• Title/Summary/Keyword: Kang Jun-seob

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Nanoparticle-Based Vaccine Delivery for Cancer Immunotherapy

  • Park, Yeong-Min;Lee, Seung Jun;Kim, Young Seob;Lee, Moon Hee;Cha, Gil Sun;Jung, In Duk;Kang, Tae Heung;Han, Hee Dong
    • IMMUNE NETWORK
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    • v.13 no.5
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    • pp.177-183
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    • 2013
  • Development of nano-sized carriers including nanoparticles, nanoemulsions or liposomes holds great potential for advanced delivery systems for cancer immunotherapy, as such nanostructures can be used to more effectively manipulate or deliver immunologically active components to specific target sites. Successful development of nanotechnology based platform in the field of immunotherapy will allow the application of vaccines, adjuvants and immunomodulatory drugs that improve clinical outcomes for immunological diseases. Here, we review current nanoparticle-based platforms in the efficacious delivery of vaccines in cancer immunotherapy.

Study on Floating to Surface for the Exercise Vehicle with Negative Buoyancy (음성부력을 갖는 연습탄의 수면부양 방안 연구)

  • Jung, Chan-Hee;Choi, Jang-Seob;Kim, Ki-Un;Kang, Myung-Koo;Lee, Jeong-Jun
    • Journal of the Korea Institute of Military Science and Technology
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    • v.15 no.2
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    • pp.121-129
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    • 2012
  • In this study, in terms of the exercise vehicles of the weapon systems having negative buoyancy, the analysis on the operation concepts was performed and the new methods of floating to surface were proposed. In case of having negative buoyancy, the additional methods for recovering the exercise vehicle have to be considered. As parts of recovering the exercise vehicle, for floating to surface the new methods of weight discharge, weight separation and sea water discharge were proposed. The conceptual design about sea water discharge method was performed. It was confirmed that those methods could be applied to the design of the exercise vehicle having negative buoyancy.

Arteriovenous Malformation of the Forehead - Case Report - (이마의 동정맥 기형 - 증 례 보 고 -)

  • Yim, Sin Gil;Oh, Min Suk;Lim, Jun Seob;Kang, Myung Gi;Kwak, Yeon Sang;Park, Seung Gyu;Song, Gyung Bae;Kim, Han Yung
    • Journal of Korean Neurosurgical Society
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    • v.30 no.sup2
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    • pp.368-372
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    • 2001
  • Arteriovenous malformations of the face and scalp are uncommon. We report a patient with facial AVM feeding from external carotid artery. This 26-year old man presented with an arteriovenous malformation involving left forehead. The patient first noted a coin-sized lesion on the site 20 years previously after blunt trauma which progressively enlarged. Surgical resection of AVM was performed after ligation of feeding artery.

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A Case Study on Development and Operation of SOL (Standards On-Line) (종합 표준정보유통망 구축 및 운영 연구)

  • Koo, Kyoung-Cheol;Song, Gi-Pyeung;Lee, Jun-Seob;Lee, Kang-Chan;Sohn, Hong
    • Proceedings of the Korea Information Processing Society Conference
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    • 2001.04a
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    • pp.495-498
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    • 2001
  • 최근의 표준화는 단순한 규격의 제정이 아니라 시장 선점의 전략적 도구로써 사용되고 있으며, 이에 따라 표준화 과정에서 다루어지는 다양한 핵심 정보의 적시 획득 및 분석은 표준화전략 수립의 기반 방법론으로 부상하고 있다. 본 논문에서는 표준화 관련 정보처리 및 유통과 관련하여, 차세대 종합 표준정보유통망 연구를 통해 추구되어야 하는 표준화전반에 걸친 역할 및 연구개발 추진체계를 제시하고, 현재 한국전자통신연구원에서 개발되어 운영되고 있는 정보서버로서의 표준정보유통망인 SOL(Standards On-Line)의 운영 현황을 소개한다.

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Surface Modified Glass-Fiber Effect on the Mechanical Properties of Glass-Fiber Reinforced Polypropylene Composites

  • Park, Sanghoo;Kim, Su-Jong;Shin, Eun Seob;Lee, Seung Jun;Kang, Beom Mo;Park, Kyu-Hwan;Hong, Seheum;Hwang, Seok-Ho
    • Elastomers and Composites
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    • v.54 no.3
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    • pp.182-187
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    • 2019
  • To improve the mechanical properties of glass-fiber-reinforced polypropylene (PP) composites through interfacial adhesion control between the PP matrix and glass fiber, the surface of the glass fiber was modified with PP-graft-maleic anhydride (MAPP). Surface modification of the glass fiber was carried out through the well-known hydrolysis-condensation reaction using 3-aminopropyltriethoxy silane, and then subsequently treated with MAPP to produce the desired MAPP-anchored glass fiber (MAPP-a-GF). The glass-fiber-reinforced PP composites were prepared by typical melt-mixing technique. The effect of chemical modification of the glass fiber surface on the mechanical properties of composites was investigated. The resulting mechanical and morphological properties showed improved interfacial adhesion between the MAPP-a-GF and PP matrix in the composites.

