• 패션비즈니스
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• 제7권4호
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• pp.43-56
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• 2003

The main purpose of this study was to investigate the difference of perceptional degree of imported make-up cosmetics brand and importance of brand image attributes, and the evaluation of brand image attributes of imported make-up cosmetics according to fashion involvement and to provide positioning the imported make-up cosmetics brands according to brand image attributes. Survey was conducted to 301 people from age 20 to 30 year female woman who is leaving in Seoul and Kyunggee Inchon using convenience editing. Material analyzing was done using t-test, factor analysis, cluster analysis, multidimensional scaling. The results were as follows. 1. The perceptional degree of brand and the importance brand image attributes showed significant difference according to fashion involvement. 2. The evaluation of brand image attributes of imported make-up cosmetics were different between high involvement group and low involvement group. 3. As a result of multidimensional scaling, the imported make-up cosmetics brands were positioned different according to brand image attributes between high involvement group and low involvement group.

• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.33-41
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• 1991

A high-performance liquid chromatographic (HPLC) method was developed for the simultaneous determination of theophylline(TP) and its metabolites, 1-methyluric acid (1-MU) and 1,3-dimethyluric acid (1,3-DMU), in rat plasma and urine. An $100\;{\mu}l$ aliquot of a plasma or urine sample was mixed with $250\;{\mu}l$ of acetonitrite and vortexed. After centrifugation, $200\;{\mu}l$ (plasma) or $20\;{\mu}l$ (urine) aliquot of the supernatant was dried by $N_2$ stream and redissolved in $100\;{\mu}l$ (plasma) or $200\;{\mu}l$ (urine) of the mobile phase. A $20\;{\mu}l$ of the mobile phase solution was injected onto a $C_{18}$ reversed-phase column. The column was maintained at $45^{\circ}C$ by the aid of electric heating jacket. The mobile phase was a 3%(v/v) methanol solution in deionized water which contains sodium acetate (100 mM) and tetrabutyl ammonium hydroxide (4 mM). pH of the mobile phase was adjusted 4.5 by the addition of acetic acid. Detection limits for TP, 1-MU, and 1,3-DMU in plasma were 0.2, 0.1 and $0.1\;{\mu}/ml$, respectively and the corresponding values in urine were all $5\;{\mu}g/ml$. Inter- and intra-day variability of the assay for all compounds in the plasma samples was less than 5.5 and 3.8%, respectively. The retention times for 1-MU, 1,3-DMU, and TP were approximately 7, 8.5 and 18 min, respectively. Sample preparation procedure used in this method was simple, rapid and reproducible. Renal clearance of TP and its metabolites in rats showed plasma concentration dependency indicating renal tubular secretion and reabsorption of them.

• Journal of the korean society of oceanography
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• 제37권1호
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• pp.1-9
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• 2002

Cable voltage was measured simultaneously at Hamada, Japan and Pusan, Korea, using an inservice telephone cable from March to December 1990. The spectral and harmonic analyses of these data sets show that tidal signals are dominant, and that tidal constituents $M_2$ and $O_1$, which are not affected by solar geomagnetic variations, have almost the same amplitude and are of opposite phase to each other. comparing the voltage difference in 1990 with that measured using the now abandoned cable in 1998, there are dominant tidal signals at the same periods in both data sets. They have approximately the same amplitude and phase for $M_2andO_1$. The relationship between the observed voltage and the volume transport through the Korea Strait can be considered robust and stable over time. The conversion factor from voltage to transport is estimated to be $11.9{\times}10^6m^3S^{-1}volt^{-1}$ by comparing the amplitude of model-derived $M_2$ tidal transport with that of the voltage difference in 1998. This value changes to $8.6{\times}10^6m^3S^{-1}volt^{-1}$ when taking into consideration the horizontal electric current effect. This effect depends on the downstream length scale of the flow. To obtain a more reliable and stable conversion factor from voltage to transport, the voltage should be compared with observed sub-tidal transports, which may have long downstream length scales.

• Radiation Oncology Journal
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• 제11권1호
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• pp.133-141
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• 1993

