• Journal of Pharmaceutical Investigation
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• v.40 no.4
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• pp.237-244
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• 2010

This study investigated basic material properties and compressibility of commonly used pharmaceutical excipients. Five classes of excipients are selected including starch, lactose, calcium phosphate, microcrystalline cellulose (MCC), and povidone. The compressibility was evaluated using compression parameters derived from Heckel and Kawakita equation. The Heckel plot for lactose and dicalcium phosphate showed almost linear relationship. However, for MCC and povidone, curves in the initial phase of compression were observed followed by linear regions. The initial curve was considered as particle rearrangement and fragmentation and then plastic deformation at the later stages of the compression cycle. The Kawakita equation showed MCC exhibited higher compressibility, followed by povidone, lactose, and calcium phosphate. MCC undergoes significant plastic deformation during compression bringing an extremely large surface area into close contact and facilitating hydrogen bond formation between the plastically deformed, adjacent cellulose particles. Lactose compacts are consolidated by both plastic deformation and fragmentation, but to a larger extent by fragmentation. Calcium phosphate has poor binding properties because of its brittle nature. When formulating tablets, selection of suitable pharmaceutical excipients is very important and they need to have good compression properties with decent powder flowability. Material properties tested in this study might give a good guide how to select excipients for tablet formulations and help the formulation scientists design the optimum ones.

• Journal of the Society of Naval Architects of Korea
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• v.37 no.4
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• pp.48-55
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• 2000

A basic research of air bubble locus around the ship hull is performed to know the bubble's behavior which is generated around the hull surface. In this paper. bubble's behavior around the ship hull is calculated and experimented with the variation of bubble size and the location of bubble generation. For the use of the equation for bubble locus, Kawakita's equation which include the effect of bubble buoyancy is adopted. For the numerical simulation. a finite difference method based on the MAC method is used. Also experiments are performed about series 60 hull form at CWC. The results of calculation are compared with those of experiment.