• Journal of the Korean Society of Safety
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• v.29 no.2
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• pp.98-105
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• 2014

Biosafety has become quite sensitive issues according to dramatic development of biotechnology and LMO(Living Modifying Organism) is one of the key issue in biosafety. This study is an exploratory research for investigating the activation strategy of biosafety training management in LMO research field. Based on the survey data, main results are derived through various statistical analysis methodology such as descriptive analysis, factor analysis, reliability analysis, analysis of variance and regression analysis. According to the analysis results, some activation strategies are required to reach the target such as extension of specialized biosafety training program, enhancement of safety consciousness from the undergraduate courses, introduction of appropriate safety regulations, unification of safety management and establishment of safety management system.

• BMB Reports
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• v.42 no.3
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• pp.131-135
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• 2009

MicroRNAs control gene expression by inhibiting translation or promoting degradation of their target mRNAs. Since the discovery of the first microRNAs, lin-4 and let-7, in C. elegans, hundreds of microRNAs have been identified as key regulators of cell fate determination, lifespan, and cancer in species ranging from plants to humans. However, while microRNAs have been shown to be particularly abundant in the brain, their role in the development and activity of the nervous system is still largely unknown. In this review, we describe recent advances in our understanding of microRNA function at synapses, the specialized structures required for communication between neurons and their targets. We also propose how these advances might inform the molecular model of memory.

• Journal of Communications and Networks
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• v.14 no.3
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• pp.243-251
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• 2012

Under the power-based capture model, a transmission is successfully received at the destination, even in the presence of other transmissions and background noise, if the received signal-to-interference-plus-noise ratio exceeds a capture threshold. We evaluate the spectral efficiency of simple multi-user channels by combining the basic capture model with a communication-theoretic model. The result is a more refined capture model that incorporates key system design parameters (such as achievable bit rate, target bit error rate, channel bandwidth, and modulation signal constellations) that are absent from the basic capture model. The relationships among these parameters can serve as a tool for optimizing the network performance.

• Molecules and Cells
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• v.39 no.12
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• pp.847-854
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• 2016

The early landmark discoveries in cancer metabolism research have uncovered metabolic processes that support rapid proliferation, such as aerobic glycolysis (Warburg effect), glutaminolysis, and increased nucleotide biosynthesis. However, there are limitations to the effectiveness of specifically targeting the metabolic processes which support rapid proliferation. First, as other normal proliferative tissues also share similar metabolic features, they may also be affected by such treatments. Secondly, targeting proliferative metabolism may only target the highly proliferating "bulk tumor" cells and not the slowergrowing, clinically relevant cancer stem cell subpopulations which may be required for an effective cure. An emerging body of research indicates that altered metabolism plays key roles in supporting proliferation-independent functions of cancer such as cell survival within the ischemic and acidic tumor microenvironment, immune system evasion, and maintenance of the cancer stem cell state. As these aspects of cancer cell metabolism are critical for tumor maintenance yet are less likely to be relevant in normal cells, they represent attractive targets for cancer therapy.

• Bulletin of the Korean Chemical Society
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• v.35 no.10
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• pp.2990-2994
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• 2014

The studies on design and synthesis of new monocyclic ${\beta}$-lactam esters 4(R/S)-(1'-methoxycarbonylpropyl- 2'(R/S)-thio)-3(R)-phenylacetamidoazetidin-2-one (3a) and 4(R/S)-(1'-methoxycarbonyl-2'-methylpropyl-2'- thio)-3(R)-phenylacetamidoazetidin-2-one (3b) were described. Compounds 3a and 3b were specifically designed to retain all penicillin substructures except the bicyclic system, which would be conceived by cleaving the C(3)-N(4) bond of penicillin G. Compounds 3a and 3b are of particular interest in the context of the structural elucidation of monocyclic ${\beta}$-lactams originated from penicillin. Key intermediates, ${\beta}$-mercapto esters 6a and 6b, were synthesized from conjugate acids 4a and 4b using three-step synthetic sequences, respectively, and 4(S)-acetoxy-3(S)-phenylacetamidoazetidin-2-one (7) was obtained from the degradation of penicillin G. Reactions of 6a and 6b with 7, thus obtained, provided the target compounds 3a and 3b, respectively.