From Jan.1982 to Dec.1990, 77 patients with rectal cancer were treated with curative surgical resection followed by postoperative adjuvant irradiation alone or combined with chemotherapy at the Department of Radiation Oncology, Korea University Hospital (KUH). Fifty-four (54/77, $70.1{\%}$) patients underwent abdominoperineal resection , 20 (20/77, $26{\%}$) patients underwent low anterior resection, and 3 (3/77, $3.9{\%}$,) patients had wide excision only. Thirty-nine (39/77, $50.5{\%}$) received sequential chemotherapy (2 cycles to 12 cycles). The 5-year survival rate for the entire group was $43{\%}:\;78.2{\%}$ in B2+B3, $39.4{\%}$ in stage C1+C2+C3. Survival rates decreased with increasing penetration of the bowel wall by tumor and the presence of regional lymph node metastasis. Those patients survival who underwent an abdominoperineal resection also experienced a significant decrease in compared to low anterior resection ($23.1{\%}$ vs. $63.8{\%}$ in 5-year survival, p <0.05). Local failure occurred in 15 ($19.5{\%}$) out of the 77 patients overall, 1($5.3{\%}$) of 19 in stage B2+B3, and 14 ($24.1{\%}$,) of 58 in stage C1+C2+C3. Presacral area was most common site of local failufre (8/17, $47.1{\%}$). Distant failure occurred in 13 ($16.9{\%}$) of 77 patients. The most frequent site of distant failure was the lung followed by the liver, the bone, and the brain. Combined locoregional and distant failure occurred in 2 ($2.6{\%}$) of 77 patients. Pathological confirmation of perirectal fat and/or regional lymph node involvement resulted in a singificant decrease in survival and local control.

• Journal of Pharmaceutical Investigation
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• 제36권1호
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• pp.1-9
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• 2006

Human solid tumors exhibit a multicellular resistance (MCR) resulting from limited drug penetration and decreased sensitivity of tumor cells when interacting with their microenvironments. Multicellular cultures represent solid tumor condition in vivo and provide clinically relevant data. There is little data on antitumor effect of paclitaxel (PTX) in multicellular cultures although its MCR has been demonstrated. In the present study, we evaluated antiproliferative effects of PTX in multicellular layers (MCL) of DLD-1 human colorectal carcinoma cells. BrdU labeling index (LI), thickness of MCL, cell cycle distribution and cellular uptake of calcein were measured before and after exposure to PTX at 0.1 to 50 ${\mu}M$ for 24, 48 and 72 hrs. BrdU LI and thickness of MCL showed a concentration- and time-dependent decrease and the changes in both parameters were similar, i.e., 34.2% and 40.6% decrease in BrdU LI and thickness, respectively, when exposed to $50\;{\mu}M$ for 72 hr. The DLD-1 cells grown in MCL showed increase in $%G_{0}/G_{1}$ and resistance to cell cycle arrest and apoptosis compared to monolayers. Calcein uptake in MCL did not change upon PTX exposure, indicating technical problems in multicellular system. Overall, these data indicate that antitumor activity of PTX may be limited in human solid tumors (a multicellular system) and MCL may be an appropriate model to study further pharmacodynamics of PTX.

• Journal of Korean Neurosurgical Society
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• 제47권1호
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• pp.26-29
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• 2010

Objective: Recurrent lumbar disc herniation has been reported to occur in 5% to 15% of surgically treated primary lumbar disc herniation cases. We investigated the molecular biologic characteristics of primary herniated discs and recurrent discs to see whether the recurrent discs has the similar biological features with primary herniated discs. Methods: Primary hemiated disc and recurrent disc cells were obtained by discectomy of lumbar disc patients and cells were isolated and then taken through monolayer cultures. We compared chondrogenic and osteogenic mRNA gene expression, and western blot between the two groups. Results: The mRNA gene expression of recurrent disc cells were increased 1.47* times for aggrecan, 1.38 times for type I collagen, 2.04 times for type II collagen, 1.22 times for both Sox-9 and osteocalcin, and 1.31 times for alkaline phosphatase, respectively, compared with the primary herniated lumbar disc cells (*indicates p < 0.05). Westem blot results for each aggrecan, type I collagen, type II collagen, Sox-9, osteocalcin, and alkaline phosphatase were similar between the primary herniated disc cells and recurrent disc cells. Conclusion: These results indicate that the recurrent disc cells have similar chondrogenic and osteogenic gene expression compared to primary herniated disc cells. Therefore, we assumed that the regeneration of remaining discs could fill the previous discectomy space and also it could be one of the factors for disc recurrence especially in the molecular biologic field.

• Ocean and Polar Research
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• 제25권1호
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• pp.63-74
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• 2003