A RFID based Operations Management for Mass Health Examination (RFID 기반 단체 건강검진 운영관리)

  • Kim, Jun Woo;Kang, Hyun Kyung;Jeong, JinYoung;Shin, Jin Seob;Ahn, Woo Young;Kim, SeokHun
    • Proceedings of the Korean Society of Computer Information Conference
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    • 2013.01a
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    • pp.237-239
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    • 2013
  • 의료 기술이나 관련 장비가 발달해온 것과 달리, 현재의 단체 건강검진 환경에는 여러 가지 비효율적 요소들이 존재한다. 이에 따라 본 논문에서는 단체 건강검진 현장의 개선을 위한 전자태그(RFID) 기반 운영관리 시스템을 제안하고자 한다. 본 시스템은 데이터베이스를 이용하여 검진과정에서 수집되는 데이터들을 실시간으로 관리하고, 이를 토대로 현장 검진의들의 작업을 지원할 수 있는 정보를 제공한다. 아울러, 수검자들은 검진현장을 순회할 때 기존처럼 문서로 된 검진서식을 지참하는 것이 아니라 개인 RFID 카드를 이용하게 되고, 수검자들의 검진 내역 역시 지속적으로 추적이 가능하다. 결과적으로 제안하는 시스템을 통하여 전체 검진현장의 실시간 통합 관리가 가능하며, 단체 건강검진 현장의 업무효율성과 수검자 편의성이 증진될 수 있다. 아울러, 제안하는 시스템은 건강검진 현장에서 여러 가지 성과지표를 수집, 산출하여 검진 서비스의 지속적인 개선을 위한 토대를 제공한다.

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Underlying mechanism of antioxidant action of Haejohwan in thyroxine-induced hyperthyroid rats (해조환(海藻丸)이 갑상선(甲狀腺) 기능항진증(機能亢進症)에서 항산화(抗酸化) 효과(效果)에 미치는 영향(影響))

  • Park, Jong-Hyuck;Yoon, Cheol-Ho;Seo, Un-Kyo;Kang, Jeong-Jun;Seo, Jong-Eun;Shin, Uk-Seob;Jeong, Ji-Cheon
    • The Journal of Internal Korean Medicine
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    • v.21 no.3
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    • pp.399-407
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    • 2000
  • This study was carried out to examine if Haejohwan (HJ) inhibits oxidant-induced lipid peroxidation and therby produces protective effect against thyroxine-induced hyperthyroid rats. Triiodothyronine $(T_3)$, thyroxine $(T_4)$, lipid peroxidation, xathine oxidase activities and type conversion ratio were increased in thyroxine treated group. However, they were decreased in HJ extract's pre-applied group. Glutathione level, activities of glutathione peroxidase, glutathione Stransferase and glutathione reductase were decreased in thyroxine treated group. But, they were increased in HJ extract's pre-applied group. These results suggest that in thyroxine-induced hyperthyroid rats HJhas an increase in the activities of oxygen free radical scavenging enzymes and inhibition of xanthine oxidase activities, and prevents lipid peroxidation.

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Evaluation of the Antinociceptive Properties of GCSB-5, a Herbal Formulation (생약복합제 GCSB-5의 급성통증 모델에서의 진통작용)

  • Lee, Chan-Ho;Kim, Sung-Hwa;Lee, Jun-Seok;Cho, Kang-Hoon;Kim, Jeoung-Seob;Cho, Soon-Hyun;Lee, Sun-Mee
    • Korean Journal of Pharmacognosy
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    • v.36 no.4 s.143
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    • pp.299-304
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    • 2005
  • This study examined the antinociceptive properties of GCSB-5, a herbal formulation consisting of 6 Oriental herbs (Ledebouriellae Radix, Achyranthis Radix, Acanthopanacis Cortex, Cibotii Rhizoma, Glycine Semen, and Eucommiae Cortex) that are used in traditional medicine to treat various bone disorders, mainly of which involve analgesic processes. Peripheral and central analgesic models were established in experimental animals in order to evaluate the antinociceptive effects of the agent. GCSB-5 significantly inhibited the number of acetic-induced writhing (33.3%-34.3% inhibition at 100-600 mg/kg) but increased the pain threshold (38.0% increase at 300 mg/kg) in the Randall-Selitto test. However, GCSB-5 had no effect on the hot plate-induced nociception and hyperalgesia from the tail-pinch method. These results suggest that the antinociceptive effect of GCSB-5 may be mediated via peripheral mechanisms.

Protective effects of extract of Brousson etiae fructus on the nitrite level and the nitric oxide synthase activity in corpus cavernosum of streptozotocin-induced diabetic rat. (저실자(楮實子) 추출물(抽出物)이 Streptozotocin에 의한 당뇨병(糖尿病) 흰쥐 음경해선체(陰莖海綿體)의 Nitric oxide synthase 활성(活性) 및 Nitrite 함량(含量)에 미치는 영향(影響))

  • Kang, Jeong-Jun;Jeong, Ji-Cheon;Shin, Uk-Seob
    • The Journal of Korean Medicine
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    • v.19 no.2
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    • pp.112-124
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    • 1998
  • The purpose of this study was to investigate the effect of Brousson etiae fructus (BF) on the urethral nitrite level and the urethral nitric oxide synthase (NOS) activity in streptozotocin (STZ) induced diabetic rats. In vitro, the urethral NOS activity was not noted in the level of Dose of extract prepared from BF. In vivo, the urethral NOS activity was increased in normal rats and STZ induced diabetic rats by dose and term of extract prerared from BF. The the NOS activity decreased in STZ induced diabetic rats was increased as highly as norma1 group by the extract of BF The level of urethral nitrite and glutathione was increased too. But the level of urethral lipid peroxide increased in STZ induced diabetic rats was decreased as lowly as normal group by the extract of BF. In conclusion, the extract of BF can restore erectile dysfunction of STZ induced diabetic rats.

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