• Current Optics and Photonics
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• v.2 no.4
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• pp.308-314
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• 2018

Visible light communication (VLC) is considered a strong future candidate for indoor wireless communication. However, its performance seems to be relatively unsatisfactory when compared to wireless local area network (WLAN) communication using millimeter waves. To improve the performance of VLC, numerous technologies have been proposed so far, in both electrical and optical domains. Among the proposals, optical beamforming (OB) is an optical-domain technology that can concentrate light in a specific direction or on a target spot. It can significantly improve VLC performance and can be widely used, because it does not depend on electrical modulation schemes. Therefore, this review discusses the concept, principle, and types of OB, the structure of a VLC system using OB, performance results of OB, and the combination of OB with electrical signal modulation in VLC. OB is expected to be one of the key techniques in future VLC implementations, similar to radio-frequency beamforming in millimeter-wave communication.

• ETRI Journal
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• v.40 no.1
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• pp.89-100
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• 2018

Millimeter wave communication is one of the main disruptive technologies in upcoming 5G mobile networks. One of the first candidate applications, which will be commercially ready by 2020, is wireless backhaul links or wireless last mile communication. This paper provides an analysis of this use-case from radio engineering and implementation perspectives. Furthermore, preliminary experimental results are shown for a proof-of-concept wireless backhaul solution developed within the EU-KR 5GCHAMPION project, which will be showcased during the 2018 Winter Olympic Games in Korea. In this paper, we verify system level calculations and a theoretical link budget analysis with conductive and radiated over-the-air measurements. The results indicate that the implemented radio solution is able to achieve the target key performance indicator, namely, a 2.5 Gbps data rate on average, over a range of up to 200 m.

• Childhood Kidney Diseases
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• v.27 no.1
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• pp.1-10
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• 2023

Pediatric nephrotic syndrome (NS) is a clinical syndrome characterized by massive proteinuria, hypoalbuminemia, and generalized edema. Most childhood NS cases are idiopathic (with an unknown etiology). Traditional therapeutic approaches based on immunosuppressive agents largely support the key role of the immune system in idiopathic NS (INS), especially in the steroid-sensitive form. Although most previous studies have suggested the main role of T cell dysfunction and/or the abnormal secretion of certain glomerular permeability factors, recent studies have emphasized the role of B cells since the therapeutic efficacy of B cell depletion therapy in inducing and/or maintaining prolonged remission in patients with INS was confirmed. Furthermore, several studies have detected circulating autoantibodies that target podocyte proteins in a subset of patients with INS, suggesting an autoimmune-mediated etiology of INS. Accordingly, a new therapeutic modality using B cell-depleting drugs has been attempted, with significant effects in a subset of patients with INS. Currently, INS is considered an immune-mediated disorder caused by a complex interplay between T cells, B cells, soluble factors, and podocytes, which may vary among patients. More in-depth investigations of the pathogenic pathways of INS are required for an effective personalized therapeutic approach and to define precise targets for therapeutic intervention.

• New & Renewable Energy
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• v.20 no.1
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• pp.26-37
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• 2024

Renewable energy sources play a key role in achieving carbon neutrality and zero net emissions in the power generation sector. Various efforts have been made to support the deployment of renewable energy, particularly solar photovoltaic and wind power, including policies to internalize the external cost of carbon emissions. In this study, we conducted a financial analysis of a 800 MW floating photovoltaic system and compared it with ground solar power generation. Additionally, we conducted a cost-benefit analysis that included the social cost of carbon. The findings showed that the floating photovoltaic project can meet the profitability target through an appropriately designed internalization of the social cost of carbon.

• New & Renewable Energy
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• v.20 no.1
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• pp.110-115
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• 2024

Global sustainable energy needs and carbon neutrality goals make hydrogen a key future energy source. South Korea and Japan lead with proactive hydrogen policies, including South Korea's Hydrogen Law and Japan's strategy updates aiming for a hydrogen-centric society by 2050. A notable advance is the solar thermal chemical water-splitting cycle for green hydrogen production, spotlighted by Korea Institute of Energy Research (KIER) and Niigata University's joint initiative. This method uses solar energy to split water into hydrogen and oxygen, offering a carbon-neutral hydrogen production route. The study focuses on international collaboration in solar energy for thermochemical water-splitting and E-fuel production, highlighting breakthroughs in catalyst and reactor design to enhance solar thermal technology's commercial viability for sustainable fuel production. Collaborations, like ARENA in Australia, target global carbon emission reduction and energy system sustainability, contributing to a cleaner, sustainable energy future.