• Archives of Pharmacal Research
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• v.17 no.1
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• pp.45-47
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• 1994

A cytotoxic sesquiterpene against L1210 and Hl-60 cells was isolated from Angelicae Koreanae Radix (bulk-kang-hwal). The component was identified as bisabolangelone by means of chemical and physical methods. The $ED_{50}$ values of it were $1.20{\;}\mu\textrm{g}/ml$ against L1210 cells and $2.30{\;}\mu\textrm{g}/ml$ against HL-60 cells. Bisabolangelone was found in bulk-kang-hwal but not in kang-hwal.

• Journal of Haehwa Medicine
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• v.16 no.1
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• pp.81-91
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• 2007

Objective : We wished to examine closely effect that Kami-KangHwalSan medicines used to atopy dermatitis disease patient get in atopy eruption control experimentally. Materials and Methods : Atopic dermatitis (AD) usually develops in patients with an individual or family history of allergic diseases, and is characterized by chronic relapsing inflammation seen specially in childhood, association with IgE hyperproduction and precipitation by environmental factors. However, the exact etiology of AD has been unclear. To further explore the pathogenesis and treatment of AD, a suitable animal model is required. We found that skin lesions, which were chnically and histologically very simlar to human AD, mite antigen-induced dermatitis on the face, neck, ears and dorsal skin of inbred NC/Nga mice. Results and Conclusion : Kami-KangHwalSan medicines controlled CD3+/CD69+, CD4+/CD25+, B220+/IgE+, and B220+/CD23+ revelation that an experiment that motive allergy immune reponse because an in vitro experiment stimulates splenocytes of a NC/Nga mouse same t1me by PWM, and interleukin-4, eotaxin 2, CCR3, TARC mRNA outturn that bear in splenocytes decreased remarkably by Kami-KangHwalSan medicines. Th1 cell and Th2 cell observe to be shifted by secretion amount of IL-4 and IFN-$\gamma$ by Kami-KangHwalSan medicines could know that Kami-KangHwalSan medicines can use usefully in allergy autoimmnune diease.

• 한국생물공학회:학술대회논문집
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• 2003.10a
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• pp.51-51
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• 2003

• Journal of Life Science
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• v.24 no.5
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• pp.567-572
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• 2014

Extracts of Platycodon grandiflorum have been reported to show anti-inflammatory, antioxidant, anti-metastatic, and hepato-protective effects. This study was designed to evaluate T-cell activation and M1/M2 differential macrophage activation by extracts of P. grandiflorum or P. grandiflorum containing various medicinal herbs. Using real-time RT-PCR, we analyzed expression levels of c-fos, and CD40L (T-cell activation markers) in splenocytes and iNOS, Ym1, and ARG1 in RAW 246.7 cells after treatment of CC (hot water extract of P. grandiflorum), MAEK (hot water extract of P. grandiflorum [82%] and six different plants), and HWAL (hot water extract of P. grandiflorum [7%] and eight different plants. The results showed that MAEK significantly elevated the expression of T-cell activation markers of splenocytes, with the c-fos gene activated more than 10-fold and the CD40L gene activated more than 6-fold. Although CD40L was significantly increased by CC and HWAL, the increase was only about 2-fold. In addition, CC and HWAL did not significantly activate the expression of the c-fos gene. On the other hand, CC elevated the M1 activation marker iNOS, and HWAL elevated the M2 activation marker Ym1 and ARG1 gene expression. In conclusion, MAEK could be used as an immune stimulant because of its ability to activate T cells (elicited c-fos and CD40L gene expression), whereas HWAL could serve as an anti-inflammatory agent because of its differential activation of M2 macrophages.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.10
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• pp.956-961
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• 2007

We propose a new distance measurement method and local positioning system for the autonomous mobile robots localization. The distance measurement method is able to measure long-range distances with a high accuracy by using ultrasonic sensors. The time of flight of the ultrasonic waves include various noises is calculated accurately by the proposed period detecting method. The proposed local positioning system is composed of four ultrasonic transmitters and one ultrasonic receiver. The ultrasonic transmitter and receiver are separated but they are synchronized by RF (Radio frequency) signal. The proposed system using ultrasonic waves is represented as USAT(Ultrasonic Satellite System). USAT is able to estimate the position using the least square estimation. The experimental results show that the proposed local positioning system enables to estimate the absolute position precisely.

