analyzed. In the exercise group, muscle mass was restored, causing in attenuation of muscle atrophy. The gastrocnemius and extensor digitorum longus muscles showed improved fiber cross-sectional area and reduced myofibrils. Further, they produced regulated atrophy-related proteins (i.e., muscle atrophy F-box, muscle RING-finger protein-1, and myosin heavy chain), indicating that aerobic exercise stimulated their muscle sensitivity to reverse skeletal muscle atrophy. In conclusion, shortness of the gastrocnemius caused by methylglyoxal may induce the dynamic imbalance of skeletal muscle atrophy, thus methylglyoxal may be a key target for treating skeletal muscle atrophy. To this end, aerobic exercise may be a powerful tool for regulating methylglyoxal-induced skeletal muscle atrophy.

Determining Behavioral Intention of Logistic and Distribution Firms to Use Electric Vehicles in Thailand

  • Somsit DUANGEKANONG
    • Journal of Distribution Science
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    • v.21 no.5
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    • pp.31-41
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    • 2023
  • Purpose: Electric vehicle (EV) technology started in 2015 in Thailand. The Thai Government has indicated that 30% of all cars produced in Thailand by 2025 will be EVs. Using EVs in Thailand will reduce road pollution and increase energy efficiency, especially in major cities. Hence, the adoption of EVs in the country has been promoted. This study pointed out that social influence, facilitating conditions, perceived enjoyment, environmental concern, attitude, and perceived behavioral control are key factors affecting the behavioral intention to adopt EVs among logistic and distribution firms in Thailand. Research design, data, and methodology: 500 top management, middle management and purchasing managers of logistic and distribution firms in Thailand are surveyed. The study employed judgmental, convenience, and snowball sampling. Confirmatory Factor Analysis (CFA) and Structural Equation Model (SEM) are the main statistical tools for data analysis. Results: The results show that all determinants impact customers' willingness to adopt EVs, except perceived enjoyment and environmental control. Conclusions: The study proposes to promote the incentives by decreasing electricity prices and endorsing EVs purchase to accelerate the adoption of EVs in Thailand. Therefore, future policies should focus on behavioral intention toward EVs amongst logistic and distribution firms for enhancing the future of mobility in Thailand.

A Study on the Restructuring Global Production Space of Korean Rechargeable Battery Companies (한국 이차전지기업의 글로벌 생산공간 재구성 연구)

  • Ja-Yeong Choe
    • Journal of the Economic Geographical Society of Korea
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    • v.25 no.4
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    • pp.499-513
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    • 2022
  • This study targets the rechargeable battery industry, which has been rapidly growing recently. The rechargeable battery industry is closely related to the electric vehicle industry. However, other factors also influence it. Currently, rechargeable battery companies show a pattern of restructuring production space by various means. To determine the causes of these production spaces, the factors affecting regional and national scales were thoroughly examined. As a result, the location factors for rechargeable battery-related companies are determined by cooperative relationships with assembled car companies, government policy regulations, and the stability of supply of key materials. And a spatial strategy was implemented to make the most of these circumstances.

The Importance of Green Fashion Product Development to Improve Consumers' Environmental Awareness

  • Suk-Kyung YANG
    • East Asian Journal of Business Economics (EAJBE)
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    • v.11 no.2
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    • pp.29-38
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    • 2023
  • Purpose - The current study aims to learn how fashion consumers now feel about environmental issues. The significance of "green fashion product creation" in resolving environmental issues is explored. It also examines how customers' environmental consciousness has evolved due to the introduction of green fashion products. Research design, data, and methodology - The study methods, procedures, and results of the 16 publications included in this literature review were critically examined. The data sources, analyses, and key findings presented in each publication were compared and contrasted. To better understand how to raise environmental consciousness among customers. Result - The investigation indicates a total of four results why eco-friendly product should be developed to attract potential green consumers. Four solutions are as follows; (1) Encourages Sustainable Consumption Behavior, (2) Increases Consumer Environmental Awareness, (3) Improves Corporate Social Responsibility, and (4) Enhances Competitive Advantage. Conclusion - Promoting sustainability in the fashion sector requires full visibility throughout the supply chain. Companies in the fashion industry would serve their customers better if they were more forthcoming about the resources, methods, and circumstances that went into making their wares. Consumers may accomplish this by including instructions on the packaging or posting them on the business's website.

