• The Korean Journal of Applied Statistics
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• v.26 no.1
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• pp.119-130
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• 2013

A system with $n$ components which functions when at least ${\kappa}$ of the components function is called ${\kappa}$-out-of-$n$ system. Most studies on ${\kappa}$-out-of-$n$ system derive the system reliability based on the assumption that the system has just two states: functioning or failed. However, the system efficiency may depend on the number of functioning components. This paper considers a Multi-state ${\kappa}$-out-of-$n$ system and derives the total system efficiency. In addition, assuming that the system is repairable, the optimal repair policy to maximize the system efficiency is studied. The system efficiency considered in this paper can be regarded as a generalized measure of the mean time to the failure of the system.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.46 no.1
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• pp.1-10
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• 2014

Xylanase (X) derived from Aurreobasidium pullulans and laccase-mediator system (LM) using Trichophyton sp. LKY-7 laccase (TrL) and N-hydroxy-2-pyridone analogue (NHP) as a mediator were applied in hardwood kraft pulp (HwKP) bleaching. The individual and the synergistic effects of X and LM stage were investigated in the enzymatic bleaching of HwKP. Also, the effects of subsequent alkaline extraction (E) and alkaline/hydrogen peroxide treatment (P) were examined. In X or LM treatment alone, an appreciable bleaching effect of HwKP was not observed, whereas subsequent E or P stage enhanced the increase of brightness and the decrease of kappa number. Especially, P stage significantly enhanced the bleaching effect of pulp. Bleaching of HwKP with XLM sequentially gave significantly higher pulp brightness and lower kappa number than that obtained after the treatment of HwKP with X+LM simultaneously. When HwKP was sequentially treated with XLM followed by P stage, the brightness increased by about 11% ISO and the kappa number decreased by about 3.6 in comparison with the initial pulp. Xylanase and laccase were strongly inactivated by NHP both in the absence and the presence of pulp.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.5
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• pp.85-90
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• 2015

To use the African tulip tree (Spathodea campanulata) as raw material for chemical pulping, soda and soda-AQ pulping was investigated. In chemical compositional analysis, lignin contents of African tulip (33.1%) was higher than other hardwood such as Yellow poplar (17.5%), Acacia (27.1%), or Eucalyptus (24.2%). Soda or soda-AQ pulping with African tulip tree resulted in yield at 43.4-44.8% with 29.5-34.5 Kappa number, pulping condition with 20-22% active alkali. Kappa number of African tulip tree pulp was quite higher than other tropical hardwood (Eucalyptus or Accacia) with less yield due to higher lignin content in wood. Fiber length and width of pulp from African tulip tree was similar to Accacia pulp and shorter than eucalyptus pulp.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.47 no.6
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• pp.73-80
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• 2015

Corn stalk is the lignocellulosic biomass, which remain as leftover after harvesting. To use the corn stalk as raw material for paper industry, soda pulping was applied. In chemical compositional analysis, extractive contents of corn stalk (45.1%) was higher than hardwood. With corn stalk pith, soda pulp yield was 25.3% at 10.6 Kappa number, but 39.5% yield with 14.8 Kappa number for corn stalk rind. Higher extractives content in pith is one of the reason for lower pulp yield than rind. Pith pulp fibers had higher fines content than rind pulp. Pith parenchyma cell was removed as fines during pulping or washing process, which caused the lower yield. To use the corn stalks as a raw material for paper making, de-pith process is essential for higher pulp yield and longer pulp length.

• Journal of the Society of Naval Architects of Korea
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• v.45 no.6
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• pp.631-636
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• 2008

In this paper, numerical analysis based on the RANS equation and the Realizable ${\kappa}-{\varepsilon}$ turbulence model is carried out for flows around an axisymmetric body at three Reynolds numbers($1.22{\times}10^7$, $1.0{\times}10^8$, $1.5{\times}10^8$) and the numerical results are compared with experiments data. Computed velocity distributions agree well with experiments as the Reynolds number increases. Pressure distributions agree well with the results of the potential flow except the tail region but differ from experiments for the parallel middle body as well as tail region. Pressure gradients show a good agreement with those of potential flow and experiment except the tail region. Friction coefficients show that the numerical results generally are lower than the experimental results estimated from the measured velocity. The difference of friction coefficients between the calculation and the experiment increases with growing of a boundary layer.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.37 no.5 s.113
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• pp.41-49
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• 2005

