• Journal of Microbiology and Biotechnology
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• 제29권1호
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• pp.160-170
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• 2019

The lactic acid bacteria species Lactobacillus plantarum (L. plantarum) has been used extensively for vaccine delivery. Considering to the critical role of dendritic cells in stimulating host immune response, in this study, we constructed a novel CD11c-targeting L. plantarum strain with surface-displayed variable fragments of anti-CD11c, single-chain antibody (scFv-CD11c). The newly designed L. plantarum strain, named 409-aCD11c, could adhere and invade more efficiently to bone marrow-derived DCs (BMDCs) in vitro due to the specific interaction between scFv-CD11c and CD11c located on the surface of BMDCs. After incubation with BMDCs, the 409-aCD11c strain harboring a eukaryotic vector pValac-GFP could lead to more efficient expression of GFP compared with wild-type strains shown by flow cytometry analysis, indicating the enhanced translocation of pValac-GFP from L. plantarum to BMDCs. Similar results were also observed in an in vivo study, which showed that oral administration resulted in efficient expression of GFP in both Peyer's patches (PP) and mesenteric lymph nodes (MLNs) within 7 days after the last administration. In addition, the CD11c-targeting strain significantly promoted the differentiation and maturation of DCs, the differentiation of $IL-4^+$ and $IL-17A^+$ T helper (Th) cells in MLNs, as well as production of $B220^+$ $IgA^+$ B cells in the PP. In conclusion, this study developed a novel DC-targeting L. plantarum strain which could increase the ability to deliver eukaryotic expression plasmid to host cells, indicating a promising approach for vaccine study.

• 통상정보연구
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• 제12권2호
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• pp.3-27
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• 2010

This paper covers a plan to build supply chain cooperation systems among stream of the textile industry to strengthen international competitiveness. To obtain the study objective, it has been reviewed the theoretical rationale relating to organizational cooperation model and discussion and performed the case study that analyzed stream group and participated firms to the textile stream policy project. The analyzed stream cooperative types that measured configuration of cooperative degree and productive type are new market creation, technology improvement, relation maintenance, and relation cease. Two types - new market creation and technology improvement - have significant effect of the textile stream cooperation. Key successful factors of these two effective types are the external intervention of specialized consulting organization and build internal coordination and integrated mechanism to the cooperative stream group and participated firms.

• Journal of Information Technology Applications and Management
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• 제17권1호
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• pp.141-155
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• 2010

We develop an intelligent information system in a multilayer electronic supply chain network. Using the internet for supply chain management (SCM) is a key interest for contemporary managers and researchers. It has been realized that the internet can facilitate SCM by making real time information available and enabling collaboration between trading partners. Here, we propose a multi-agent system to analyze the performance of the elements of a supply network based on the attributes of the information flow. Each layer consists of elements which are differentiated by their performance throughout the supply network. The proposed agents measure and record the performance flow of elements considering their web interactions for a dynamic route selection. A dynamic programming approach is applied to determine the optimal route for a customer in the end-user layer.

• Industrial Engineering and Management Systems
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• 제16권1호
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• pp.44-51
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• 2017

In today's competitive environment, supply chain management is a major concern for a company. Two of the key issues in supply chain management are transportation and inventory management. To achieve significant savings, companies should integrate these two issues instead of treating them separately. In this paper we develop a framework for modeling stochastic programming in a supply chain that is subject to demand uncertainty. With reasonable assumptions, two stochastic programming models are presented, respectively, including a single-period and a multi-period situations. Our assumptions allow us to capture the stochastic nature of the problem and translate it into a deterministic model. And then, based on the genetic algorithm and stochastic simulation, a solution method is developed to solve the model. Finally, the computational results are provided to demonstrate the effectiveness of our model and algorithm.

• 한국산업정보학회논문지
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• 제23권3호
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• pp.117-129
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• 2018

This study examines the impact of severe weather on lean supply chains. First, this paper reviewed the literature on the disruptions and damages that severe weather events cause on supply chain. Then, several recent examples of lean supply chain disruptions due to severe weather were discussed. The results of the study indicated that the frequency of weather related disasters is increasing and extreme weather events will increase potential risks to supply chains. First, building organizational resilience will help firms look beyond efficiency and profits in managing lean supply chains. Second, the concept of sole sourcing may need rethinking to maintain a supply chain that is lean and resilient. Third, organizations must plan ahead for supply chains in unpredictable weather. Fifth, communication is a key for anticipating and avoiding the impact of severe weather. This study proposes of a set of strategies, both theoretical and practical, that business firms should develop to effectively prevent and respond to severe weather related disruptions in lean supply chains.