• 한국신재생에너지학회:학술대회논문집
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• 2009.06a
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• pp.328-330
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• 2009

1 kW class Polymer Electrolyte Fuel Cell(PEFC) co-generation systems have been developed from 2001 and evaluated for improvement of efficiency, durability and reliability of the system. This paper introduce new version system including with excellent reliability, durability and user friendly applications. Its electrical and overall efficiency showed 35 % and 80 %, respectively, and noise level of the system was less than 45 dB. In addition, this system have various functions such as load change, $N_2$ less purge, low emission and low temperature operation ($-15^{\circ}C$) through development of operation logic. This system was designed for convenient installation in indoor and outdoor due to the compactness of size and the separation of electrical and heat recovery units, which means a user can select the size of heat recovery unit.

• Journal of the Korean Society for Precision Engineering
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• v.24 no.8 s.197
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• pp.41-49
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• 2007

In this paper, we proposed a new ultrasonic distance measurement system with high accuracy and long range. To improve accuracy and enlarge range, the time of flight of ultrasonic is calculated by the period detecting method. In the proposed ultrasonic distance measurement system, the ultrasonic transmitter and receiver are separated but synchronized by RF(Radio frequency) module. The experiment has been implemented from short distance 1m to maximum available distance 30m. And the period detecting method is compared with the conventional threshold level method. Experimental results show the accuracy and range of the distance measurement are improved by this period detecting method.

• Child Health Nursing Research
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• v.26 no.3
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• pp.385-392
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• 2020

Purpose: The number of Korean adolescents engaging in gambling is increasing, especially among out-of-school adolescents. This study aimed to identify patterns of gambling activities and factors related to specific subgroups of out-of-school adolescent gambling activities. Methods: This descriptive study analyzed secondary data from the 2015 Korea Youth Gambling Problem Survey, including 1,200 out-of-school adolescents. Latent class analysis was conducted to identify patterns of gambling activities. The factors related to gambling subgroups were verified with multinomial logistic regression. Results: Three latent classes of gambling activities were identified: rarely gambling (RG), immediate gain gambling (IGG), and broad gambling (BG). These subgroups differed significantly in terms of gender, age at and type of first gambling experience, number and type of gambling activities, gambling frequency, time and money spent on gambling, problem gambling severity, and motivation for gambling. Compared to the RG subgroup, both the IGG and BG subgroups were strongly associated with an older age at the first gambling experience. Conclusion: Out-of-school adolescents who first gambled at an older age and who gambled mainly in order to gain money immediately were at risk of problem gambling. Developing strategies for early screening and referral to professionals is necessary to prevent gambling problems from worsening.

• International Journal of Highway Engineering
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• v.16 no.5
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• pp.39-47
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• 2014

PURPOSES : This study aimed to analyze economic effect of recycled aggregate production on job-site airport pavement. METHODS : The validation of site recycling for waste concrete as economic efficiency is analyzed through the case study of site recycling at an O airport pavement construction. The break-even point for the cost of site recycling was estimated according to two different waste concrete processing methods such as job-site recycling and processing on commission (or plant). RESULTS : Job-site recycling cost decreases as the use rate of job-site recycled concrete aggregate increases, or the amount of concrete waste increases, but transporting distance decreases. It was shown in an O airport case that as the use rate of job-site recycled concrete aggregate exceeds 61.4 %, the job-site recycling cost is cheaper than the processing cost on commission. CONCLUSIONS : The results of this study can utilize basic data of feasibility for site recycling of waste concrete on airport pavement construction.

• The Journal of the Korea Contents Association
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• v.9 no.4
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• pp.142-153
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• 2009

As many companies have adopted and used ERP systems, concerns about ERP performance also have increased. The purpose of this research is to examine the relationships between qualitative variables and quantitative variables measuring ERP performances. Qualitative research, widely used in MIS research, typically examines perceived usefulness of ERP, such as information quality, system quality, system satisfaction. Quantitative research, often done in accounting research, usually examines ERP performance based on financial statements. An empirical study led to the following conclusions: 1) There were significant correlations among the qualitative variables measuring perceived usefulness of ERP; 2) Significant correlations were also observed among the quantitative variables based on financial statements; 3) However, no significant correlations was found between the qualitative variables and quantitative variables measuring ERP performance.