• Molecules and Cells
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• v.26 no.4
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• pp.350-355
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• 2008

Chk2 is a well characterized protein kinase with key roles in the DNA damage response. Chk2 is activated by phosphorylation following DNA damage, and relays that signal to various substrate proteins to induce cell cycle arrest, DNA repair, and apoptosis. In order to identify novel components of the Chk2 signaling pathway in Drosophila, we screened 2,240 EP misexpression lines for dominant modifiers of an adult rough eye phenotype caused by Chk2 overexpression in postmitotic cells of the eye imaginal disc. The rough eye phenotype was suppressed by mutation of the ATM kinase, a well-described activator of Chk2. Twenty-five EP modifiers were identified (three enhancers and 22 suppressors), none of which correspond to previously known components of Chk2 signaling. Three EPs caused defects in G2 arrest after irradiation with incomplete penetrance when homozygous, and are likely directly involved in the response to DNA damage. Possible roles for these modifiers in the DNA damage response and Chk2 signaling are discussed.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.5
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• pp.58-63
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• 2018

Recently in weapon systems development, the importance of reliability has been emphasized due to the increase in complexity and the rapid development of key components and components. Accordingly, the importance of lifespan testing is increased. However, lifespan testing to verify the reliability of a system is costly and takes a lot of time. Therefore in this paper, it was demonstrated that the most critical item of a bladder type accumulator is the bladder. Fatigue life is sensitive to temperature and pressure, with temperature having more impact. The fatigue life of the bladder was estimated to be 18,140 hr through fatigue analysis, which satisfies the required life expectancy of 10,000 hr.

• Journal of the Korean Society of Industry Convergence
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• v.25 no.4_2
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• pp.603-609
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• 2022

Bottom hole assembly(BHA) is a key component of the drilling system, consisting of various components and tools(including the drill bit and mud motor) which operate at the bottom of the wellbore and physically drill the rock. This paper investigates the dynamic characteristics of the mud motor which is a drilling propulsion tool. And computational structural analysis is performed to calculate the von-Mises stress and the safety factor of components constituting the mud motor. In this process, the field test data of onshore drilling are used for analysis.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2023.05a
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• pp.142-143
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• 2023

A contact accident with gantry cranes involving the container ship MV Milano Bridge in Busan New Port took place on 6 April 2020. The report concluded that the pilot unreasonably piloted the ship with impaired maneuverability and without a proper pilotage plan. Analyzing the entire system by CAST model gives a holistic approach in linking all the key components and their roles as well as violations that led to the accident, stepping away from placing the blame on only one component in the system. Furthermore, analyzing the accident as an system theory gives a clear overview of the relationships between system components and how these interactions led to the accident.

• International Journal of Aeronautical and Space Sciences
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• v.16 no.2
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• pp.223-246
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• 2015

Structural vibration control using a piezoelectric shunt is an established control technique. This technique involves connecting a piezoelectric patch, which is bonded onto or embedded into the vibrating structure, to an electric shunt circuit. Thus, vibration energy is converted into electrical energy and is dissipated through a network of electrical components. Different configurations of shunt have been researched, among which the negative capacitance-inductance shunt has gained prominence recently. It is basically an analog, active circuit consisting of operational amplifiers and passive elements to introduce real and imaginary impedance on the vibrating structure. The present study attempts to model the behavior of a negative capacitance-inductance shunt in terms of power output and efficiency using circuit modeling software. The shunt model is validated experimentally and is used to control the structural vibration of an aluminum beam, connected to a pair of piezoelectric patches, under broadband excitation. The model is also used to determine the optimal parameters of a negative capacitance-inductance shunt to increase the efficiency and predict the voltage output limit of op-amp against the supply voltage.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.11
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• pp.1477-1486
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• 2009

Female germ cell meiotic divisions are typically asymmetric, giving rise to two daughter cells with different sizes. Spindle movements including spindle migration from the oocyte center to the cortex and spindle rotation from parallel to perpendicular (typically in the mouse) at the cortex are crucial for these asymmetric divisions and therefore are crucial for gamete production. Different regulatory mechanisms for spindle movements have been determined in different species and a wide variety of different molecular components and processes that are involved in spindle movements have also been identified in different species. Here, we review the current state of knowledge as well as our understanding of mechanisms for spindle movements in different systems with focus on three main aspects: microtubules (MT), microfilaments (MF) and molecules associated with cytoskeletal organization as well as molecules that are not directly related to the cytoskeleton. How they might interact or function independently during female meiotic divisions in different species is discussed in detail.

