• Archives of Pharmacal Research
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• 제17권1호
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• pp.45-47
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• 1994

A cytotoxic sesquiterpene against L1210 and Hl-60 cells was isolated from Angelicae Koreanae Radix (bulk-kang-hwal). The component was identified as bisabolangelone by means of chemical and physical methods. The $ED_{50}$ values of it were $1.20{\;}\mu\textrm{g}/ml$ against L1210 cells and $2.30{\;}\mu\textrm{g}/ml$ against HL-60 cells. Bisabolangelone was found in bulk-kang-hwal but not in kang-hwal.

• 혜화의학회지
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• 제16권1호
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• pp.81-91
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• 2007

Objective : We wished to examine closely effect that Kami-KangHwalSan medicines used to atopy dermatitis disease patient get in atopy eruption control experimentally. Materials and Methods : Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. However, the exact etiology of AD has been unclear. To further explore the pathogenesis and treatment of AD, a suitable animal model is required. We found that skin lesions, which were chnically and histologically very simlar to human AD, mite antigen-induced dermatitis on the face, neck, ears and dorsal skin of inbred NC/Nga mice. Results and Conclusion : Kami-KangHwalSan medicines controlled CD3+/CD69+, CD4+/CD25+, B220+/IgE+, and B220+/CD23+ revelation that an experiment that motive allergy immune reponse because an in vitro experiment stimulates splenocytes of a NC/Nga mouse same t1me by PWM, and interleukin-4, eotaxin 2, CCR3, TARC mRNA outturn that bear in splenocytes decreased remarkably by Kami-KangHwalSan medicines. Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-$\gamma$ by Kami-KangHwalSan medicines could know that Kami-KangHwalSan medicines can use usefully in allergy autoimmnune diease.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2003년도 생물공학의 동향(XIII)
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• pp.51-51
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• 2003

• 생명과학회지
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• 제24권5호
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• pp.567-572
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• 2014

초롱꽃과에 속하는 도라지는 항염증, 항산화, 항암작용뿐 아니라 간기능 강화에도 작용하여 한방에서 만성염증성 질환의 치료제로 널리 사용되고 있다. 이번 연구에서 마우스 대식세포주인 RAW 246.7 세포와 비장으로부터 분리한 T세포에서 도라지 추출액(CC), 도라지 추출물이 함유된 활맥단 추출액(HWAL, 도라지 82% 함유) 및 맥환추출액(MAEK, 도라지 7% 함유)을 처리하여 대식세포와 T세포의 활성과 관련 있는 유전자의 발현을 통해 면역증진 및 항염증 효과를 real-time RT-PCR 기법을 통해 확인해 보았다. 그 결과, 활성화된 T세포에서 많이 발현되는 c-fos (10배 이상), CD40L 유전자(6배 이상)의 경우, 맥환 추출액 처리군에서 가장 높은 발현이 유도되어 면역활성 효과가 높을 것으로 사료되었다. 도라지 추출액과 활맥단 추출액의 경우도 c-fos 유전자의 발현을 유의적으로 증가시켰지만 미약하였고, CD40L의 경우는 영향을 주지 않았다. 도라지 추출액을 처리한 군에서 면역활성을 유도하는 M1 대식세포에서 많이 발현되는 iNOS 유전자의 발현이 유의하게 증가되었다. 반면에 활맥단 추출액을 처리한 대식세포는 M2 표식인자인 Ym1, arginase1 (ARG1) 유전자의 발현이 유의적으로 상승하였다. 결론적으로 도라지가 다량 포함된 맥환 추출액은 면역활성을 유도하는데 탁월한 효과를 나타내며, 도라지 함유가 적게 포함된 활맥단 추출액은 항염증 작용에 탁월한 효과가 있을 것으로 사료된다.

• 제어로봇시스템학회논문지
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• 제13권10호
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• pp.956-961
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• 2007

We propose a new distance measurement method and local positioning system for the autonomous mobile robots localization. The distance measurement method is able to measure long-range distances with a high accuracy by using ultrasonic sensors. The time of flight of the ultrasonic waves include various noises is calculated accurately by the proposed period detecting method. The proposed local positioning system is composed of four ultrasonic transmitters and one ultrasonic receiver. The ultrasonic transmitter and receiver are separated but they are synchronized by RF (Radio frequency) signal. The proposed system using ultrasonic waves is represented as USAT(Ultrasonic Satellite System). USAT is able to estimate the position using the least square estimation. The experimental results show that the proposed local positioning system enables to estimate the absolute position precisely.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2009년도 춘계학술대회 논문집
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• pp.328-330
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• 2009

1 kW class Polymer Electrolyte Fuel Cell(PEFC) co-generation systems have been developed from 2001 and evaluated for improvement of efficiency, durability and reliability of the system. This paper introduce new version system including with excellent reliability, durability and user friendly applications. Its electrical and overall efficiency showed 35 % and 80 %, respectively, and noise level of the system was less than 45 dB. In addition, this system have various functions such as load change, $N_2$ less purge, low emission and low temperature operation ($-15^{\circ}C$) through development of operation logic. This system was designed for convenient installation in indoor and outdoor due to the compactness of size and the separation of electrical and heat recovery units, which means a user can select the size of heat recovery unit.