This paper deals the effect of anthraquinone (AQ) on the contribution of sulphidity in kraft pulping of sapwood. The pulping conditions namely- active alkali concentration, pulpingtime, temperature and liquor ratio were varied in low ($15\%$) and high ($30\%$) sulphidity. $0.1\%$ AQ was added in the low and high sulphidity pulping with varying active alkali concentration and cooking time. At optimum conditions, low sulphidity kraft process produced about $44\%$ pulp yield with kappa number of about 23. But in high sulphidity kraft process kappa number was reduced to about 20 at the same yield. An addition of AQ reduced alkali requirement by $2\%$ on oven dried raw material and cooking time by 1 hour to produce pulp yield of about $44\%$ at kappa number 20. AQ is more effective in low sulphidity pulping than the high sulphidity pulping. The breaking length of kraft-AQ pulp was slightly higher than that of kraft pulp.

• Molecules and Cells
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• v.25 no.2
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• pp.253-257
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• 2008

Acrolein is a highly electrophilic ${\alpha},{\beta}$-unsaturated aldehyde present in a number of environmental sources, especially cigarette smoke. It reacts strongly with the thiol groups of cysteine residues by Michael addition and has been reported to inhibit nuclear $factor-{\kappa}B$ ($NF-{\kappa}B$) activation by lipopolysaccharide (LPS). The mechanism by which it inhibits $NF-{\kappa}B$ is not clear. Toll-like receptors (TLRs) play a key role in sensing microbial components and inducing innate immune responses, and LPS-induced dimerization of TLR4 is required for activation of downstream signaling pathways. Thus, dimerization of TLR4 may be one of the first events involved in activating TLR4-mediated signaling pathways. Stimulation of TLR4 by LPS activates both myeloid differential factor 88 (MyD88)- and TIR domain-containing adapter inducing $IFN{\beta}$ (TRIF)-dependent signaling pathways leading to activation of $NF-{\kappa}B$ and IFN-regulatory factor 3 (IRF3). Acrolein inhibited $NF-{\kappa}B$ and IRF3 activation by LPS, but it did not inhibit $NF-{\kappa}B$ or IRF3 activation by MyD88, inhibitor ${\kappa}B$ kinase $(IKK){\beta}$, TRIF, or TNF-receptor-associated factor family member-associated $NF-{\kappa}B$ activator (TANK)-binding kinase 1 (TBK1). Acrolein inhibited LPS-induced dimerization of TLR4, which resulted in the down-regulation of $NF-{\kappa}B$ and IRF3 activation. These results suggest that activation of TLRs and subsequent immune/inflammatory responses induced by endogenous molecules or chronic infection can be modulated by certain chemicals with a structural motif that enables Michael addition.

• Korean Journal of Metals and Materials
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• v.48 no.5
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• pp.377-386
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• 2010

An investigation was conducted into the effects of $\kappa$-carbides on the cracking phenomenon, which often occurred in cold-rolled light-weight steel plates. Three kinds of steels were fabricated by varying the C content, and their microstructures and tensile properties were investigated. In the two steels that contained a high carbon content, the band structures of ferrites and $\kappa$-carbides that were severely elongated along the rolling direction were well developed, whereas continuous arrays of $\kappa$-carbides were formed in the steel that contained a low carbon content. Detailed microstructural analyses of the deformed region beneath the tensile fracture surface showed that the cracks initiated at arrays of $\kappa$-carbides or $\kappa$-carbides formed interfaces between the band structures, which initiated cleavage fractures in the ferrite bands, while the bands populated with a number of $\kappa$-carbides did not play an important role in propagating the cracks. Thus, the minimization of interfacial $\kappa$-carbides or $\kappa$-carbide arrays by increasing the carbon content was essential for preventing cracking from occurring during cold rolling.