• 해양환경안전학회지
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• 제18권3호
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• pp.261-266
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• 2012

공급 체인 관리 및 물류 개발에 RFID 기술에 대한 국제적 적용에 대한 분석과 향후 활성화 방안에 대하여 연구를 수행하였다. 국제 물류의 RFID의 최근 응용 프로그램을 연구 분석하고 제조업체, 보관업체, 물류업체, 운송업체, 항만 및 유통업체간의 RFID 채택 및 사용의 핵심 요소를 범국가적, 국제적 물류체인과 연계하여 필요한 내용을 분석하고 국내에 필요한 요소 및 방안에 대하여 연구 기술하였다.

• 정보와 통신
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• 제20권11호
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• pp.1550-1559
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• 2003

The convergence of fixed and wireless networks in data communication is providing the necessary driver for M2M commerce to take-off. The opportunities provided by M2M Commerce areonly limited by imagination. Automotive Fleet and Freight, Tolling, Water and Power Metering, Supply Chain Management including Asset Management, Remote Monitoring and Diagnostics, Energy Management and Access Control and Security are among the many M2M applications that are currently getting rolled out. ARC Group expects the worldwide solutions market to be worth in excess of US$ 100 billion by 2007. In addition, operator revenues worldwide from the transport of Telematics data alone will rise from US$ 3.5 billion in 2002 to US$ 78 billion by 2007. This paper discusses some of the lifestyle and business opportunities provided by M2M Commerce in the new ear of network convergence. It also provides some case studies to demonstrate the benefits of M2M Commerce across the supply chain. The key focus of the paper is on achieving enhanced lifestyle, cost reduction, improved profitability and enhanced customer relationship management through M2M Commerce.

• 경영정보학연구
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• 제3권1호
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• pp.191-203
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• 2001

The purpose of this research is to investigate success factors for supply chain management. According to the statistical analysis of 98 survey data, we find that the success factors mentioned in this literature(Supplier-Buyer relations, Inter-organizational Coordination, Planning & Control, Information Technology) positively affect the corporate performance. This research also indicates that supply chain management should be implemented according to dependent industrial characteristics and external conditions. We used three key environmental factors: (1) The product exchanged and its technology, (2) the competitive condition in downstream market, (3) capabilities of the suppliers available.

• 한국산학기술학회논문지
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• 제10권3호
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• pp.560-566
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• 2009

저전력 RFID 시스템은 무선 주파수를 이용하여 물리적인 접촉 없이 사물에 대한 정보를 읽거나 기록하는 자동인식 기술이다. 이 시스템은 무선 주파수와 RFID 태그 사용으로 불법적인 위변조, 도청, 추적, 프라이버시 침해 등은 불가피하다 따라서 본 논문에서는 태그와 데이터베이스간에 해시 체인을 이용하여 키를 생성하는데 이를 통해 공격자는 위의 공격을 수행할 수 없다. 또한 계산 량을 줄이기 위해 해시 함수를 이용하여 효율성을 높였다.

• 한국정보과학회:학술대회논문집
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• 한국정보과학회 2012년도 한국컴퓨터종합학술대회논문집 Vol.39 No.1(C)
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• pp.286-288
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• 2012

Facing the counterfeiting acts towards various products, many manufacturers implement ePedigree system to secure their supply chain. Using ePedigree, a distribution history including a valid product identifier from the manufacturer until the final retailer is recorded. And this ePedigree is signed by each involved supply chain party using digital signature. With this digital signature, any unauthorized alteration to the ePedigree document would generate a failed verification process. If there is a counterfeit product using a fake ePedigree document, it wouldn't be able to pass the verification process either. Hence, there wouldn't be any counterfeit product that could enter the legal supply chain and bought by the consumer. We are proposing to use ECDSA instead of RSA since it has faster performance and shorter key size. At a certain same security level, ECDSA only needs 163 bits, while RSA needs 1024 bits.