• 한국정밀공학회지
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• 제24권8호통권197호
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• pp.41-49
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• 2007

In this paper, we proposed a new ultrasonic distance measurement system with high accuracy and long range. To improve accuracy and enlarge range, the time of flight of ultrasonic is calculated by the period detecting method. In the proposed ultrasonic distance measurement system, the ultrasonic transmitter and receiver are separated but synchronized by RF(Radio frequency) module. The experiment has been implemented from short distance 1m to maximum available distance 30m. And the period detecting method is compared with the conventional threshold level method. Experimental results show the accuracy and range of the distance measurement are improved by this period detecting method.

• Child Health Nursing Research
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• 제26권3호
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• pp.385-392
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• 2020

Purpose: The number of Korean adolescents engaging in gambling is increasing, especially among out-of-school adolescents. This study aimed to identify patterns of gambling activities and factors related to specific subgroups of out-of-school adolescent gambling activities. Methods: This descriptive study analyzed secondary data from the 2015 Korea Youth Gambling Problem Survey, including 1,200 out-of-school adolescents. Latent class analysis was conducted to identify patterns of gambling activities. The factors related to gambling subgroups were verified with multinomial logistic regression. Results: Three latent classes of gambling activities were identified: rarely gambling (RG), immediate gain gambling (IGG), and broad gambling (BG). These subgroups differed significantly in terms of gender, age at and type of first gambling experience, number and type of gambling activities, gambling frequency, time and money spent on gambling, problem gambling severity, and motivation for gambling. Compared to the RG subgroup, both the IGG and BG subgroups were strongly associated with an older age at the first gambling experience. Conclusion: Out-of-school adolescents who first gambled at an older age and who gambled mainly in order to gain money immediately were at risk of problem gambling. Developing strategies for early screening and referral to professionals is necessary to prevent gambling problems from worsening.

• 한국도로학회논문집
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• 제16권5호
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• pp.39-47
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• 2014

PURPOSES : This study aimed to analyze economic effect of recycled aggregate production on job-site airport pavement. METHODS : The validation of site recycling for waste concrete as economic efficiency is analyzed through the case study of site recycling at an O airport pavement construction. The break-even point for the cost of site recycling was estimated according to two different waste concrete processing methods such as job-site recycling and processing on commission (or plant). RESULTS : Job-site recycling cost decreases as the use rate of job-site recycled concrete aggregate increases, or the amount of concrete waste increases, but transporting distance decreases. It was shown in an O airport case that as the use rate of job-site recycled concrete aggregate exceeds 61.4 %, the job-site recycling cost is cheaper than the processing cost on commission. CONCLUSIONS : The results of this study can utilize basic data of feasibility for site recycling of waste concrete on airport pavement construction.

• 한국콘텐츠학회논문지
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• 제9권4호
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• pp.142-153
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• 2009

많은 기업들이 ERP시스템 도입하여 사용함에 따라 ERP의 성과에 대한 관심이 증가하고 있으며, 객관적인 성과 측정의 필요성을 느끼고 있다. 본 연구는 국내 기업의 ERP 도입으로 인한 성과를 정성적인 성과와 정량적인 성과간의 상관관계를 분석하고자 한다. 즉, 본 연구는 ERP시스템 도입성과 측정을 위해 경영정보시스템 분야에서 주로 사용하고 있는 시스템 만족도 등과 같은 사용자에 의해 인지된 성과와 회계학에서 주로 사용되고 있는 ERP관련 정량적 성과 변수들 간의 관련성을 실증 분석하여, 두 변수 집단 간의 관련성을 검토하고자 한다. ERP의 정성적 성과를 분석하기 위해 시스템 품질, 정보품질, 업무의 만족도, 업무개선 정도 등의 변수를 사용하였으며, 정량적 성과를 분석하기 위해 재고자산회전율, 매출액 대비 재고자산, 매출액 대비 종업원 수, 매출액 대비 인건비, 총자산 순이익률 변수를 사용하였다. 실증분석 결과는 다음과 같이 요약될 수 있다. 첫째, ERP도입의 측면의 정성적인 성과 변수간의 상관관계는 통계적으로 유의하게 분석된 것이다. 둘째 정량적인 성과 변수간의 상관관계는 ERP 도입 전 후의 평균의 값을 통하여 ERP 도입의 성과를 분석한 결과 통계적으로 유의한 상관관계를 나타내고 있었다. 끝으로 정성적인 성과와 정량적인 성과의 상관관계는 통계적으로 유의하지 않은 상관관계로 분석되었다.