Kennicutt-Schmidt law with H I velocity profile decomposition in NGC 6822

  • Park, Hye-Jin;Oh, Se-Heon;Wang, Jing;Zheng, Yun;Zhang, Hong-Xin;de Blok, W.J.G.
    • The Bulletin of The Korean Astronomical Society
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    • v.46 no.1
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    • pp.32.3-33
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    • 2021
  • We present H I gas kinematics and star formation activities of NGC 6822, a dwarf galaxy located in the Local Volume at a distance of ~ 490 kpc. We perform profile decomposition of the line-of-sight velocity profiles of the high-resolution (42.4" × 12" spatial; 1.6 km/s spectral) H I data cube taken with the Australia Telescope Compact Array (ATCA). For this, we use a new tool, the so-called BAYGAUD (BAYesian GAUssian Decompositor) which is based on Bayesian Markov Chain Monte Carlo (MCMC) techniques, allowing us to decompose a line-of-sight velocity profile into an optimal number of Gaussian components in a quantitative manner. We classify the decomposed H I gas components of NGC 6822 into bulk-narrow, bulk-broad, and non_bulk with respect to their velocity and velocity dispersion. We correlate their gas surface densities with the surface star formation rates derived using both GALEX far-ultraviolet and WISE 22 micron data to examine the impact of gas turbulence caused by stellar feedback on the Kennicutt-Schmidt (K-S) law. The bulk-narrow component that resides within r25 is likely to follow the linear extension of the Kennicutt-Schmidt (K-S) law for molecular hydrogen (H2) at the low gas surface density regime where H I is not saturated.

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MAGRU: Multi-layer Attention with GRU for Logistics Warehousing Demand Prediction

  • Ran Tian;Bo Wang;Chu Wang
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.18 no.3
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    • pp.528-550
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    • 2024
  • Warehousing demand prediction is an essential part of the supply chain, providing a fundamental basis for product manufacturing, replenishment, warehouse planning, etc. Existing forecasting methods cannot produce accurate forecasts since warehouse demand is affected by external factors such as holidays and seasons. Some aspects, such as consumer psychology and producer reputation, are challenging to quantify. The data can fluctuate widely or do not show obvious trend cycles. We introduce a new model for warehouse demand prediction called MAGRU, which stands for Multi-layer Attention with GRU. In the model, firstly, we perform the embedding operation on the input sequence to quantify the external influences; after that, we implement an encoder using GRU and the attention mechanism. The hidden state of GRU captures essential time series. In the decoder, we use attention again to select the key hidden states among all-time slices as the data to be fed into the GRU network. Experimental results show that this model has higher accuracy than RNN, LSTM, GRU, Prophet, XGboost, and DARNN. Using mean absolute error (MAE) and symmetric mean absolute percentage error(SMAPE) to evaluate the experimental results, MAGRU's MAE, RMSE, and SMAPE decreased by 7.65%, 10.03%, and 8.87% over GRU-LSTM, the current best model for solving this type of problem.

Online Music Distribution Strategy to Develop the future Hallyu Music Industry

  • Woo-Jun JANG;Min-Ho CHANG
    • Journal of Distribution Science
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    • v.22 no.6
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    • pp.115-122
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    • 2024
  • Purpose: The main aim of this study is to analyze and suggest new online music distribution models targeted to facilitate the development of the Korean Wave (Hallyu) music market in all locations of the world. This study is conducted through a close analysis of the prevailing distribution models, the unique challenges of the K-pop market, and the trends in new technologies. Research design, data and methodology: To address the issue of how the online music distribution market could be domesticated for the Korean music industry, a systematic review of the previous studies was conducted. The use of the PRISMA approach was followed so that an accurate and transparent method for choosing the studies is ensured. Results: According to the investigation of literature analysis, the online distribution strategy may consist of four key plannings as follows, 1. Leveraging Social Media and User-Generated Content Platforms, 2. Embracing Immersive and Interactive Experiences, 3. Fostering Direct-to-Fan Connections and Monetization, 4. Harnessing Artificial Intelligence and Big Data Analytics. Conclusions: Finally, collaboration and strategic partnerships will be vital. The Korean music companies should seek to cooperate with the technology companies, social media platforms, and the global music streaming services so that they can grow their market, acquire new technologies, and to better their online distribution strategies.