• Journal of Information Technology Services
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• v.8 no.2
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• pp.117-136
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• 2009

Over the years a password has been used as a popular authentication method between a client and a server because of its easy-to-memorize property. But, most password-based authentication services have focused on a same password authentication scheme which provides an authentication and key exchange between a client and a server with the same password. With rapid change of communication environments in the fields such as mobile networks, home networking, etc., the end-to-end security allowing users to hold different password is considered as one of main concerns. In this paper, we consider a new authentication service of how each client with different own password is able to authenticate each other, which is a quite new service paradigm among the existing services. This new service can be used in the current or next generation network environment where a mobile user in cell A wants to establish a secure end-to-end channel with users in ceil B, C, and D using only their memorable passwords. This end-to-end security service minimizes the interferences from the operator controlled by network components. To achieve this end-to-end security, we propose an authentication and key exchange service for group users in different realm, and analyze its security in a formal way. We also discuss a generic construction with the existing authentication schemes.

• Perspectives in Nursing Science
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• v.17 no.2
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• pp.80-89
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• 2020

Purpose: The aim of this study is to review literature on anger management intervention programs for parents published over the last 10 years and to extract the key elements of the interventions through an integrative review. Methods: This research was carried out in stages following Whittemore and Knafl's integrative literature methodology. Key words in Korean and English were used to search the PubMed, MEDLINE, EMbase, CINAHL, RISS, KISS and National Assembly Library databases. Several intervention factors were extracted from the selected papers on the basis of the framework which was helpful to identify the intervention patterns and were classified into meaningful themes. Results: The extracted intervention factors from the final nine studies classified into four themes: 1) Modifying irrational beliefs through cognitive approaches, 2) Empowering parenting competencies through learning a parent's role, 3) Utilizing emotion management skills, and 4) Parent-child relationship improvement training based on self-reflection. Conclusion: Four main themes were drawn from the key components of the various interventions. These findings should be considered in practice, and further intervention development studies for parents using these findings should be conducted.

• Computers and Concrete
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• v.19 no.4
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• pp.387-394
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• 2017

To study the effects of water-cement ratio changes and cracks on chloride ion transmission rate in cracked concrete, RCM method was adopted to accelerate the diffusion of chloride ion in cracked concrete, and the changes in chloride ion concentration and around the cracks are inferred by finite-element method. The test results show that as far as prefabricated cracks on concrete components are concerned, the width thresholds of two cracks on the concrete specimens with a water-cement ratio of 0.5 and 0.6 are 0.05 mm and 0.1 mm respectively, the width threshold of two cracks on the concrete specimens with a water-cement ratio of 0.4 is 0.05 mm and 0.2 mm respectively; and the results of numerical simulation show that the smaller the water-cement ratio is, the more significant effects of cracks on chloride ion transmission rate are. As a result, more attention shall be paid to the crack prevention, repairing and strengthening for high-strength concrete.

• Computers and Concrete
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• v.20 no.5
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• pp.595-603
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• 2017

Piezoceramic transducers have been widely used in the health monitoring of civil structures. However, in most cases, they are used as sensors either to measure strain or receive stress waves. This paper proposes a method of using piezoelectric transducers as strain gauges and acoustic emission (AE) sensors simultaneously. The signals received by piezoceramic transducers are decomposed into different frequency components for various analysis purposes. The low-frequency signals are used to measure strain, whereas the high-frequency signals are used as acoustic emission signal associated with local damage. The b-value theory is used to process the AE signal in piezoceramic transducers. The proposed method was applied in the bending failure experiments of two reinforced concrete beams to verify its feasibility. The results showed that the extracted low-frequency signals from the piezoceramic transducers had good agreement with that from the strain gauge, and the processed high-frequency signal from piezoceramic transducers as AE could indicate the local damage to concrete. The experimental results verified the feasibly of structural health monitoring using piezoceramic transducers as strain gauges and AE sensors simultaneously, which can advance their application in civil engineering.