The build-up of the heat field in shallow coastal water due to a point source has been investigated using an analytical solution of a time-integral form derived by extending the solutions by Holley(1969) and also presented in Harleman (1971). The uniform water depth is assumed with non-isotropic turbulent dispersion. The alongshore-flow is assumed to be uni-directional, spatially uniform and oscillatory. Due to the presence of the oscillatory alongshore-flow, the heat build-up occurs in an oscillatory manner, and the excess temperature thereby fluctuates in that course and even in the quasi-steady state. A series of calculations reveal that proper choices of the decay coefficient as well as dispersion coefficients are critical to the reliable prediction of the excess temperature field. The dispersion coefficients determine the absolute values of the excess temperature and characterize the shoreline profile, particularly within the tidal excursion distance, while the decay coefficient determines the absolute value of the excess temperature and the convergence rate to that of the quasi-steady state. Within the e-folding time scale $1/k_d$ (where $k_d$ is the heat decay coefficient), heat build-up occurs more than 90% of the quasi-steady state values in a region within a tidal excursion distance (L), while occurs increasingly less the farther we go to the downstream direction (about 80% at 1.25L, and 70% at 1.5L). Calculations with onshore and offshore discharges indicate that thermal spreading in the direction of the shoreline is reduced as the shoreline constraint which controls the lateral mixing is reduced. The importance of collecting long-term records of in situ meteorological conditions and clarifying the definition of the heat loss coefficient is addressed. Interactive use of analytical and numerical modeling is recommended as a desirable way to obtain a reliable estimate of the far-field excess temperature along with extensive field measurements.

• Journal of Chest Surgery
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• 제47권1호
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• pp.20-25
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• 2014

Background: Symptomatic or asymptomatic patients with significant carotid artery stenosis (range, 70% to 99%) generally undergo either carotid artery endarterectomy (CEA) or carotid artery stenting (CAS) to prevent stroke. In this study, we evaluated the cost effectiveness of these two treatment modalities. Methods: A total of 47 patients (mean age, $67.1{\pm}9.1$ years; male, 87.2%) undergoing either CEA (n=28) or CAS (n=19) for the treatment of significant carotid artery stenosis were enrolled in this study. Hospitalization costs were subdivided into three parts, namely pre-procedure, procedure and resource, and post-procedure costs. Results: Total hospitalization costs were similar in both groups of CEA and CAS (6,377 thousand won [TW] vs. 6,703 TW, p=0.255); however, the total cost minus the pre-procedure cost was higher in the CAS group than in the CEA group (4,948 TW vs. 5,941 TW, p<0.0001). The pre-procedure cost of the CEA group was higher than that of the CAS group (1,429 TW vs. 762 TW, p<0.0001). However, the procedure and resource cost was higher in the CAS group because the resource cost was approximately three times higher in the CAS group than in the CEA group. The post-procedure cost was higher in the CEA group because hospital stays were approximately two times longer. Conclusion: The total hospitalization cost was not different between the CEA and the CAS groups. The pre-procedure cost was high in the CEA group, but the cost from procedure onset to discharge, including the resource cost, was significantly lower in this group.

• Journal of Pharmaceutical Investigation
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• 제36권6호
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• pp.385-392
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• 2006

Paclitaxel is an important chemotherapeutic agent for the treatment of human solid tumors. Multicellular resistance(MCR) is considered to be a major mechanism of resistance of human solid tumors to chemotherapeutic agent such as paclitaxel, which includes barriers to drug penetration through tumor tissues. Multicellular layers(MCL) cultures resemble in vivo tumor condition in terms of MCR and has been used successfully to produce clinically relevant data. In the present study, we evaluated the penetration characteristics and post-penetration anti-proliferative activity of paclitaxel using MCL of human colorectal cancer cells(DLD-1 and HT-29) grown in Transwell inserts. The penetration of $[^{14}C]-paclitaxel$ was slower than that of mannitol which penetrates via paracellular pathway in DLD-1 MCL. The penetration of $[^{14}C]-paclitaxel$ was faster in HT-29 MCL compared to DLD-1 MCL, i.e., at 10 ${\mu}M$ 100% and 40% penetration were observed after 48 hr incubation for HT-29 and DLD-1 cells, respectively. When calculated using anti-proliferative activity in the conditioned media of bottom chamber, the penetration after 24 hr was very limited(less than 50%) and concentration-dependent at the concentrations tested in both MCL's. These results suggest that limited and differential penetration of paclitaxel in tumor tissues may contribute to lower and differential efficacy against human solid tumors.

• 한국해안해양공학회지
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• 제7권1호
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• pp.126-134
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• 1995

국립수산진흥원이 관측한 염분자료를 분석하여 여름철 남해의 저염화 현상을 규명하였다. 6월과 8월에 남해 전 수심의 저염화는 강수량과 강물의 유입으로는 설명될 수 없고, 주위 해역 중 유일하게 저염수가 존재하는 제주해협 서편 해역 저염수의 유입으로만 설명이 가능하다. 염보존 Box 모델의 결과에 의하면, 대한해협 서수도의 수송량을 1.4-2.0$\times$$10^{6}$ ㎥/sec이라고 할 때, 이 수송량의 31-36% 정도인 0.5-0.6$\times$$10^{6}$ ㎥/sec(평균유속은 10-13cm/sec)의 수송량이 제주해협을 경유하여 남해로 유입되고, 나머지는 제주도와 대마도 사이로 유입된다.