IL-6-6331 (T/C, rs10499563) is Associated with Decreased Risk of Gastric Cancer in Northern Chinese

  • Yang, Li;Sun, Ming-Jun;Liu, Jing-Wei;Xu, Qian;Yuan, Yuan
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.12
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    • pp.7467-7472
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    • 2013
  • Background: Polymorphisms of genes encoding cytokines could be potential biomarkers to predict risk of gastric cancer (GC). Here, we investigated the association between the IL-6 -6331 (T/C, rs10499563) polymorphism in its promoter region and GC risk. Methods: In this case-control study of 215 GC cases and 518 non-cancer controls, the IL-6 -6331 (T/C, rs10499563) polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results: Individuals with the TC or CC genotype were associated with a significantly decreased risk of GC (OR=0.710, 95%CI: 0.504-0.999, P=0.049) compared with TT wild-type carriers. Ther C allele was also associated with significantly decreased risk of GC (OR=0.715, 95%CI: 0.536-0.954, P=0.023) compared with the T allele. In the stratification analysis, TC or CC genotypes were associated with significantly decreased GC risk in subgroups of males, people older than 60, and H. pylori-positive cases. However, no significant interaction was observed for TC or CC genotypes with H. pylori infection. On stratification with the Lauren classification, TC or CC genotypes were associated with significantly decreased risk of diffuse-type GC (OR=0.497, 95%CI: 0.266-0.925, P=0.027), also in subgroups of males, people older than 60, and H. pylori-positive cases. Conclusions: The IL-6 -6331 (T/C, rs10499563) polymorphism is associated with genetic susceptibility of GC and may have the potential to predict GC risk.

The Impact of Key Success Factors and Implementation Typology of SCM on the Business Performance -Using the Balanced Scorecard- (공급사슬관리(SCM)의 핵심성공요인과 추진유형이 기업의 경영성과에 미치는 영향 -균형성과표(BSC)를 활용한 성과측정-)

  • Lee, Jae-Sik
    • Management & Information Systems Review
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    • v.28 no.1
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    • pp.45-69
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    • 2009
  • Today, SCM is used as a important tool of management innovation for enterprise's survival and development. BSC forces managers to focus on balanced measures of business performance that are most critical. The purpose of this study is to find out the determinants of SCM adoption through the analysis which examine the relationship among the key success factors, and business performance using the BSC perspective. This study also gives the suggestion for the effective SCM implementation in the korean companies. This study has been conducted using the data collected from 107 companies implementing SCM. By analyses of the questionnaires, empirical results shows that the implementation of SCM has positive effect on organizational performance with 4 perspectives of BSC. The contribution of this study is that it provides a conceptual framework and empirical evidence of the causal relationship between key success factors, and business performance with 4 perspectives of BSC concept. This study showed that more consideration are essential to obtain balanced business performance for companies with SCM adoption plan.

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A Secure Micro-Payment Protocol based on Credit Card in Wireless Internet (무선인터넷에서 신용카드기반의 안전한 소액 지불 프로토콜)

  • Kim Seok mai;Kim Jang Hwan;Lee Chung sei
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.29 no.12C
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    • pp.1692-1706
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    • 2004
  • Recently, there are rapid development of information and communication and rapid growth of e-business users. Therefore we try to solve security problem on the internet environment which charges from wire internet to wireless internet or wire/wireless internet. Since the wireless mobile environment is limited, researches such as small size, end-to-end and privacy security are performed by many people. Wireless e-business adopts credit card WPP protocol and AIP protocol proposed by ASPeCT. WAP, one of the protocol used by WPP has weakness of leaking out information from WG which conned wire and wireless communication. certification chain based AIP protocol requires a lot of computation time and user IDs are known to others. We propose a Micro-Payment protocol based on credit card. Our protocol use the encryption techniques of the public key with ID to ensure the secret of transaction in the step of session key generation. IDs are generated using ECC based Weil Paring. We also use the certification with hidden electronic sign to transmit the payment result. The proposed protocol solves the privacy protection and Non-repudiation p개blem. We solve not only the safety and efficiency problem but also independent of specific wireless platform. The protocol requires the certification organization attent the certification process of payment. Therefore, other domain provide also receive an efficient and safe service.