• Proceedings of the PSK Conference
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• 2001.10a
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• pp.109-113
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• 2001

Oxidized low-density lipoprotein (oxLDL) has been shown to modulate transactivations by the peroxisome proliferator activated receptor (PPAR)$\gamma$ and nuclear factor-kappa B (NF$\kappa$B). In this study, the oxLDL signaling pathways involved with the NF$\kappa$B transactivation were investigated by utilizing a reporter construct driven by three upstream NF$\kappa$B binding sites, and various pharmacological inhibitors. OxLDL and its constituent lysophophatidylcholine (lysoPC) induced a rapid and transient increase of intracellular calcium and stimulated the NF-KB transactivation in resting RAW264.7 macrophage cells in an oxidation-dependent manner. The NF$\kappa$B activation by oxLDL or lysoPC was inhibited by protein kinase C inhibitors or an intracellular calcium chelator. Tyrosine kinase or PI3 kinase inhibitors did not block the NF$\kappa$B transactivation. Furthermore, the oxLDL-induced NF$\kappa$B activity was abolished by the PPAR$\gamma$ ligands. When the endocytosis of oxLDL was blocked by cytochalasin B, the NF$\kappa$B transactivation by oxLDL was synergistically increased, while PPAR transactivation was blocked. These results suggest that oxLDL activates NF-$\kappa$B in resting macrophages via protein kinase C- and/or calcium-dependent pathways, which does not involve the endocytic processing of oxLDL. The endocytosis-dependent PPAR$\gamma$ activation by oxLDL may function as an inactivation route of the oxLDL induced NF$\kappa$B signal. Short heterodimer partner (SHP), specifically expressed in liver and a limited number of other tissues, is an unusual orphan nuclear receptor that lacks the conventional DNA-binding domain. In this work, we found that SHP expression is abundant in murine macrophage cell line RAW 264.7 but suppressed by oxLDL and its constituent I3-HODE, a ligand for peroxisome proliferator-activated receptor y. Furthermore, SHP acted as a transcription coactivator of nuclear factor-$\kappa$B (NF$\kappa$B) and was essential for the previously described NF$\kappa$B transactivation by lysoPC, one of the oxLDL constituents. Accordingly, NF$\kappa$B, transcriptionally active in the beginning, became progressively inert in oxLDL-treated RAW 264.7 cells, as oxLDL decreased the SHP expression. Thus, SHP appears to be an important modulatory component to regulate the transcriptional activities of NF$\kappa$B in oxLDL-treated, resting macrophage cells.

• Journal of Preventive Medicine and Public Health
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• v.38 no.4
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• pp.443-448
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• 2005

Objectives : This study was done to evaluate the reliability of education and occupational class between using the health survey and the death certificate data. Methods : The 1998 National Health and Nutrition Examination Survey (NHANES) was conducted on a cross-sectional probability sample of South Korean households, and it contained unique 13-digit personal identification numbers that were linked to the data on mortality from the Korean National Statistical Office. The data from 263 deaths were used to estimate the agreement rates and the Kappa indices of the education and occupational class between using the NHANES data and the death certificate data. Results : The simple and weighted Kappa indices for education were 0.60 (95% CI=0.53-0.68) and 0.73 (95% CI=0.67-0.79) respectively, if the educational level was grouped into five categories: no-formal-education, elementary-school, middle-school, high-school and college or over. The overall agreement rate was 71.9% for these educational groups. The magnitude of reliability, as measured by the overall agreement rates and Kappa indices, tended to increase with a decrease in the educational class. The number of non-educated people with using the death certificate data was smaller than that with using the NHANES data. For the occupational class (manual workers, non-manual workers and others), the Kappa index was 0.40 (95% CI=0.30-0.51), which was relatively lower than that for the educational class. Compared with the NHANES, the number of non-manual workers for the deceased who were aged 30-64 tended to be increased (8 to 12) when using the death certificate data, whereas the number of manual workers tended to be decreased (59 to 41). Conclusions : The socioeconomic inequalities in the mortality rates that were based on the previous unlinked studies in South Korea were not due to a numerator/denominator bias. The mortality rates for the manual workers and the no-education groups might have been underestimated.